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Associations were analyzed using linear regression.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Overall, 44% of participants did not meet physical activity recommendations. Median weekly duration of vigorous-intensity and moderate-intensity activity was 45\u00a0min (Q1\u2013Q3 15\u2013105) and 120\u00a0min (Q1\u2013Q3 45\u2013175), respectively. Median sedentary time was 8\u00a0h per day (Q1\u2013Q3 5\u201311). Not meeting recommendations was significantly associated with greater fatigue (total MFI-20 score \u03b2\u2009=\u20091.7, 95% CI 0.1 to 3.3,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.033) and lower physical and mental health components of HRQoL (SF-36 PCS \u03b2\u2009=\u2009-3.3, 95% CI -5 to -1.5,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001; SF-36 MCS \u03b2\u2009=\u2009-4.2, 95% CI -6 to -1.8,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001). Sedentary time\u2009\u2265\u20097\u00a0h per day was significantly associated with lower mental HRQoL (SF-36 MCS \u03b2\u2009=\u2009-3.6, 95% CI -5.9 to -1.2,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.003).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Many adult survivors of childhood ALL had insufficient levels of physical activity and accumulated considerable sedentary time. Insufficient physical activity was associated with greater fatigue and lower HRQoL, while greater sedentary time was associated with lower mental HRQoL. However, given the cross-sectional design, causality cannot be inferred.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Implications for Cancer Survivors<\/jats:title>\n                    <jats:p>Physical activity promotion is a potential strategy to reduce fatigue and enhance HRQoL among adult survivors of childhood ALL.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1007\/s11764-026-02027-z","type":"journal-article","created":{"date-parts":[[2026,4,30]],"date-time":"2026-04-30T10:39:00Z","timestamp":1777545540000},"page":"1916-1926","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["The importance of meeting physical activity recommendations and limiting sedentary time in adult survivors of childhood acute lymphoblastic leukemia \u2013 associations with fatigue and HRQoL"],"prefix":"10.1007","volume":"20","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7324-9630","authenticated-orcid":false,"given":"Laura","family":"Jess","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4260-7399","authenticated-orcid":false,"given":"Katarina","family":"Aili","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3576-2393","authenticated-orcid":false,"given":"Jens M.","family":"Nygren","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6031-7478","authenticated-orcid":false,"given":"Maria","family":"B\u00e4ck","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9482-5366","authenticated-orcid":false,"given":"Marianne","family":"Jarfelt","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,4,30]]},"reference":[{"issue":"10230","key":"2027_CR1","doi-asserted-by":"publisher","first-page":"1146","DOI":"10.1016\/S0140-6736(19)33018-1","volume":"395","author":"F Malard","year":"2020","unstructured":"Malard F, Mohty M. 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