{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,8]],"date-time":"2026-09-08T13:21:44Z","timestamp":1788873704500,"version":"build-2803163510"},"reference-count":37,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2025,11,29]],"date-time":"2025-11-29T00:00:00Z","timestamp":1764374400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2025,11,29]],"date-time":"2025-11-29T00:00:00Z","timestamp":1764374400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Ir J Med Sci"],"published-print":{"date-parts":[[2026,2]]},"DOI":"10.1007\/s11845-025-04198-7","type":"journal-article","created":{"date-parts":[[2025,11,29]],"date-time":"2025-11-29T07:27:05Z","timestamp":1764401225000},"page":"149-157","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Apoptosis, inflammation, and oxidative\/nitrosative stress-related miRNA expression in vitiligo patients"],"prefix":"10.1007","volume":"195","author":[{"given":"Nuray","family":"\u00dcremi\u015f","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Erg\u00fcl Belge","family":"Kuruta\u015f","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Perihan","family":"\u00d6zt\u00fcrk","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Muhammed Mehdi","family":"\u00dcremi\u015f","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2025,11,29]]},"reference":[{"issue":"6","key":"4198_CR1","doi-asserted-by":"publisher","first-page":"571","DOI":"10.1159\/000506103","volume":"236","author":"C Bergqvist","year":"2020","unstructured":"Bergqvist C, Ezzedine K (2020) Vitiligo: a review. Dermatology 236(6):571\u2013592","journal-title":"Dermatology"},{"key":"4198_CR2","doi-asserted-by":"publisher","first-page":"1017","DOI":"10.12659\/MSM.914898","volume":"25","author":"Y Wang","year":"2019","unstructured":"Wang Y, Li S, Li C (2019) Perspectives of new advances in the pathogenesis of vitiligo: from oxidative stress to autoimmunity. Med Sci Monit 25:1017\u20131023","journal-title":"Med Sci Monit"},{"issue":"3","key":"4198_CR3","doi-asserted-by":"publisher","first-page":"1011","DOI":"10.1111\/jocd.15493","volume":"22","author":"S Arslan","year":"2023","unstructured":"Arslan S, Altunisik N, Turkmen D et al (2023) Evaluation of plasma zonulin level and its relationship with inflammatory cytokines in patients with vitiligo. J Cosmet Dermatol 22(3):1011\u20131016","journal-title":"J Cosmet Dermatol"},{"key":"4198_CR4","doi-asserted-by":"publisher","DOI":"10.3390\/cells12060936","author":"WL Chang","year":"2023","unstructured":"Chang WL, Ko CH (2023) The role of oxidative stress in vitiligo: an update on its pathogenesis and therapeutic implications. Cells. https:\/\/doi.org\/10.3390\/cells12060936","journal-title":"Cells"},{"issue":"1","key":"4198_CR5","doi-asserted-by":"publisher","first-page":"70","DOI":"10.1038\/s41420-022-00863-3","volume":"8","author":"P Kang","year":"2022","unstructured":"Kang P, Chen J, Zhang W et al (2022) Oxeiptosis: a novel pathway of melanocytes death in response to oxidative stress in vitiligo. Cell Death Discov 8(1):70","journal-title":"Cell Death Discov"},{"issue":"6","key":"4198_CR6","doi-asserted-by":"publisher","first-page":"1512","DOI":"10.1038\/jid.2014.65","volume":"134","author":"L Denat","year":"2014","unstructured":"Denat L, Kadekaro AL, Marrot L et al (2014) Melanocytes as instigators and victims of oxidative stress. J Invest Dermatol 134(6):1512\u20131518","journal-title":"J Invest Dermatol"},{"issue":"1","key":"4198_CR7","doi-asserted-by":"publisher","first-page":"e70133","DOI":"10.1002\/jbt.70133","volume":"39","author":"N Uremis","year":"2025","unstructured":"Uremis N, Uremis MM (2025) Oxidative\/nitrosative stress, apoptosis, and redox signaling: key players in neurodegenerative diseases. J Biochem Mol Toxicol 39(1):e70133","journal-title":"J Biochem Mol Toxicol"},{"issue":"6","key":"4198_CR8","doi-asserted-by":"publisher","first-page":"723","DOI":"10.1007\/s40291-023-00672-z","volume":"27","author":"A Bialczyk","year":"2023","unstructured":"Bialczyk A, Welniak A, Kaminska B, Czajkowski R (2023) Oxidative stress and potential antioxidant therapies in vitiligo: a narrative review. Mol Diagn Ther 27(6):723\u2013739","journal-title":"Mol Diagn Ther"},{"key":"4198_CR9","doi-asserted-by":"publisher","first-page":"1821780","DOI":"10.1155\/2022\/1821780","volume":"2022","author":"J Zhang","year":"2022","unstructured":"Zhang J, Hu W, Wang P et al (2022) Research progress on targeted antioxidant therapy and vitiligo. Oxid Med Cell Longev 2022:1821780","journal-title":"Oxid Med Cell Longev"},{"key":"4198_CR10","doi-asserted-by":"publisher","first-page":"964982","DOI":"10.3389\/fcell.2022.964982","volume":"10","author":"X Yu","year":"2022","unstructured":"Yu X, Cui Y, Zhu X et al (2022) Micrornas: emerging players in the pathogenesis of vitiligo. Front Cell Dev Biol 10:964982","journal-title":"Front Cell Dev Biol"},{"issue":"5","key":"4198_CR11","doi-asserted-by":"publisher","first-page":"1263","DOI":"10.1111\/bjd.13109","volume":"171","author":"MS Mansuri","year":"2014","unstructured":"Mansuri MS, Singh M, Dwivedi M et al (2014) MicroRNA profiling reveals differentially expressed microRNA signatures from the skin of patients with nonsegmental vitiligo. Br J Dermatol 171(5):1263\u20131267","journal-title":"Br J Dermatol"},{"issue":"6","key":"4198_CR12","first-page":"742","volume":"96","author":"L \u0160ahmatova","year":"2016","unstructured":"\u0160ahmatova L, Tankov S, Prans E et al (2016) Microrna-155 is dysregulated in the skin of patients with Vitiligo and inhibits melanogenesis-associated genes in melanocytes and keratinocytes. Acta Derm Venereol 96(6):742\u2013747","journal-title":"Acta Derm Venereol"},{"issue":"4","key":"4198_CR13","doi-asserted-by":"publisher","first-page":"3211","DOI":"10.1007\/s11033-020-05336-3","volume":"47","author":"S Yan","year":"2020","unstructured":"Yan S, Shi J, Sun D, Lyu L (2020) Current insight into the roles of microRNA in vitiligo. Mol Biol Rep 47(4):3211\u20133219","journal-title":"Mol Biol Rep"},{"issue":"6","key":"4198_CR14","doi-asserted-by":"publisher","first-page":"833","DOI":"10.1172\/JCI103672","volume":"37","author":"E Beutler","year":"1958","unstructured":"Beutler E, Blaisdell RK (1958) Iron enzymes in iron deficiency. Part II. Catalase in human erythrocytes. J Clin Invest 37(6):833\u2013835","journal-title":"J Clin Invest"},{"key":"4198_CR15","doi-asserted-by":"publisher","first-page":"35","DOI":"10.1002\/9780470122860.ch2","volume":"41","author":"I Fridovich","year":"1974","unstructured":"Fridovich I (1974) Superoxide dismutases. Adv Enzymol Relat Areas Mol Biol 41:35\u201397","journal-title":"Adv Enzymol Relat Areas Mol Biol"},{"issue":"2","key":"4198_CR16","doi-asserted-by":"publisher","first-page":"351","DOI":"10.1016\/0003-2697(79)90738-3","volume":"95","author":"H Ohkawa","year":"1979","unstructured":"Ohkawa H, Ohishi N, Yagi K (1979) Assay for lipid peroxides in animal tissues by thiobarbituric acid reaction. Anal Biochem 95(2):351\u2013358","journal-title":"Anal Biochem"},{"issue":"3","key":"4198_CR17","doi-asserted-by":"publisher","first-page":"405","DOI":"10.1007\/s40291-023-00646-1","volume":"27","author":"HY Abdallah","year":"2023","unstructured":"Abdallah HY, Faisal S, Tawfik NZ et al (2023) Expression signature of immune-related microRNAs in autoimmune skin disease: psoriasis and vitiligo insights. Mol Diagn Ther 27(3):405\u2013423","journal-title":"Mol Diagn Ther"},{"issue":"3","key":"4198_CR18","doi-asserted-by":"publisher","first-page":"164","DOI":"10.2174\/2211536610666210716153929","volume":"10","author":"Y Xu","year":"2021","unstructured":"Xu Y, Huang X, Luo Q, Zhang X (2021) Micrornas involved in oxidative stress processes regulating physiological and pathological responses. Microrna 10(3):164\u2013180","journal-title":"Microrna"},{"issue":"2","key":"4198_CR19","doi-asserted-by":"publisher","first-page":"122","DOI":"10.1097\/SHK.0000000000000604","volume":"46","author":"K Essandoh","year":"2016","unstructured":"Essandoh K, Li Y, Huo J, Fan GC (2016) Mirna-mediated macrophage polarization and its potential role in the regulation of inflammatory response. Shock 46(2):122\u2013131","journal-title":"Shock"},{"key":"4198_CR20","doi-asserted-by":"publisher","DOI":"10.3390\/ph17040426","author":"A Lui","year":"2024","unstructured":"Lui A, Do T, Alzayat O et al (2024) Tumor suppressor microRNAs in clinical and preclinical trials for neurological disorders. Pharmaceuticals (Basel). https:\/\/doi.org\/10.3390\/ph17040426","journal-title":"Pharmaceuticals (Basel)"},{"key":"4198_CR21","doi-asserted-by":"publisher","first-page":"402","DOI":"10.3389\/fendo.2018.00402","volume":"9","author":"J O'Brien","year":"2018","unstructured":"O\u2019Brien J, Hayder H, Zayed Y, Peng C (2018) Overview of microrna biogenesis, mechanisms of actions, and circulation. Front Endocrinol (Lausanne) 9:402","journal-title":"Front Endocrinol (Lausanne)"},{"issue":"2","key":"4198_CR22","doi-asserted-by":"publisher","first-page":"217","DOI":"10.1111\/pcmr.12334","volume":"28","author":"X Dai","year":"2015","unstructured":"Dai X, Rao C, Li H et al (2015) Regulation of pigmentation by microRNAs: MITF-dependent microRNA-211 targets TGF-\u03b2 receptor 2. Pigment Cell Melanoma Res 28(2):217\u2013222","journal-title":"Pigment Cell Melanoma Res"},{"issue":"9","key":"4198_CR23","doi-asserted-by":"publisher","first-page":"1965","DOI":"10.1016\/j.jid.2017.04.025","volume":"137","author":"A Sahoo","year":"2017","unstructured":"Sahoo A, Lee B, Boniface K et al (2017) Microrna-211 regulates oxidative phosphorylation and energy metabolism in human vitiligo. J Invest Dermatol 137(9):1965\u20131974","journal-title":"J Invest Dermatol"},{"issue":"4","key":"4198_CR24","doi-asserted-by":"publisher","first-page":"615","DOI":"10.2174\/0113862073275508231229112157","volume":"28","author":"M Su","year":"2025","unstructured":"Su M, Shi Y (2025) Screening for biomarkers related to pigmentation and formation in vitiligo. Comb Chem High Throughput Screen 28(4):615\u2013626","journal-title":"Comb Chem High Throughput Screen"},{"issue":"6","key":"4198_CR25","doi-asserted-by":"publisher","first-page":"705","DOI":"10.4103\/ijd.ijd_383_21","volume":"67","author":"SD Pekta\u015f","year":"2022","unstructured":"Pekta\u015f SD, Kara M, Do\u011fan G et al (2022) Differential expression and in silico functional analysis of plasma microRNAs in the pathogenesis of non-segmental vitiligo. Indian J Dermatol 67(6):705\u2013714","journal-title":"Indian J Dermatol"},{"key":"4198_CR26","doi-asserted-by":"publisher","first-page":"100955","DOI":"10.1016\/j.genrep.2020.100955","volume":"21","author":"YW Issa","year":"2020","unstructured":"Issa YW, Salih SM (2020) Impact of miR-155, miR-145 and miR-328 on pigmentary process in Iraqi patients with vitiligo. Gene Rep 21:100955","journal-title":"Gene Rep"},{"issue":"2","key":"4198_CR27","doi-asserted-by":"publisher","first-page":"42","DOI":"10.1016\/j.jdermsci.2023.12.006","volume":"113","author":"Y Wei","year":"2024","unstructured":"Wei Y, Zhou T, Pan R et al (2024) Exosomes containing miR-1469 regulate natural killer cells by targeting CD122 in non-segmental vitiligo. J Dermatol Sci 113(2):42\u201350","journal-title":"J Dermatol Sci"},{"issue":"6","key":"4198_CR28","doi-asserted-by":"publisher","first-page":"441","DOI":"10.5021\/ad.2020.32.6.441","volume":"32","author":"L Li","year":"2020","unstructured":"Li L (2020) The role of MicroRNAs in vitiligo: regulators and therapeutic targets. Ann Dermatol 32(6):441\u2013451","journal-title":"Ann Dermatol"},{"issue":"1","key":"4198_CR29","doi-asserted-by":"publisher","first-page":"22","DOI":"10.1016\/j.jdermsci.2020.10.014","volume":"101","author":"M Aguennouz","year":"2021","unstructured":"Aguennouz M, Guarneri F, Oteri R et al (2021) Serum levels of miRNA-21-5p in vitiligo patients and effects of miRNA-21-5p on SOX5, beta-catenin, CDK2 and MITF protein expression in normal human melanocytes. J Dermatol Sci 101(1):22\u201329","journal-title":"J Dermatol Sci"},{"issue":"4","key":"4198_CR30","doi-asserted-by":"publisher","first-page":"e0122517","DOI":"10.1371\/journal.pone.0122517","volume":"10","author":"N Arts","year":"2015","unstructured":"Arts N, Can\u00e9 S, Hennequart M et al (2015) microRNA-155, induced by interleukin-1\u00df, represses the expression of microphthalmia-associated transcription factor (MITF-M) in melanoma cells. PLoS One 10(4):e0122517","journal-title":"PLoS One"},{"issue":"8","key":"4198_CR31","doi-asserted-by":"publisher","first-page":"683","DOI":"10.1007\/s00403-015-1563-1","volume":"307","author":"TT Cui","year":"2015","unstructured":"Cui TT, Yi XL, Zhang WG et al (2015) miR-196a-2 rs11614913 polymorphism is associated with vitiligo by affecting heterodimeric molecular complexes of Tyr and Tyrp1. Arch Dermatol Res 307(8):683\u2013692","journal-title":"Arch Dermatol Res"},{"issue":"12","key":"4198_CR32","doi-asserted-by":"publisher","first-page":"3262","DOI":"10.1016\/j.jid.2022.05.1086","volume":"142","author":"D Li","year":"2022","unstructured":"Li D, Zhou T, She Q et al (2022) Circulating exosomal miR-493-3p affects melanocyte survival and function by regulating epidermal dopamine concentration in segmental vitiligo. J Invest Dermatol 142(12):3262-3273.e11","journal-title":"J Invest Dermatol"},{"issue":"2","key":"4198_CR33","doi-asserted-by":"publisher","first-page":"199","DOI":"10.1111\/ijd.15669","volume":"61","author":"M Alhelf","year":"2022","unstructured":"Alhelf M, Rashed LA, Ragab N, Elmasry MF (2022) Association between long noncoding RNA taurine-upregulated gene 1 and microRNA-377 in vitiligo. Int J Dermatol 61(2):199\u2013207","journal-title":"Int J Dermatol"},{"key":"4198_CR34","doi-asserted-by":"publisher","first-page":"663091","DOI":"10.3389\/fgene.2021.663091","volume":"12","author":"L Li","year":"2021","unstructured":"Li L, Xie Z, Qian X et al (2021) Identification of a potentially functional circRNA-miRNA-mRNA regulatory network in melanocytes for investigating pathogenesis of vitiligo. Front Genet 12:663091","journal-title":"Front Genet"},{"issue":"5","key":"4198_CR35","doi-asserted-by":"publisher","first-page":"624","DOI":"10.4103\/ijd.ijd_917_20","volume":"67","author":"MK Mulayim","year":"2022","unstructured":"Mulayim MK, Kurutas EB, Nazik H, Ozturk P (2022) Assessment of oxidative\/nitrosative stress and raftlin in vitiligo. Indian J Dermatol 67(5):624","journal-title":"Indian J Dermatol"},{"key":"4198_CR36","doi-asserted-by":"publisher","DOI":"10.1111\/jocd.13499","author":"S Mathachan","year":"2020","unstructured":"Mathachan S, Khurana A, Gautam R et al (2020) Does oxidative stress correlate with disease activity and severity in vitiligo? An analytical study. J Cosmet Dermatol. https:\/\/doi.org\/10.1111\/jocd.13499","journal-title":"J Cosmet Dermatol"},{"issue":"4","key":"4198_CR37","doi-asserted-by":"publisher","first-page":"306","DOI":"10.1111\/phpp.12653","volume":"37","author":"ER Said","year":"2021","unstructured":"Said ER, Nagui N, Rashed LA, Mostafa WZ (2021) Oxidative stress and the cholinergic system in non-segmental vitiligo: effect of narrow band ultraviolet b. Photodermatol Photoimmunol Photomed 37(4):306\u2013312","journal-title":"Photodermatol Photoimmunol Photomed"}],"container-title":["Irish Journal of Medical Science (1971 -)"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s11845-025-04198-7.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s11845-025-04198-7","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s11845-025-04198-7.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,3,7]],"date-time":"2026-03-07T21:02:04Z","timestamp":1772917324000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s11845-025-04198-7"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,11,29]]},"references-count":37,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2026,2]]}},"alternative-id":["4198"],"URL":"https:\/\/doi.org\/10.1007\/s11845-025-04198-7","relation":{},"ISSN":["0021-1265","1863-4362"],"issn-type":[{"value":"0021-1265","type":"print"},{"value":"1863-4362","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,11,29]]},"assertion":[{"value":"21 October 2025","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"17 November 2025","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"29 November 2025","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The KSU Medical Research Ethics Committee approved this study with protocol number 2015\/15\u2013194.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical approval"}},{"value":"The authors declare that they have no competing interests.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}]}}