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No new human samples, identifiable personal information, or patient contact were involved in the current analysis; therefore, our institutional review board determined that additional approval was not required for this secondary analysis. (2) In vitro experiments using the established immortalized human chondrocyte line C28\/I2, which was obtained from a commercial\/research cell bank. The use of established immortalized human cell lines does not require new IRB approval at our institution. Based on the above, no additional ethics approval or consent to participate was required for the present study.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"All transcriptomic data analyzed in this study were obtained from a public repository in de-identified form; no individual person\u2019s identifiable data are included. Not applicable.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}]}}