{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T02:03:39Z","timestamp":1761962619645,"version":"build-2065373602"},"reference-count":33,"publisher":"Springer Science and Business Media LLC","issue":"5","license":[{"start":{"date-parts":[[2025,8,11]],"date-time":"2025-08-11T00:00:00Z","timestamp":1754870400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2025,8,11]],"date-time":"2025-08-11T00:00:00Z","timestamp":1754870400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Ir J Med Sci"],"published-print":{"date-parts":[[2025,10]]},"DOI":"10.1007\/s11845-025-04030-2","type":"journal-article","created":{"date-parts":[[2025,8,11]],"date-time":"2025-08-11T08:12:14Z","timestamp":1754899934000},"page":"1651-1658","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Effect of antibiotic treatment and exercise on knee synovitis in patients with diabetes mellitus"],"prefix":"10.1007","volume":"194","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0912-159X","authenticated-orcid":false,"given":"Suleyman","family":"Varsak","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6049-0705","authenticated-orcid":false,"given":"Abdurrahim","family":"Yildiz","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0638-8918","authenticated-orcid":false,"given":"Askeri","family":"Turken","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2025,8,11]]},"reference":[{"issue":"10053","key":"4030_CR1","doi-asserted-by":"publisher","first-page":"1545","DOI":"10.1016\/S0140-6736(16)31678-6","volume":"388","author":"T Vos","year":"2016","unstructured":"Vos T, Allen C, Arora M et al (2016) Global, regional, and national incidence, prevalence, and years lived with disability for 310 diseases and injuries, 1990\u20132015: a systematic analysis for the global burden of disease study 2015. Lancet 388(10053):1545\u20131602. https:\/\/doi.org\/10.1016\/S0140-6736(16)31678-6","journal-title":"Lancet"},{"issue":"11","key":"4030_CR2","doi-asserted-by":"publisher","first-page":"1097","DOI":"10.1016\/j.autrev.2018.06.002","volume":"17","author":"A Bortoluzzi","year":"2018","unstructured":"Bortoluzzi A, Furini F, Scir\u00e8 CA (2018) Osteoarthritis and its management - epidemiology, nutritional aspects and environmental factors. Autoimmun Rev 17(11):1097\u20131104. https:\/\/doi.org\/10.1016\/j.autrev.2018.06.002","journal-title":"Autoimmun Rev"},{"key":"4030_CR3","unstructured":"TUIK Research on the Use of Information Technologies in Enterprises. Available online: https:\/\/data.tuik.gov.tr\/Bulten:Index;2019."},{"issue":"9991","key":"4030_CR4","doi-asserted-by":"publisher","first-page":"376","DOI":"10.1016\/S0140-6736(14)60802-3","volume":"386","author":"S Glyn-Jones","year":"2015","unstructured":"Glyn-Jones S, Palmer AJR, Agricola R et al (2015) Osteoarthritis. Lancet 386(9991):376\u2013387. https:\/\/doi.org\/10.1016\/S0140-6736(14)60802-3","journal-title":"Lancet"},{"issue":"5","key":"4030_CR5","doi-asserted-by":"publisher","first-page":"917","DOI":"10.2337\/dci18-0007","volume":"41","author":"AD Association","year":"2018","unstructured":"Association AD (2018) Economic costs of diabetes in the US in 2017. Diabetes Care 41(5):917\u2013928","journal-title":"Diabetes Care"},{"key":"4030_CR6","unstructured":"\u0130lkova H,\u00a0Akt\u00fcrk, MY, \u00d6zkan S (2023) The economic and financial burden of type 9 diabetes on the country. National diabetes strategy 10th year final report 2023, diabetes 2020-2030 vision and goals, Ankara: Turkish Diabetes Foundation. pp 56\u201358"},{"issue":"1","key":"4030_CR7","doi-asserted-by":"publisher","first-page":"67","DOI":"10.1016\/j.cger.2014.08.019","volume":"31","author":"SR Piva","year":"2015","unstructured":"Piva SR, Susko AM, Khoja SS et al (2015) Links between osteoarthritis and diabetes: implications for management from a physical activity perspective. Clin Geriatr Med 31(1):67\u201387. https:\/\/doi.org\/10.1016\/j.cger.2014.08.019","journal-title":"Clin Geriatr Med"},{"issue":"6","key":"4030_CR8","doi-asserted-by":"publisher","first-page":"461","DOI":"10.1177\/1941738109350438","volume":"1","author":"AJ Sophia Fox","year":"2009","unstructured":"Sophia Fox AJ, Bedi A, Rodeo SA (2009) The basic science of articular cartilage: structure, composition, and function. Sports Health 1(6):461\u2013468. https:\/\/doi.org\/10.1177\/1941738109350438","journal-title":"Sports Health"},{"issue":"2","key":"4030_CR9","doi-asserted-by":"publisher","first-page":"153","DOI":"10.1007\/s13105-019-00666-8","volume":"75","author":"A Hosseinzadeh","year":"2019","unstructured":"Hosseinzadeh A, Bahrampour Juybari K, Kamarul T, Sharifi AM (2019) Protective effects of atorvastatin on high glucose-induced oxidative stress and mitochondrial apoptotic signaling pathways in cultured chondrocytes. J Physiol Biochem 75(2):153\u2013162. https:\/\/doi.org\/10.1007\/s13105-019-00666-8","journal-title":"J Physiol Biochem"},{"key":"4030_CR10","doi-asserted-by":"publisher","first-page":"258","DOI":"10.1016\/j.lfs.2019.04.011","volume":"228","author":"H Liang","year":"2019","unstructured":"Liang H, Wang H, Luo L and others (2019) Toll-like receptor 4 promotes high glucose-induced catabolic and inflammatory responses in chondrocytes in an NF-\u03baB-dependent manner. Life Sci 228:258\u2013265. https:\/\/doi.org\/10.1016\/j.lfs.2019.04.011","journal-title":"Life Sci"},{"issue":"3","key":"4030_CR11","doi-asserted-by":"publisher","first-page":"373","DOI":"10.1002\/jor.22770","volume":"33","author":"YJ Chen","year":"2015","unstructured":"Chen YJ, Chan DC, Lan KC and others (2015) PPAR\u03b3 is involved in the hyperglycemia-induced inflammatory responses and collagen degradation in human chondrocytes and diabetic mouse cartilages. J Orthop Res 33(3):373\u2013381. https:\/\/doi.org\/10.1002\/jor.22770","journal-title":"J Orthop Res"},{"issue":"12","key":"4030_CR12","doi-asserted-by":"publisher","first-page":"2116","DOI":"10.1016\/j.joca.2016.06.019","volume":"24","author":"M Ribeiro","year":"2016","unstructured":"Ribeiro M, De Figueroa PL, Nogueira-Recalde U et al (2016) Diabetes-accelerated experimental osteoarthritis is prevented by autophagy activation. Osteoarthritis Cartilage. 24(12):2116\u201325. https:\/\/doi.org\/10.1016\/j.joca.2016.06.019","journal-title":"Osteoarthritis Cartilage."},{"issue":"7","key":"4030_CR13","doi-asserted-by":"publisher","first-page":"1063","DOI":"10.2106\/00004623-198769070-00015","volume":"69","author":"RL Smith","year":"1987","unstructured":"Smith RL, Schurman DJ, Kajiyama G et al (1987) The effect of antibiotics on the destruction of cartilage in experimental infectious arthritis. JBJS 69(7):1063\u20131068","journal-title":"JBJS"},{"issue":"9","key":"4030_CR14","doi-asserted-by":"publisher","first-page":"848","DOI":"10.1111\/ans.14816","volume":"88","author":"T Symonds","year":"2018","unstructured":"Symonds T, Parkinson B, Hazratwala K et al (2018) Use of regional administration of prophylactic antibiotics in total knee arthroplasty. ANZ J Surg 88(9):848\u2013853. https:\/\/doi.org\/10.1111\/ans.14816","journal-title":"ANZ J Surg"},{"issue":"3","key":"4030_CR15","doi-asserted-by":"publisher","first-page":"232","DOI":"10.1136\/ard.41.3.232","volume":"41","author":"I Caruso","year":"1982","unstructured":"Caruso I, Montrone F, Fumagalli M et al (1982) Rheumatoid knee synovitis successfully treated with intra-articular rifamycin SV. Ann Rheum Dis 41(3):232. https:\/\/doi.org\/10.1136\/ard.41.3.232","journal-title":"Ann Rheum Dis"},{"key":"4030_CR16","doi-asserted-by":"publisher","unstructured":"Braid HR. Does the intra-articular injection of antimicrobials alongside corticosteroids or other medications reduce the risk of synovial sepsis?. Veterinary Evidence. 2019 Oct 30;4(4). https:\/\/doi.org\/10.18849\/ve.v4i4.194.","DOI":"10.18849\/ve.v4i4.194"},{"issue":"5","key":"4030_CR17","doi-asserted-by":"publisher","first-page":"952","DOI":"10.1111\/1756-185x.13082","volume":"21","author":"L Huang","year":"2018","unstructured":"Huang L, Guo B, Xu F, Zhao J (2018) Effects of quadriceps functional exercise with isometric contraction in the treatment of knee osteoarthritis. Int J Rheum Dis 21(5):952\u2013959. https:\/\/doi.org\/10.1111\/1756-185x.13082","journal-title":"Int J Rheum Dis"},{"issue":"6","key":"4030_CR18","doi-asserted-by":"publisher","first-page":"853","DOI":"10.3233\/thc-161234","volume":"24","author":"AO Ojoawo","year":"2016","unstructured":"Ojoawo AO, Olaogun MO, Hassan MA (2016) Comparative effects of proprioceptive and isometric exercises on pain intensity and difficulty in patients with knee osteoarthritis: a randomised control study. Technol Health Care 24(6):853\u2013863. https:\/\/doi.org\/10.3233\/thc-161234","journal-title":"Technol Health Care"},{"issue":"6","key":"4030_CR19","doi-asserted-by":"publisher","first-page":"434","DOI":"10.1016\/j.rehab.2013.06.001","volume":"56","author":"S Anwer","year":"2013","unstructured":"Anwer S, Equebal A, Nezamuddin M et al (2013) Effect of gender on strength gains after isometric exercise coupled with electromyographic biofeedback in knee osteoarthritis: a preliminary study. Ann Phys Rehabil Med 56(6):434\u2013442. https:\/\/doi.org\/10.1016\/j.rehab.2013.06.001","journal-title":"Ann Phys Rehabil Med"},{"issue":"7","key":"4030_CR20","doi-asserted-by":"publisher","first-page":"749","DOI":"10.1007\/s10067-010-1398-2","volume":"29","author":"S Basaran","year":"2010","unstructured":"Basaran S, Guzel R, Seydaoglu G, Guler-Uysal F (2010) Validity, reliability, and comparison of the WOMAC osteoarthritis index and Lequesne algofunctional index in Turkish patients with hip or knee osteoarthritis. Clinic Rheumatol 29(7):749\u201356. https:\/\/doi.org\/10.1007\/s10067-010-1398-2","journal-title":"Clinic Rheumatol"},{"issue":"8","key":"4030_CR21","doi-asserted-by":"publisher","first-page":"602","DOI":"10.1053\/joca.2002.0533","volume":"10","author":"M Faucher","year":"2002","unstructured":"Faucher M, Poiraudeau S, Lefevre-Colau MM et al (2002) Algo-functional assessment of knee osteoarthritis: comparison of the test-retest reliability and construct validity of the WOMAC and Lequesne indexes. Osteoarthritis Cartilage 10(8):602\u2013610. https:\/\/doi.org\/10.1053\/joca.2002.0533","journal-title":"Osteoarthritis Cartilage"},{"issue":"11","key":"4030_CR22","doi-asserted-by":"publisher","first-page":"1129","DOI":"10.1016\/j.jpain.2010.02.003","volume":"11","author":"I Unal-Cevik","year":"2010","unstructured":"Unal-Cevik I, Sarioglu-Ay S, Evcik D (2010) A comparison of the DN4 and LANSS questionnaires in the assessment of neuropathic pain: validity and reliability of the Turkish version of DN4. J Pain 11(11):1129\u20131135. https:\/\/doi.org\/10.1016\/j.jpain.2010.02.003","journal-title":"J Pain"},{"issue":"8","key":"4030_CR23","doi-asserted-by":"publisher","first-page":"1247","DOI":"10.1002\/ejp.2312","volume":"28","author":"A Alc\u00e1ntara Montero","year":"2024","unstructured":"Alc\u00e1ntara Montero A (2024) Importance of understanding pain phenotypes in knee osteoarthritis for selecting appropriate pain-management strategies. Eur J Pain 28(8):1247\u20131248. https:\/\/doi.org\/10.1002\/ejp.2312","journal-title":"Eur J Pain"},{"issue":"1","key":"4030_CR24","doi-asserted-by":"publisher","first-page":"309","DOI":"10.21608\/tnhcj.2024.241537.1032","volume":"8","author":"SA Ahmed","year":"2024","unstructured":"Ahmed SA (2024) Effect of educational module about heat therapy on pain and morning stiffness among patients with knee osteoarthritis. Trends in Nursing and Health Care Journal 8(1):309\u201338. https:\/\/doi.org\/10.21608\/tnhcj.2024.241537.1032","journal-title":"Trends in Nursing and Health Care Journal"},{"issue":"1","key":"4030_CR25","doi-asserted-by":"publisher","first-page":"75","DOI":"10.1093\/fampra\/cmac074","volume":"40","author":"AC van Berkel","year":"2022","unstructured":"van Berkel AC, Ringelenberg R, Bindels PJE et al (2022) Nocturnal pain, is the pain different compared with pain during the day? An exploratory cross-sectional study in patients with hip and knee osteoarthritis. Fam Pract 40(1):75\u201382. https:\/\/doi.org\/10.1093\/fampra\/cmac074","journal-title":"Fam Pract"},{"issue":"4","key":"4030_CR26","doi-asserted-by":"publisher","first-page":"358","DOI":"10.1159\/000521783","volume":"30","author":"M Li","year":"2022","unstructured":"Li M, Liu Z, Huang Y (2022) Evaluating, \u201ccomparing the effects of massage therapy and aromatherapy on knee pain, morning stiffness, daily life function, and quality of life in patients with knee osteoarthritis.\u201d Complement Med Res 30(4):358\u2013359. https:\/\/doi.org\/10.1159\/000521783","journal-title":"Complement Med Res"},{"issue":"10","key":"4030_CR27","doi-asserted-by":"publisher","first-page":"e47666","DOI":"10.7759\/cureus.47666","volume":"15","author":"KA Bashekah","year":"2023","unstructured":"Bashekah KA, Zagzoug ME, Banaja AW and others (2023) Prevalence and characteristics of knee osteoarthritis among the general public in Saudi Arabia. Cureus 15(10):e47666. https:\/\/doi.org\/10.7759\/cureus.47666","journal-title":"Cureus"},{"issue":"Suppl 1","key":"4030_CR28","doi-asserted-by":"publisher","first-page":"1827","DOI":"10.1136\/annrheumdis-2023-eular.4661","volume":"82","author":"H Fouzia","year":"2023","unstructured":"Fouzia H, Taik FZ, Berrichi I et al (2023) AB1196 Neuropathic Pain In Gonarthrosis: Prevalence And Associated Factors. Ann Rheum Dis 82(Suppl 1):1827\u20131828. https:\/\/doi.org\/10.1136\/annrheumdis-2023-eular.4661","journal-title":"Ann Rheum Dis"},{"issue":"4","key":"4030_CR29","doi-asserted-by":"publisher","first-page":"186","DOI":"10.2478\/rjim-2023-0017","volume":"61","author":"A Mougui","year":"2023","unstructured":"Mougui A, Belouaham S, El Bouchti I (2023) Neuropathic pain in patients with primary knee osteoarthritis: a cross-sectional study. Rom J Intern Med 61(4):186\u2013194. https:\/\/doi.org\/10.2478\/rjim-2023-0017","journal-title":"Rom J Intern Med"},{"issue":"Suppl 1","key":"4030_CR30","doi-asserted-by":"publisher","first-page":"1821","DOI":"10.1136\/annrheumdis-2023-eular.4771","volume":"82","author":"A Mougui","year":"2023","unstructured":"Mougui A, Belouaham S, El Bouchti I (2023) AB1183 Neuropathic Pain In Primary Knee Osteoarthritis. Ann Rheum Dis 82(Suppl 1):1821\u20131822. https:\/\/doi.org\/10.1136\/annrheumdis-2023-eular.4771","journal-title":"Ann Rheum Dis"},{"issue":"1","key":"4030_CR31","doi-asserted-by":"publisher","first-page":"67","DOI":"10.1186\/s42358-021-00225-0","volume":"61","author":"U G\u00fcng\u00f6rDemir","year":"2021","unstructured":"G\u00fcng\u00f6rDemir U, Demir AN, Toraman NF (2021) Neuropathic pain in knee osteoarthritis. Adv Rheumatol 61(1):67. https:\/\/doi.org\/10.1186\/s42358-021-00225-0","journal-title":"Adv Rheumatol"},{"issue":"79","key":"4030_CR32","doi-asserted-by":"publisher","first-page":"1745","DOI":"10.1136\/annrheumdis-2020-eular.3740","volume":"1","author":"AB Tekaya","year":"2020","unstructured":"Tekaya AB, Rouached L, Slimi A et al (2020) AB0880 Neuropathic pain in patients with knee osteoarthritis: prevalence and related factors. Ann Rheumat Dis 1(79):1745. https:\/\/doi.org\/10.1136\/annrheumdis-2020-eular.3740","journal-title":"Ann Rheumat Dis"},{"issue":"8","key":"4030_CR33","doi-asserted-by":"publisher","first-page":"847","DOI":"10.1080\/08820139.2017.1373900","volume":"46","author":"C Ruh","year":"2017","unstructured":"Ruh C, Banjade R, Mandadi S et al (2017) Immunomodulatory effects of antimicrobial drugs. Immunol Invest 46(8):847\u2013863","journal-title":"Immunol Invest"}],"container-title":["Irish Journal of Medical Science (1971 -)"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s11845-025-04030-2.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s11845-025-04030-2\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s11845-025-04030-2.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T02:01:21Z","timestamp":1761962481000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s11845-025-04030-2"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,8,11]]},"references-count":33,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2025,10]]}},"alternative-id":["4030"],"URL":"https:\/\/doi.org\/10.1007\/s11845-025-04030-2","relation":{},"ISSN":["0021-1265","1863-4362"],"issn-type":[{"type":"print","value":"0021-1265"},{"type":"electronic","value":"1863-4362"}],"subject":[],"published":{"date-parts":[[2025,8,11]]},"assertion":[{"value":"2 May 2025","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"27 July 2025","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"11 August 2025","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The study was conducted in accordance with the Declaration of Helsinki and approved by the Dicle University Faculty of Medicine Noninterventional Clinical Research Ethics Committee on 01.09.2021 with the number 413.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"Informed consent was obtained from all subjects involved in the study.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Informed consent"}},{"value":"The authors declare no competing interests.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}}]}}