{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,4]],"date-time":"2026-08-04T10:43:05Z","timestamp":1785840185322,"version":"3.56.0"},"reference-count":49,"publisher":"Springer Science and Business Media LLC","issue":"2","license":[{"start":{"date-parts":[[2022,5,20]],"date-time":"2022-05-20T00:00:00Z","timestamp":1653004800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2022,5,20]],"date-time":"2022-05-20T00:00:00Z","timestamp":1653004800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Ir J Med Sci"],"published-print":{"date-parts":[[2023,4]]},"DOI":"10.1007\/s11845-022-03030-w","type":"journal-article","created":{"date-parts":[[2022,5,20]],"date-time":"2022-05-20T04:03:14Z","timestamp":1653019394000},"page":"775-783","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Quantitative detection of methylated SOCS-1 in schizophrenia and bipolar disorder considering SOCS-1 -1478CA\/del polymorphism and clinical parameters"],"prefix":"10.1007","volume":"192","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1053-6808","authenticated-orcid":false,"given":"Hasan Mervan","family":"Aytac","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1272-5845","authenticated-orcid":false,"given":"Sacide","family":"Pehlivan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6692-085X","authenticated-orcid":false,"given":"Mustafa","family":"Pehlivan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1338-0087","authenticated-orcid":false,"given":"Yasemin","family":"Oyaci","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2022,5,20]]},"reference":[{"issue":"2","key":"3030_CR1","doi-asserted-by":"publisher","first-page":"368","DOI":"10.1080\/08820139.2020.1832115","volume":"51","author":"HM Aytac","year":"2022","unstructured":"Aytac HM, Ozdilli K, Tuncel FC et al (2022) Tumor necrosis factor-alpha (TNF-\u03b1)\u2212238 G\/A polymorphism is associated with the treatment resistance and attempted suicide in schizophrenia. Immunol Invest 51(2):368\u2013380","journal-title":"Immunol Invest"},{"key":"3030_CR2","first-page":"176","volume":"47","author":"AF Nursal","year":"2021","unstructured":"Nursal AF, Aytac HM, Ciftci HS et al (2021) TNF-\u03b1-308 G\/A variant may be associated with bipolar disorder in a Turkish population. Archives of Clinical Psychiatry (S\u00e3o Paulo) 47:176\u2013179","journal-title":"Archives of Clinical Psychiatry (S\u00e3o Paulo)"},{"key":"3030_CR3","doi-asserted-by":"publisher","first-page":"59","DOI":"10.1016\/j.neures.2016.11.002","volume":"115","author":"T Tanaka","year":"2017","unstructured":"Tanaka T, Matsuda T, Hayes LN et al (2017) Infection and inflammation in schizophrenia and bipolar disorder. Neurosci Res 115:59\u201363","journal-title":"Neurosci Res"},{"issue":"1","key":"3030_CR4","doi-asserted-by":"publisher","first-page":"4","DOI":"10.1007\/s00406-004-0481-6","volume":"254","author":"FM Leweke","year":"2004","unstructured":"Leweke FM, Gerth CW, Koethe D et al (2004) Antibodies to infectious agents in individuals with recent onset schizophrenia. Eur Arch Psychiatry Clin Neurosci 254(1):4\u20138","journal-title":"Eur Arch Psychiatry Clin Neurosci"},{"key":"3030_CR5","doi-asserted-by":"crossref","unstructured":"Sutterland A, Fond G, Kuin A et al (2015) Beyond the association. T oxoplasma gondii in schizophrenia, bipolar disorder, and addiction: systematic review and meta-analysis. Acta Psychiatr Scand 132(3):161\u201379","DOI":"10.1111\/acps.12423"},{"issue":"2\u20133","key":"3030_CR6","doi-asserted-by":"publisher","first-page":"444","DOI":"10.1016\/j.jad.2012.11.034","volume":"148","author":"N Hamdani","year":"2013","unstructured":"Hamdani N, Daban-Huard C, Lajnef M et al (2013) Relationship between Toxoplasma gondii infection and bipolar disorder in a French sample. J Affect Disord 148(2\u20133):444\u2013448","journal-title":"J Affect Disord"},{"key":"3030_CR7","doi-asserted-by":"crossref","unstructured":"Prossin A, Yolken R, Kamali M et al (2015) Cytomegalovirus antibody elevation in bipolar disorder: relation to elevated mood states. Neural Plast\u00a02015","DOI":"10.1155\/2015\/939780"},{"issue":"4","key":"3030_CR8","first-page":"346","volume":"26","author":"HM Aytac","year":"2021","unstructured":"Aytac HM, Yazar MS, Erol A, Pehlivan S (2021) Investigation of inflammation related gene polymorphism of the mannose-binding lectin 2 in schizophrenia and bipolar disorder. Neurosci J 26(4):346\u2013356","journal-title":"Neurosci J"},{"issue":"2\u20133","key":"3030_CR9","doi-asserted-by":"publisher","first-page":"247","DOI":"10.1016\/S0920-9964(01)00296-1","volume":"57","author":"XY Zhang","year":"2002","unstructured":"Zhang XY, Zhou DF, Zhang PY et al (2002) Elevated interleukin-2, interleukin-6 and interleukin-8 serum levels in neuroleptic-free schizophrenia: association with psychopathology. Schizophr Res 57(2\u20133):247\u2013258","journal-title":"Schizophr Res"},{"key":"3030_CR10","doi-asserted-by":"publisher","first-page":"160","DOI":"10.3389\/fpsyt.2020.00160","volume":"11","author":"G Fond","year":"2020","unstructured":"Fond G, Lan\u00e7on C, Korchia T et al (2020) The role of inflammation in the treatment of schizophrenia. Front Psych 11:160","journal-title":"Front Psych"},{"issue":"1\u20132","key":"3030_CR11","doi-asserted-by":"publisher","first-page":"16","DOI":"10.1016\/j.jad.2012.06.010","volume":"144","author":"K Munkholm","year":"2013","unstructured":"Munkholm K, Vinberg M, Kessing LV (2013) Cytokines in bipolar disorder: a systematic review and meta-analysis. J Affect Disord 144(1\u20132):16\u201327","journal-title":"J Affect Disord"},{"issue":"6","key":"3030_CR12","doi-asserted-by":"publisher","first-page":"454","DOI":"10.1038\/nri2093","volume":"7","author":"A Yoshimura","year":"2007","unstructured":"Yoshimura A, Naka T, Kubo M (2007) SOCS proteins, cytokine signalling and immune regulation. Nat Rev Immunol 7(6):454\u2013465","journal-title":"Nat Rev Immunol"},{"issue":"5","key":"3030_CR13","doi-asserted-by":"publisher","first-page":"537","DOI":"10.1016\/j.tice.2017.06.005","volume":"49","author":"C Du","year":"2017","unstructured":"Du C, Yao F, Ren Y et al (2017) SOCS-1 is involved in TNF-\u03b1-induced mitochondrial dysfunction and apoptosis in renal tubular epithelial cells. Tissue Cell 49(5):537\u2013544","journal-title":"Tissue Cell"},{"key":"3030_CR14","doi-asserted-by":"publisher","first-page":"121","DOI":"10.1016\/j.neuroscience.2014.09.052","volume":"302","author":"D Walker","year":"2015","unstructured":"Walker D, Whetzel A, Lue L-F (2015) Expression of suppressor of cytokine signaling genes in human elderly and Alzheimer\u2019s disease brains and human microglia. Neuroscience 302:121\u2013137","journal-title":"Neuroscience"},{"issue":"1\u20132","key":"3030_CR15","doi-asserted-by":"publisher","first-page":"117","DOI":"10.1016\/j.jneuroim.2014.05.013","volume":"273","author":"V Sede\u00f1o-Monge","year":"2014","unstructured":"Sede\u00f1o-Monge V, Arcega-Revilla R, Rojas-Morales E et al (2014) Quantitative analysis of the suppressors of cytokine signaling 1 and 3 in peripheral blood leukocytes of patients with multiple sclerosis. J Neuroimmunol 273(1\u20132):117\u2013119","journal-title":"J Neuroimmunol"},{"issue":"3\u20134","key":"3030_CR16","first-page":"149","volume":"7","author":"MM Eftekharian","year":"2019","unstructured":"Eftekharian MM, Omrani MD, Komaki A et al (2019) Expression analysis of suppressor of cytokine signaling (SOCS) genes in blood of autistic patients. Adv Neuroimmune Biol 7(3\u20134):149\u2013154","journal-title":"Adv Neuroimmune Biol"},{"issue":"1","key":"3030_CR17","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1186\/s12888-019-2396-9","volume":"19","author":"A Keshavarzi","year":"2019","unstructured":"Keshavarzi A, Eftekharian MM, Komaki A et al (2019) Sexual dimorphism in up-regulation of suppressors of cytokine signaling genes in patients with bipolar disorder. BMC Psychiatry 19(1):1\u20136","journal-title":"BMC Psychiatry"},{"key":"3030_CR18","doi-asserted-by":"crossref","unstructured":"Pehlivan S, Aytac HM, Aydin PC et al (2021) Global and glucocorticoid receptor gene-specific (NR3C1) DNA methylation analysis in patients with cannabinoid or synthetic cannabinoid use disorder. Psychiatry Res 298:113774","DOI":"10.1016\/j.psychres.2021.113774"},{"key":"3030_CR19","doi-asserted-by":"crossref","unstructured":"Oyaci Y, Aytac HM, Pasin O et al (2021) Detection of altered methylation of MB-COMT promotor and DRD2 gene in cannabinoid or synthetic cannabinoid use disorder regarding gene variants and clinical parameters. J Addict Dis 1\u201319","DOI":"10.1080\/10550887.2021.1906618"},{"issue":"7","key":"3030_CR20","doi-asserted-by":"publisher","first-page":"1335","DOI":"10.1038\/sj.bjc.6602133","volume":"91","author":"K To","year":"2004","unstructured":"To K, Chan M, Leung W et al (2004) Constitutional activation of IL-6-mediated JAK\/STAT pathway through hypermethylation of SOCS-1 in human gastric cancer cell line. Br J Cancer 91(7):1335\u20131341","journal-title":"Br J Cancer"},{"issue":"1","key":"3030_CR21","doi-asserted-by":"publisher","first-page":"29","DOI":"10.1038\/ng0501-29","volume":"28","author":"H Yoshikawa","year":"2001","unstructured":"Yoshikawa H, Matsubara K, Qian G-S et al (2001) SOCS-1, a negative regulator of the JAK\/STAT pathway, is silenced by methylation in human hepatocellular carcinoma and shows growth-suppression activity. Nat Genet 28(1):29\u201335","journal-title":"Nat Genet"},{"issue":"20","key":"3030_CR22","doi-asserted-by":"publisher","first-page":"2191","DOI":"10.1001\/jama.2013.281053","volume":"310","author":"WM Association","year":"2013","unstructured":"Association WM (2013) World Medical Association Declaration of Helsinki: ethical principles for medical research involving human subjects. JAMA 310(20):2191\u20132194","journal-title":"JAMA"},{"key":"3030_CR23","unstructured":"First MB, Spitzer RL, Gibbon M, Williams JB (1997) User's guide for the Structured clinical interview for DSM-IV axis I disorders SCID-I: clinician version. Washington, DC, American Psychiatric Association"},{"key":"3030_CR24","unstructured":"\u00c7orap\u00e7\u0131o\u011flu A, Aydemir \u00d6, Y\u0131ld\u0131z M et al (1999) DSM-IV Eksen I bozukluklar\u0131 i\u00e7in yap\u0131land\u0131r\u0131lm\u0131\u015f Klinik G\u00f6r\u00fc\u015fme: Klinik Versiyon. Ankara: Hekimler Yay\u0131n Birli\u011fi"},{"issue":"2","key":"3030_CR25","doi-asserted-by":"publisher","first-page":"261","DOI":"10.1093\/schbul\/13.2.261","volume":"13","author":"SR Kay","year":"1987","unstructured":"Kay SR, Fiszbein A, Opler LA (1987) The positive and negative syndrome scale (PANSS) for schizophrenia. Schizophr Bull 13(2):261\u2013276","journal-title":"Schizophr Bull"},{"issue":"44","key":"3030_CR26","first-page":"23","volume":"14","author":"A Kostako\u011flu","year":"1999","unstructured":"Kostako\u011flu A, Batur S, Tiryaki A, G\u00f6\u011f\u00fc\u015f A (1999) Pozitif ve negatif sendrom \u00f6l\u00e7e\u011finin (PANSS) T\u00fcrk\u00e7e uyarlamas\u0131n\u0131n ge\u00e7erlilik ve g\u00fcvenilirli\u011fi. T\u00fcrk Psikoloji Dergisi 14(44):23\u201332","journal-title":"T\u00fcrk Psikoloji Dergisi"},{"key":"3030_CR27","doi-asserted-by":"publisher","first-page":"56","DOI":"10.1136\/jnnp.23.1.56","volume":"23","author":"M Hamilton","year":"1960","unstructured":"Hamilton M (1960) A rating scale for depression. J Neurol Neurosurg Psychiatry 23:56\u201362","journal-title":"J Neurol Neurosurg Psychiatry"},{"issue":"4","key":"3030_CR28","first-page":"251","volume":"4","author":"A Akdemir","year":"1996","unstructured":"Akdemir A, \u00d6rsel S, Da\u011f \u0130 et al (1996) Hamilton Depresyon Derecelendirme \u00d6l\u00e7e\u011fi (HDD\u00d6)\u2019nin ge\u00e7erli\u011fi, g\u00fcvenirli\u011fi ve klinikte kullan\u0131m\u0131. Psikiyatri Psikoloji Psikofarmakoloji Dergisi 4(4):251\u2013259","journal-title":"Psikiyatri Psikoloji Psikofarmakoloji Dergisi"},{"issue":"5","key":"3030_CR29","doi-asserted-by":"publisher","first-page":"429","DOI":"10.1192\/bjp.133.5.429","volume":"133","author":"RC Young","year":"1978","unstructured":"Young RC, Biggs JT, Ziegler VE, Meyer DA (1978) A rating scale for mania: reliability, validity and sensitivity. Br J Psychiatry 133(5):429\u2013435","journal-title":"Br J Psychiatry"},{"issue":"2","key":"3030_CR30","first-page":"107","volume":"13","author":"F Karada\u011f","year":"2001","unstructured":"Karada\u011f F, Oral ET, Aran Yal\u00e7\u0131n F, Erten E (2001) Young mani derecelendirme \u00f6l\u00e7e\u011finin T\u00fcrkiye\u2019de ge\u00e7erlik ve g\u00fcvenilirli\u011fi. Turk Psikiyatri Derg 13(2):107\u2013114","journal-title":"Turk Psikiyatri Derg"},{"issue":"16","key":"3030_CR31","doi-asserted-by":"publisher","first-page":"1289","DOI":"10.1023\/B:BILE.0000044922.43572.2d","volume":"26","author":"MW Chan","year":"2004","unstructured":"Chan MW, Chu ES, To K-F, Leung WK (2004) Quantitative detection of methylated SOCS-1, a tumor suppressor gene, by a modified protocol of quantitative real time methylation-specific PCR using SYBR green and its use in early gastric cancer detection. Biotech Lett 26(16):1289\u20131293","journal-title":"Biotech Lett"},{"key":"3030_CR32","doi-asserted-by":"publisher","first-page":"15","DOI":"10.1016\/j.imlet.2017.06.011","volume":"190","author":"B Li","year":"2017","unstructured":"Li B, Chen X, Jiang Y et al (2017) CCL2 promoter hypomethylation is associated with gout risk in Chinese Han male population. Immunol Lett 190:15\u201319","journal-title":"Immunol Lett"},{"issue":"6","key":"3030_CR33","first-page":"9017","volume":"15","author":"H Ma","year":"2018","unstructured":"Ma H, Chen X, Hu H et al (2018) Hypermethylation of MDFI promoter with NSCLC is specific for females, non-smokers and people younger than 65. Oncol Lett 15(6):9017\u20139024","journal-title":"Oncol Lett"},{"issue":"7","key":"3030_CR34","doi-asserted-by":"publisher","first-page":"896","DOI":"10.1080\/01443615.2017.1309011","volume":"37","author":"O Oz Gul","year":"2017","unstructured":"Oz Gul O, Cander S, Gul CB et al (2017) Cytokine signal suppressor (SOCS) 1\u20131478 CA\/del gene polymorphism in Turkish patients with polycystic ovary syndrome. J Obstet Gynaecol 37(7):896\u2013901","journal-title":"J Obstet Gynaecol"},{"issue":"1","key":"3030_CR35","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1186\/s12863-016-0332-2","volume":"17","author":"N Teroganova","year":"2016","unstructured":"Teroganova N, Girshkin L, Suter CM, Green MJ (2016) DNA methylation in peripheral tissue of schizophrenia and bipolar disorder: a systematic review. BMC Genet 17(1):1\u201315","journal-title":"BMC Genet"},{"issue":"1","key":"3030_CR36","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1186\/s13059-016-1041-x","volume":"17","author":"E Hannon","year":"2016","unstructured":"Hannon E, Dempster E, Viana J et al (2016) An integrated genetic-epigenetic analysis of schizophrenia: evidence for co-localization of genetic associations and differential DNA methylation. Genome Biol 17(1):1\u201316","journal-title":"Genome Biol"},{"issue":"3","key":"3030_CR37","doi-asserted-by":"publisher","first-page":"255","DOI":"10.1001\/jamapsychiatry.2013.3730","volume":"71","author":"KA Aberg","year":"2014","unstructured":"Aberg KA, McClay JL, Nerella S et al (2014) Methylome-wide association study of schizophrenia: identifying blood biomarker signatures of environmental insults. JAMA Psychiat 71(3):255\u2013264","journal-title":"JAMA Psychiat"},{"issue":"4","key":"3030_CR38","doi-asserted-by":"publisher","first-page":"769","DOI":"10.1093\/schbul\/sbt080","volume":"40","author":"J Liu","year":"2014","unstructured":"Liu J, Chen J, Ehrlich S et al (2014) Methylation patterns in whole blood correlate with symptoms in schizophrenia patients. Schizophr Bull 40(4):769\u2013776","journal-title":"Schizophr Bull"},{"key":"3030_CR39","doi-asserted-by":"crossref","unstructured":"Sabunciyan S, Maher B, Bahn S et al (2015) Association of DNA methylation with acute mania and inflammatory markers. PLoS ONE 10(7):e0132001","DOI":"10.1371\/journal.pone.0132001"},{"key":"3030_CR40","doi-asserted-by":"publisher","first-page":"481","DOI":"10.1016\/j.jns.2017.02.015","volume":"375","author":"M Toghi","year":"2017","unstructured":"Toghi M, Taheri M, Arsang-Jang S et al (2017) SOCS gene family expression profile in the blood of multiple sclerosis patients. J Neurol Sci 375:481\u2013485","journal-title":"J Neurol Sci"},{"issue":"6","key":"3030_CR41","doi-asserted-by":"publisher","first-page":"2712","DOI":"10.1096\/fj.11-202069","volume":"26","author":"PA Melas","year":"2012","unstructured":"Melas PA, Rogdaki M, \u00d6sby U et al (2012) Epigenetic aberrations in leukocytes of patients with schizophrenia: association of global DNA methylation with antipsychotic drug treatment and disease onset. FASEB J 26(6):2712\u20132718","journal-title":"FASEB J"},{"key":"3030_CR42","doi-asserted-by":"crossref","unstructured":"Aytac HM, Oyaci Y, Pehlivan M, Pehlivan S (2021) DNA methylation pattern of gene promoters of MB-COMT, DRD2, and NR3C1 in Turkish patients diagnosed with schizophrenia. Clin Psychopharmacol Neurosci","DOI":"10.9758\/cpn.2022.20.4.685"},{"issue":"1","key":"3030_CR43","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1186\/2049-9256-1-19","volume":"1","author":"MG Melka","year":"2013","unstructured":"Melka MG, Castellani CA, Laufer BI et al (2013) Olanzapine induced DNA methylation changes support the dopamine hypothesis of psychosis. J Mol Psychiatry 1(1):1\u20137","journal-title":"J Mol Psychiatry"},{"issue":"4","key":"3030_CR44","doi-asserted-by":"publisher","first-page":"952","DOI":"10.1016\/j.pnpbp.2007.02.018","volume":"31","author":"F Dickerson","year":"2007","unstructured":"Dickerson F, Stallings C, Origoni A et al (2007) Elevated serum levels of C-reactive protein are associated with mania symptoms in outpatients with bipolar disorder. Prog Neuropsychopharmacol Biol Psychiatry 31(4):952\u2013955","journal-title":"Prog Neuropsychopharmacol Biol Psychiatry"},{"issue":"1\u20133","key":"3030_CR45","doi-asserted-by":"publisher","first-page":"36","DOI":"10.1016\/j.schres.2012.12.023","volume":"145","author":"S Hope","year":"2013","unstructured":"Hope S, Ueland T, Steen NE et al (2013) Interleukin 1 receptor antagonist and soluble tumor necrosis factor receptor 1 are associated with general severity and psychotic symptoms in schizophrenia and bipolar disorder. Schizophr Res 145(1\u20133):36\u201342","journal-title":"Schizophr Res"},{"issue":"1","key":"3030_CR46","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1186\/s12929-021-00742-6","volume":"28","author":"GH Jones","year":"2021","unstructured":"Jones GH, Vecera CM, Pinjari OF, Machado-Vieira R (2021) Inflammatory signaling mechanisms in bipolar disorder. J Biomed Sci 28(1):1\u201322","journal-title":"J Biomed Sci"},{"issue":"3","key":"3030_CR47","first-page":"195","volume":"22","author":"D De Berardis","year":"2008","unstructured":"De Berardis D, Conti C, Campanella D et al (2008) Evaluation of plasma antioxidant levels during different phases of illness in adult patients with bipolar disorder. J Biol Regul Homeost Agents 22(3):195","journal-title":"J Biol Regul Homeost Agents"},{"issue":"3","key":"3030_CR48","doi-asserted-by":"publisher","first-page":"196","DOI":"10.1111\/j.1463-1326.2008.00900.x","volume":"11","author":"T Gylvin","year":"2009","unstructured":"Gylvin T, Ek J, Nols\u00f8e R et al (2009) Functional SOCS1 polymorphisms are associated with variation in obesity in whites. Diabetes Obes Metab 11(3):196\u2013203","journal-title":"Diabetes Obes Metab"},{"key":"3030_CR49","doi-asserted-by":"crossref","unstructured":"Harada M, Nakashima K, Hirota T et al (2007) Functional polymorphism in the suppressor of cytokine signaling 1 gene associated with adult asthma.\u00a0Am J Respir Cell Mol Biol\u00a036(4):491\u20136","DOI":"10.1165\/rcmb.2006-0090OC"}],"container-title":["Irish Journal of Medical Science (1971 -)"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s11845-022-03030-w.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s11845-022-03030-w\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s11845-022-03030-w.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,4,2]],"date-time":"2023-04-02T17:02:46Z","timestamp":1680454966000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s11845-022-03030-w"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,5,20]]},"references-count":49,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2023,4]]}},"alternative-id":["3030"],"URL":"https:\/\/doi.org\/10.1007\/s11845-022-03030-w","relation":{},"ISSN":["0021-1265","1863-4362"],"issn-type":[{"value":"0021-1265","type":"print"},{"value":"1863-4362","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,5,20]]},"assertion":[{"value":"24 April 2022","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"12 May 2022","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"20 May 2022","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors express that all procedures contributing to this work comply with the suitable national and institutional committees\u2019 ethical standards on human experimentation and the Helsinki Declaration of 1975, as revised in 2013 [].","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical standards"}},{"value":"The authors declare no competing interests.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}}]}}