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CDKN2B-AS1 polymorphisms have been reported to be involved in the pathogenesis of POAG. However, the results of the genetic associations between the CDKN2B-AS1 polymorphisms and POAG risk were inconclusive.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Aims<\/jats:title>\n                <jats:p>This study aimed to evaluate the correlation of CDKN2B-AS1 polymorphisms and POAG susceptibility using a meta-analysis.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Methods<\/jats:title>\n                <jats:p>Meta-analysis was performed by searching PubMed, Web of science, the Cochrane database of system reviews, CNKI, and Embase databases. The relationship of CDKN2B-AS1 rs4977756, rs10120688, rs2157719, and rs7049105 polymorphisms and POAG risk was evaluated by the odds ratios (ORs) and 95% confidence intervals (CIs).<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Results<\/jats:title>\n                <jats:p>Eleven studies with 8290 cases and 13,485 controls were included in the present meta-analysis. The alleles of rs4977756 and rs10120688 significantly increased the risk of POAG (rs4977756: OR\u2009=\u20091.20, 95%CI\u2009=\u20091.03\u20131.39, <jats:italic>p<\/jats:italic>\u2009=\u20090.02; rs10120688: OR\u2009=\u20091.36, 95%CI\u2009=\u20091.29\u20131.44, <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.00001). As for ethnicity, rs4977756 polymorphism significantly increased POAG risk in Caucasians (OR\u2009=\u20091.33, 95%CI\u2009=\u20091.12\u20131.57, <jats:italic>p<\/jats:italic>\u2009=\u20090.0009), but not in Asians. In addition, the rs2157719 allele was significantly associated with POAG risk in Asians (OR\u2009=\u20090.66, 95%CI\u2009=\u20090.55\u20130.80, <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.0001), but not in Caucasians (<jats:italic>p<\/jats:italic>\u2009&gt;\u20090.05).<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Conclusions<\/jats:title>\n                <jats:p>The CDKN2B-AS1 rs4977756 might increase the POAG risk in Caucasian population, and rs2157719 might decrease the POAG risk in Asian population, while rs10120688 might increase the risk of POAG.<\/jats:p>\n              <\/jats:sec>","DOI":"10.1007\/s11845-021-02794-x","type":"journal-article","created":{"date-parts":[[2021,10,14]],"date-time":"2021-10-14T10:09:16Z","timestamp":1634206156000},"page":"2385-2392","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Genetic association between CDKN2B-AS1 polymorphisms and the susceptibility of primary open-angle glaucoma (POAG): a meta-analysis from 21,775 subjects"],"prefix":"10.1007","volume":"191","author":[{"given":"Shanshan","family":"Liu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Siwen","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tongtong","family":"Niu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2021,10,14]]},"reference":[{"key":"2794_CR1","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1007\/s10792-017-0795-9","volume":"10","author":"K Evangelho","year":"2017","unstructured":"Evangelho K, Mogilevskaya M, Losada-Barragan M et al (2017) Pathophysiology of primary open-angle glaucoma from a neuroinflammatory and neurotoxicity perspective: a review of the literature. 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