{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,17]],"date-time":"2026-09-17T11:54:53Z","timestamp":1789646093242,"version":"4.0.0"},"reference-count":27,"publisher":"Springer Science and Business Media LLC","issue":"2","license":[{"start":{"date-parts":[[2023,10,12]],"date-time":"2023-10-12T00:00:00Z","timestamp":1697068800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2023,10,12]],"date-time":"2023-10-12T00:00:00Z","timestamp":1697068800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Ir J Med Sci"],"published-print":{"date-parts":[[2024,4]]},"DOI":"10.1007\/s11845-023-03529-w","type":"journal-article","created":{"date-parts":[[2023,10,12]],"date-time":"2023-10-12T09:02:21Z","timestamp":1697101341000},"page":"909-916","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["MicroRNA-582-3p knockdown alleviates non-alcoholic steatohepatitis by altering the gut microbiota composition and moderating TMBIM1"],"prefix":"10.1007","volume":"193","author":[{"given":"Shuo","family":"Huang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xia","family":"Xiao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hongman","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Feng","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chenchao","family":"Fu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2023,10,12]]},"reference":[{"key":"3529_CR1","doi-asserted-by":"publisher","first-page":"22","DOI":"10.1097\/tp.0000000000002484","volume":"103","author":"ZM Younossi","year":"2019","unstructured":"Younossi ZM, Marchesini G, Pinto-Cortez H, Petta S (2019) Epidemiology of nonalcoholic fatty liver disease and nonalcoholic steatohepatitis: implications for liver transplantation. Transplantation 103:22\u201327. https:\/\/doi.org\/10.1097\/tp.0000000000002484","journal-title":"Transplantation"},{"key":"3529_CR2","doi-asserted-by":"publisher","first-page":"131","DOI":"10.1007\/s11845-022-02988-x","volume":"192","author":"X Yu","year":"2023","unstructured":"Yu X, Wang Y, Lai J et al (2023) Comparative efficacy of exercise training processes in improving nonalcoholic fatty liver disease: a systematic review and meta-analysis. Ir J Med Sci 192:131\u2013142. https:\/\/doi.org\/10.1007\/s11845-022-02988-x","journal-title":"Ir J Med Sci"},{"key":"3529_CR3","doi-asserted-by":"publisher","first-page":"2212","DOI":"10.1016\/s0140-6736(20)32511-3","volume":"397","author":"EE Powell","year":"2021","unstructured":"Powell EE, Wong VW, Rinella M (2021) Non-alcoholic fatty liver disease. Lancet (London, England) 397:2212\u20132224. https:\/\/doi.org\/10.1016\/s0140-6736(20)32511-3","journal-title":"Lancet (London, England)"},{"key":"3529_CR4","doi-asserted-by":"publisher","unstructured":"Luci C, Bourinet M, Lecl\u00e8re PS et al (2020) Chronic inflammation in non-alcoholic steatohepatitis: molecular mechanisms and therapeutic strategies. Front Endocrinol 11:597648. https:\/\/doi.org\/10.3389\/fendo.2020.597648","DOI":"10.3389\/fendo.2020.597648"},{"key":"3529_CR5","doi-asserted-by":"publisher","first-page":"1559","DOI":"10.1056\/NEJMoa2029349","volume":"385","author":"AJ Sanyal","year":"2021","unstructured":"Sanyal AJ, Van Natta ML, Clark J et al (2021) Prospective study of outcomes in adults with nonalcoholic fatty liver disease. N Engl J Med 385:1559\u20131569. https:\/\/doi.org\/10.1056\/NEJMoa2029349","journal-title":"N Engl J Med"},{"key":"3529_CR6","doi-asserted-by":"publisher","first-page":"478","DOI":"10.1002\/hep4.1479","volume":"4","author":"G Parthasarathy","year":"2020","unstructured":"Parthasarathy G, Revelo X, Malhi H (2020) Pathogenesis of nonalcoholic steatohepatitis: an overview. Hepatol Commun 4:478\u2013492. https:\/\/doi.org\/10.1002\/hep4.1479","journal-title":"Hepatol Commun"},{"key":"3529_CR7","doi-asserted-by":"publisher","first-page":"77","DOI":"10.3350\/cmh.2022.0237","volume":"29","author":"KC Lee","year":"2023","unstructured":"Lee KC, Wu PS, Lin HC (2023) Pathogenesis and treatment of non-alcoholic steatohepatitis and its fibrosis. Clin Mol Hepatol 29:77\u201398. https:\/\/doi.org\/10.3350\/cmh.2022.0237","journal-title":"Clin Mol Hepatol"},{"key":"3529_CR8","doi-asserted-by":"publisher","unstructured":"Milosevic I, Vujovic A, Barac A et al (2019) Gut-liver axis, gut microbiota, and its modulation in the management of liver diseases: a review of the literature. Int J Mol Sci 20. https:\/\/doi.org\/10.3390\/ijms20020395","DOI":"10.3390\/ijms20020395"},{"key":"3529_CR9","doi-asserted-by":"publisher","first-page":"328","DOI":"10.1002\/hep.26494","volume":"59","author":"B Chassaing","year":"2014","unstructured":"Chassaing B, Etienne-Mesmin L, Gewirtz AT (2014) Microbiota-liver axis in hepatic disease. Hepatology (Baltimore, MD) 59:328\u2013339. https:\/\/doi.org\/10.1002\/hep.26494","journal-title":"Hepatology (Baltimore, MD)"},{"key":"3529_CR10","doi-asserted-by":"publisher","first-page":"940","DOI":"10.1016\/j.jhep.2013.12.019","volume":"60","author":"JS Bajaj","year":"2014","unstructured":"Bajaj JS, Heuman DM, Hylemon PB et al (2014) Altered profile of human gut microbiome is associated with cirrhosis and its complications. J Hepatol 60:940\u2013947. https:\/\/doi.org\/10.1016\/j.jhep.2013.12.019","journal-title":"J Hepatol"},{"key":"3529_CR11","doi-asserted-by":"publisher","first-page":"645","DOI":"10.1007\/s11684-018-0645-9","volume":"12","author":"R Han","year":"2018","unstructured":"Han R, Ma J, Li H (2018) Mechanistic and therapeutic advances in non-alcoholic fatty liver disease by targeting the gut microbiota. Front Med 12:645\u2013657. https:\/\/doi.org\/10.1007\/s11684-018-0645-9","journal-title":"Front Med"},{"key":"3529_CR12","doi-asserted-by":"publisher","first-page":"2503","DOI":"10.1111\/febs.12806","volume":"281","author":"DM Ferreira","year":"2014","unstructured":"Ferreira DM, Sim\u00e3o AL, Rodrigues CM, Castro RE (2014) Revisiting the metabolic syndrome and paving the way for microRNAs in non-alcoholic fatty liver disease. FEBS J 281:2503\u20132524. https:\/\/doi.org\/10.1111\/febs.12806","journal-title":"FEBS J"},{"key":"3529_CR13","doi-asserted-by":"publisher","unstructured":"Cuevas-Sierra A, Ramos-Lopez O, Riezu-Boj JI et al (2019) Diet, gut microbiota, and obesity: links with host genetics and epigenetics and potential applications. Adv Nutr (Bethesda, Md) 10:S17-s30. https:\/\/doi.org\/10.1093\/advances\/nmy078","DOI":"10.1093\/advances\/nmy078"},{"key":"3529_CR14","doi-asserted-by":"publisher","first-page":"351","DOI":"10.2147\/ceg.S262879","volume":"13","author":"L Longo","year":"2020","unstructured":"Longo L, Tonin Ferrari J, Rampelotto PH et al (2020) Gut dysbiosis and increased intestinal permeability drive microRNAs, NLRP-3 inflammasome and liver fibrosis in a nutritional model of non-alcoholic steatohepatitis in adult male Sprague Dawley rats. Clin Exp Gastroenterol 13:351\u2013368. https:\/\/doi.org\/10.2147\/ceg.S262879","journal-title":"Clin Exp Gastroenterol"},{"key":"3529_CR15","doi-asserted-by":"publisher","first-page":"17","DOI":"10.1016\/j.trsl.2019.07.007","volume":"214","author":"Z Zhao","year":"2019","unstructured":"Zhao Z, Lin CY, Cheng K (2019) siRNA- and miRNA-based therapeutics for liver fibrosis. Transl Res 214:17\u201329. https:\/\/doi.org\/10.1016\/j.trsl.2019.07.007","journal-title":"Transl Res"},{"key":"3529_CR16","doi-asserted-by":"publisher","first-page":"742","DOI":"10.1038\/nm.4334","volume":"23","author":"GN Zhao","year":"2017","unstructured":"Zhao GN, Zhang P, Gong J et al (2017) Tmbim1 is a multivesicular body regulator that protects against non-alcoholic fatty liver disease in mice and monkeys by targeting the lysosomal degradation of Tlr4. Nat Med 23:742\u2013752. https:\/\/doi.org\/10.1038\/nm.4334","journal-title":"Nat Med"},{"key":"3529_CR17","doi-asserted-by":"publisher","first-page":"461","DOI":"10.1007\/s11154-019-09512-0","volume":"20","author":"M Schoeler","year":"2019","unstructured":"Schoeler M, Caesar R (2019) Dietary lipids, gut microbiota and lipid metabolism. Rev Endocr Metab Disord 20:461\u2013472. https:\/\/doi.org\/10.1007\/s11154-019-09512-0","journal-title":"Rev Endocr Metab Disord"},{"key":"3529_CR18","doi-asserted-by":"publisher","first-page":"2170","DOI":"10.1016\/j.drudis.2022.05.003","volume":"27","author":"AA Khan","year":"2022","unstructured":"Khan AA, Gupta V, Mahapatra NR (2022) Key regulatory miRNAs in lipid homeostasis: implications for cardiometabolic diseases and development of novel therapeutics. Drug Discov Today 27:2170\u20132180. https:\/\/doi.org\/10.1016\/j.drudis.2022.05.003","journal-title":"Drug Discov Today"},{"key":"3529_CR19","doi-asserted-by":"publisher","unstructured":"D\u00edaz-Garrido N, Bonnin S, Riera M et al (2020) Transcriptomic microRNA profiling of dendritic cells in response to gut microbiota-secreted vesicles. Cells 9. https:\/\/doi.org\/10.3390\/cells9061534","DOI":"10.3390\/cells9061534"},{"key":"3529_CR20","doi-asserted-by":"publisher","first-page":"1716","DOI":"10.1136\/gutjnl-2018-316723","volume":"67","author":"PD Cani","year":"2018","unstructured":"Cani PD (2018) Human gut microbiome: hopes, threats and promises. Gut 67:1716\u20131725. https:\/\/doi.org\/10.1136\/gutjnl-2018-316723","journal-title":"Gut"},{"key":"3529_CR21","doi-asserted-by":"publisher","first-page":"425","DOI":"10.1111\/tra.12488","volume":"18","author":"A Guerrero-Mandujano","year":"2017","unstructured":"Guerrero-Mandujano A, Hern\u00e1ndez-Cortez C, Ibarra JA, Castro-Escarpulli G (2017) The outer membrane vesicles: secretion system type zero. Traffic (Copenhagen, Denmark) 18:425\u2013432. https:\/\/doi.org\/10.1111\/tra.12488","journal-title":"Traffic (Copenhagen, Denmark)"},{"key":"3529_CR22","doi-asserted-by":"publisher","first-page":"206","DOI":"10.1016\/j.tim.2018.10.011","volume":"27","author":"C Aguilar","year":"2019","unstructured":"Aguilar C, Mano M, Eulalio A (2019) MicroRNAs at the host-bacteria interface: host defense or bacterial offense. Trends Microbiol 27:206\u2013218. https:\/\/doi.org\/10.1016\/j.tim.2018.10.011","journal-title":"Trends Microbiol"},{"key":"3529_CR23","doi-asserted-by":"publisher","first-page":"197","DOI":"10.1111\/imm.12390","volume":"144","author":"LA Smyth","year":"2015","unstructured":"Smyth LA, Boardman DA, Tung SL et al (2015) MicroRNAs affect dendritic cell function and phenotype. Immunology 144:197\u2013205. https:\/\/doi.org\/10.1111\/imm.12390","journal-title":"Immunology"},{"key":"3529_CR24","doi-asserted-by":"publisher","first-page":"125","DOI":"10.1016\/j.jnutbio.2017.02.003","volume":"43","author":"N Sud","year":"2017","unstructured":"Sud N, Zhang H, Pan K et al (2017) Aberrant expression of microRNA induced by high-fructose diet: implications in the pathogenesis of hyperlipidemia and hepatic insulin resistance. J Nutr Biochem 43:125\u2013131. https:\/\/doi.org\/10.1016\/j.jnutbio.2017.02.003","journal-title":"J Nutr Biochem"},{"key":"3529_CR25","doi-asserted-by":"publisher","first-page":"269","DOI":"10.1038\/s41366-021-00985-1","volume":"46","author":"LV Mennitti","year":"2005","unstructured":"Mennitti LV, Carpenter AAM, Loche E et al (2005) Ozanne SE (2022) Effects of maternal diet-induced obesity on metabolic disorders and age-associated miRNA expression in the liver of male mouse offspring. Int J Obes 46:269\u2013278. https:\/\/doi.org\/10.1038\/s41366-021-00985-1","journal-title":"Int J Obes"},{"key":"3529_CR26","doi-asserted-by":"publisher","first-page":"27","DOI":"10.1016\/j.addr.2017.05.007","volume":"121","author":"T Higashi","year":"2017","unstructured":"Higashi T, Friedman SL, Hoshida Y (2017) Hepatic stellate cells as key target in liver fibrosis. Adv Drug Deliv Rev 121:27\u201342. https:\/\/doi.org\/10.1016\/j.addr.2017.05.007","journal-title":"Adv Drug Deliv Rev"},{"key":"3529_CR27","doi-asserted-by":"publisher","unstructured":"Kitano M, Bloomston PM (2016) Hepatic stellate cells and microRNAs in pathogenesis of liver fibrosis. J Clin Med 5. https:\/\/doi.org\/10.3390\/jcm5030038","DOI":"10.3390\/jcm5030038"}],"container-title":["Irish Journal of Medical Science (1971 -)"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s11845-023-03529-w.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s11845-023-03529-w\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s11845-023-03529-w.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,3,25]],"date-time":"2024-03-25T00:03:01Z","timestamp":1711324981000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s11845-023-03529-w"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,10,12]]},"references-count":27,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2024,4]]}},"alternative-id":["3529"],"URL":"https:\/\/doi.org\/10.1007\/s11845-023-03529-w","relation":{},"ISSN":["0021-1265","1863-4362"],"issn-type":[{"value":"0021-1265","type":"print"},{"value":"1863-4362","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,10,12]]},"assertion":[{"value":"10 May 2023","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"12 September 2023","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"12 October 2023","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"This study had been approved by the Ethics Committee of Xiangya Hospital of Central South University. The procedures used in this study adhere to the tenets of the Declaration of Helsinki.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval"}},{"value":"Informed consent was obtained from all individual participants included in the study.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent to participate"}},{"value":"Not applicable.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"The authors declare no competing interests.","order":5,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}}]}}