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We assessed the prevalence of EIS in CCS and identified associated risk factors.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We included CCS aged 6\u201321 years who were diagnosed with cancer\u2009\u2265\u20091 year before study entry, were treated with\u00a0systemic anticancer treatment, chest surgery, radiotherapy, or hematopoietic stem cell transplantation,\u00a0completed cancer treatment,\u00a0and\u00a0received pediatric oncology follow-up care.\u00a0Participants completed a questionnaire on respiratory symptoms and lifestyle. To explore risk factors of EIS, we used multivariable logistic regression and calculated population attributable fractions (PAFs).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Of 196 participants (median age 14 years [IQR 10\u201317]), 46 (24%) reported EIS, including dyspnea (14%), cough (12%), and wheeze (7%). EIS were more common among females (OR 2.5, 95% CI 1.1\u20135.9), older survivors (OR 1.2 per year, 95% CI 1.1\u20131.3,), and those with obesity (OR 4.7, 95% CI 1.1\u201319.6), asthma (OR 10.1, 95% CI 3.3\u201331.2), and physical inactivity (OR 2.9, 95% CI 1.3\u20136.6). Chest-directed radiotherapy tended also to increase the risk (OR 2.4, 95% CI 0.6\u20139.2). Twenty percent of EIS were attributable to asthma, 18% to physical inactivity, and 7% to obesity, with a combined PAF of 44%.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>EIS affect one in four CCS and are primarily associated with risk factors common in the general population rather than cancer treatments.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Implications for Cancer Survivors<\/jats:title>\n                    <jats:p>Clinical investigation and management of common causes of EIS, particularly asthma, physical inactivity, and obesity, could reduce symptom burden and support long-term health in CCS.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1007\/s11764-025-01877-3","type":"journal-article","created":{"date-parts":[[2025,8,15]],"date-time":"2025-08-15T16:28:37Z","timestamp":1755275317000},"page":"1894-1902","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Exercise-induced symptoms in young childhood cancer survivors"],"prefix":"10.1007","volume":"20","author":[{"given":"Ma\u0161a","family":"\u017darkovi\u0107","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carina","family":"Nigg","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christina","family":"Schindera","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Myrofora","family":"Goutaki","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sonja","family":"L\u00fcer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marc","family":"Ansari","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claudia E.","family":"Kuehni","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2025,8,15]]},"reference":[{"key":"1877_CR1","doi-asserted-by":"publisher","first-page":"217","DOI":"10.1002\/PPUL.25126","volume":"56","author":"ESL Pedersen","year":"2021","unstructured":"Pedersen ESL, Ardura-Garcia C, de Jong CCM, et al. 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