{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,11]],"date-time":"2025-09-11T19:02:25Z","timestamp":1757617345458,"version":"3.44.0"},"reference-count":26,"publisher":"Springer Science and Business Media LLC","issue":"4","license":[{"start":{"date-parts":[[2025,7,23]],"date-time":"2025-07-23T00:00:00Z","timestamp":1753228800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2025,7,23]],"date-time":"2025-07-23T00:00:00Z","timestamp":1753228800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Ir J Med Sci"],"published-print":{"date-parts":[[2025,8]]},"DOI":"10.1007\/s11845-025-04021-3","type":"journal-article","created":{"date-parts":[[2025,7,23]],"date-time":"2025-07-23T05:34:14Z","timestamp":1753248854000},"page":"1477-1484","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Exploring the neuroprotective effects of bevacizumab in a preclinical animal model of spinal cord trauma"],"prefix":"10.1007","volume":"194","author":[{"given":"Ali Samet","family":"Topsakal","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8721-5113","authenticated-orcid":false,"given":"Mehmet","family":"Aktoklu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mehmet Orbay","family":"B\u0131y\u0131k","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ali R\u0131za","family":"G\u00fcvercin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ertu\u011frul","family":"\u00c7ak\u0131r","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2025,7,23]]},"reference":[{"key":"4021_CR1","doi-asserted-by":"publisher","first-page":"382","DOI":"10.1097\/01.ta.0000226154.38852.e6","volume":"61","author":"JL Antevil","year":"2006","unstructured":"Antevil JL, Sise MJ, Sack DI et al (2006) Spiral computed tomography for the \u0131nitial evaluation of spine trauma: a new standard of care? J Trauma Inj Infect Crit Care 61:382\u2013387. https:\/\/doi.org\/10.1097\/01.ta.0000226154.38852.e6","journal-title":"J Trauma Inj Infect Crit Care"},{"key":"4021_CR2","doi-asserted-by":"publisher","first-page":"923","DOI":"10.1016\/j.jocn.2005.03.013","volume":"12","author":"E Cakir","year":"2005","unstructured":"Cakir E, Usul H, Peksoylu B et al (2005) Effects of citicoline on experimental spinal cord injury. J Clin Neurosci 12:923\u2013926. https:\/\/doi.org\/10.1016\/j.jocn.2005.03.013","journal-title":"J Clin Neurosci"},{"key":"4021_CR3","doi-asserted-by":"publisher","unstructured":"Pinchi E, Frati A, Cantatore S et al (2019) Acute spinal cord \u0131njury: a systematic review \u0131nvestigating miRNA families \u0131nvolved. Int J Mol Sci 20. https:\/\/doi.org\/10.3390\/IJMS20081841","DOI":"10.3390\/IJMS20081841"},{"key":"4021_CR4","doi-asserted-by":"publisher","first-page":"67","DOI":"10.1007\/s10143-002-0233-x","volume":"26","author":"E \u00c7akir","year":"2003","unstructured":"\u00c7akir E, Baykal S, Karahan C et al (2003) Acute phase effects of ATP-MgCl 2 on experimental spinal cord injury. Neurosurg Rev 26:67\u201370. https:\/\/doi.org\/10.1007\/s10143-002-0233-x","journal-title":"Neurosurg Rev"},{"key":"4021_CR5","unstructured":"Kaptano\u011flu E (2005) Temel n\u00f6ro\u015firurji; Omurilik yaralanmas\u0131 ve patofizyolojisi. Ankara"},{"key":"4021_CR6","doi-asserted-by":"publisher","first-page":"1027","DOI":"10.1097\/00006123-199905000-00052","volume":"44","author":"AP Amar","year":"1999","unstructured":"Amar AP, Levy ML (1999) Pathogenesis and pharmacological strategies for mitigating secondary damage in acute spinal cord \u0131njury. Neurosurgery 44:1027\u20131039. https:\/\/doi.org\/10.1097\/00006123-199905000-00052","journal-title":"Neurosurgery"},{"key":"4021_CR7","doi-asserted-by":"crossref","unstructured":"Koyanagi I, Tator CH, Lea PJ (1993) Three-dimensional analysis of the vascular system in the rat spinal cord with scanning electron microscopy of vascular corrosion casts. Part 2: Acute spinal cord injury. Neurosurgery 33:285\u201391. discussion 292","DOI":"10.1097\/00006123-199308000-00016"},{"key":"4021_CR8","doi-asserted-by":"publisher","first-page":"804","DOI":"10.1097\/00006123-199610000-00032","volume":"39","author":"DL Anthes","year":"1996","unstructured":"Anthes DL, Theriault E, Tator CH (1996) Ultrastructural evidence for arteriolar vasospasm after spinal cord trauma. Neurosurgery 39:804\u2013814. https:\/\/doi.org\/10.1097\/00006123-199610000-00032","journal-title":"Neurosurgery"},{"key":"4021_CR9","doi-asserted-by":"publisher","first-page":"1125","DOI":"10.1242\/DMM.025833","volume":"9","author":"J Kjell","year":"2016","unstructured":"Kjell J, Olson L (2016) Rat models of spinal cord injury: from pathology to potential therapies. Dis Model Mech 9:1125\u20131137. https:\/\/doi.org\/10.1242\/DMM.025833","journal-title":"Dis Model Mech"},{"key":"4021_CR10","doi-asserted-by":"publisher","first-page":"341","DOI":"10.1016\/S0301-0082(98)00049-5","volume":"56","author":"Y Taoka","year":"1998","unstructured":"Taoka Y, Okajima K (1998) Spinal cord injury in the rat. Prog Neurobiol 56:341\u2013358. https:\/\/doi.org\/10.1016\/S0301-0082(98)00049-5","journal-title":"Prog Neurobiol"},{"key":"4021_CR11","doi-asserted-by":"publisher","unstructured":"\u0130Ldan F, Polat S, \u00d6Ner A et al (1995) Effects of naloxone on sodium- and potassium-activated and magnesium-dependent adenosine-5\u2019-triphosphatase activity and lipid peroxidation and early ultrastructural findings after experimental spinal cord injury. Neurosurgery 36:797\u2013805. https:\/\/doi.org\/10.1227\/00006123-199504000-00022","DOI":"10.1227\/00006123-199504000-00022"},{"key":"4021_CR12","doi-asserted-by":"publisher","first-page":"987","DOI":"10.1016\/S0196-0644(05)82739-8","volume":"22","author":"DK Anderson","year":"1993","unstructured":"Anderson DK, Hall ED (1993) Pathophysiology of spinal cord trauma. Ann Emerg Med 22:987\u2013992. https:\/\/doi.org\/10.1016\/S0196-0644(05)82739-8","journal-title":"Ann Emerg Med"},{"key":"4021_CR13","doi-asserted-by":"publisher","first-page":"858","DOI":"10.4149\/BLL_2020_141","volume":"121","author":"E Arslan","year":"2020","unstructured":"Arslan E, Biyik MO, Kosucu M et al (2020) Is ceftriaxone effective in experimental brain ischemia\/reperfusion injury? Bratislava Med J 121:858\u2013863. https:\/\/doi.org\/10.4149\/BLL_2020_141","journal-title":"Bratislava Med J"},{"key":"4021_CR14","doi-asserted-by":"publisher","first-page":"109","DOI":"10.1080\/10799893.2023.2291566","volume":"43","author":"U Yazar","year":"2023","unstructured":"Yazar U, Guvercin AR, Rouhikia M et al (2023) Cerebrolysin provides effective protection on high glucose-induced neuropathy in cultured rat dorsal root ganglion neurons. J Recept Signal Transduct 43:109\u2013114. https:\/\/doi.org\/10.1080\/10799893.2023.2291566","journal-title":"J Recept Signal Transduct"},{"key":"4021_CR15","doi-asserted-by":"publisher","unstructured":"G\u00fcvercin AR, Aktoklu M, Arslan E et al (2025) Protective evidence of clarithromycin after \u0131schemic cerebral \u0131njury; an experimental study. Middle Black Sea J Health Sci 11:44\u201356. https:\/\/doi.org\/10.19127\/mbsjohs.1574851","DOI":"10.19127\/mbsjohs.1574851"},{"key":"4021_CR16","doi-asserted-by":"publisher","first-page":"115","DOI":"10.3171\/JNS.1985.62.1.0115","volume":"62","author":"TE Anderson","year":"1985","unstructured":"Anderson TE (1985) Spinal cord contusion injury: experimental dissociation of hemorrhagic necrosis and subacute loss of axonal conduction. J Neurosurg 62:115\u2013119. https:\/\/doi.org\/10.3171\/JNS.1985.62.1.0115","journal-title":"J Neurosurg"},{"key":"4021_CR17","doi-asserted-by":"publisher","first-page":"170","DOI":"10.1016\/J.ADDR.2018.02.010","volume":"146","author":"S Korntner","year":"2019","unstructured":"Korntner S, Lehner C, Gehwolf R et al (2019) Limiting angiogenesis to modulate scar formation. Adv Drug Deliv Rev 146:170\u2013189. https:\/\/doi.org\/10.1016\/J.ADDR.2018.02.010","journal-title":"Adv Drug Deliv Rev"},{"key":"4021_CR18","doi-asserted-by":"publisher","first-page":"326","DOI":"10.1016\/J.EXPNEUROL.2017.09.008","volume":"299","author":"N Zhang","year":"2018","unstructured":"Zhang N, Chen J, Ferraro GB et al (2018) Anti-VEGF treatment improves neurological function in tumors of the nervous system. Exp Neurol 299:326\u2013333. https:\/\/doi.org\/10.1016\/J.EXPNEUROL.2017.09.008","journal-title":"Exp Neurol"},{"key":"4021_CR19","doi-asserted-by":"publisher","first-page":"14676","DOI":"10.1073\/PNAS.1512570112","volume":"112","author":"X Gao","year":"2015","unstructured":"Gao X, Zhao Y, Stemmer-Rachamimov AO et al (2015) Anti-VEGF treatment improves neurological function and augments radiation response in NF2 schwannoma model. Proc Natl Acad Sci U S A 112:14676\u201314681. https:\/\/doi.org\/10.1073\/PNAS.1512570112","journal-title":"Proc Natl Acad Sci U S A"},{"key":"4021_CR20","doi-asserted-by":"publisher","first-page":"692","DOI":"10.1248\/BPB.B18-00628","volume":"42","author":"SQ Feng","year":"2019","unstructured":"Feng SQ, Zong SY, Liu JX et al (2019) VEGF antagonism attenuates cerebral \u0131schemia\/reperfusion-\u0131nduced \u0131njury via \u0131nhibiting endoplasmic reticulum stress-mediated apoptosis. Biol Pharm Bull 42:692\u2013702. https:\/\/doi.org\/10.1248\/BPB.B18-00628","journal-title":"Biol Pharm Bull"},{"key":"4021_CR21","doi-asserted-by":"publisher","first-page":"335","DOI":"10.1016\/j.ajo.2006.09.014","volume":"143","author":"PT Finger","year":"2007","unstructured":"Finger PT (2007) Anti-VEGF bevacizumab (Avastin\u00ae) for radiation optic neuropathy. Am J Ophthalmol 143:335\u2013338. https:\/\/doi.org\/10.1016\/j.ajo.2006.09.014","journal-title":"Am J Ophthalmol"},{"key":"4021_CR22","doi-asserted-by":"publisher","first-page":"995","DOI":"10.1038\/NRD1601","volume":"3","author":"M Muhsin","year":"2004","unstructured":"Muhsin M, Graham J, Kirkpatrick P (2004) Bevacizumab. Nat Rev Drug Discov 3:995\u2013996. https:\/\/doi.org\/10.1038\/NRD1601","journal-title":"Nat Rev Drug Discov"},{"key":"4021_CR23","doi-asserted-by":"publisher","first-page":"241","DOI":"10.1016\/0168-5597(89)90055-5","volume":"74","author":"MG Fehlings","year":"1989","unstructured":"Fehlings MG, Tator CH, Linden RD (1989) The relationships among the severity of spinal cord injury, motor and somatosensory evoked potentials and spinal cord blood flow. Electroencephalogr Clin Neurophysiol 74:241\u2013259. https:\/\/doi.org\/10.1016\/0168-5597(89)90055-5","journal-title":"Electroencephalogr Clin Neurophysiol"},{"key":"4021_CR24","doi-asserted-by":"publisher","first-page":"15","DOI":"10.3171\/JNS.1991.75.1.0015","volume":"75","author":"CH Tator","year":"1991","unstructured":"Tator CH, Fehlings MG (1991) Review of the secondary injury theory of acute spinal cord trauma with emphasis on vascular mechanisms. J Neurosurg 75:15\u201326. https:\/\/doi.org\/10.3171\/JNS.1991.75.1.0015","journal-title":"J Neurosurg"},{"key":"4021_CR25","doi-asserted-by":"publisher","unstructured":"Bradbury EJ, Burnside ER (2019) Moving beyond the glial scar for spinal cord repair. Nat Commun 10. https:\/\/doi.org\/10.1038\/S41467-019-11707-7","DOI":"10.1038\/S41467-019-11707-7"},{"key":"4021_CR26","doi-asserted-by":"publisher","first-page":"2698","DOI":"10.3390\/ijms20112698","volume":"20","author":"F Cofano","year":"2019","unstructured":"Cofano F, Boido M, Monticelli M et al (2019) Mesenchymal stem cells for spinal cord \u0131njury: current options, limitations, and future of cell therapy. Int J Mol Sci 20:2698. https:\/\/doi.org\/10.3390\/ijms20112698","journal-title":"Int J Mol Sci"}],"container-title":["Irish Journal of Medical Science (1971 -)"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s11845-025-04021-3.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s11845-025-04021-3\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s11845-025-04021-3.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,9,6]],"date-time":"2025-09-06T01:54:32Z","timestamp":1757123672000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s11845-025-04021-3"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,7,23]]},"references-count":26,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2025,8]]}},"alternative-id":["4021"],"URL":"https:\/\/doi.org\/10.1007\/s11845-025-04021-3","relation":{},"ISSN":["0021-1265","1863-4362"],"issn-type":[{"type":"print","value":"0021-1265"},{"type":"electronic","value":"1863-4362"}],"subject":[],"published":{"date-parts":[[2025,7,23]]},"assertion":[{"value":"6 May 2025","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"15 July 2025","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"23 July 2025","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"Not applicable.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Patient consent for publication"}},{"value":"The authors declare no competing interests.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}}]}}