{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,30]],"date-time":"2026-08-30T23:16:58Z","timestamp":1788131818192,"version":"build-2803163510"},"reference-count":35,"publisher":"Springer Science and Business Media LLC","issue":"4","license":[{"start":{"date-parts":[[2022,9,17]],"date-time":"2022-09-17T00:00:00Z","timestamp":1663372800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2022,9,17]],"date-time":"2022-09-17T00:00:00Z","timestamp":1663372800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Ir J Med Sci"],"published-print":{"date-parts":[[2023,8]]},"DOI":"10.1007\/s11845-022-03152-1","type":"journal-article","created":{"date-parts":[[2022,9,17]],"date-time":"2022-09-17T06:02:36Z","timestamp":1663394556000},"page":"1779-1784","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Kisspeptin: a potential therapeutic target in patients with unexplained infertility?"],"prefix":"10.1007","volume":"192","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3874-8797","authenticated-orcid":false,"given":"Nil","family":"Atakul","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0103-0709","authenticated-orcid":false,"given":"Berna Sermin","family":"K\u0131l\u0131c","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1235-3957","authenticated-orcid":false,"given":"Sahabettin","family":"Selek","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0934-4278","authenticated-orcid":false,"given":"Y\u0131ld\u0131z","family":"Atamer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8182-2051","authenticated-orcid":false,"given":"Fehmi","family":"Unal","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2022,9,17]]},"reference":[{"issue":"3","key":"3152_CR1","doi-asserted-by":"publisher","first-page":"465","DOI":"10.1016\/j.fertnstert.2020.06.038","volume":"114","author":"ST Ruohonen","year":"2020","unstructured":"Ruohonen ST, Poutanen M, Tena-Sempere M (2020) Role of kisspeptins in the control of the hypothalamic-pituitary-ovarian axis: old dogmas and new challenges. Fertil Steril 114(3):465\u2013474","journal-title":"Fertil Steril"},{"issue":"2","key":"3152_CR2","doi-asserted-by":"publisher","first-page":"98","DOI":"10.1080\/09674845.2020.1856496","volume":"78","author":"Z Siahpoosh","year":"2021","unstructured":"Siahpoosh Z, Farsimadan M, Pazhohan M et al (2021) KISS1R polymorphism rs587777844 (Tyr313His) is linked to female infertility. Br J Biomed Sci 78(2):98\u2013100","journal-title":"Br J Biomed Sci"},{"issue":"6","key":"3152_CR3","doi-asserted-by":"publisher","first-page":"559","DOI":"10.1097\/JCMA.0000000000000538","volume":"84","author":"WL Lee","year":"2021","unstructured":"Lee WL, Lee FK, Wang PH (2021) Kisspeptin in female reproduction. J Chin Med Assoc 84(6):559\u2013560","journal-title":"J Chin Med Assoc"},{"issue":"12","key":"3152_CR4","doi-asserted-by":"publisher","first-page":"6611","DOI":"10.3390\/ijms23126611","volume":"23","author":"M Szyde\u0142ko-Gorzkowicz","year":"2022","unstructured":"Szyde\u0142ko-Gorzkowicz M, Poniedzia\u0142ek-Czajkowska E et al (2022) The role of kisspeptin in the pathogenesis of pregnancy complications: a narrative review. Int J Mol Sci 23(12):6611","journal-title":"Int J Mol Sci"},{"key":"3152_CR5","doi-asserted-by":"publisher","DOI":"10.4274\/jcrpe.galenos.2022.2022-3-18","author":"P Zhou","year":"2022","unstructured":"Zhou P, Wu JA (2022) Novel KISS1R loss-of-function variant in a Chinese child with congenital hypogonadotropic hypogonadism. J Clin Res Pediatr Endocrinol. https:\/\/doi.org\/10.4274\/jcrpe.galenos.2022.2022-3-18","journal-title":"J Clin Res Pediatr Endocrinol"},{"key":"3152_CR6","doi-asserted-by":"publisher","first-page":"81","DOI":"10.1186\/s12958-022-00953-y","volume":"20","author":"KL Hu","year":"2022","unstructured":"Hu KL, Chen Z, Li X et al (2022) Advances in clinical applications of kisspeptin-GnRH pathway in female reproduction. Reprod Biol Endocrinol 20:81","journal-title":"Reprod Biol Endocrinol"},{"key":"3152_CR7","doi-asserted-by":"crossref","unstructured":"Amodei R, Jonker SS, Whitler W et al (2022) The GnRH antagonist degarelix suppresses gonadotropin secretion and pituitary sensitivity in midgestation sheep fetuses. Endocrinol 163(2):bqab262","DOI":"10.1210\/endocr\/bqab262"},{"issue":"5","key":"3152_CR8","doi-asserted-by":"publisher","first-page":"349","DOI":"10.1111\/j.1365-2826.2006.01420.x","volume":"18","author":"M Patterson","year":"2006","unstructured":"Patterson M, Murphy KG, Thompson EL et al (2006) Administration of kisspeptin-54 into discrete regions of the hypothalamus potently increases plasma luteinising hormone and testosterone in male adult rats. J Neuroendocrinol 18(5):349\u2013354","journal-title":"J Neuroendocrinol"},{"issue":"3","key":"3152_CR9","doi-asserted-by":"publisher","first-page":"393","DOI":"10.1016\/j.fertnstert.2017.06.005","volume":"108","author":"F Zegers-Hochschild","year":"2017","unstructured":"Zegers-Hochschild F, Adamson GD, Dyer S et al (2017) The international glossary on infertility and fertility care. Fertil Steril 108(3):393\u2013406","journal-title":"Fertil Steril"},{"key":"3152_CR10","doi-asserted-by":"publisher","first-page":"3","DOI":"10.1007\/978-1-4939-2140-9_1","volume-title":"Unexplained infertility: pathophysiology, evaluation and treatment","author":"SC Esteves","year":"2015","unstructured":"Esteves SC, Schattman GL, Agarwal A (2015) Definitions and relevance of unexplained infertility in reproductive medicine. In: Schattman G, Esteves SC, Agarwal A (eds) Unexplained infertility: pathophysiology, evaluation and treatment, 1st edn. Springer, New York, pp 3\u20135","edition":"1"},{"issue":"3","key":"3152_CR11","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejcb.2022.151243","volume":"101","author":"A Jaiswal","year":"2022","unstructured":"Jaiswal A, Baliu-Souza T, Turner K et al (2022) Sperm centriole assessment identifies male factor infertility in couples with unexplained infertility - a pilot study. Eur J Cell Biol 101(3):151243","journal-title":"Eur J Cell Biol"},{"key":"3152_CR12","doi-asserted-by":"publisher","first-page":"19","DOI":"10.1016\/j.fertnstert.2003.10.004","volume":"81","author":"ESHRE, ASRM","year":"2004","unstructured":"ESHRE, ASRM (2004) Rotterdam Sponsored PCOS Consensus Workshop Group Revised 2003 consensus on diagnostic criteria and long-term health risks related to polycystic ovary syndrome. Fertil Steril 81:19\u201325","journal-title":"Fertil Steril"},{"issue":"3","key":"3152_CR13","doi-asserted-by":"publisher","first-page":"231","DOI":"10.1093\/humupd\/dmp048","volume":"16","author":"TG Cooper","year":"2010","unstructured":"Cooper TG, Noonan E, von Eckardstein S et al (2010) World Health Organization reference values for human semen characteristics. Hum Reprod Update 16(3):231\u2013245","journal-title":"Hum Reprod Update"},{"key":"3152_CR14","volume-title":"WHO laboratory manual for the examination and processing of human semen","author":"World Health Organisation","year":"2010","unstructured":"World Health Organisation (2010) WHO laboratory manual for the examination and processing of human semen, 5th edn. World Health Organization, Geneva","edition":"5"},{"key":"3152_CR15","doi-asserted-by":"publisher","first-page":"1630","DOI":"10.1093\/humrep\/deaa137","volume":"35","author":"PA Romanski","year":"2020","unstructured":"Romanski PA, Bortoletto P, Rosenwaks Z et al (2020) Delay in IVF treatment up to 180 days does not affect pregnancy outcomes in women with diminished ovarian reserve. Hum Reprod 35:1630\u20131636","journal-title":"Hum Reprod"},{"issue":"2","key":"3152_CR16","doi-asserted-by":"publisher","first-page":"109","DOI":"10.1097\/OGX.0000000000000043","volume":"69","author":"TA Gelbaya","year":"2014","unstructured":"Gelbaya TA, Potdar N, Jeve YB et al (2014) Definition and epidemiology of unexplained infertility. Obstet Gynecol Surv 69(2):109\u2013115","journal-title":"Obstet Gynecol Surv"},{"key":"3152_CR17","doi-asserted-by":"publisher","first-page":"53","DOI":"10.1016\/j.jri.2013.11.002","volume":"103","author":"ZS Ozkan","year":"2014","unstructured":"Ozkan ZS, Deveci D, Kumbak B et al (2014) What is the impact of Th1\/Th2 ratio, SOCS3, IL17, and IL35 levels in unexplained infertility? J Reprod Immunol 103:53\u201358","journal-title":"J Reprod Immunol"},{"issue":"1","key":"3152_CR18","doi-asserted-by":"publisher","first-page":"13420","DOI":"10.1038\/s41598-021-92955-w","volume":"11","author":"M Enciso","year":"2021","unstructured":"Enciso M, Aizpurua J, Rodr\u00edguez-Estrada B et al (2021) The precise determination of the window of implantation significantly improves ART outcomes. Sci Rep 11(1):13420","journal-title":"Sci Rep"},{"key":"3152_CR19","doi-asserted-by":"publisher","first-page":"228","DOI":"10.1080\/09513590.2018.1519792","volume":"35","author":"C Kaya","year":"2019","unstructured":"Kaya C, Alay I, Babayeva G et al (2019) Serum kisspeptin levels in unexplained infertility, polycystic ovary syndrome, and male factor infertility. Gynecol Endocrinol 35:228\u2013232","journal-title":"Gynecol Endocrinol"},{"issue":"2","key":"3152_CR20","first-page":"99","volume":"11","author":"A Mumtaz","year":"2017","unstructured":"Mumtaz A, Khalid A, Jamil Z et al (2017) Kisspeptin: a potential factor for unexplained infertility and impaired embryo implantation. Int J Fertil Steril 11(2):99\u2013104","journal-title":"Int J Fertil Steril"},{"issue":"44","key":"3152_CR21","doi-asserted-by":"publisher","first-page":"12088","DOI":"10.1523\/JNEUROSCI.2748-07.2007","volume":"27","author":"HM Dungan","year":"2007","unstructured":"Dungan HM, Gottsch ML, Zeng H et al (2007) The role of kisspeptin-GPR54 signaling in the tonic regulation and surge release of gonadotropin-releasing hormone\/luteinizing hormone. J Neurosci 27(44):12088\u201312095","journal-title":"J Neurosci"},{"issue":"6","key":"3152_CR22","doi-asserted-by":"publisher","first-page":"939","DOI":"10.1111\/cen.12977","volume":"84","author":"S Narayanaswamy","year":"2016","unstructured":"Narayanaswamy S, Jayasena CN, Ng N et al (2016) Subcutaneous infusion of kisspeptin-54 stimulates gonadotrophin release in women and the response correlates with basal oestradiol levels. Clin Endocrinol (Oxf) 84(6):939\u2013945","journal-title":"Clin Endocrinol (Oxf)"},{"issue":"12","key":"3152_CR23","doi-asserted-by":"publisher","first-page":"6739","DOI":"10.1172\/JCI139681","volume":"30","author":"A Abbara","year":"2020","unstructured":"Abbara A, Eng PC, Phylactou M et al (2020) Kisspeptin receptor agonist has therapeutic potential for female reproductive disorders. J Clin Invest 30(12):6739\u20136753","journal-title":"J Clin Invest"},{"issue":"10","key":"3152_CR24","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0239142","volume":"15","author":"R Rehman","year":"2020","unstructured":"Rehman R, Zafar A, Ali AA et al (2020) Impact of serum and follicular fluid kisspeptin and estradiol on oocyte maturity and endometrial thickness among unexplained infertile females during ICSI. PLoS ONE 15(10):e0239142","journal-title":"PLoS ONE"},{"issue":"2","key":"3152_CR25","doi-asserted-by":"publisher","first-page":"147","DOI":"10.1016\/j.rbmo.2016.11.004","volume":"34","author":"Z Jamil","year":"2017","unstructured":"Jamil Z, Fatima SS, Arif S et al (2017) Kisspeptin and embryo implantation after ICSI. Reprod Biomed Online 34(2):147\u2013153","journal-title":"Reprod Biomed Online"},{"key":"3152_CR26","doi-asserted-by":"publisher","first-page":"2736","DOI":"10.1093\/humrep\/deu247","volume":"29","author":"J Garc\u00eda-Ortega","year":"2014","unstructured":"Garc\u00eda-Ortega J, Pinto FM, Fern\u00e1ndez-S\u00e1nchez M et al (2014) Expression of neurokinin B\/NK3 receptor and kisspeptin\/KISS1 receptor in human granulosa cells. Hum Reprod 29:2736\u20132746","journal-title":"Hum Reprod"},{"key":"3152_CR27","doi-asserted-by":"publisher","first-page":"3088","DOI":"10.1210\/en.2014-1110","volume":"155","author":"F Gaytan","year":"2014","unstructured":"Gaytan F, Garcia-Galiano D, Dorfman MD et al (2014) Kisspeptin receptor haplo-insufficiency causes premature ovarian failure despite preserved gonadotropin secretion. Endocrinology 155:3088\u20133997","journal-title":"Endocrinology"},{"key":"3152_CR28","doi-asserted-by":"publisher","first-page":"543","DOI":"10.1210\/jendso\/bvab048.1107","volume":"5","author":"N Nandankar","year":"2021","unstructured":"Nandankar N, Negron AL, Wolfe AM et al (2021) Mice with targeted deletion of ARC kisspeptin exhibit immature gametogenesis and impaired fertility. Journal of the Endocrine Society 5:543\u2013544","journal-title":"Journal of the Endocrine Society"},{"issue":"4","key":"3152_CR29","doi-asserted-by":"publisher","first-page":"869","DOI":"10.1016\/j.fertnstert.2020.05.006","volume":"114","author":"V Blasco","year":"2020","unstructured":"Blasco V, Pinto FM, Fern\u00e1ndez-Atucha A et al (2020) Female infertility is associated with an altered expression of the neurokinin B\/neurokinin B receptor and kisspeptin\/kisspeptin receptor systems in ovarian granulosa and cumulus cells. Fertil Steril 114(4):869\u2013878","journal-title":"Fertil Steril"},{"issue":"4","key":"3152_CR30","doi-asserted-by":"publisher","first-page":"300060519879330","DOI":"10.1177\/0300060519879330","volume":"48","author":"J B\u00f3dis","year":"2020","unstructured":"B\u00f3dis J, Sulyok E, K\u0151szegi T et al (2020) Serum and follicular fluid levels of serotonin, kisspeptin, and brain-derived neurotrophic factor in patients undergoing in vitro fertilization: an observational study: neurohormones in patients receiving IVF. J Int Med Res 48(4):300060519879330","journal-title":"J Int Med Res"},{"key":"3152_CR31","doi-asserted-by":"publisher","unstructured":"Ibrahim RO, Omer SH, Fattah CN (2020) The correlation between hormonal disturbance in PCOS women and serum level of kisspeptin. Int J Endocrinol 6237141. https:\/\/doi.org\/10.1155\/2020\/6237141","DOI":"10.1155\/2020\/6237141"},{"issue":"1","key":"3152_CR32","doi-asserted-by":"publisher","first-page":"113","DOI":"10.1007\/s10815-018-1338-7","volume":"36","author":"V Blasco","year":"2019","unstructured":"Blasco V, Pinto FM, Fern\u00e1ndez-Atucha A et al (2019) Altered expression of the kisspeptin\/KISS1R and neurokinin B\/NK3R systems in mural granulosa and cumulus cells of patients with polycystic ovarian syndrome. J Assist Reprod Genet 36(1):113\u2013120","journal-title":"J Assist Reprod Genet"},{"key":"3152_CR33","doi-asserted-by":"publisher","first-page":"407","DOI":"10.1038\/s41574-020-0363-7","volume":"8","author":"VM Navarro","year":"2020","unstructured":"Navarro VM (2020) Metabolic regulation of kisspeptin - the link between energy balance and reproduction. Nat Rev Endocrinol 8:407\u2013420","journal-title":"Nat Rev Endocrinol"},{"key":"3152_CR34","doi-asserted-by":"publisher","first-page":"2233","DOI":"10.1210\/en.2009-1190","volume":"151","author":"K Backholer","year":"2010","unstructured":"Backholer K, Smith JT, Rao A et al (2010) Kisspeptin cells in the ewe brain respond to leptin and communicate with neuropeptide y and proopiomelanocortin cells. Endocrinology 151:2233\u20132243","journal-title":"Endocrinology"},{"issue":"9","key":"3152_CR35","doi-asserted-by":"publisher","first-page":"718","DOI":"10.3109\/09513590.2016.1161019","volume":"32","author":"O Emekci Ozay","year":"2016","unstructured":"Emekci Ozay O, Ozay AC, Acar B et al (2016) Role of kisspeptin in polycystic ovary syndrome (PCOS). Gynecol Endocrinol 32(9):718\u2013722","journal-title":"Gynecol Endocrinol"}],"container-title":["Irish Journal of Medical Science (1971 -)"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s11845-022-03152-1.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s11845-022-03152-1\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s11845-022-03152-1.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,7,31]],"date-time":"2023-07-31T10:17:41Z","timestamp":1690798661000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s11845-022-03152-1"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,9,17]]},"references-count":35,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2023,8]]}},"alternative-id":["3152"],"URL":"https:\/\/doi.org\/10.1007\/s11845-022-03152-1","relation":{},"ISSN":["0021-1265","1863-4362"],"issn-type":[{"value":"0021-1265","type":"print"},{"value":"1863-4362","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,9,17]]},"assertion":[{"value":"5 August 2022","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"5 September 2022","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"17 September 2022","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors declare no competing interests.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}}]}}