{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,24]],"date-time":"2026-10-24T01:09:32Z","timestamp":1792804172979,"version":"4.5.0"},"reference-count":22,"publisher":"Springer Science and Business Media LLC","issue":"4","license":[{"start":{"date-parts":[[2025,7,25]],"date-time":"2025-07-25T00:00:00Z","timestamp":1753401600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2025,7,25]],"date-time":"2025-07-25T00:00:00Z","timestamp":1753401600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Ir J Med Sci"],"published-print":{"date-parts":[[2025,8]]},"DOI":"10.1007\/s11845-025-04008-0","type":"journal-article","created":{"date-parts":[[2025,7,25]],"date-time":"2025-07-25T05:51:41Z","timestamp":1753422701000},"page":"1309-1315","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Diagnostic yield of bidirectional gastrointestinal system endoscopy for iron deficiency anemia"],"prefix":"10.1007","volume":"194","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5616-9580","authenticated-orcid":false,"given":"G\u00f6kmen","family":"G\u00fczel","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9233-0570","authenticated-orcid":false,"given":"Muhammer","family":"Ergen\u00e7","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2025,7,25]]},"reference":[{"key":"4008_CR1","unstructured":"World Health Organization (2024) Guideline on haemoglobin cutoffs to define anaemia in individuals and populations. World Health Organization. https:\/\/www.who.int\/publications\/i\/item\/978924008854. Accessed Jan 2025"},{"issue":"1","key":"4008_CR2","doi-asserted-by":"publisher","first-page":"185","DOI":"10.1186\/s13045-021-01202-2","volume":"14","author":"S Safiri","year":"2021","unstructured":"Safiri S, Kolahi A-A, Noori M, et al (2021) Burden of anemia and its underlying causes in 204 countries and territories, 1990\u20132019: results from the Global Burden of Disease Study 2019. J Hematol Oncol 14(1):185","journal-title":"J Hematol Oncol"},{"issue":"4","key":"4008_CR3","first-page":"C5072","volume":"62","author":"JF Dahlerup","year":"2015","unstructured":"Dahlerup JF, Eivindson M, Jacobsen BA, et al (2015) Diagnosis and treatment of unexplained anemia with iron deficiency without overt bleeding. Dan Med J 62(4):C5072","journal-title":"Dan Med J"},{"issue":"4","key":"4008_CR4","doi-asserted-by":"publisher","first-page":"225","DOI":"10.1016\/j.blre.2017.02.004","volume":"31","author":"C Camaschella","year":"2017","unstructured":"Camaschella C (2017) New insights into iron deficiency and iron deficiency anemia. Blood Rev 31(4):225\u2013233","journal-title":"Blood Rev"},{"issue":"3","key":"4008_CR5","doi-asserted-by":"publisher","first-page":"242","DOI":"10.7861\/clinmedicine.18-3-242","volume":"18","author":"S Bouri","year":"2018","unstructured":"Bouri S, Martin J (2018) Investigation of iron deficiency anaemia. Clin Med (Lond) 18(3):242\u2013244","journal-title":"Clin Med (Lond)"},{"issue":"7","key":"4008_CR6","doi-asserted-by":"publisher","first-page":"e108","DOI":"10.1002\/hem3.108","volume":"8","author":"A Iolascon","year":"2024","unstructured":"Iolascon A, Andolfo I, Russo R, et al (2024) Recommendations for diagnosis, treatment, and prevention of iron deficiency and iron deficiency anemia. Hemasphere 8(7):e108","journal-title":"Hemasphere"},{"issue":"3","key":"4008_CR7","doi-asserted-by":"publisher","first-page":"249","DOI":"10.1080\/17474124.2018.1404905","volume":"12","author":"AK Banerjee","year":"2018","unstructured":"Banerjee AK, Celentano V, Khan J, et al (2018) Practical gastrointestinal investigation of iron deficiency anaemia. Expert Rev Gastroenterol Hepatol 12(3):249\u2013256","journal-title":"Expert Rev Gastroenterol Hepatol"},{"issue":"4","key":"4008_CR8","first-page":"428","volume":"54","author":"A Calim","year":"2020","unstructured":"Calim A, Kanat E, Mazi EE, et al (2020) Evaluation of in-patients with iron deficiency anemia in terms of etiology. Sisli Etfal Hastan Tip Bul 54(4):428\u2013432","journal-title":"Sisli Etfal Hastan Tip Bul"},{"issue":"3","key":"4008_CR9","doi-asserted-by":"publisher","first-page":"1085","DOI":"10.1053\/j.gastro.2020.06.046","volume":"159","author":"CW Ko","year":"2020","unstructured":"Ko CW, Siddique SM, Patel A, et al (2020) AGA clinical practice guidelines on the gastrointestinal evaluation of iron deficiency anemia. Gastroenterology 159(3):1085\u20131094","journal-title":"Gastroenterology"},{"issue":"11","key":"4008_CR10","doi-asserted-by":"publisher","first-page":"2030","DOI":"10.1136\/gutjnl-2021-325210","volume":"70","author":"J Snook","year":"2021","unstructured":"Snook J, Bhala N, Beales ILP, et al (2021) British Society of Gastroenterology guidelines for the management of iron deficiency anaemia in adults. Gut 70(11):2030\u20132051","journal-title":"Gut"},{"issue":"1","key":"4008_CR11","doi-asserted-by":"publisher","first-page":"269","DOI":"10.1186\/s12876-024-03372-y","volume":"24","author":"BR Abramowitz","year":"2024","unstructured":"Abramowitz BR, Saba H, Aytaman A, et al (2024) Diagnostic yield of bidirectional endoscopy for iron deficiency anemia in young patients. BMC Gastroenterol 24(1):269","journal-title":"BMC Gastroenterol"},{"issue":"19","key":"4008_CR12","doi-asserted-by":"publisher","first-page":"1832","DOI":"10.1056\/NEJMra1401038","volume":"372","author":"C Camaschella","year":"2015","unstructured":"Camaschella C (2015) Iron-deficiency anemia. N Engl J Med 372(19):1832\u20131843","journal-title":"N Engl J Med"},{"issue":"1","key":"4008_CR13","doi-asserted-by":"publisher","first-page":"471","DOI":"10.14744\/scie.2022.15013","volume":"35","author":"M Ergen\u00e7","year":"2024","unstructured":"Ergen\u00e7 M, Uprak TK (2024) Lower gastrointestinal endoscopy in elderly: a single-center experience. South Clin Ist Euras 35(1):471\u2013477","journal-title":"South Clin Ist Euras"},{"issue":"47","key":"4008_CR14","doi-asserted-by":"publisher","first-page":"e5339","DOI":"10.1097\/MD.0000000000005339","volume":"95","author":"R Clere-Jehl","year":"2016","unstructured":"Clere-Jehl R, Sauleau E, Ciuca S, et al (2016) Outcome of endoscopy-negative iron deficiency anemia in patients above 65: a longitudinal multicenter cohort. Medicine (Baltimore) 95(47):e5339","journal-title":"Medicine (Baltimore)"},{"issue":"2","key":"4008_CR15","volume":"14","author":"M Ergenc","year":"2022","unstructured":"Ergenc M, Uprak TK (2022) Esophagogastroduodenoscopy in patients aged 75 years and older: a single-center study. Cureus 14(2):e21846","journal-title":"Cureus"},{"issue":"3","key":"4008_CR16","doi-asserted-by":"publisher","first-page":"1097","DOI":"10.1053\/j.gastro.2020.06.045","volume":"159","author":"DC Rockey","year":"2020","unstructured":"Rockey DC, Altayar O, Falck-Ytter Y, Kalmaz D (2020) AGA technical review on gastrointestinal evaluation of iron deficiency anemia. Gastroenterology 159(3):1097\u20131119","journal-title":"Gastroenterology"},{"issue":"5","key":"4008_CR17","doi-asserted-by":"publisher","first-page":"1299","DOI":"10.1007\/s10620-012-2496-6","volume":"58","author":"D Carter","year":"2013","unstructured":"Carter D, Levi G, Tzur D, et al (2013) Prevalence and predictive factors for gastrointestinal pathology in young men evaluated for iron deficiency anemia. Dig Dis Sci 58(5):1299\u20131305","journal-title":"Dig Dis Sci"},{"key":"4008_CR18","unstructured":"National Institute for Health and Care Excellence (NICE) (2023) Suspected cancer: recognition and referral (NICE Guideline No. 12). NICE. https:\/\/www.ncbi.nlm.nih.gov\/books\/NBK555330\/. Accessed Jan 2025"},{"issue":"6","key":"4008_CR19","doi-asserted-by":"publisher","first-page":"1084","DOI":"10.3904\/kjim.2016.421","volume":"33","author":"NH Kim","year":"2018","unstructured":"Kim NH, Park JH, Park DI, et al (2018) Should asymptomatic young men with iron deficiency anemia necessarily undergo endoscopy? Korean J Intern Med 33(6):1084\u20131092","journal-title":"Korean J Intern Med"},{"issue":"11","key":"4008_CR20","doi-asserted-by":"publisher","first-page":"e2341516","DOI":"10.1001\/jamanetworkopen.2023.41516","volume":"6","author":"J Demb","year":"2023","unstructured":"Demb J, Liu L, Murphy CC, et al (2023) Time to endoscopy or colonoscopy among adults younger than 50 years with iron-deficiency anemia and\/or hematochezia in the VHA. JAMA Netw Open 6(11):e2341516","journal-title":"JAMA Netw Open"},{"issue":"4","key":"4008_CR21","doi-asserted-by":"publisher","first-page":"853","DOI":"10.1111\/codi.15467","volume":"23","author":"M Ploug","year":"2021","unstructured":"Ploug M, Kroijer R, Qvist N, et al (2021) Iron deficiency in colorectal cancer patients: a cohort study on prevalence and associations. Colorectal Dis 23(4):853\u2013859","journal-title":"Colorectal Dis"},{"issue":"11","key":"4008_CR22","doi-asserted-by":"publisher","first-page":"1617","DOI":"10.1007\/s00384-017-2898-1","volume":"32","author":"MJ Wilson","year":"2017","unstructured":"Wilson MJ, Dekker JWT, Harlaar JJ, et al (2017) The role of preoperative iron deficiency in colorectal cancer patients: prevalence and treatment. Int J Colorectal Dis 32(11):1617\u20131624","journal-title":"Int J Colorectal Dis"}],"container-title":["Irish Journal of Medical Science (1971 -)"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s11845-025-04008-0.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s11845-025-04008-0\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s11845-025-04008-0.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,9,6]],"date-time":"2025-09-06T01:54:27Z","timestamp":1757123667000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s11845-025-04008-0"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,7,25]]},"references-count":22,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2025,8]]}},"alternative-id":["4008"],"URL":"https:\/\/doi.org\/10.1007\/s11845-025-04008-0","relation":{},"ISSN":["0021-1265","1863-4362"],"issn-type":[{"value":"0021-1265","type":"print"},{"value":"1863-4362","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,7,25]]},"assertion":[{"value":"21 January 2025","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"12 July 2025","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"25 July 2025","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"This study was performed in accordance with the principles of the Declaration of Helsinki. This study was approved by the Ethics Committee of Suleyman Demirel University Health Sciences (number: 2024\/79\/22). Written informed consent was obtained from all the patients before the procedure was performed. The Ethics Committee of Suleyman Demirel University Health Sciences granted a full waiver of informed consent for reviewing the patient charts and data analysis.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"The authors declare no competing interests.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}}]}}