{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,14]],"date-time":"2026-05-14T08:10:56Z","timestamp":1778746256554,"version":"3.51.4"},"reference-count":20,"publisher":"Springer Science and Business Media LLC","license":[{"start":{"date-parts":[[2026,5,14]],"date-time":"2026-05-14T00:00:00Z","timestamp":1778716800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2026,5,14]],"date-time":"2026-05-14T00:00:00Z","timestamp":1778716800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"DOI":"10.13039\/100007613","name":"Ankara University","doi-asserted-by":"crossref","id":[{"id":"10.13039\/100007613","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Ir J Med Sci"],"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background\/aim<\/jats:title>\n                    <jats:p>Primary hyperparathyroidism (PHPT) is usually caused by a parathyroid adenoma. Parathyroid autotransplantation is commonly performed during thyroidectomy when gland perfusion is impaired. However, the development of adenomas in autotransplanted tissue is extremely rare. We present a case of PHPT caused by an adenoma arising from autotransplanted parathyroid tissue, which occurred 30 years after total thyroidectomy.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>A 60-year-old woman with a history of total thyroidectomy and parathyroid autotransplantation to the sternocleidomastoid muscle presented with hypercalcemia and elevated parathyroid hormone levels. Ultrasonography suggested a small lesion, but sestamibi scintigraphy was negative. Definitive localization was achieved using 4D-CT and targeted ultrasonography.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Minimally invasive parathyroidectomy was performed, and intraoperative PTH level decreased from 318 pg\/mL to 70 pg\/mL. Histopathology confirmed a parathyroid adenoma originating from autotransplanted tissue. Postoperatively, calcium and PTH levels normalized.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Adenoma formation in autotransplanted parathyroid tissue is very rare but may occur even decades after surgery. Clinicians should systematically evaluate previous autotransplantation sites when they are investigating unexplained or recurrent PHPT, even decades after thyroid or parathyroid surgery.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1007\/s11845-026-04438-4","type":"journal-article","created":{"date-parts":[[2026,5,14]],"date-time":"2026-05-14T07:31:45Z","timestamp":1778743905000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Autotransplanted parathyroid adenoma as a rare cause of primary hyperparathyroidism: focused literature review"],"prefix":"10.1007","author":[{"ORCID":"https:\/\/orcid.org\/0009-0001-7848-6827","authenticated-orcid":false,"given":"\u0130lgiz","family":"T\u00fczken","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mustafa An\u0131l","family":"Turhan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8638-8688","authenticated-orcid":false,"given":"Ay\u015feg\u00fcl G\u00fcrsoy","family":"\u00c7oruh","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0001-9975-7788","authenticated-orcid":false,"given":"\u0130rem","family":"\u015eeker","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4718-0083","authenticated-orcid":false,"given":"Mustafa","family":"\u015eahin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3883-4791","authenticated-orcid":false,"given":"Volkan","family":"Gen\u00e7","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2026,5,14]]},"reference":[{"issue":"2","key":"4438_CR1","doi-asserted-by":"publisher","first-page":"115","DOI":"10.1038\/nrendo.2017.104","volume":"14","author":"MD Walker","year":"2018","unstructured":"Walker MD, Silverberg SJ (2018) Primary hyperparathyroidism. Nat Rev Endocrinol 14(2):115\u2013125. https:\/\/doi.org\/10.1038\/nrendo.2017.104","journal-title":"Nat Rev Endocrinol"},{"issue":"9684","key":"4438_CR2","doi-asserted-by":"publisher","first-page":"145","DOI":"10.1016\/S0140-6736(09)60507-9","volume":"374","author":"WD Fraser","year":"2009","unstructured":"Fraser WD (2009) Hyperparathyroidism. Lancet 374(9684):145\u2013158. https:\/\/doi.org\/10.1016\/S0140-6736(09)60507-9","journal-title":"Lancet"},{"issue":"1","key":"4438_CR3","first-page":"34","volume":"78","author":"SA Wells Jr","year":"1975","unstructured":"Wells SA Jr, Gunnells JC, Shelburne JD et al (1975) Transplantation of the parathyroid glands in man: clinical indications and results. Surgery 78(1):34\u201344 PMID:1138398","journal-title":"Surgery"},{"issue":"3","key":"4438_CR4","doi-asserted-by":"publisher","first-page":"309","DOI":"10.1007\/s00423-018-1654-5","volume":"403","author":"A Sitges-Serra","year":"2018","unstructured":"Sitges-Serra A, Lorente-Poch L, Sancho J (2018) Parathyroid autotransplantation in thyroid surgery. Langenbecks Arch Surg 403(3):309\u2013315. https:\/\/doi.org\/10.1007\/s00423-018-1654-5","journal-title":"Langenbecks Arch Surg"},{"issue":"1","key":"4438_CR5","doi-asserted-by":"publisher","first-page":"27","DOI":"10.1007\/s12020-024-04011-y","volume":"87","author":"G Koimtzis","year":"2025","unstructured":"Koimtzis G, Stefanopoulos L, Geropoulos G et al (2025) The outcomes of parathyroid autotransplantation in thyroid surgery: a systematic review and meta-analysis. Endocrine 87(1):27\u201338. https:\/\/doi.org\/10.1007\/s12020-024-04011-y","journal-title":"Endocrine"},{"issue":"8","key":"4438_CR6","doi-asserted-by":"publisher","first-page":"e0221173","DOI":"10.1371\/journal.pone.0221173","volume":"14","author":"B Wang","year":"2019","unstructured":"Wang B, Zhu CR, Liu H et al (2019) The effectiveness of parathyroid autotransplantation in preventing hypoparathyroidism after thyroidectomy: a systematic review and meta-analysis. PLoS ONE 14(8):e0221173. https:\/\/doi.org\/10.1371\/journal.pone.0221173","journal-title":"PLoS ONE"},{"issue":"2","key":"4438_CR7","doi-asserted-by":"publisher","first-page":"281","DOI":"10.1007\/s00423-016-1548-3","volume":"402","author":"L Lorente-Poch","year":"2017","unstructured":"Lorente-Poch L, Sancho J, Mu\u00f1oz JL et al (2017) Failure of fresh autograft after total thyroidectomy: A result of the institutional learning curve? Langenbecks Arch Surg 402(2):281\u2013287. https:\/\/doi.org\/10.1007\/s00423-016-1548-3 PMID:28064342","journal-title":"Langenbecks Arch Surg"},{"issue":"2","key":"4438_CR8","doi-asserted-by":"publisher","first-page":"89","DOI":"10.7156\/najms.2015.0802089","volume":"8","author":"Y Hu","year":"2015","unstructured":"Hu Y, Ondracek TC, Chen F (2015) Parathyroid adenoma arising from auto-transplanted parathyroid tissue in the forearm. North Am J Med Sci 8(2):89\u201391. https:\/\/doi.org\/10.7156\/najms.2015.0802089","journal-title":"North Am J Med Sci"},{"key":"4438_CR9","doi-asserted-by":"publisher","first-page":"414","DOI":"10.1186\/s12882-019-1606-5","volume":"20","author":"HR Won","year":"2019","unstructured":"Won HR, Kang JY, Lee IH et al (2019) Parathyroid carcinoma arising from auto-transplanted parathyroid tissue after total parathyroidectomy in a chronic kidney disease patient: a case report. BMC Nephrol 20:414. https:\/\/doi.org\/10.1186\/s12882-019-1606-5","journal-title":"BMC Nephrol"},{"key":"4438_CR10","doi-asserted-by":"publisher","first-page":"bcr2015213184","DOI":"10.1136\/bcr-2015-213184","volume":"2016","author":"P Touska","year":"2016","unstructured":"Touska P, Srikanthan A, Amarasinghe K et al (2016) Parathyroid adenoma in a forearm parathyroid autograft. BMJ Case Rep 2016:bcr2015213184. https:\/\/doi.org\/10.1136\/bcr-2015-213184","journal-title":"BMJ Case Rep"},{"key":"4438_CR11","unstructured":"Yozawitz J, Zarnegar R, Fahey TJ (2017) Recurrent Primary Hyperparathyroidism: A Case of an Incompletely Excised Parathyroid Adenoma. https:\/\/www.facs.org\/media\/vwclto1p\/recurrent-primary-hyperparathyroidism-a-case-of-an-incompletely-excised-parathyroid-adenoma-2890.pdf. Accessed\u00a0 12 Dec 2025"},{"issue":"4","key":"4438_CR12","first-page":"948","volume":"100","author":"AR McCall","year":"1986","unstructured":"McCall AR, Calandra DB, Lawrence AM et al (1986) Parathyroid autotransplantation in hyperparathyroidism: the role of thallium scanning. Surgery 100(4):948\u2013955","journal-title":"Surgery"},{"issue":"5","key":"4438_CR13","doi-asserted-by":"publisher","first-page":"546","DOI":"10.1016\/S1072-7515(00)00242-8","volume":"190","author":"A D\u2019Avanzo","year":"2000","unstructured":"D\u2019Avanzo A, Parangi S, Morita E et al (2000) Hyperparathyroidism after thyroid surgery and autotransplantation of histologically normal parathyroid glands. J Am Coll Surg 190(5):546\u2013552. https:\/\/doi.org\/10.1016\/S1072-7515(00)00242-8","journal-title":"J Am Coll Surg"},{"issue":"11","key":"4438_CR14","doi-asserted-by":"publisher","first-page":"2312","DOI":"10.1002\/ccr3.3136","volume":"8","author":"K Harada","year":"2020","unstructured":"Harada K, Otsuka F (2020) Ectopic hyperparathyroidism due to parathyroid adenoma arising in the thyroid gland. Clin Case Rep 8(11):2312\u20132313. https:\/\/doi.org\/10.1002\/ccr3.3136","journal-title":"Clin Case Rep"},{"issue":"2","key":"4438_CR15","doi-asserted-by":"publisher","first-page":"e252221","DOI":"10.1136\/bcr-2022-252221","volume":"16","author":"V Boggiano","year":"2023","unstructured":"Boggiano V, Barnhouse K, Ghorbani Rodriguez T et al (2023) Recurrent hyperparathyroidism due to parathyroid adenoma in an autotransplanted sternocleidomastoid muscle after thyroidectomy. BMJ Case Rep 16(2):e252221. https:\/\/doi.org\/10.1136\/bcr-2022-252221","journal-title":"BMJ Case Rep"},{"issue":"6","key":"4438_CR16","doi-asserted-by":"publisher","first-page":"654","DOI":"10.1016\/j.ando.2023.10.002","volume":"84","author":"M Thumerel","year":"2023","unstructured":"Thumerel M, Belaroussi Y, McSweeney J et al (2023) Parathyroid adenoma arising from autotransplanted tissue in the forearm: A rare cause of recurrent hyperparathyroidism. Ann Endocrinol (Paris) 84(6):654\u2013657. https:\/\/doi.org\/10.1016\/j.ando.2023.10.002","journal-title":"Ann Endocrinol (Paris)"},{"issue":"9","key":"4438_CR17","doi-asserted-by":"publisher","first-page":"1957","DOI":"10.1111\/ans.70167","volume":"95","author":"W MacFaul","year":"2025","unstructured":"MacFaul W, Hulf T, Khan S (2025) Primary hyperparathyroidism from an ectopic parathyroid adenoma in an autotransplanted sternomastoid muscle. ANZ J Surg 95(9):1957\u20131959. https:\/\/doi.org\/10.1111\/ans.70167","journal-title":"ANZ J Surg"},{"key":"4438_CR18","unstructured":"Jalalimehr R, Balasubramanian SP (2024) Forearm auto-transplantation of parathyroid glands: complications and outcomes (review). West Afr J Med. https:\/\/wajmed.org\/index.php\/wajmed\/article\/view\/1051\/656. Accessed 12\u00a0Dec 2025"},{"issue":"6","key":"4438_CR19","doi-asserted-by":"publisher","first-page":"1706","DOI":"10.2214\/AJR.06.0938","volume":"188","author":"NA Johnson","year":"2007","unstructured":"Johnson NA, Tublin ME, Ogilvie JB (2007) Parathyroid imaging: technique and role in the preoperative evaluation of primary hyperparathyroidism. AJR Am J Roentgenol 188(6):1706\u20131715. https:\/\/doi.org\/10.2214\/AJR.06.0938","journal-title":"AJR Am J Roentgenol"},{"key":"4438_CR20","doi-asserted-by":"publisher","first-page":"141593","DOI":"10.1155\/2011\/141593","volume":"2011","author":"ML Taubman","year":"2011","unstructured":"Taubman ML, Goldfarb M, Lew JI (2011) Role of SPECT and SPECT\/CT in the diagnosis and management of primary hyperparathyroidism. Int J Mol Imaging 2011:141593. https:\/\/doi.org\/10.1155\/2011\/141593","journal-title":"Int J Mol Imaging"}],"container-title":["Irish Journal of Medical Science (1971 -)"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s11845-026-04438-4.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s11845-026-04438-4","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s11845-026-04438-4.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,14]],"date-time":"2026-05-14T07:31:48Z","timestamp":1778743908000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s11845-026-04438-4"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,5,14]]},"references-count":20,"alternative-id":["4438"],"URL":"https:\/\/doi.org\/10.1007\/s11845-026-04438-4","relation":{},"ISSN":["0021-1265","1863-4362"],"issn-type":[{"value":"0021-1265","type":"print"},{"value":"1863-4362","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,5,14]]},"assertion":[{"value":"27 December 2025","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"7 May 2026","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"14 May 2026","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"Ethics committee approval was not required according to our institutional policy for a single, fully anonymized case report.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval"}},{"value":"Written informed consent was obtained from the patient for publication of this case and accompanying images.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Informed consent"}},{"value":"The authors declare that they have no conflicts of interest to disclose.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}}]}}