{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,15]],"date-time":"2026-05-15T15:11:31Z","timestamp":1778857891358,"version":"3.51.4"},"reference-count":23,"publisher":"Springer Science and Business Media LLC","license":[{"start":{"date-parts":[[2026,5,15]],"date-time":"2026-05-15T00:00:00Z","timestamp":1778803200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2026,5,15]],"date-time":"2026-05-15T00:00:00Z","timestamp":1778803200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"DOI":"10.13039\/501100003356","name":"Gazi University","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100003356","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Ir J Med Sci"],"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>\n                      <jats:italic>Candida<\/jats:italic>\n                      meningitis is a rare but life-threatening infection, most commonly caused by\n                      <jats:italic>Candida albicans<\/jats:italic>\n                      .\n                      <jats:italic>Candida dubliniensis<\/jats:italic>\n                      , despite its close phenotypic similarity to\n                      <jats:italic>C. albicans<\/jats:italic>\n                      , is an uncommon cause of central nervous system (CNS) infections, with limited data available. To date, only 12 cases of\n                      <jats:italic>C. dubliniensis<\/jats:italic>\n                      meningitis have been reported worldwide. This study presents the 13th documented case and the first reported from T\u00fcrkiye, together with a systematic review of the literature.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Case presentation<\/jats:title>\n                    <jats:p>\n                      A 44-year-old immunocompetent male developed meningitis caused by\n                      <jats:italic>C. dubliniensis<\/jats:italic>\n                      following subtotal resection of a clival meningioma. The diagnosis was established through fungal culture, MALDI-TOF MS, and ITS region DNA sequencing. The isolate was deposited in GenBank (accession number PV088619). Antifungal therapy with fluconazole was initiated based on susceptibility results. Despite appropriate antifungal management, the patient developed secondary\n                      <jats:italic>Klebsiella pneumoniae<\/jats:italic>\n                      sepsis and subsequently died, highlighting the complexity and high mortality risk associated with post-neurosurgical fungal CNS infections.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      A systematic review was conducted according to PRISMA guidelines using PubMed and Web of Science databases, including studies published up to February 2025. Search terms included \u201c\n                      <jats:italic>Candida dubliniensis<\/jats:italic>\n                      \u201d and \u201cmeningitis.\u201d Only microbiologically confirmed cases with individual patient data were included. Studies older than 25\u00a0years or lacking sufficient diagnostic detail were excluded.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results and conclusion<\/jats:title>\n                    <jats:p>\n                      Thirteen cases were identified. Most patients were immunocompetent, and infections were frequently acquired outside neurosurgical settings. Mortality was reported in four cases. These findings emphasize the extreme rarity of\n                      <jats:italic>C. dubliniensis<\/jats:italic>\n                      meningitis and underscore the importance of early species-level identification strategies.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1007\/s11845-026-04433-9","type":"journal-article","created":{"date-parts":[[2026,5,15]],"date-time":"2026-05-15T14:24:58Z","timestamp":1778855098000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Meningitis caused by Candida dubliniensis in a patient with meningioma: a systematic review of the literature"],"prefix":"10.1007","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1993-1342","authenticated-orcid":false,"given":"Nurg\u00fcl","family":"Samanc\u0131","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2215-2756","authenticated-orcid":false,"given":"Elif Ay\u00e7a","family":"\u015eahin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3006-4112","authenticated-orcid":false,"given":"Yesim","family":"Yildiz","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5733-7542","authenticated-orcid":false,"given":"Emrah","family":"\u00c7eltik\u00e7i","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1804-2730","authenticated-orcid":false,"given":"Muammer Melih","family":"\u015eahin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0000-6686-9604","authenticated-orcid":false,"given":"Derya G\u00f6ksu","family":"Fidan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0961-7325","authenticated-orcid":false,"given":"Ay\u015fe","family":"Kalkanc\u0131","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7257-6453","authenticated-orcid":false,"given":"Kayhan","family":"\u00c7a\u011flar","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2026,5,15]]},"reference":[{"issue":"Pt 7","key":"4433_CR1","doi-asserted-by":"publisher","first-page":"1507","DOI":"10.1099\/13500872-141-7-1507","volume":"141","author":"DJ Sullivan","year":"1995","unstructured":"Sullivan DJ, Westerneng TJ, Haynes KA et al (1995) Candida dubliniensis sp nov.: phenotypic and molecular characterization of a novel species associated with oral candidosis in HIV-infected individuals. Microbiology (Reading) 141(Pt 7):1507\u20131521. https:\/\/doi.org\/10.1099\/13500872-141-7-1507","journal-title":"Microbiology (Reading)"},{"key":"4433_CR2","doi-asserted-by":"publisher","first-page":"5755","DOI":"10.2147\/IDR.S497862","volume":"17","author":"M G\u00f3mez-Gaviria","year":"2024","unstructured":"G\u00f3mez-Gaviria M, Baruch-Mart\u00ednez DA, Mora-Montes HM (2024) Exploring the biology, virulence, and general aspects of Candida dubliniensis. Infect Drug Resist 17:5755\u20135773. https:\/\/doi.org\/10.2147\/IDR.S497862","journal-title":"Infect Drug Resist"},{"issue":"4","key":"4433_CR3","doi-asserted-by":"publisher","first-page":"443","DOI":"10.1007\/s15010-018-1152-2","volume":"46","author":"K G\u00f3ralska","year":"2018","unstructured":"G\u00f3ralska K, Blaszkowska J, Dzikowiec M (2018) Neuroinfections caused by fungi. Infection 46(4):443\u2013459. https:\/\/doi.org\/10.1007\/s15010-018-1152-2","journal-title":"Infection"},{"key":"4433_CR4","doi-asserted-by":"publisher","DOI":"10.1016\/j.jns.2021.117325","volume":"422","author":"CL Nathan","year":"2021","unstructured":"Nathan CL, Emmert BE, Nelson E, Berger JR (2021) CNS fungal infections: a review. J Neurol Sci 422:117325. https:\/\/doi.org\/10.1016\/j.jns.2021.117325","journal-title":"J Neurol Sci"},{"key":"4433_CR5","doi-asserted-by":"publisher","first-page":"41","DOI":"10.1016\/j.wneu.2017.08.115","volume":"108","author":"KJ Bridges","year":"2017","unstructured":"Bridges KJ, Li R, Fleseriu M, Cetas JS (2017) Candida meningitis after transsphenoidal surgery: a single-institution case series and literature review. World Neurosurg 108:41\u201349. https:\/\/doi.org\/10.1016\/j.wneu.2017.08.115","journal-title":"World Neurosurg"},{"key":"4433_CR6","doi-asserted-by":"publisher","first-page":"22","DOI":"10.1016\/j.mmcr.2019.12.009","volume":"27","author":"M Gheshlaghi","year":"2019","unstructured":"Gheshlaghi M, Helweg-Larsen J (2019) Fatal chronic meningitis caused by Candida dubliniensis after liver transplantation. Med Mycol Case Rep 27:22\u201324. https:\/\/doi.org\/10.1016\/j.mmcr.2019.12.009","journal-title":"Med Mycol Case Rep"},{"issue":"8","key":"4433_CR7","doi-asserted-by":"publisher","first-page":"947","DOI":"10.1001\/jamaneurol.2018.0463","volume":"75","author":"MR Wilson","year":"2018","unstructured":"Wilson MR, O\u2019Donovan BD, Gelfand JM, Sample HA, Chow FC, Betjemann JP, Shah MP, Richie MB, Gorman MP, Hajj-Ali RA, Calabrese LH, Zorn KC, Chow ED, Greenlee JE, Blum JH, Green G, Khan LM, Banerji D, Langelier C, Bryson-Cahn C, Harrington W, Lingappa JR, Shanbhag NM, Green AJ, Brew BJ, Soldatos A, Strnad L, Doernberg SB, Jay CA, Douglas V, Josephson SA, DeRisi JL (2018) Chronic meningitis investigated via metagenomic next-generation sequencing. JAMA Neurol 75(8):947\u2013955. https:\/\/doi.org\/10.1001\/jamaneurol.2018.0463","journal-title":"JAMA Neurol"},{"issue":"2","key":"4433_CR8","doi-asserted-by":"publisher","first-page":"327","DOI":"10.3201\/eid1402.070985","volume":"14","author":"SJ van Hal","year":"2008","unstructured":"van Hal SJ, Stark D, Harkness J, Marriott D (2008) Candida dubliniensis meningitis as delayed sequela of treated C. dubliniensis fungemia. Emerg Infect Dis 14(2):327\u2013329. https:\/\/doi.org\/10.3201\/eid1402.070985","journal-title":"Emerg Infect Dis"},{"key":"4433_CR9","doi-asserted-by":"publisher","DOI":"10.1136\/bcr.06.2011.4384","volume":"2011","author":"NH Andrew","year":"2011","unstructured":"Andrew NH, Ruberu RP, Gabb G (2011) The first documented case of Candida dubliniensis leptomeningeal disease in an immunocompetent host. BMJ Case Rep 2011:bcr0620114384. https:\/\/doi.org\/10.1136\/bcr.06.2011.4384","journal-title":"BMJ Case Rep"},{"key":"4433_CR10","doi-asserted-by":"publisher","DOI":"10.3389\/fneur.2020.601242","volume":"11","author":"M Tahir","year":"2020","unstructured":"Tahir M, Peseski AM, Jordan SJ (2020) Case report: Candida dubliniensis as a cause of chronic meningitis. Front Neurol 11:601242. https:\/\/doi.org\/10.3389\/fneur.2020.601242","journal-title":"Front Neurol"},{"issue":"7\u20138","key":"4433_CR11","doi-asserted-by":"publisher","first-page":"589","DOI":"10.1007\/s11046-016-0006-7","volume":"181","author":"A Yamahiro","year":"2016","unstructured":"Yamahiro A, Lau KH, Peaper DR, Villanueva M (2016) Meningitis caused by Candida dubliniensis in a patient with cirrhosis: a case report and review of the literature. Mycopathologia 181(7\u20138):589\u2013593. https:\/\/doi.org\/10.1007\/s11046-016-0006-7","journal-title":"Mycopathologia"},{"key":"4433_CR12","doi-asserted-by":"publisher","DOI":"10.1016\/j.idcr.2022.e01665","volume":"31","author":"C Price","year":"2023","unstructured":"Price C, Wilson I, Catchpoole E (2023) Candida dubliniensis chronic meningitis in an immunocompetent patient: case report and literature review. IDCases 31:e01665. https:\/\/doi.org\/10.1016\/j.idcr.2022.e01665","journal-title":"IDCases"},{"key":"4433_CR13","doi-asserted-by":"publisher","DOI":"10.1016\/j.mmcr.2024.100678","volume":"46","author":"M Absar","year":"2024","unstructured":"Absar M, Alduwayriji A, Al-Arfaji A, Alduwayrij A, Al-Arfaj A, Shah Z, Nashmy F, Yacoubi MT (2024) Meningitis caused by Candida dubliniensis in a patient with liver cirrhosis: a case report and review of the literature. Med Mycol Case Rep 46:100678. https:\/\/doi.org\/10.1016\/j.mmcr.2024.100678","journal-title":"Med Mycol Case Rep"},{"key":"4433_CR14","doi-asserted-by":"publisher","DOI":"10.1016\/j.ensci.2024.100519","volume":"36","author":"D Babici","year":"2024","unstructured":"Babici D, Mohamed AA, Mattner O et al (2024) Candida dubliniensis meningitis in an immunocompetent patient: A case report and review of the literature. eNeurologicalSci 36:100519. https:\/\/doi.org\/10.1016\/j.ensci.2024.100519","journal-title":"eNeurologicalSci"},{"key":"4433_CR15","doi-asserted-by":"publisher","first-page":"41","DOI":"10.1016\/j.mmcr.2019.03.004","volume":"24","author":"S Herrera","year":"2019","unstructured":"Herrera S, Pavone P, Kumar D et al (2019) Chronic Candida dubliniensis meningitis in a lung transplant recipient. Med Mycol Case Rep 24:41\u201343. https:\/\/doi.org\/10.1016\/j.mmcr.2019.03.004","journal-title":"Med Mycol Case Rep"},{"issue":"2","key":"4433_CR16","doi-asserted-by":"publisher","first-page":"227","DOI":"10.1080\/02688697.2022.2054947","volume":"37","author":"L Kelly","year":"2023","unstructured":"Kelly L, Walsh J, Skally M et al (2023) Candida meningitis\/ventriculitis over a decade. Increased morbidity and length of stay a concern. Br J Neurosurg 37(2):227\u2013230. https:\/\/doi.org\/10.1080\/02688697.2022.2054947","journal-title":"Br J Neurosurg"},{"issue":"4","key":"4433_CR17","doi-asserted-by":"publisher","DOI":"10.1212\/CPJ.0000000000200279","volume":"14","author":"A Askari","year":"2024","unstructured":"Askari A, Benson J, Felipe Bastos Horta L et al (2024) Candida dublinensis meningitis in an immunocompetent host: a case report and review of the literature. Neurol Clin Pract 14(4):e200279. https:\/\/doi.org\/10.1212\/CPJ.0000000000200279","journal-title":"Neurol Clin Pract"},{"key":"4433_CR18","doi-asserted-by":"publisher","first-page":"512","DOI":"10.1093\/oxfordjournals.molbev.a040023","volume":"10","author":"K Tamura","year":"1993","unstructured":"Tamura K, Nei M (1993) Estimation of the number of nucleotide substitutions in the control region of mitochondrial DNA in humans and chimpanzees. Mol Biol Evol 10:512\u2013526. https:\/\/doi.org\/10.1093\/oxfordjournals.molbev.a040023","journal-title":"Mol Biol Evol"},{"issue":"7","key":"4433_CR19","doi-asserted-by":"publisher","first-page":"3022","DOI":"10.1093\/molbev\/msab120","volume":"38","author":"K Tamura","year":"2021","unstructured":"Tamura K, Stecher G, Kumar S (2021) MEGA11: molecular evolutionary genetics analysis version 11. Mol Biol Evol 38(7):3022\u20133027. https:\/\/doi.org\/10.1093\/molbev\/msab120","journal-title":"Mol Biol Evol"},{"key":"4433_CR20","unstructured":"Clinical and Laboratory Standards Institute. Reference method for broth dilution antifungal susceptibility testing of yeasts,. 2nd ed., Clinical and Laboratory Standards Institute, Wayne PA; 2008. [Approved standard M27-A3\/S4]"},{"issue":"7","key":"4433_CR21","doi-asserted-by":"publisher","first-page":"e428","DOI":"10.1016\/S1473-3099(23)00692-8","volume":"24","author":"DW Denning","year":"2024","unstructured":"Denning DW (2024) Global incidence and mortality of severe fungal disease. Lancet Infect Dis 24(7):e428\u2013e438. https:\/\/doi.org\/10.1016\/S1473-3099(23)00692-8","journal-title":"Lancet Infect Dis"},{"key":"4433_CR22","doi-asserted-by":"publisher","DOI":"10.1155\/2012\/205921","volume":"2012","author":"GP Moran","year":"2012","unstructured":"Moran GP, Coleman DC, Sullivan DJ (2012) Candida albicans versus Candida dubliniensis: why is C. albicans more pathogenic? Int J Microbiol 2012:205921. https:\/\/doi.org\/10.1155\/2012\/205921","journal-title":"Int J Microbiol"},{"key":"4433_CR23","doi-asserted-by":"publisher","first-page":"36","DOI":"10.1016\/j.wneu.2024.08.150","volume":"192","author":"NJ Coulibaly","year":"2024","unstructured":"Coulibaly NJ, Fassina GR, Donkor EO, Spence CA (2024) Cervical intradural fungal infection masquerading as a meningioma in an immunocompetent patient: a case report and systematic review. World Neurosurg 192:36\u201342. https:\/\/doi.org\/10.1016\/j.wneu.2024.08.150","journal-title":"World Neurosurg"}],"container-title":["Irish Journal of Medical Science (1971 -)"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s11845-026-04433-9.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s11845-026-04433-9","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s11845-026-04433-9.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,15]],"date-time":"2026-05-15T14:25:01Z","timestamp":1778855101000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s11845-026-04433-9"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,5,15]]},"references-count":23,"alternative-id":["4433"],"URL":"https:\/\/doi.org\/10.1007\/s11845-026-04433-9","relation":{},"ISSN":["0021-1265","1863-4362"],"issn-type":[{"value":"0021-1265","type":"print"},{"value":"1863-4362","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,5,15]]},"assertion":[{"value":"26 December 2025","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"28 April 2026","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"15 May 2026","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The study was conducted in accordance with the Declaration of Helsinki, and approved by the Ethics Committee of Gazi University (Decision No: 061, dated April 18, 2025).","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"Informed consent was obtained from a first-degree relative of the patient.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"The authors declare no conflicts of interest.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}]}}