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People with Parkinson\u2019s (PwP) present with a variety of motor symptoms, such as tremor, bradykinesia, and rigidity. Freezing of gait (FoG) is a significant motor symptom that manifests as temporary episodes of inability to move one\u2019s feet, despite the intention to walk.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Aims<\/jats:title>\n                <jats:p>This study examined the impact of FoG on quality of life (QoL) within an Irish cohort of PwP, from the perspectives of both PwP and their carers, using validated questionnaires that had been adapted for online use.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Methods<\/jats:title>\n                <jats:p>PwP and their carers were recruited by outreach to the Irish Parkinson\u2019s Community. Anonymous online questionnaires were distributed, which combined a demographic survey with several clinically validated surveys, including Freezing of Gait Questionnaire (FoG-Q), Parkinson\u2019s Disease Questionnaire 8 (PDQ-8), and Parkinson\u2019s Disease Carer Questionnaire (PDQ-C).<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Results<\/jats:title>\n                <jats:p>There was a strong correlation (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001) between severity of FoG and lower QoL among PwP. Significant correlation was also found between FoG severity and several motor symptoms, such as postural instability and difficulty with balance, and non-motor symptoms, such as cognitive changes and pain\/discomfort. FoG severity correlated with disease progression. Significant correlation was also found between FoG and symptoms, as assessed from the perspective of the patients\u2019 carers.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Conclusions<\/jats:title>\n                <jats:p>This study shows that FoG is a significant detriment to the QoL of PwP, from the perspectives of patients and carers. This method of assessing FoG and QoL using online questionnaires has potential to enhance the reach and flexibility of this type of research. These findings will inform future studies on larger cohorts and highlight unmet clinical needs in PwP.<\/jats:p>\n              <\/jats:sec>","DOI":"10.1007\/s11845-024-03673-x","type":"journal-article","created":{"date-parts":[[2024,4,19]],"date-time":"2024-04-19T05:01:38Z","timestamp":1713502898000},"page":"2041-2050","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":15,"title":["Impacts of gait freeze on quality of life in Parkinson\u2019s disease, from the perspectives of patients and their carers"],"prefix":"10.1007","volume":"193","author":[{"ORCID":"https:\/\/orcid.org\/0009-0008-1594-7359","authenticated-orcid":false,"given":"Padraig","family":"Cronin","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5754-2981","authenticated-orcid":false,"given":"Lucy M.","family":"Collins","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9692-6438","authenticated-orcid":false,"given":"Aideen M.","family":"Sullivan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2024,4,19]]},"reference":[{"key":"3673_CR1","unstructured":"Launch of WHO\u2019s Parkinson disease technical brief. https:\/\/www.who.int\/news\/item\/14-06-2022-launch-of-who-s-parkinson-disease-technical-brief"},{"key":"3673_CR2","doi-asserted-by":"publisher","first-page":"384","DOI":"10.1212\/01.wnl.0000247740.47667.03","volume":"68","author":"ER Dorsey","year":"2007","unstructured":"Dorsey ER, Constantinescu R, Thompson JP et al (2007) Projected number of people with Parkinson disease in the most populous nations, 2005 through 2030. 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