{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,2]],"date-time":"2026-08-02T22:08:56Z","timestamp":1785708536587,"version":"3.56.0"},"reference-count":47,"publisher":"Springer Science and Business Media LLC","issue":"5","license":[{"start":{"date-parts":[[2020,7,18]],"date-time":"2020-07-18T00:00:00Z","timestamp":1595030400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2020,7,18]],"date-time":"2020-07-18T00:00:00Z","timestamp":1595030400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"DOI":"10.13039\/100004440","name":"Wellcome Trust","doi-asserted-by":"publisher","award":["215859\/Z\/19\/Z"],"award-info":[{"award-number":["215859\/Z\/19\/Z"]}],"id":[{"id":"10.13039\/100004440","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["J Cancer Surviv"],"published-print":{"date-parts":[[2020,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Purpose<\/jats:title><jats:p>To collate evidence of changes in body composition following treatment of leukaemia in children, teenagers and young adults (CTYA, 0\u201324\u00a0years) with allogeneic haematopoietic stem cell transplant and total body irradiation (HSCT+TBI).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Papers were identified by searching Medline and Google Scholar, reference lists\/citations and contacting key authors, with no date or language restrictions. Inclusion criteria were as follows: leukaemia, HSCT+TBI, aged \u2264\u200924\u00a0years at HSCT and changes in body composition (total fat, central adiposity, adipose tissue function, muscle mass, muscle function). Quality was assessed using a brief Newcastle\u2013Ottawa scale.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Of 900 papers, 20 were included: seven controlled, five uncontrolled studies and eight case reports. Study quality appeared good. There was little evidence of differences in total fat\/weight for HSCT + TBI groups (compared to healthy controls\/population norms\/short stature controls). There was some evidence of significantly higher central adiposity and differences in adipose tissue function (compared to leukaemic\/non-leukaemic controls). Muscle mass was significantly lower (compared to healthy\/obese controls). Muscle function results were inconclusive but suggested impairment. Case reports confirmed a lipodystrophic phenotype.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Early remodelling of adipose tissue and loss of skeletal muscle are evident following HSCT + TBI for CTYA leukaemia, with extreme phenotype of overt lipodystrophy. There is some evidence for reduced muscle effectiveness.<\/jats:p><\/jats:sec><jats:sec><jats:title>Implications for Cancer Survivors<\/jats:title><jats:p>Body composition changes in patients after HSCT + TBI are apparent by early adult life and link with the risk of excess cardiometabolic morbidity seen in adult survivors. Interventions to improve muscle and\/or adipose function, perhaps utilizing nutritional manipulation and\/or targeted activity, should be investigated.<\/jats:p><\/jats:sec>","DOI":"10.1007\/s11764-020-00871-1","type":"journal-article","created":{"date-parts":[[2020,5,9]],"date-time":"2020-05-09T23:03:08Z","timestamp":1589065388000},"page":"624-642","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":17,"title":["Body composition after allogeneic haematopoietic cell transplantation\/total body irradiation in children and young people: a restricted systematic review"],"prefix":"10.1007","volume":"14","author":[{"given":"Ava","family":"Lorenc","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julian","family":"Hamilton-Shield","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rachel","family":"Perry","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Stevens","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"on behalf of the CTYA HSCT Adipose and Muscle Late Effects Working Group","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephen","family":"Wootton","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martin","family":"Feelisch","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lars O.","family":"Dragsted","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marlou","family":"Dirks","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Saeed","family":"Shoaie","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adil","family":"Mardinoglu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Helen","family":"Roche","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2020,7,18]]},"reference":[{"issue":"9","key":"871_CR1","doi-asserted-by":"publisher","first-page":"1657","DOI":"10.1002\/jbmr.2512","volume":"30","author":"S Mostoufi-Moab","year":"2015","unstructured":"Mostoufi-Moab S, Magland J, Isaacoff EJ, Sun W, Rajapakse CS, Zemel B, et al. Adverse fat depots and marrow adiposity are associated with skeletal deficits and insulin resistance in long-term survivors of pediatric hematopoietic stem cell transplantation. J Bone Miner Res. 2015;30(9):1657\u201366.","journal-title":"J Bone Miner Res"},{"issue":"10","key":"871_CR2","doi-asserted-by":"publisher","first-page":"1267","DOI":"10.1001\/jamaoncol.2016.0877","volume":"2","author":"R Skinner","year":"2016","unstructured":"Skinner R, von Zglinicki T. Accelerated aging in bone marrow transplant survivors accelerated aging in bone marrow transplant survivors editorial. JAMA Oncol. 2016;2(10):1267\u20138. https:\/\/doi.org\/10.1001\/jamaoncol.2016.0877.","journal-title":"JAMA Oncol"},{"issue":"2","key":"871_CR3","doi-asserted-by":"publisher","first-page":"575","DOI":"10.1182\/blood.V97.2.575","volume":"97","author":"N Rufer","year":"2001","unstructured":"Rufer N, Br\u00fcmmendorf TH, Chapuis B, Helg C, Lansdorp PM, Roosnek E. Accelerated telomere shortening in hematological lineages is limited to the first year following stem cell transplantation. Blood. 2001;97(2):575\u20137. https:\/\/doi.org\/10.1182\/blood.V97.2.575.","journal-title":"Blood"},{"issue":"11","key":"871_CR4","doi-asserted-by":"publisher","first-page":"1438","DOI":"10.1038\/bmt.2015.167","volume":"50","author":"C Oudin","year":"2015","unstructured":"Oudin C, Auquier P, Bertrand Y, Contet A, Kanold J, Sirvent N, et al. Metabolic syndrome in adults who received hematopoietic stem cell transplantation for acute childhood leukemia: an LEA study. Bone Marrow Transplant. 2015;50(11):1438\u201344.","journal-title":"Bone Marrow Transplant"},{"issue":"1","key":"871_CR5","doi-asserted-by":"publisher","first-page":"122","DOI":"10.1016\/j.jpeds.2011.06.041","volume":"160","author":"S Mostoufi-Moab","year":"2012","unstructured":"Mostoufi-Moab S, Ginsberg JP, Bunin N, Zemel BS, Shults J, Thayu M, et al. Body composition abnormalities in long-term survivors of pediatric hematopoietic stem cell transplantation. J Pediatr. 2012;160(1):122\u20138.","journal-title":"J Pediatr"},{"issue":"10","key":"871_CR6","doi-asserted-by":"publisher","first-page":"1277","DOI":"10.1001\/jamaoncol.2016.0855","volume":"2","author":"M Arora","year":"2016","unstructured":"Arora M, Sun CL, Ness KK, Teh JB, Wu J, Francisco L, et al. Physiologic frailty in nonelderly hematopoietic cell transplantation patients: results from the Bone Marrow Transplant Survivor Study. JAMA Oncol. 2016;2(10):1277\u201386.","journal-title":"JAMA Oncol"},{"key":"871_CR7","doi-asserted-by":"publisher","first-page":"2665","DOI":"10.1007\/s00520-018-4555-9","volume":"27","author":"D Tomlinson","year":"2018","unstructured":"Tomlinson D, Baggott C, Dix D, Gibson P, Hyslop S, Johnston DL, et al. Severely bothersome fatigue in children and adolescents with cancer and hematopoietic stem cell transplant recipients. Support Care Cancer. 2018;27:2665\u201371. https:\/\/doi.org\/10.1007\/s00520-018-4555-9.","journal-title":"Support Care Cancer"},{"issue":"4","key":"871_CR8","doi-asserted-by":"publisher","first-page":"614","DOI":"10.3324\/haematol.2016.150250","volume":"102","author":"Y Inamoto","year":"2017","unstructured":"Inamoto Y, Lee SJ. Late effects of blood and marrow transplantation. Haematologica. 2017;102(4):614\u201325. https:\/\/doi.org\/10.3324\/haematol.2016.150250.","journal-title":"Haematologica."},{"issue":"6","key":"871_CR9","doi-asserted-by":"publisher","first-page":"32","DOI":"10.1007\/s11892-018-0998-0","volume":"18","author":"B Bielorai","year":"2018","unstructured":"Bielorai B, Pinhas-Hamiel O. Type 2 diabetes mellitus, the metabolic syndrome, and its components in adult survivors of acute lymphoblastic leukemia and hematopoietic stem cell transplantations. Curr Diab Rep. 2018;18(6):32. https:\/\/doi.org\/10.1007\/s11892-018-0998-0.","journal-title":"Curr Diab Rep"},{"issue":"11","key":"871_CR10","doi-asserted-by":"publisher","first-page":"1992","DOI":"10.1002\/pbc.25601","volume":"62","author":"C Wei","year":"2015","unstructured":"Wei C, Thyagiarajan MS, Hunt LP, Shield JP, Stevens MC, Crowne EC. Reduced insulin sensitivity in childhood survivors of haematopoietic stem cell transplantation is associated with lipodystropic and sarcopenic phenotypes. Pediatr Blood Cancer. 2015;62(11):1992\u20139.","journal-title":"Pediatr Blood Cancer"},{"issue":"5\u20136","key":"871_CR11","doi-asserted-by":"publisher","first-page":"231","DOI":"10.1242\/dmm.001180","volume":"2","author":"PL Huang","year":"2009","unstructured":"Huang PL. A comprehensive definition for metabolic syndrome. Dis Model Mech. 2009;2(5\u20136):231\u20137. https:\/\/doi.org\/10.1242\/dmm.001180.","journal-title":"Dis Model Mech"},{"issue":"2","key":"871_CR12","doi-asserted-by":"publisher","first-page":"172","DOI":"10.1001\/jama.2010.923","volume":"304","author":"RC Reulen","year":"2010","unstructured":"Reulen RC, Winter DL, Frobisher C, Lancashire ER, Stiller CA, Jenney ME, et al. Long-term cause-specific mortality among survivors of childhood cancer. JAMA. 2010;304(2):172\u20139. https:\/\/doi.org\/10.1001\/jama.2010.923.","journal-title":"JAMA"},{"key":"871_CR13","doi-asserted-by":"publisher","first-page":"129","DOI":"10.1016\/j.critrevonc.2018.10.010","volume":"133","author":"VG Pluimakers","year":"2019","unstructured":"Pluimakers VG, van Waas M, Neggers S, van den Heuvel-Eibrink MM. Metabolic syndrome as cardiovascular risk factor in childhood cancer survivors. Crit Rev Oncol Hematol. 2019;133:129\u201341. https:\/\/doi.org\/10.1016\/j.critrevonc.2018.10.010.","journal-title":"Crit Rev Oncol Hematol"},{"key":"871_CR14","doi-asserted-by":"publisher","unstructured":"Williams HE, Howell CR, Chemaitilly W, Wilson CL, Karol SE, Nolan VG, et al. Diabetes mellitus among adult survivors oc childhood acute lymphoblastic leukemia: a report from the St Jude Lifetime Cohort Study. Cancer. 2019. https:\/\/doi.org\/10.1002\/cncr.32596.","DOI":"10.1002\/cncr.32596"},{"issue":"6","key":"871_CR15","doi-asserted-by":"publisher","first-page":"201","DOI":"10.1136\/bmjebm-2018-110990","volume":"23","author":"A Pl\u00fcddemann","year":"2018","unstructured":"Pl\u00fcddemann A, Aronson JK, Onakpoya I, Heneghan C, Mahtani KR. Redefining rapid reviews: a flexible framework for restricted systematic reviews. BMJ Evid Based Med. 2018;23(6):201\u20133. https:\/\/doi.org\/10.1136\/bmjebm-2018-110990.","journal-title":"BMJ Evid Based Med"},{"issue":"3","key":"871_CR16","doi-asserted-by":"publisher","first-page":"M146","DOI":"10.1093\/gerona\/56.3.m146","volume":"56","author":"LP Fried","year":"2001","unstructured":"Fried LP, Tangen CM, Walston J, Newman AB, Hirsch C, Gottdiener J, et al. Frailty in older adults: evidence for a phenotype. J Gerontol A Biol Sci Med Sci. 2001;56(3):M146\u201356. https:\/\/doi.org\/10.1093\/gerona\/56.3.m146.","journal-title":"J Gerontol A Biol Sci Med Sci"},{"key":"871_CR17","unstructured":"Wells GA, Shea B, O\u2019Connell D, Peterson J, Welch V, Losos M et al. The Newcastle-Ottawa Scale (NOS) for assessing the quality of nonrandomised studies in meta-analyses. 2019. http:\/\/www.ohri.ca\/programs\/clinical_epidemiology\/oxford.asp."},{"issue":"12","key":"871_CR18","doi-asserted-by":"publisher","first-page":"1674","DOI":"10.1016\/j.bbmt.2010.05.016","volume":"16","author":"EJ Chow","year":"2010","unstructured":"Chow EJ, Simmons JH, Roth CL, Baker KS, Hoffmeister PA, Sanders JE, et al. Increased cardiometabolic traits in pediatric survivors of acute lymphoblastic leukemia treated with total body irradiation. Biol Blood Marrow Transplant. 2010;16(12):1674\u201381.","journal-title":"Biol Blood Marrow Transplant"},{"issue":"4","key":"871_CR19","doi-asserted-by":"publisher","first-page":"508","DOI":"10.1111\/cen.12773","volume":"83","author":"NL Davis","year":"2015","unstructured":"Davis NL, Stewart CE, Moss AD, Woltersdorf WW, Hunt LP, Elson RA, et al. Growth hormone deficiency after childhood bone marrow transplantation with total body irradiation: interaction with adiposity and age. Clin Endocrinol. 2015;83(4):508\u201317.","journal-title":"Clin Endocrinol"},{"issue":"8","key":"871_CR20","doi-asserted-by":"publisher","first-page":"817","DOI":"10.1038\/sj.bmt.1703012","volume":"27","author":"K Nysom","year":"2001","unstructured":"Nysom K, Holm K, Michaelsen KF, Hertz H, Jacobsen N, Muller J, et al. Degree of fatness after allogeneic BMT for childhood leukaemia or lymphoma. Bone Marrow Transplant. 2001;27(8):817\u201320.","journal-title":"Bone Marrow Transplant"},{"issue":"4","key":"871_CR21","doi-asserted-by":"publisher","first-page":"276","DOI":"10.1097\/MPH.0b013e3182830ffa","volume":"35","author":"MH Taskinen","year":"2013","unstructured":"Taskinen MH, Kurimo M, Kanerva J, Hovi L. Physical performance of nontransplanted childhood ALL survivors is comparable to healthy controls. J Pediatr Hematol Oncol. 2013;35(4):276\u201380.","journal-title":"J Pediatr Hematol Oncol"},{"issue":"2","key":"871_CR22","doi-asserted-by":"publisher","first-page":"116","DOI":"10.1159\/000455046","volume":"87","author":"C Wei","year":"2017","unstructured":"Wei C, Hunt L, Cox R, Bradley K, Elson R, Shield J, et al. Identifying cardiovascular risk in survivors of childhood leukaemia treated with haematopoietic stem cell transplantation and total body irradiation. Horm Res Paediatr. 2017;87(2):116\u201322.","journal-title":"Horm Res Paediatr"},{"key":"871_CR23","unstructured":"Davis NL, Tolfrey K, Jenney ME, Elson R, Stewart CB, Moss AD et al. Combined resistance and aerobic exercise intervention improves fitness, insulin resistance, and quality of life (QoL) in survivors of childhood haemopoietic stem cell transplantation (HSCT) with total body irradiation (TBI). IN PREPARATION. ND."},{"issue":"4","key":"871_CR24","doi-asserted-by":"publisher","first-page":"313","DOI":"10.3109\/08880018.2012.666781","volume":"29","author":"F Freycon","year":"2012","unstructured":"Freycon F, Trombert-Paviot B, Casagranda L, Mialou V, Berlier P, Berger C, et al. Final height and body mass index after fractionated total body irradiation and allogeneic stem cell transplantation in childhood leukemia. Pediatr Hematol Oncol. 2012;29(4):313\u201321.","journal-title":"Pediatr Hematol Oncol"},{"issue":"6","key":"871_CR25","doi-asserted-by":"publisher","first-page":"339","DOI":"10.1038\/bmt.2009.40","volume":"44","author":"W Chemaitilly","year":"2009","unstructured":"Chemaitilly W, Boulad F, Oeffinger KC, Sklar CA. Disorders of glucose homeostasis in young adults treated with total body irradiation during childhood: a pilot study. Bone Marrow Transplant. 2009;44(6):339\u201343.","journal-title":"Bone Marrow Transplant"},{"issue":"2","key":"871_CR26","doi-asserted-by":"publisher","first-page":"99","DOI":"10.1297\/cpe.26.99","volume":"26","author":"M Adachi","year":"2017","unstructured":"Adachi M, Oto Y, Muroya K, Hanakawa J, Asakura Y, Goto H. Partial lipodystrophy in patients who have undergone hematopoietic stem cell transplantation during childhood: an institutional cross-sectional survey. Clin Pediatr Endocrinol. 2017;26(2):99\u2013108.","journal-title":"Clin Pediatr Endocrinol"},{"issue":"32","key":"871_CR27","doi-asserted-by":"publisher","first-page":"3991","DOI":"10.1200\/JCO.2011.40.0457","volume":"30","author":"H Inaba","year":"2012","unstructured":"Inaba H, Yang J, Kaste SC, Hartford CM, Motosue MS, Chemaitilly W, et al. Longitudinal changes in body mass and composition in survivors of childhood hematologic malignancies after allogeneic hematopoietic stem-cell transplantation. J Clin Oncol. 2012;30(32):3991\u20137.","journal-title":"J Clin Oncol"},{"issue":"11","key":"871_CR28","doi-asserted-by":"publisher","first-page":"1273","DOI":"10.1007\/s40618-017-0731-x","volume":"40","author":"G Ceccarini","year":"2017","unstructured":"Ceccarini G, Ferrari F, Santini F. Acquired partial lipodystrophy after bone marrow transplant during childhood: a novel syndrome to be added to the disease classification list. J Endocrinol Investig. 2017;40(11):1273\u20134.","journal-title":"J Endocrinol Investig"},{"key":"871_CR29","doi-asserted-by":"crossref","unstructured":"Kimura L, Alvarez G, Li N, Pawlikowska-Haddal A, Moore TB, Casillas J, et al. Temporary resolution of insulin requirement in acquired partial lipodystrophy associated with chronic graft-versus-host disease. Pediatr Blood Cancer. 2017;64(7).","DOI":"10.1002\/pbc.26427"},{"issue":"8","key":"871_CR30","doi-asserted-by":"publisher","first-page":"e239","DOI":"10.1111\/dme.12234","volume":"30","author":"R Rajendran","year":"2013","unstructured":"Rajendran R, Abu E, Fadl A, Byrne CD. Late effects of childhood cancer treatment: severe hypertriglyceridaemia, central obesity, non alcoholic fatty liver disease and diabetes as complications of childhood total body irradiation. Diabet Med. 2013;30(8):e239\u2013e42. https:\/\/doi.org\/10.1111\/dme.12234.","journal-title":"Diabet Med"},{"issue":"4","key":"871_CR31","doi-asserted-by":"publisher","first-page":"436","DOI":"10.1111\/j.1464-5491.2006.01855.x","volume":"23","author":"DP Rooney","year":"2006","unstructured":"Rooney DP, Ryan MF. Diabetes with partial lipodystrophy following sclerodermatous chronic graft vs. host disease. Diabet Med. 2006;23(4):436\u201340.","journal-title":"Diabet Med"},{"issue":"4","key":"871_CR32","doi-asserted-by":"publisher","first-page":"53","DOI":"10.1297\/cpe.22.53","volume":"22","author":"M Adachi","year":"2013","unstructured":"Adachi M, Asakura Y, Muroya K, Goto H, Kigasawa H. Abnormal adipose tissue distribution with unfavorable metabolic profile in five children following hematopoietic stem cell transplantation: a new etiology for acquired partial lipodystrophy. Clin Pediatr Endocrinol. 2013;22(4):53\u201364.","journal-title":"Clin Pediatr Endocrinol"},{"issue":"5","key":"871_CR33","doi-asserted-by":"publisher","first-page":"537","DOI":"10.1515\/jpem-2018-0356","volume":"32","author":"M Hosokawa","year":"2019","unstructured":"Hosokawa M, Shibata H, Hosokawa T, Irie J, Ito H, Hasegawa T. Acquired partial lipodystrophy with metabolic disease in children following hematopoietic stem cell transplantation: a report of two cases and a review of the literature. J Pediatr Endocrinol Metab. 2019;32(5):537. https:\/\/doi.org\/10.1515\/jpem-2018-0356.","journal-title":"J Pediatr Endocrinol Metab"},{"issue":"1","key":"871_CR34","doi-asserted-by":"publisher","first-page":"51","DOI":"10.4158\/EP12115.OR","volume":"19","author":"SE Mayson","year":"2013","unstructured":"Mayson SE, Parker VE, Schutta MH, Semple RK, Rickels MR. Severe insulin resistance and hypertriglyceridemia after childhood total body irradiation. Endocr Pract. 2013;19(1):51\u20138.","journal-title":"Endocr Pract"},{"issue":"10","key":"871_CR35","doi-asserted-by":"publisher","first-page":"849","DOI":"10.1046\/j.1464-5491.2001.00591.x","volume":"18","author":"P Amin","year":"2001","unstructured":"Amin P, Shah S, Walker D, Page SR. Adverse metabolic and cardiovascular risk following treatment of acute lymphoblastic leukaemia in childhood; two case reports and a literature review. Diabet Med. 2001;18(10):849\u201353. https:\/\/doi.org\/10.1046\/j.1464-5491.2001.00591.x.","journal-title":"Diabet Med"},{"issue":"3","key":"871_CR36","doi-asserted-by":"crossref","first-page":"97","DOI":"10.4103\/2230-8229.97535","volume":"13","author":"AI Al-Sultan","year":"2006","unstructured":"Al-Sultan AI, Al-Elq AH. Leptin levels in normal weight and obese saudi adults. J Fam Community Med. 2006;13(3):97\u2013102.","journal-title":"J Fam Community Med"},{"issue":"11","key":"871_CR37","doi-asserted-by":"publisher","first-page":"4401","DOI":"10.1210\/jc.2006-0128","volume":"91","author":"KA Neville","year":"2006","unstructured":"Neville KA, Cohn RJ, Steinbeck KS, Johnston K, Walker JL. Hyperinsulinemia, impaired glucose tolerance, and diabetes mellitus in survivors of childhood cancer: prevalence and risk factors. J Clin Endocrinol Metab. 2006;91(11):4401\u20137.","journal-title":"J Clin Endocrinol Metab"},{"issue":"9234","key":"871_CR38","doi-asserted-by":"publisher","first-page":"993","DOI":"10.1016\/s0140-6736(00)02717-3","volume":"356","author":"M Taskinen","year":"2000","unstructured":"Taskinen M, Saarinen-Pihkala UM, Hovi L, Lipsanen-Nyman M. Impaired glucose tolerance and dyslipidaemia as late effects after bone-marrow transplantation in childhood. Lancet. 2000;356(9234):993\u20137. https:\/\/doi.org\/10.1016\/s0140-6736(00)02717-3.","journal-title":"Lancet"},{"issue":"3","key":"871_CR39","doi-asserted-by":"publisher","first-page":"93","DOI":"10.1016\/j.retram.2018.12.001","volume":"67","author":"J Jabbour","year":"2019","unstructured":"Jabbour J, Manana B, Zahreddine A, Saade C, Charafeddine M, Bazarbachi A, et al. Sarcopenic obesity derived from PET\/CT predicts mortality in lymphoma patients undergoing hematopoietic stem cell transplantation. Curr Res Transl Med. 2019;67(3):93\u20139. https:\/\/doi.org\/10.1016\/j.retram.2018.12.001.","journal-title":"Curr Res Transl Med"},{"issue":"1","key":"871_CR40","doi-asserted-by":"publisher","first-page":"1","DOI":"10.5144\/1658-3876.2012.1","volume":"5","author":"NS Majhail","year":"2012","unstructured":"Majhail NS, Douglas Rizzo J, Lee SJ, Aljurf M, Atsuta Y, Bonfim C, et al. Recommended screening and preventive practices for long-term survivors after hematopoietic cell transplantation. Hematol\/Oncol Stem Cell Ther. 2012;5(1):1\u201330. https:\/\/doi.org\/10.5144\/1658-3876.2012.1.","journal-title":"Hematol\/Oncol Stem Cell Ther"},{"issue":"8","key":"871_CR41","doi-asserted-by":"publisher","first-page":"1197","DOI":"10.1182\/blood-2010-03-276576","volume":"116","author":"ML Griffith","year":"2010","unstructured":"Griffith ML, Savani BN, Boord JB. Dyslipidemia after allogeneic hematopoietic stem cell transplantation: evaluation and management. Blood. 2010;116(8):1197\u2013204. https:\/\/doi.org\/10.1182\/blood-2010-03-276576.","journal-title":"Blood"},{"issue":"6","key":"871_CR42","doi-asserted-by":"crossref","first-page":"1045","DOI":"10.1249\/MSS.0b013e3181c4dac1","volume":"42","author":"C Chamorro-Vina","year":"2010","unstructured":"Chamorro-Vina C, Ruiz JR, Santana-Sosa E, Gonzalez Vicent M, Madero L, Perez M, et al. Exercise during hematopoietic stem cell transplant hospitalization in children. Med Sci Sports Exerc. 2010;42(6):1045\u201353.","journal-title":"Med Sci Sports Exerc"},{"issue":"2","key":"871_CR43","doi-asserted-by":"publisher","first-page":"148","DOI":"10.1111\/j.1600-0609.2011.01640.x","volume":"87","author":"FT Baumann","year":"2011","unstructured":"Baumann FT, Zopf EM, Nykamp E, Kraut L, Sch\u00fcle K, Elter T, et al. Physical activity for patients undergoing an allogeneic hematopoietic stem cell transplantation: benefits of a moderate exercise intervention. Eur J Haematol. 2011;87(2):148\u201356. https:\/\/doi.org\/10.1111\/j.1600-0609.2011.01640.x.","journal-title":"Eur J Haematol"},{"issue":"5","key":"871_CR44","doi-asserted-by":"publisher","first-page":"331","DOI":"10.1038\/sj.bmt.1703867","volume":"31","author":"S Hayes","year":"2003","unstructured":"Hayes S, Davies PS, Parker T, Bashford J. Total energy expenditure and body composition changes following peripheral blood stem cell transplantation and participation in an exercise programme. Bone Marrow Transplant. 2003;31(5):331\u20138.","journal-title":"Bone Marrow Transplant"},{"key":"871_CR45","doi-asserted-by":"publisher","first-page":"68","DOI":"10.1016\/j.nutres.2017.08.002","volume":"46","author":"G Ren","year":"2017","unstructured":"Ren G, Zhang J, Li M, Yi S, Xie J, Zhang H, et al. Protein blend ingestion before allogeneic stem cell transplantation improves protein-energy malnutrition in patients with leukemia. Nutr Res. 2017;46:68\u201377.","journal-title":"Nutr Res"},{"issue":"2","key":"871_CR46","doi-asserted-by":"publisher","first-page":"216","DOI":"10.1188\/11.ONF.216-223","volume":"38","author":"ED Hacker","year":"2011","unstructured":"Hacker ED, Larson JL, Peace D. Exercise in patients receiving hematopoietic stem cell transplantation: lessons learned and results from a feasibility study. Oncol Nurs Forum. 2011;38(2):216\u201323.","journal-title":"Oncol Nurs Forum"},{"issue":"9","key":"871_CR47","doi-asserted-by":"publisher","first-page":"1239","DOI":"10.1038\/s41430-018-0239-2","volume":"72","author":"C Maffeis","year":"2018","unstructured":"Maffeis C, Morandi A. Body composition and insulin resistance in children. Eur J Clin Nutr. 2018;72(9):1239\u201345. https:\/\/doi.org\/10.1038\/s41430-018-0239-2.","journal-title":"Eur J Clin Nutr"}],"container-title":["Journal of Cancer Survivorship"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s11764-020-00871-1.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s11764-020-00871-1\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s11764-020-00871-1.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,30]],"date-time":"2023-09-30T21:32:31Z","timestamp":1696109551000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s11764-020-00871-1"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,7,18]]},"references-count":47,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2020,10]]}},"alternative-id":["871"],"URL":"https:\/\/doi.org\/10.1007\/s11764-020-00871-1","relation":{},"ISSN":["1932-2259","1932-2267"],"issn-type":[{"value":"1932-2259","type":"print"},{"value":"1932-2267","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,7,18]]},"assertion":[{"value":"25 November 2019","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"29 February 2020","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"18 July 2020","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Compliance with ethical standards"}},{"value":"The views expressed in this publication are those of the authors and not necessarily those of the NHS, the National Institute for Health Research or the Department of Health.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Disclaimer"}},{"value":"The authors declare that they have no conflict of interest.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}},{"value":"This article does not contain any studies with human participants performed by any of the authors","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical approval"}}]}}