{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,3]],"date-time":"2026-10-03T18:52:30Z","timestamp":1791053550241,"version":"4.1.0"},"reference-count":17,"publisher":"Springer Science and Business Media LLC","license":[{"start":{"date-parts":[[2026,10,3]],"date-time":"2026-10-03T00:00:00Z","timestamp":1790985600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2026,10,3]],"date-time":"2026-10-03T00:00:00Z","timestamp":1790985600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Gen Thorac Cardiovasc Surg"],"DOI":"10.1007\/s11748-026-02414-4","type":"journal-article","created":{"date-parts":[[2026,10,3]],"date-time":"2026-10-03T05:30:31Z","timestamp":1791005431000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Physiological response following inhaled nitric oxide administration during one-lung ventilation in minimally invasive cardiac surgery: an exploratory prospective cohort study"],"prefix":"10.1007","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0385-6966","authenticated-orcid":false,"given":"Satoshi","family":"Kometani","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shiro","family":"Matsuo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eri","family":"Watanabe","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tomohide","family":"Takei","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Toshiki","family":"Nakamura","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kenichiro","family":"Takahashi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mimiko","family":"Tabata","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,10,3]]},"reference":[{"key":"2414_CR1","doi-asserted-by":"publisher","first-page":"47","DOI":"10.21037\/acs.2017.01.10","volume":"6","author":"KH Rehfeldt","year":"2017","unstructured":"Rehfeldt KH, Andre JV, Ritter MJ. Anesthetic considerations in robotic mitral valve surgery. Ann Cardiothorac Surg. 2017;6:47\u201353.","journal-title":"Ann Cardiothorac Surg"},{"key":"2414_CR2","doi-asserted-by":"publisher","first-page":"99","DOI":"10.1016\/j.xjtc.2023.04.008","volume":"20","author":"H Nakanaga","year":"2023","unstructured":"Nakanaga H, Kinoshita T, Fujii H, Nagashima K, Tabata M. Temporary venovenous extracorporeal membrane oxygenation after cardiopulmonary bypass in minimally invasive cardiac surgery via right minithoracotomy. JTCVS Tech. 2023;20:99\u2013104.","journal-title":"JTCVS Tech"},{"key":"2414_CR3","doi-asserted-by":"publisher","first-page":"311","DOI":"10.1007\/s11748-023-01971-2","volume":"72","author":"E Matsugi","year":"2024","unstructured":"Matsugi E, Takashima S, Doteguchi S, Kobayashi T, Okayasu M. Real-world safety and effectiveness of inhaled nitric oxide therapy for pulmonary hypertension during the perioperative period of cardiac surgery: a post-marketing study of 2817 patients in Japan. Gen Thorac Cardiovasc Surg. 2024;72:311\u201323.","journal-title":"Gen Thorac Cardiovasc Surg"},{"key":"2414_CR4","doi-asserted-by":"publisher","first-page":"1402","DOI":"10.1097\/ALN.0b013e31819fb15d","volume":"110","author":"W Karzai","year":"2009","unstructured":"Karzai W, Schwarzkopf K. Hypoxemia during one-lung ventilation: prediction, prevention, and treatment. Anesthesiology. 2009;110:1402\u201311.","journal-title":"Anesthesiology"},{"key":"2414_CR5","doi-asserted-by":"publisher","first-page":"1029","DOI":"10.1213\/ANE.0000000000007306","volume":"140","author":"A Zorrilla-Vaca","year":"2025","unstructured":"Zorrilla-Vaca A, Grant MC, Mendez-Pino L, Rehman MJ, Sarin P, Nasra S, et al. Preoperative multivariable model for risk stratification of hypoxemia during one-lung ventilation. Anesth Analg. 2025;140:1029\u201336.","journal-title":"Anesth Analg"},{"key":"2414_CR6","doi-asserted-by":"publisher","first-page":"328","DOI":"10.1016\/j.bjae.2023.05.006","volume":"23","author":"S Shum","year":"2023","unstructured":"Shum S, Huang A, Slinger P. Hypoxaemia during one lung ventilation. BJA Educ. 2023;23:328\u201336.","journal-title":"BJA Educ"},{"key":"2414_CR7","doi-asserted-by":"publisher","first-page":"47","DOI":"10.1111\/j.1540-8191.2009.00823.x","volume":"25","author":"E Apostolakis","year":"2010","unstructured":"Apostolakis E, Filos KS, Koletsis E, Dougenis D. Lung dysfunction following cardiopulmonary bypass. J Card Surg. 2010;25:47\u201355.","journal-title":"J Card Surg"},{"key":"2414_CR8","doi-asserted-by":"publisher","first-page":"482","DOI":"10.1016\/S0022-5223(97)70197-1","volume":"114","author":"KA Shastri","year":"1997","unstructured":"Shastri KA, Logue GL, Stern MP, Rehman S, Raza S. Complement activation by heparin-protamine complexes during cardiopulmonary bypass: effect of C4A null allele. J Thorac Cardiovasc Surg. 1997;114:482\u20138.","journal-title":"J Thorac Cardiovasc Surg"},{"key":"2414_CR9","doi-asserted-by":"publisher","first-page":"273","DOI":"10.1186\/s13019-024-02775-y","volume":"19","author":"W Yu","year":"2024","unstructured":"Yu W, Liang Y, Gao J, Xiong J. Study on risk factors and treatment strategies of hypoxemia after acute type A aortic dissection surgery. J Cardiothorac Surg. 2024;19:273.","journal-title":"J Cardiothorac Surg"},{"key":"2414_CR10","doi-asserted-by":"publisher","first-page":"231","DOI":"10.1111\/j.1365-2044.2007.04954.x","volume":"62","author":"E Kottenberg-Assenmacher","year":"2007","unstructured":"Kottenberg-Assenmacher E, Kamler M, Peters J. Minimally invasive endoscopic port-access intracardiac surgery with one lung ventilation: impact on gas exchange and anaesthesia resources. Anaesthesia. 2007;62:231\u20138.","journal-title":"Anaesthesia"},{"key":"2414_CR11","doi-asserted-by":"publisher","first-page":"302","DOI":"10.1213\/ANE.0000000000000808","volume":"121","author":"J Lohser","year":"2015","unstructured":"Lohser J, Slinger P. Lung injury after one-lung ventilation: A review of the pathophysiologic mechanisms affecting the ventilated and the collapsed lung. Anesth Analg. 2015;121:302\u201318.","journal-title":"Anesth Analg"},{"key":"2414_CR12","doi-asserted-by":"publisher","first-page":"478","DOI":"10.1111\/apha.12740","volume":"219","author":"NC Netzer","year":"2017","unstructured":"Netzer NC, Strohl KP, H\u00f6gel J, Gatterer H, Schilz R. Right ventricle dimensions and function in response to acute hypoxia in healthy human subjects. Acta Physiol (Oxf). 2017;219:478\u201385.","journal-title":"Acta Physiol (Oxf)"},{"key":"2414_CR13","first-page":"155698452514058","volume":"1","author":"H Mitsuo","year":"2026","unstructured":"Mitsuo H, Ushijima T, Uchiyama H, Matsuda K, Nishijima T, Shimada M, et al. Inhaled nitric oxide reduces lung injury during cardiac surgery with one-lung ventilation in an experimental pig model. Innovations (Phila). 2026;1:15569845251405829.","journal-title":"Innovations (Phila)"},{"key":"2414_CR14","doi-asserted-by":"publisher","first-page":"488","DOI":"10.1016\/S1010-7940(98)00227-9","volume":"14","author":"B Prendergast","year":"1998","unstructured":"Prendergast B, Scott DH, Mankad PS. Beneficial effects of inhaled nitric oxide in hypoxaemic patients after coronary artery bypass surgery. Eur J Cardiothorac Surg. 1998;14:488\u201393.","journal-title":"Eur J Cardiothorac Surg"},{"key":"2414_CR15","doi-asserted-by":"publisher","first-page":"1372","DOI":"10.1164\/ajrccm.157.5.96-10089","volume":"157","author":"JR Michael","year":"1998","unstructured":"Michael JR, Barton RG, Saffle JR, Mone M, Markewitz BA, Hillier K, et al. Inhaled nitric oxide versus conventional therapy: effect on oxygenation in ARDS. Am J Respir Crit Care Med. 1998;157:1372\u201380.","journal-title":"Am J Respir Crit Care Med"},{"key":"2414_CR16","doi-asserted-by":"publisher","first-page":"1286","DOI":"10.1513\/AnnalsATS.201404-159FR","volume":"11","author":"MG Shashaty","year":"2014","unstructured":"Shashaty MG, Stapleton RD. Physiological and management implications of obesity in critical illness. Ann Am Thorac Soc. 2014;11:1286\u201397.","journal-title":"Ann Am Thorac Soc"},{"key":"2414_CR17","doi-asserted-by":"publisher","first-page":"131","DOI":"10.1183\/20734735.000318","volume":"14","author":"A LoMauro","year":"2018","unstructured":"LoMauro A, Aliverti A. Sex differences in respiratory function. Breathe (Sheff). 2018;14:131\u201340.","journal-title":"Breathe (Sheff)"}],"container-title":["General Thoracic and Cardiovascular Surgery"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s11748-026-02414-4.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s11748-026-02414-4","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s11748-026-02414-4.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,10,3]],"date-time":"2026-10-03T18:02:21Z","timestamp":1791050541000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s11748-026-02414-4"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,10,3]]},"references-count":17,"alternative-id":["2414"],"URL":"https:\/\/doi.org\/10.1007\/s11748-026-02414-4","relation":{},"ISSN":["1863-6705","1863-6713"],"issn-type":[{"value":"1863-6705","type":"print"},{"value":"1863-6713","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,10,3]]},"assertion":[{"value":"25 July 2026","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"25 September 2026","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"3 October 2026","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"The study was approved by the Institutional Review Board of Yamato Seiwa Hospital (Approval No. 1023). Written informed consent was obtained from all patients prior to their inclusion in the study.","order":1,"name":"Ethics","label":"Ethics approval and consent to participate","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"Not applicable.","order":2,"name":"Ethics","label":"Consent for publication","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors declare that they have no competing interests.","order":3,"name":"Ethics","label":"Competing interests","group":{"name":"EthicsHeading","label":"Declarations"}}]}}