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We sought to assess independent and combined effects of these factors on healthcare utilization and self-reported well-being.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>All of Us Research Program was used to identify participants with cancer and\/or PTSD, as well as individuals with neither. SDoH burden, healthcare utilization, and well-being were assessed relative to PTSD on multivariable logistic regression adjusting for sociodemographic factors.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Among 16,261 participants, 11.6% (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u20091895) had cancer, 1.4% (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u2009228) had cancer and PTSD, and 20.1% (\n                      <jats:italic>n\u2009<\/jats:italic>\n                      =\u20093281) had PTSD alone. PTSD was associated with higher odds of emergency room visits (aOR 4.16, 95% CI 3.80\u20134.55), poor mental (aOR 3.77, 95% CI 3.43\u20134.14), and emotional health (aOR 3.76, 95% CI 3.41\u20134.16) (all\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001). High SDoH burden independently predicted increased inpatient and emergency visits (aOR 1.24, 95% CI 1.13\u20131.36), as well as greater risk of poor quality of life (aOR 3.71, 95% CI 3.20\u20134.32) (all\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001). Cancer patients with PTSD and high SDoH burden had substantially greater odds of poor mental health (aOR 10.92, 95% CI 9.33\u201312.77) and poor emotional health (aOR 12.20, 95% CI 10.33\u201314.41) (all\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Cancer, PTSD, and high SDoH burden were independently associated with greater healthcare use and worse well-being with combined exposures amplifying risk among cancer survivors.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Implications for cancer survivors<\/jats:title>\n                    <jats:p>Survivors with PTSD and high SDoH burden are especially vulnerable. Integrating trauma-informed care and SDoH screening strengthens survivorship equity and outcome.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1007\/s11764-026-01993-8","type":"journal-article","created":{"date-parts":[[2026,3,3]],"date-time":"2026-03-03T22:09:16Z","timestamp":1772575756000},"page":"1636-1648","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Post-traumatic stress disorder and social determinants of health among individuals with cancer: association with healthcare utilization and outcomes in the All of Us Research Program"],"prefix":"10.1007","volume":"20","author":[{"given":"Sebastian O.","family":"Ekenze","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Odysseas P.","family":"Chatzipanagiotou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Azza","family":"Sarfraz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qaidar","family":"Alizai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrea","family":"Baldo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7994-9870","authenticated-orcid":false,"given":"Timothy M.","family":"Pawlik","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,3,3]]},"reference":[{"issue":"1","key":"1993_CR1","doi-asserted-by":"publisher","first-page":"12","DOI":"10.3322\/caac.21820","volume":"74","author":"RL Siegel","year":"2024","unstructured":"Siegel RL, Giaquinto AN, Jemal A. 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