{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,4,25]],"date-time":"2025-04-25T14:48:38Z","timestamp":1745592518408,"version":"3.37.3"},"reference-count":32,"publisher":"Springer Science and Business Media LLC","issue":"5","license":[{"start":{"date-parts":[[2024,6,26]],"date-time":"2024-06-26T00:00:00Z","timestamp":1719360000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2024,6,26]],"date-time":"2024-06-26T00:00:00Z","timestamp":1719360000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"DOI":"10.13039\/501100008386","name":"Marmara University","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100008386","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Ir J Med Sci"],"published-print":{"date-parts":[[2024,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec>\n                <jats:title>Background\/aims<\/jats:title>\n                <jats:p>Necrosis is an important pathological feature that reflects high malignancy potential in tumors such as hepatocellular carcinoma and renal cell carcinoma. We aimed to elucidate the prognostic impact of necrosis in ampullary carcinomas.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Materials and methods<\/jats:title>\n                <jats:p>We reviewed 101 consecutive cases of ampullary carcinoma for tumor necrosis, types of necrosis, macroscopic and microscopic histopathological subtypes, lymphatic-vascular-perineural invasions, and other histopathological parameters.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Results<\/jats:title>\n                <jats:p>Tumor necrosis was present in 19 (18.8%) cases and was identified as an independent poor prognostic indicator in multivariate survival analysis (<jats:italic>p<\/jats:italic>\u2009=\u20090.029).<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Conclusion<\/jats:title>\n                <jats:p>The presence of necrosis in ampullary carcinomas is directly related to vascular and perineural invasion and is a poor prognostic indicator independent of tumor stage. Including the presence of necrosis in the pathology reports of ampullary carcinomas will facilitate risk stratification.<\/jats:p>\n              <\/jats:sec>","DOI":"10.1007\/s11845-024-03740-3","type":"journal-article","created":{"date-parts":[[2024,6,26]],"date-time":"2024-06-26T14:04:45Z","timestamp":1719410685000},"page":"2179-2185","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Prognostic significance of necrosis in ampullary carcinomas"],"prefix":"10.1007","volume":"193","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1512-1166","authenticated-orcid":false,"given":"Kadriye Ebru","family":"Akar","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pelin","family":"Bagci","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2024,6,26]]},"reference":[{"key":"3740_CR1","doi-asserted-by":"publisher","first-page":"598","DOI":"10.1002\/jso.21374","volume":"100","author":"J Albores-Saavedra","year":"2009","unstructured":"Albores-Saavedra J, Schwartz AM, Batich K, Henson DE (2009) Cancers of the ampulla of Vater: demographics, morphology, and survival based on 5,625 cases from the SEER program. J Surg Oncol 100:598\u2013605. https:\/\/doi.org\/10.1002\/jso.21374","journal-title":"J Surg Oncol"},{"key":"3740_CR2","doi-asserted-by":"publisher","first-page":"301","DOI":"10.1007\/s00534-004-0898-3","volume":"11","author":"HP Fischer","year":"2004","unstructured":"Fischer HP, Zhou H (2004) Pathogenesis of carcinoma of the papilla of Vater. J Hepatobiliary Pancreat Surg 11:301\u2013309. https:\/\/doi.org\/10.1007\/s00534-004-0898-3","journal-title":"J Hepatobiliary Pancreat Surg"},{"key":"3740_CR3","doi-asserted-by":"publisher","first-page":"266","DOI":"10.1002\/jso.22090","volume":"105","author":"WS Kim","year":"2012","unstructured":"Kim WS, Choi DW, Choi SH et al (2012) Clinical significance of pathologic subtype in curatively resected ampulla of Vater cancer. J Surg Oncol 105:266\u2013272. https:\/\/doi.org\/10.1002\/jso.22090","journal-title":"J Surg Oncol"},{"key":"3740_CR4","doi-asserted-by":"publisher","first-page":"210","DOI":"10.1016\/j.jamcollsurg.2008.01.028","volume":"207","author":"JT Carter","year":"2008","unstructured":"Carter JT, Grenert JP, Rubenstein L et al (2008) Tumors of the ampulla of Vater: histopathologic classification and predictors of survival. J Am Coll Surg 207:210\u2013218. https:\/\/doi.org\/10.1016\/j.jamcollsurg.2008.01.028","journal-title":"J Am Coll Surg"},{"key":"3740_CR5","doi-asserted-by":"publisher","first-page":"991","DOI":"10.1245\/s10434-009-0883-9","volume":"17","author":"I Hatzaras","year":"2010","unstructured":"Hatzaras I, George N, Muscarella P et al (2010) Predictors of survival in periampullary cancers following pancreaticoduodenectomy. Ann Surg Oncol 17:991\u2013997. https:\/\/doi.org\/10.1245\/s10434-009-0883-9","journal-title":"Ann Surg Oncol"},{"key":"3740_CR6","doi-asserted-by":"publisher","first-page":"3195","DOI":"10.1245\/s10434-007-9537-y","volume":"14","author":"SM Woo","year":"2007","unstructured":"Woo SM, Ryu JK, Lee SH et al (2007) Recurrence and prognostic factors of ampullary carcinoma after radical resection: comparison with distal extrahepatic cholangiocarcinoma. Ann Surg Oncol 14:3195\u20133201. https:\/\/doi.org\/10.1245\/s10434-007-9537-y","journal-title":"Ann Surg Oncol"},{"key":"3740_CR7","doi-asserted-by":"publisher","first-page":"1592","DOI":"10.1097\/PAS.0b013e31826399d8","volume":"36","author":"V Adsay","year":"2012","unstructured":"Adsay V, Ohike N, Tajiri T et al (2012) Ampullary region carcinomas: definition and site specific classification with delineation of four clinicopathologically and prognostically distinct subsets in an analysis of 249 cases. Am J Surg Pathol 36:1592\u20131608. https:\/\/doi.org\/10.1097\/PAS.0b013e31826399d8","journal-title":"Am J Surg Pathol"},{"key":"3740_CR8","doi-asserted-by":"publisher","first-page":"247","DOI":"10.1016\/s0039-6060(05)80197-7","volume":"117","author":"JH Allema","year":"1995","unstructured":"Allema JH, Reinders ME, van Gulik TM et al (1995) Results of pancreaticoduodenectomy for ampullary carcinoma and analysis of prognostic factors for survival. Surgery 117:247\u2013253. https:\/\/doi.org\/10.1016\/s0039-6060(05)80197-7","journal-title":"Surgery"},{"key":"3740_CR9","doi-asserted-by":"publisher","first-page":"93","DOI":"10.3322\/caac.21388","volume":"67","author":"MB Amin","year":"2017","unstructured":"Amin MB, Greene FL, Edge SB et al (2017) The Eighth Edition AJCC Cancer Staging Manual: continuing to build a bridge from a population-based to a more \u201cpersonalized\u201d approach to cancer staging. CA Cancer J Clin 67:93\u201399. https:\/\/doi.org\/10.3322\/caac.21388","journal-title":"CA Cancer J Clin"},{"key":"3740_CR10","unstructured":"Odze RD, Goldblum JR (2015) odze and goldblum surgical pathology of the gi tract, liver, biliary tract, and pancreas, 3rd edn. Saunders\/Elsevier,\u00a0Philadelphia, PA"},{"key":"3740_CR11","doi-asserted-by":"publisher","first-page":"1668","DOI":"10.1016\/j.athoracsur.2010.12.028","volume":"91","author":"SY Park","year":"2011","unstructured":"Park SY, Lee HS, Jang HJ et al (2011) Tumor necrosis as a prognostic factor for stage IA non-small cell lung cancer. Ann Thorac Surg 91:1668\u20131673. https:\/\/doi.org\/10.1016\/j.athoracsur.2010.12.028","journal-title":"Ann Thorac Surg"},{"key":"3740_CR12","doi-asserted-by":"publisher","first-page":"1929","DOI":"10.1200\/JCO.1993.11.10.1929","volume":"11","author":"KW Gilchrist","year":"1993","unstructured":"Gilchrist KW, Gray R, Fowble B et al (1993) Tumor necrosis is a prognostic predictor for early recurrence and death in lymph node-positive breast cancer: a 10-year follow-up study of 728 Eastern Cooperative Oncology Group patients. J Clin Oncol 11:1929\u20131935. https:\/\/doi.org\/10.1200\/JCO.1993.11.10.1929","journal-title":"J Clin Oncol"},{"key":"3740_CR13","doi-asserted-by":"publisher","first-page":"511","DOI":"10.1002\/cncr.21206","volume":"104","author":"S Sengupta","year":"2005","unstructured":"Sengupta S, Lohse CM, Leibovich BC et al (2005) Histologic coagulative tumor necrosis as a prognostic indicator of renal cell carcinoma aggressiveness. Cancer 104:511\u2013520. https:\/\/doi.org\/10.1002\/cncr.21206","journal-title":"Cancer"},{"key":"3740_CR14","doi-asserted-by":"publisher","first-page":"634","DOI":"10.1097\/MPA.0000000000001539","volume":"49","author":"M Kudo","year":"2020","unstructured":"Kudo M, Kobayashi T, Gotohda N et al (2020) Clinical utility of histological and radiological evaluations of tumor necrosis for predicting prognosis in pancreatic cancer. Pancreas 49:634\u2013641. https:\/\/doi.org\/10.1097\/MPA.0000000000001539","journal-title":"Pancreas"},{"key":"3740_CR15","doi-asserted-by":"publisher","first-page":"287","DOI":"10.1002\/bjs.7755","volume":"99","author":"CH Richards","year":"2012","unstructured":"Richards CH, Roxburgh CS, Anderson JH et al (2012) Prognostic value of tumour necrosis and host inflammatory responses in colorectal cancer. Br J Surg 99:287\u2013294. https:\/\/doi.org\/10.1002\/bjs.7755","journal-title":"Br J Surg"},{"key":"3740_CR16","doi-asserted-by":"publisher","first-page":"1568","DOI":"10.1016\/s0959-8049(03)00369-1","volume":"39","author":"P Gustafson","year":"2003","unstructured":"Gustafson P, Akerman M, Alvegard TA et al (2003) Prognostic information in soft tissue sarcoma using tumour size, vascular invasion and microscopic tumour necrosis-the SIN-system. Eur J Cancer 39:1568\u20131576. https:\/\/doi.org\/10.1016\/s0959-8049(03)00369-1","journal-title":"Eur J Cancer"},{"key":"3740_CR17","doi-asserted-by":"publisher","first-page":"1916","DOI":"10.1378\/chest.124.5.1916","volume":"124","author":"JG Edwards","year":"2003","unstructured":"Edwards JG, Swinson DE, Jones JL et al (2003) Tumor necrosis correlates with angiogenesis and is a predictor of poor prognosis in malignant mesothelioma. Chest 124:1916\u20131923. https:\/\/doi.org\/10.1378\/chest.124.5.1916","journal-title":"Chest"},{"key":"3740_CR18","doi-asserted-by":"publisher","first-page":"480","DOI":"10.1097\/PAS.0000000000000165","volume":"38","author":"NV Adsay","year":"2014","unstructured":"Adsay NV, Basturk O, Saka B et al (2014) Whipple made simple for surgical pathologists: orientation, dissection, and sampling of pancreaticoduodenectomy specimens for a more practical and accurate evaluation of pancreatic, distal common bile duct, and ampullary tumors. Am J Surg Pathol 38:480\u2013493. https:\/\/doi.org\/10.1097\/PAS.0000000000000165","journal-title":"Am J Surg Pathol"},{"key":"3740_CR19","doi-asserted-by":"publisher","first-page":"4392","DOI":"10.1245\/s10434-015-4499-y","volume":"22","author":"S Balci","year":"2015","unstructured":"Balci S, Basturk O, Saka B et al (2015) Substaging nodal status in ampullary carcinomas has significant prognostic value: proposed revised staging based on an analysis of 313 well-characterized cases. Ann Surg Oncol 22:4392\u20134401. https:\/\/doi.org\/10.1245\/s10434-015-4499-y","journal-title":"Ann Surg Oncol"},{"key":"3740_CR20","doi-asserted-by":"publisher","first-page":"066008","DOI":"10.1117\/1.JBO.19.6.066008","volume":"19","author":"L Li","year":"2014","unstructured":"Li L, Jiang W, Yang Y et al (2014) Identification of dirty necrosis in colorectal carcinoma based on multiphoton microscopy. J Biomed Opt 19:066008. https:\/\/doi.org\/10.1117\/1.JBO.19.6.066008","journal-title":"J Biomed Opt"},{"key":"3740_CR21","doi-asserted-by":"publisher","first-page":"1089","DOI":"10.1007\/s00432-020-03505-2","volume":"147","author":"T Kuroe","year":"2021","unstructured":"Kuroe T, Watanabe R, Kojima M et al (2021) Evaluation of the morphological features and unfavorable prognostic impact of dirty necrosis in renal cell carcinoma. J Cancer Res Clin Oncol 147:1089\u20131100. https:\/\/doi.org\/10.1007\/s00432-020-03505-2","journal-title":"J Cancer Res Clin Oncol"},{"key":"3740_CR22","unstructured":"Balci S (2024) ClinicoPath Jamovi Module 10.17605\/OSF.IO\/9SZUD"},{"key":"3740_CR23","doi-asserted-by":"publisher","first-page":"523","DOI":"10.1016\/s0046-8177(78)80133-6","volume":"9","author":"ER Fisher","year":"1978","unstructured":"Fisher ER, Palekar AS, Gregorio RM et al (1978) Pathological findings from the national surgical adjuvant breast project (Protocol No. 4). IV. Significance of tumor necrosis. Hum Pathol 9:523\u2013530. https:\/\/doi.org\/10.1016\/s0046-8177(78)80133-6","journal-title":"Hum Pathol"},{"key":"3740_CR24","doi-asserted-by":"publisher","first-page":"235","DOI":"10.1016\/s0169-5002(02)00172-1","volume":"37","author":"DE Swinson","year":"2002","unstructured":"Swinson DE, Jones JL, Richardson D et al (2002) Tumour necrosis is an independent prognostic marker in non-small cell lung cancer: correlation with biological variables. Lung Cancer 37:235\u2013240. https:\/\/doi.org\/10.1016\/s0169-5002(02)00172-1","journal-title":"Lung Cancer"},{"key":"3740_CR25","doi-asserted-by":"publisher","first-page":"108","DOI":"10.1016\/j.humpath.2017.06.010","volume":"66","author":"J Collins","year":"2017","unstructured":"Collins J, Epstein JI (2017) Prognostic significance of extensive necrosis in renal cell carcinoma. Hum Pathol 66:108\u2013114. https:\/\/doi.org\/10.1016\/j.humpath.2017.06.010","journal-title":"Hum Pathol"},{"key":"3740_CR26","doi-asserted-by":"publisher","first-page":"453","DOI":"10.1007\/s00432-015-1997-z","volume":"142","author":"X Zhang","year":"2016","unstructured":"Zhang X, Chen L (2016) The recent progress of the mechanism and regulation of tumor necrosis in colorectal cancer. J Cancer Res Clin Oncol 142:453\u2013463. https:\/\/doi.org\/10.1007\/s00432-015-1997-z","journal-title":"J Cancer Res Clin Oncol"},{"key":"3740_CR27","doi-asserted-by":"publisher","first-page":"1749","DOI":"10.1016\/j.humpath.2010.04.018","volume":"41","author":"MJ Pollheimer","year":"2010","unstructured":"Pollheimer MJ, Kornprat P, Lindtner RA et al (2010) Tumor necrosis is a new promising prognostic factor in colorectal cancer. Hum Pathol 41:1749\u20131757. https:\/\/doi.org\/10.1016\/j.humpath.2010.04.018","journal-title":"Hum Pathol"},{"key":"3740_CR28","doi-asserted-by":"publisher","first-page":"607","DOI":"10.1186\/s12885-020-07097-5","volume":"20","author":"YH Ling","year":"2020","unstructured":"Ling YH, Chen JW, Wen SH et al (2020) Tumor necrosis as a poor prognostic predictor on postoperative survival of patients with solitary small hepatocellular carcinoma. BMC Cancer 20:607. https:\/\/doi.org\/10.1186\/s12885-020-07097-5","journal-title":"BMC Cancer"},{"key":"3740_CR29","first-page":"699","volume":"55","author":"Y Shimizu","year":"2008","unstructured":"Shimizu Y, Kimura F, Shimizu H et al (2008) The morbidity, mortality, and prognostic factors for ampullary carcinoma and distal cholangiocarcinoma. Hepatogastroenterology 55:699\u2013703","journal-title":"Hepatogastroenterology"},{"key":"3740_CR30","doi-asserted-by":"publisher","first-page":"1057","DOI":"10.1038\/sj.bjc.6605854","volume":"103","author":"N Hiraoka","year":"2010","unstructured":"Hiraoka N, Ino Y, Sekine S et al (2010) Tumour necrosis is a postoperative prognostic marker for pancreatic cancer patients with a high interobserver reproducibility in histological evaluation. Br J Cancer 103:1057\u20131065. https:\/\/doi.org\/10.1038\/sj.bjc.6605854","journal-title":"Br J Cancer"},{"issue":"9","key":"3740_CR31","doi-asserted-by":"publisher","first-page":"507","DOI":"10.1038\/nrclinonc.2009.110","volume":"6","author":"A Grothey","year":"2009","unstructured":"Grothey A, Galanis E (2009) Targeting angiogenesis: progress with anti-VEGF treatment with large molecules. Nat Rev Clin Oncol 6(9):507\u2013518. https:\/\/doi.org\/10.1038\/nrclinonc.2009.110","journal-title":"Nat Rev Clin Oncol"},{"issue":"33","key":"3740_CR32","doi-asserted-by":"publisher","first-page":"3839","DOI":"10.2174\/138161209789649402","volume":"15","author":"GL Semenza","year":"2009","unstructured":"Semenza GL (2009) HIF-1 inhibitors for cancer therapy: from gene expression to drug discovery. Curr Pharm Des 15(33):3839\u20133843. https:\/\/doi.org\/10.2174\/138161209789649402","journal-title":"Curr Pharm Des"}],"container-title":["Irish Journal of Medical Science (1971 -)"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s11845-024-03740-3.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s11845-024-03740-3\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s11845-024-03740-3.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,10,3]],"date-time":"2024-10-03T11:23:39Z","timestamp":1727954619000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s11845-024-03740-3"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,6,26]]},"references-count":32,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2024,10]]}},"alternative-id":["3740"],"URL":"https:\/\/doi.org\/10.1007\/s11845-024-03740-3","relation":{},"ISSN":["0021-1265","1863-4362"],"issn-type":[{"type":"print","value":"0021-1265"},{"type":"electronic","value":"1863-4362"}],"subject":[],"published":{"date-parts":[[2024,6,26]]},"assertion":[{"value":"9 May 2024","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"12 June 2024","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"26 June 2024","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"This study was reviewed and approved by the Clinical Research Ethics Committee of Marmara University (issue date 08\/01\/2021, number 08.01.2021.44).The authors declare that this study complies with the ethical standards of the institutional research committee and with the 1964 Helsinki Declaration and its later amendments or comparable ethical standards.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval"}},{"value":"The authors declare no competing interests.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}]}}