{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,21]],"date-time":"2026-02-21T09:12:31Z","timestamp":1771665151652,"version":"3.50.1"},"reference-count":19,"publisher":"Springer Science and Business Media LLC","license":[{"start":{"date-parts":[[2026,2,21]],"date-time":"2026-02-21T00:00:00Z","timestamp":1771632000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"},{"start":{"date-parts":[[2026,2,21]],"date-time":"2026-02-21T00:00:00Z","timestamp":1771632000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["J Cancer Surviv"],"DOI":"10.1007\/s11764-026-01989-4","type":"journal-article","created":{"date-parts":[[2026,2,21]],"date-time":"2026-02-21T08:13:59Z","timestamp":1771661639000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Understanding the lived experience of colorectal cancer: a qualitative study of patient and clinician perspectives"],"prefix":"10.1007","author":[{"given":"Barry D.","family":"Stein","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lois","family":"Downes","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nicole","family":"Sheahan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zorana","family":"Maravic","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Akihito","family":"Kawazoe","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Isabelle","family":"Guillemin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael","family":"Leibfried","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Peter","family":"Trask","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2026,2,21]]},"reference":[{"key":"1989_CR1","unstructured":"WHO. Colorectal cancer [Internet]. 2025. Available from: https:\/\/www.who.int\/news-room\/fact-sheets\/detail\/colorectal-cancer"},{"issue":"1","key":"1989_CR2","doi-asserted-by":"publisher","DOI":"10.1038\/srep29765","volume":"6","author":"M Riihim\u00e4ki","year":"2016","unstructured":"Riihim\u00e4ki M, Hemminki A, Sundquist J, Hemminki K. Patterns of metastasis in colon and rectal cancer. Sci Rep. 2016;6(1):29765. https:\/\/doi.org\/10.1038\/srep29765.","journal-title":"Sci Rep"},{"key":"1989_CR3","unstructured":"CDC. Symptoms of Colorectal Cancer [Internet]. Colorectal Cancer. 2024 Jun 12. Available from: https:\/\/www.cdc.gov\/colorectal-cancer\/symptoms\/index.html"},{"key":"1989_CR4","unstructured":"Wang L. Study Identifies Potential Warning Signs of Colorectal Cancer in Younger Adults was originally published by the National Cancer Institute. (nciglobal, ncienterprise) [CgvBlogPost]. 2023 Jun 15. Available from: https:\/\/www.cancer.gov\/news-events\/cancer-currents-blog\/2023\/colorectal-cancer-young-people-warning-signs"},{"issue":"3","key":"1989_CR5","doi-asserted-by":"publisher","first-page":"761","DOI":"10.1007\/s11764-022-01279-9","volume":"18","author":"I Guillemin","year":"2024","unstructured":"Guillemin I, Darpelly M, Wong B, Ingelg\u00e5rd A, Griebsch I. Development of a disease conceptual model of patient experience with metastatic colorectal cancer: identification of the most salient symptoms and impacts. J Cancer Surviv. 2024;18(3):761\u201371. https:\/\/doi.org\/10.1007\/s11764-022-01279-9.","journal-title":"J Cancer Surviv"},{"key":"1989_CR6","unstructured":"NHS (UK). Treatment options for colon cancer [Internet]. 2025. Available from: https:\/\/www.cancerresearchuk.org\/about-cancer\/bowel-cancer\/treatment\/treatment-colon\/treatment-decisions"},{"key":"1989_CR7","unstructured":"Menon G, Cagir B. Colon Cancer. In: StatPearls. StatPearls Publishing; 2025. Available from: http:\/\/www.ncbi.nlm.nih.gov\/books\/NBK470380\/"},{"issue":"12","key":"1989_CR8","doi-asserted-by":"publisher","first-page":"1683","DOI":"10.1093\/jnci\/djab124","volume":"113","author":"A Cercek","year":"2021","unstructured":"Cercek A, Chatila WK, Yaeger R, Walch H, Fernandes GDS, Krishnan A, et al. A comprehensive comparison of early-onset and average-onset colorectal cancers. J Natl Cancer Inst. 2021;113(12):1683\u201392. https:\/\/doi.org\/10.1093\/jnci\/djab124.","journal-title":"J Natl Cancer Inst"},{"issue":"8","key":"1989_CR9","doi-asserted-by":"publisher","first-page":"883","DOI":"10.1093\/jnci\/djad093","volume":"115","author":"T Yen","year":"2023","unstructured":"Yen T, Patel SG. Symptoms and early-onset colorectal cancer: red flags are common flags! J Natl Cancer Inst. 2023;115(8):883\u20135. https:\/\/doi.org\/10.1093\/jnci\/djad093.","journal-title":"J Natl Cancer Inst"},{"issue":"4","key":"1989_CR10","doi-asserted-by":"publisher","first-page":"293","DOI":"10.1016\/j.clcc.2017.06.002","volume":"16","author":"H Yeo","year":"2017","unstructured":"Yeo H, Betel D, Abelson JS, Zheng XE, Yantiss R, Shah MA. Early-onset colorectal cancer is distinct from traditional colorectal cancer. Clin Colorectal Cancer. 2017;16(4):293-9.e6. https:\/\/doi.org\/10.1016\/j.clcc.2017.06.002.","journal-title":"Clin Colorectal Cancer"},{"key":"1989_CR11","doi-asserted-by":"crossref","unstructured":"Demb J, Kolb JM, Dounel J, Fritz CDL, Advani SM, Cao Y, et al. Red flag signs and symptoms for patients with early-onset colorectal cancer: a systematic review and meta-analysis. JAMA Netw Open. 2024 May 1;7(5):e2413157. Available from: https:\/\/jamanetwork.com\/journals\/jamanetworkopen\/fullarticle\/2819248","DOI":"10.1001\/jamanetworkopen.2024.13157"},{"key":"1989_CR12","doi-asserted-by":"publisher","DOI":"10.1007\/s00520-024-08903-7","volume":"32","author":"D Fernandes","year":"2024","unstructured":"Fernandes D, Nelson D, Ortega M, et al. Non-gastrointestinal symptom burden following colorectal cancer treatment\u2014a systematic review. Support Care Cancer. 2024;32:699. https:\/\/doi.org\/10.1007\/s00520-024-08903-7.","journal-title":"Support Care Cancer"},{"key":"1989_CR13","doi-asserted-by":"publisher","unstructured":"Russel A, Reid H, Coleman HG, Santin O. Understanding the treatment experiences of adults diagnosed with early-onset colorectal cancer: a qualitative study. Psycho-Oncology. 2024;33(7). Available from: https:\/\/doi.org\/10.1002\/pon.6367","DOI":"10.1002\/pon.6367"},{"issue":"12","key":"1989_CR14","doi-asserted-by":"publisher","first-page":"2179","DOI":"10.1136\/gutjnl-2019-319511","volume":"68","author":"RL Siegel","year":"2019","unstructured":"Siegel RL, Torre LA, Soerjomataram I, Hayes RB, Bray F, Weber TK, et al. Global patterns and trends in colorectal cancer incidence in young adults. Gut. 2019;68(12):2179\u201385. https:\/\/doi.org\/10.1136\/gutjnl-2019-319511.","journal-title":"Gut"},{"issue":"8","key":"1989_CR15","doi-asserted-by":"publisher","first-page":"967","DOI":"10.1016\/j.jval.2011.06.014","volume":"14","author":"DL Patrick","year":"2011","unstructured":"Patrick DL, Burke LB, Gwaltney CJ, Leidy NK, Martin ML, Molsen E, et al. Content validity - establishing and reporting the evidence in newly developed patient-reported outcomes (PRO) instruments for medical product evaluation: ISPOR PRO good research practices task force report: part 1 - eliciting concepts for a new PRO instrument. Value Health. 2011;14(8):967\u201377. https:\/\/doi.org\/10.1016\/j.jval.2011.06.014.","journal-title":"Value Health"},{"issue":"8","key":"1989_CR16","doi-asserted-by":"publisher","first-page":"978","DOI":"10.1016\/j.jval.2011.06.013","volume":"14","author":"DL Patrick","year":"2011","unstructured":"Patrick DL, Burke LB, Gwaltney CJ, Leidy NK, Martin ML, Molsen E, et al. Content validity\u2013establishing and reporting the evidence in newly developed patient-reported outcomes (PRO) instruments for medical product evaluation: ISPOR PRO good research practices task force report: part 2\u2013assessing respondent understanding. Value Health. 2011;14(8):978\u201388. https:\/\/doi.org\/10.1016\/j.jval.2011.06.013.","journal-title":"Value Health"},{"issue":"20","key":"1989_CR17","doi-asserted-by":"publisher","first-page":"2191","DOI":"10.1001\/jama.2013.281053","volume":"310","author":"World Medical Association","year":"2013","unstructured":"World Medical Association. World Medical Association declaration of Helsinki: ethical principles for medical research involving human subjects. JAMA. 2013;310(20):2191\u20134. https:\/\/doi.org\/10.1001\/jama.2013.281053.","journal-title":"JAMA"},{"key":"1989_CR18","unstructured":"Center for Drug Evaluation and Research. Patient-focused drug development: methods to identify what is important to patients [Internet]. FDA. 2025 Jan 31. Available from: https:\/\/www.fda.gov\/regulatory-information\/search-fda-guidance-documents\/patient-focused-drug-development-methods-identify-what-important-patients"},{"issue":"6","key":"1989_CR19","doi-asserted-by":"publisher","first-page":"349","DOI":"10.1093\/intqhc\/mzm042","volume":"19","author":"A Tong","year":"2007","unstructured":"Tong A, Sainsbury P, Craig J. Consolidated criteria for reporting qualitative research (COREQ): a 32-item checklist for interviews and focus groups. Int J Qual Health Care. 2007;19(6):349\u201357. https:\/\/doi.org\/10.1093\/intqhc\/mzm042.","journal-title":"Int J Qual Health Care"}],"container-title":["Journal of Cancer Survivorship"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s11764-026-01989-4.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s11764-026-01989-4","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s11764-026-01989-4.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,2,21]],"date-time":"2026-02-21T08:14:01Z","timestamp":1771661641000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s11764-026-01989-4"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,2,21]]},"references-count":19,"alternative-id":["1989"],"URL":"https:\/\/doi.org\/10.1007\/s11764-026-01989-4","relation":{},"ISSN":["1932-2259","1932-2267"],"issn-type":[{"value":"1932-2259","type":"print"},{"value":"1932-2267","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,2,21]]},"assertion":[{"value":"14 November 2025","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"9 February 2026","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"21 February 2026","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"This was a non-interventional, qualitative interview study conducted in the United States, United Kingdom, Germany, and Japan. Ethical approval or exemption was obtained in accordance with local regulations in each country\n                      .\n                      The study was conducted in line with the Declaration of Helsinki and, where applicable, Good Clinical Practice and Institutional Review Board (IRB) requirements.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval"}},{"value":"Informed consent was obtained from all individual participants included in the study.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent to participate"}},{"value":"Not applicable, as no identifiable personal data, images, or quotes have been included in the manuscript.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"B. D. Stein has received grants, support for attending and travel to meetings, and honoraria in an advisory role from Roche Canada, unrelated to this manuscript. L. Downes is an employee of Roche. N. Sheahan has received grants on behalf of Global Colon Cancer Association from Amgen, Bayer, Bristol Myers Squibb, Boehringer Ingelheim, Daiichi Sankyo, Exeloxis, GSK, Novartis, Roche and Takeda. Z. Maravic has received grants on behalf of Digestive Cancers Europe from Amgen, Astellas, AstraZeneca, Bayer, BeiGene, BI, BMS, Daiichi-Sankyo, GSK, Jazz Pharmaceuticals, Merck, MSD, Novartis, Pierre-Fabre, Roche, Sandoz, Servier and Takeda. A. Kawazone has received grants from AstraZeneca and Abbvie, honoraria from Abbvie, Taiho Pharmaceutical, Bristol Myers Squibb, Merck Serono, Ono and Daiichi Sankyo, and has participated in data safety monitoring\/advisory boards for Zymeworks, Abbvie and GSK. I. Guillemin is an employee of IQVIA who received payment as a consultancy company for Roche. M. Leibfried is an employee of Genentech. P. Trask is an employee of and holds stock options in Roche\/Genentech.\u00a0The results of the study have been presented clearly, honestly, and without fabrication, falsification, or inappropriate data manipulation.","order":5,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}]}}