{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,6]],"date-time":"2026-04-06T05:21:13Z","timestamp":1775452873530,"version":"3.50.1"},"reference-count":19,"publisher":"Springer Science and Business Media LLC","issue":"3","license":[{"start":{"date-parts":[[2019,11,30]],"date-time":"2019-11-30T00:00:00Z","timestamp":1575072000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2019,11,30]],"date-time":"2019-11-30T00:00:00Z","timestamp":1575072000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Ir J Med Sci"],"published-print":{"date-parts":[[2020,8]]},"DOI":"10.1007\/s11845-019-02148-8","type":"journal-article","created":{"date-parts":[[2019,12,2]],"date-time":"2019-12-02T12:31:18Z","timestamp":1575289878000},"page":"953-959","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":23,"title":["Risk of drug interactions and prescription appropriateness in elderly patients"],"prefix":"10.1007","volume":"189","author":[{"given":"Elisa","family":"Petrini","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0529-9481","authenticated-orcid":false,"given":"Gian Paolo","family":"Caviglia","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3438-0649","authenticated-orcid":false,"given":"Rinaldo","family":"Pellicano","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5310-4143","authenticated-orcid":false,"given":"Giorgio Maria","family":"Saracco","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4540-1409","authenticated-orcid":false,"given":"Mario","family":"Morino","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9421-3087","authenticated-orcid":false,"given":"Davide Giuseppe","family":"Ribaldone","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2019,11,30]]},"reference":[{"key":"2148_CR1","doi-asserted-by":"publisher","first-page":"383","DOI":"10.1093\/geront\/gnv152","volume":"56","author":"P Mazzola","year":"2016","unstructured":"Mazzola P, Rimoldi SML, Rossi P et al (2016) Aging in Italy: the need for new welfare strategies in an old country. Gerontologist 56:383\u2013390. https:\/\/doi.org\/10.1093\/geront\/gnv152","journal-title":"Gerontologist"},{"key":"2148_CR2","unstructured":"European Commission (2018) The 2018 Ageing Report: economic and budgetary projections for the EU member states (2016\u20132070)."},{"key":"2148_CR3","doi-asserted-by":"publisher","first-page":"1255","DOI":"10.1016\/S0140-6736(00)02799-9","volume":"356","author":"IR Edwards","year":"2000","unstructured":"Edwards IR, Aronson JK (2000) Adverse drug reactions: definitions, diagnosis, and management. Lancet 356:1255\u20131259. https:\/\/doi.org\/10.1016\/S0140-6736(00)02799-9","journal-title":"Lancet"},{"key":"2148_CR4","doi-asserted-by":"publisher","first-page":"385","DOI":"10.2165\/00002018-200629050-00003","volume":"29","author":"L Hazell","year":"2006","unstructured":"Hazell L, Shakir SAW (2006) Under-reporting of adverse drug reactions. Drug Saf 29:385\u2013396. https:\/\/doi.org\/10.2165\/00002018-200629050-00003","journal-title":"Drug Saf"},{"key":"2148_CR5","doi-asserted-by":"publisher","first-page":"14","DOI":"10.1590\/S1518-8787.2016050006122","volume":"50","author":"I Ribeiro-Vaz","year":"2016","unstructured":"Ribeiro-Vaz I, Santos CC, Cruz-Correia R (2016) Promoting adverse drug reaction reporting: comparison of different approaches. Rev. Saude Publica 50:14. https:\/\/doi.org\/10.1590\/S1518-8787.2016050006122","journal-title":"Rev. Saude Publica"},{"key":"2148_CR6","doi-asserted-by":"crossref","unstructured":"Chan M, Nicklason F, Vial JH Adverse drug events as a cause of hospital admission in the elderly. Intern Med J 31:199\u2013205","DOI":"10.1046\/j.1445-5994.2001.00044.x"},{"key":"2148_CR7","doi-asserted-by":"publisher","first-page":"641","DOI":"10.1002\/pds.1351","volume":"16","author":"ML Becker","year":"2007","unstructured":"Becker ML, Kallewaard M, Caspers PWJ et al (2007) Hospitalisations and emergency department visits due to drug-drug interactions: a literature review. Pharmacoepidemiol Drug Saf 16:641\u2013651. https:\/\/doi.org\/10.1002\/pds.1351","journal-title":"Pharmacoepidemiol Drug Saf"},{"key":"2148_CR8","doi-asserted-by":"publisher","first-page":"233339281879216","DOI":"10.1177\/2333392818792169","volume":"5","author":"J Laursen","year":"2018","unstructured":"Laursen J, Kornholt J, Betzer C et al (2018) General practitioners\u2019 barriers toward medication reviews in polymedicated multimorbid patients: how can a focus on the pharmacotherapy in an outpatient clinic support GPs? Heal Serv Res Manag Epidemiol 5:2333392818792169. https:\/\/doi.org\/10.1177\/2333392818792169","journal-title":"Heal Serv Res Manag Epidemiol"},{"key":"2148_CR9","doi-asserted-by":"publisher","first-page":"2227","DOI":"10.1111\/jgs.13702","volume":"63","author":"By the American Geriatrics Society 2015 Beers Criteria Update Expert Panel","year":"2015","unstructured":"By the American Geriatrics Society 2015 Beers Criteria Update Expert Panel (2015) American Geriatrics Society 2015 Updated Beers criteria for potentially inappropriate medication use in older adults. J Am Geriatr Soc 63:2227\u20132246. https:\/\/doi.org\/10.1111\/jgs.13702","journal-title":"J Am Geriatr Soc"},{"key":"2148_CR10","doi-asserted-by":"publisher","first-page":"1013","DOI":"10.1001\/archinternmed.2011.215","volume":"171","author":"H Hamilton","year":"2011","unstructured":"Hamilton H, Gallagher P, Ryan C et al (2011) Potentially inappropriate medications defined by STOPP criteria and the risk of adverse drug events in older hospitalized patients. Arch Intern Med 171:1013\u20131019. https:\/\/doi.org\/10.1001\/archinternmed.2011.215","journal-title":"Arch Intern Med"},{"key":"2148_CR11","doi-asserted-by":"publisher","first-page":"e52","DOI":"10.1016\/j.ejim.2015.07.004","volume":"26","author":"S Antoniazzi","year":"2015","unstructured":"Antoniazzi S, Chiarelli MT, Nobili A et al (2015) The value of software that provides clinically relevant information on drug interactions. Eur J Intern Med 26:e52\u2013e53. https:\/\/doi.org\/10.1016\/j.ejim.2015.07.004","journal-title":"Eur J Intern Med"},{"key":"2148_CR12","doi-asserted-by":"publisher","first-page":"169","DOI":"10.1186\/s12875-018-0856-9","volume":"19","author":"S Mantelli","year":"2018","unstructured":"Mantelli S, Jungo KT, Rozsnyai Z et al (2018) How general practitioners would deprescribe in frail oldest-old with polypharmacy \u2014 the LESS study. BMC Fam Pract 19:169. https:\/\/doi.org\/10.1186\/s12875-018-0856-9","journal-title":"BMC Fam Pract"},{"key":"2148_CR13","doi-asserted-by":"publisher","first-page":"31","DOI":"10.1016\/j.amjopharm.2007.03.004","volume":"5","author":"JL Green","year":"2007","unstructured":"Green JL, Hawley JN, Rask KJ (2007) Is the number of prescribing physicians an independent risk factor for adverse drug events in an elderly outpatient population? Am J Geriatr Pharmacother 5:31\u201339","journal-title":"Am J Geriatr Pharmacother"},{"key":"2148_CR14","doi-asserted-by":"publisher","first-page":"377","DOI":"10.1111\/j.1365-2710.2009.01021.x","volume":"34","author":"A Nobili","year":"2009","unstructured":"Nobili A, Pasina L, Tettamanti M et al (2009) Potentially severe drug interactions in elderly outpatients: results of an observational study of an administrative prescription database. J Clin Pharm Ther 34:377\u2013386. https:\/\/doi.org\/10.1111\/j.1365-2710.2009.01021.x","journal-title":"J Clin Pharm Ther"},{"key":"2148_CR15","doi-asserted-by":"publisher","first-page":"153","DOI":"10.1080\/02813430310001806","volume":"21","author":"L Bjerrum","year":"2003","unstructured":"Bjerrum L, Andersen M, Petersen G, Kragstrup J (2003) Exposure to potential drug interactions in primary health care. Scand J Prim Health Care 21:153\u2013158. https:\/\/doi.org\/10.1080\/02813430310001806","journal-title":"Scand J Prim Health Care"},{"key":"2148_CR16","doi-asserted-by":"publisher","first-page":"911","DOI":"10.2165\/00002018-200730100-00009","volume":"30","author":"K Johnell","year":"2007","unstructured":"Johnell K, Klarin I (2007) The relationship between number of drugs and potential drug-drug interactions in the elderly: a study of over 600,000 elderly patients from the Swedish Prescribed Drug Register. Drug Saf 30:911\u2013918. https:\/\/doi.org\/10.2165\/00002018-200730100-00009","journal-title":"Drug Saf"},{"key":"2148_CR17","doi-asserted-by":"publisher","first-page":"1021","DOI":"10.2165\/0002512-200825120-00004","volume":"25","author":"S Iyer","year":"2008","unstructured":"Iyer S, Naganathan V, McLachlan AJ, Le Couteur DG (2008) Medication withdrawal trials in people aged 65 years and older: a systematic review. Drugs Aging 25:1021\u20131031. https:\/\/doi.org\/10.2165\/0002512-200825120-00004","journal-title":"Drugs Aging"},{"key":"2148_CR18","doi-asserted-by":"publisher","first-page":"141","DOI":"10.20344\/amp.10683","volume":"32","author":"J Urzal","year":"2019","unstructured":"Urzal J, Pedro AB, Oliveira IF et al (2019) Inappropriate prescribing to elderly patients in an internal medicine ward. Acta Med Port 32:141\u2013148. https:\/\/doi.org\/10.20344\/amp.10683","journal-title":"Acta Med Port"},{"key":"2148_CR19","doi-asserted-by":"publisher","first-page":"2","DOI":"10.1136\/bmj.39406.449456.BE","volume":"336","author":"I Forgacs","year":"2008","unstructured":"Forgacs I, Loganayagam A (2008) Overprescribing proton pump inhibitors. BMJ 336:2\u20133. https:\/\/doi.org\/10.1136\/bmj.39406.449456.BE","journal-title":"BMJ"}],"container-title":["Irish Journal of Medical Science (1971 -)"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s11845-019-02148-8.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s11845-019-02148-8\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s11845-019-02148-8.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,11,29]],"date-time":"2020-11-29T00:42:07Z","timestamp":1606610527000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s11845-019-02148-8"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,11,30]]},"references-count":19,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2020,8]]}},"alternative-id":["2148"],"URL":"https:\/\/doi.org\/10.1007\/s11845-019-02148-8","relation":{},"ISSN":["0021-1265","1863-4362"],"issn-type":[{"value":"0021-1265","type":"print"},{"value":"1863-4362","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,11,30]]},"assertion":[{"value":"4 October 2019","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"15 November 2019","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"30 November 2019","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"Informed consent was obtained from all individual participants included in the study.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Compliance with ethical standards"}},{"value":"The authors declare that they have no conflict of interest.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}}]}}