{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T20:49:56Z","timestamp":1792788596412,"version":"4.5.0"},"reference-count":18,"publisher":"Springer Science and Business Media LLC","issue":"4","license":[{"start":{"date-parts":[[2026,4,21]],"date-time":"2026-04-21T00:00:00Z","timestamp":1776729600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2026,4,21]],"date-time":"2026-04-21T00:00:00Z","timestamp":1776729600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"name":"Sanko University","id":[{"id":"https:\/\/ror.org\/04a94ee43","id-type":"ROR","asserted-by":"crossref"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Ir J Med Sci"],"published-print":{"date-parts":[[2026,8]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Sacroiliitis is a major cause of inflammatory low back pain in young adults and a key feature of spondyloarthritis (SpA), but it may also occur with infection, pregnancy, or drug exposure. Isotretinoin, widely used for severe acne, can rarely induce sacroiliitis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Aim<\/jats:title>\n                    <jats:p>This study aimed to compare the MRI characteristics of isotretinoin-induced sacroiliitis with those of axial spondyloarthritis (axSpA).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>The study population consisted of 68 patients, comprising 28 with isotretinoin-induced sacroiliitis (median age 24 years; 5 males) and 40 with axSpA (median age 30 years; 26 males). MRI scans were assessed for active inflammatory lesions (bone marrow edema, synovitis, capsulitis, enthesitis) and early structural lesions (erosion, fat metaplasia). SPARCC scoring was performed using the standardized 0\u201372 system. Ankylosis and sclerosis were not included as it was absent in both groups. Group comparisons were conducted using the Mann\u2013Whitney U test, chi-square test, or Fisher\u2019s exact test.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      While isotretinoin-induced sacroiliitis showed a purely inflammatory pattern without structural lesions, patients with axSpA exhibited both active inflammatory and structural lesions. Erosions and fat metaplasia were observed exclusively in axSpA patients (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001). Bilateral and symmetric involvement, as well as higher SPARCC scores, were significantly more frequent in axSpA (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.05).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Isotretinoin-induced and axSpA sacroiliitis exhibit distinct MRI characteristics. Erosions and fat metaplasia are specific markers of axSpA, whereas isotretinoin-induced sacroiliitis represents a reversible, non-destructive inflammatory process. The present results may assist clinicians and radiologists in distinguishing between these two conditions in clinical practice.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1007\/s11845-026-04414-y","type":"journal-article","created":{"date-parts":[[2026,4,21]],"date-time":"2026-04-21T04:24:18Z","timestamp":1776745458000},"page":"2369-2376","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Comparative radiologic characteristics of isotretinoin-induced sacroiliitis and axial spondyloarthritis"],"prefix":"10.1007","volume":"195","author":[{"given":"Mehmet Gurdal","family":"Demirci","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nurcihan Yavuz","family":"Savas","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ozlem","family":"Kudas","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Muhammed","family":"Aslan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Toktamis","family":"Savas","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fatma Elif","family":"Yildirim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Irada","family":"Ibramkhalilova","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fatih","family":"Albayrak","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Orhan","family":"Zengin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bunyamin","family":"Kisacik","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,4,21]]},"reference":[{"key":"4414_CR1","doi-asserted-by":"publisher","first-page":"1520","DOI":"10.1136\/ard.2009.110767","volume":"68","author":"M Rudwaleit","year":"2009","unstructured":"Rudwaleit M, Jurik AG, Hermann KG et al (2009) Defining active sacroiliitis on magnetic resonance imaging for classification of axial spondyloarthritis: a consensual approach by the ASAS\/OMERACT MRI group. 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The names for the two author were incorrectly written; Incorrect names were Toktam\u0131s Savas and Irada Ibramxalilova. The correct names should read; Toktamis Savas and Irada Ibramkhalilova .The original article has been corrected.","order":7,"name":"change_details","label":"Change Details","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"3 June 2026","order":8,"name":"change_date","label":"Change Date","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"Correction","order":9,"name":"change_type","label":"Change Type","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"A Correction to this paper has been published:","order":10,"name":"change_details","label":"Change Details","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"https:\/\/doi.org\/10.1007\/s11845-026-04471-3","URL":"https:\/\/doi.org\/10.1007\/s11845-026-04471-3","order":11,"name":"change_details","label":"Change Details","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"The study was approved by the Clinical Research Ethics Committee of Sanko University Faculty of Medicine (approval date: July 10, 2025; decision no: 2).","order":1,"name":"Ethics","label":"Ethics approval","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors declare no conflicts of interest.","order":2,"name":"Ethics","label":"Conflict of interest","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"Written informed consent was obtained from all individual participants included in the study.","order":3,"name":"Ethics","label":"Consent to participate","group":{"name":"EthicsHeading","label":"Declarations"}}]}}