{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,7]],"date-time":"2026-05-07T03:11:02Z","timestamp":1778123462844,"version":"3.51.4"},"reference-count":15,"publisher":"Springer Science and Business Media LLC","license":[{"start":{"date-parts":[[2026,5,7]],"date-time":"2026-05-07T00:00:00Z","timestamp":1778112000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2026,5,7]],"date-time":"2026-05-07T00:00:00Z","timestamp":1778112000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"name":"Inonu University"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Ir J Med Sci"],"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>This study aimed to identify independent clinical predictors of failure to develop tolerance to IgE-mediated cow\u2019s milk allergy in children with multiple food allergies.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Method<\/jats:title>\n                    <jats:p>\n                      This retrospective cohort study included 134 children diagnosed with IgE-mediated cow\u2019s milk allergy with multiple food allergies. Patients were divided into two groups based on tolerance development: those who developed tolerance and those who did not. Demographic characteristics, clinical findings after food intake, and laboratory parameters were compared between groups. To identify independent clinical risk factors associated with the lack of tolerance development, clinical variables found to be statistically significant (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.05) in univariate analyses were included in multivariate logistic regression analysis.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Ninety-six patients (71.6%) were male, with a median age of 84 months (range: 33\u2013146 months). The median age at symptom onset was 5 months (range: 1\u201336 months), and the median follow-up duration was 79 months (range: 1\u201393 months). Atopic eczema was present in 42.5% of patients, and a history of recurrent wheezing or asthma was present in 14.2%. Among concomitant food allergies, egg allergy was the most common (50.7%). While cutaneous findings were most frequently observed in initial reactions, wheezing (18.7%) was the most common respiratory symptom. Anaphylaxis was diagnosed in 24.6% of patients. In the multivariate logistic regression analysis performed to determine the clinical risk factors associated with the failure to develop tolerance to IgE-mediated cow\u2019s milk allergy in patients, the following factors were identified: as the initial reaction after cow\u2019s milk intake are anaphylaxis [OR: 4.95 (1.82\u201313.5),\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.002], hypotension [OR: 3.97 (1.19\u201313.2),\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.025)], wheezing [OR: 2.86 (1.11\u20137.36),\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.029] and lethargy [OR: 3.53 (1.23\u201310.1),\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.019)] were identified as independent risk factors.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Severe clinical reactions initially presenting with systemic and respiratory involvement are independent clinical predictors of failure to develop tolerance to IgE-mediated cow\u2019s milk allergy in children with multiple food allergies.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1007\/s11845-026-04417-9","type":"journal-article","created":{"date-parts":[[2026,5,7]],"date-time":"2026-05-07T02:21:10Z","timestamp":1778120470000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Clinical predictors of persistence in IgE-mediated cow\u2019s milk allergy in children with multiple food allergies"],"prefix":"10.1007","author":[{"given":"Ercan","family":"Y\u0131lmaz","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4439-2689","authenticated-orcid":false,"given":"Erdem","family":"Topal","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2026,5,7]]},"reference":[{"issue":"2","key":"4417_CR1","doi-asserted-by":"publisher","first-page":"291","DOI":"10.1016\/j.jaci.2013.11.020","volume":"133","author":"SH Sicherer","year":"2014","unstructured":"Sicherer SH, Sampson HA (2014) Food allergy: Epidemiology, pathogenesis, diagnosis, and treatment. 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An honorarium, grant, or other form of payment was not given to any author to produce the manuscript. All authors significantly contributed to the work, have approved the final manuscript and takes full responsibility for the manuscript. There is no conflicts of interest statement for each author.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"Ethical approval for this study was obtained from the the ethical committee of Non-Invasive Clinical Research of Inonu University, Turkey (Approval number: 2025\/6111).","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical Approval"}},{"value":"The authors declare that they have no conflict of interest.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}}]}}