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Our aim was to characterize symptom burden among long-term survivors of YA cancer.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Project Milestones is a cross-sectional cohort survey study assessing benchmarks of emerging adulthood among 3\u201310-year cancer survivors diagnosed 21\u201339\u00a0years old. We analyzed responses from the first half of cohort participants to 22 questions that screened for current, clinically significant symptoms. Statistical analyses included Chi-square, Fisher exact, and negative binomial regression tests.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>There were 1,025 evaluable participants (68.9% female; 34.2% Hispanic; median age at diagnosis and survey 31 and 39\u00a0years, respectively; and 73%\u2009\u2265\u20095\u00a0years post-treatment). Cancer types were reproductive (male\/female, 30.4%), leukemia\/lymphoma (28.2%), thyroid (13.5%), breast (10.3%), melanoma (8.9%), and colorectal (8.8%). The most-endorsed symptoms were fatigue (39.4%), altered appearance (35.8%), cognitive problems (31.7%), general pain (28.0%), sensory neuropathy (24%), and urinary incontinence (20%). Over 70% reported at least 1 symptom; one-third reported\u2009\u2265\u20094. In adjusted analysis, cumulative symptom count was significantly higher among participants who were female (vs. male), Hispanic (vs. non-Hispanic White), had public insurance (vs. employer-sponsored), and received chemotherapy\/radiation (vs. surgery) by 44%, 21%, 49%, and 71%, respectively.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Long-term survivors of YA cancer report a substantial burden of persistent, clinically significant symptoms.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Implications for Cancer Survivors<\/jats:title>\n                    <jats:p>Clinicians should emphasize the importance of sustained survivorship care and monitor for symptoms suggesting late effects. Further research is needed to understand their contributing factors and functional impact.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1007\/s11764-026-01986-7","type":"journal-article","created":{"date-parts":[[2026,2,20]],"date-time":"2026-02-20T00:14:06Z","timestamp":1771546446000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Symptom burden among long-term survivors of young adult cancer: a report from the Project Milestones cohort"],"prefix":"10.1007","author":[{"given":"David R.","family":"Freyer","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marcie D.","family":"Haydon","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rebecca K.","family":"Kelly","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Erin M.","family":"Mobley","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wendy","family":"Mack","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael E.","family":"Roth","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kimberly A.","family":"Miller","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ann S.","family":"Hamilton","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joel E.","family":"Milam","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,2,20]]},"reference":[{"key":"1986_CR1","unstructured":"Surveillance, E., and End Results (SEER) Program, National Cancer Institute, Cancer Stat Facts: Cancer Among Adolescents and Young Adults (AYAs) (Ages 15\u201339). 2021."},{"issue":"11","key":"1986_CR2","doi-asserted-by":"publisher","first-page":"1784","DOI":"10.1093\/jnci\/djae135","volume":"116","author":"E Tonorezos","year":"2024","unstructured":"Tonorezos E, et al. 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