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A comprehensive search of seven electronic databases was performed from inception to January 2026 to identify randomized controlled trials evaluating intraoperative intravenous methylene blue administration and postoperative delirium in adult surgical populations. Study selection, data extraction, and methodological quality assessment were independently conducted by two reviewers using predefined eligibility criteria. Risk of bias was assessed using the Cochrane Risk of Bias 2 tool. Pooled odds ratios with 95% confidence intervals were calculated using a fixed-effect model due to the absence of between-study heterogeneity. Publication bias was evaluated using funnel plot inspection, Egger\u2019s regression test, and Kendall\u2019s tau test.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Three randomized controlled trials involving 779 patients were included. Intraoperative methylene blue administration was associated with a statistically significant reduction in postoperative delirium (OR\u2009=\u20090.35; 95% CI: 0.23\u20130.53; I\n                      <jats:sup>2<\/jats:sup>\n                      \u2009=\u20090%).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Intraoperative methylene blue administration was associated with a reduction in postoperative delirium in surgical patients. However, given the limited number of included studies, further large-scale randomized controlled trials are required.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1007\/s11845-026-04440-w","type":"journal-article","created":{"date-parts":[[2026,5,21]],"date-time":"2026-05-21T07:59:18Z","timestamp":1779350358000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Intraoperative methylene blue administration and postoperative delirium: a meta-analysis of surgical patients"],"prefix":"10.1007","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7243-0734","authenticated-orcid":false,"given":"Se\u00e7il","family":"Taylan","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8325-3198","authenticated-orcid":false,"given":"G\u00fclden","family":"K\u00fc\u00e7\u00fckak\u00e7a \u00c7elik","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4576-2204","authenticated-orcid":false,"given":"Derya","family":"Gezer","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2026,5,21]]},"reference":[{"key":"4440_CR1","doi-asserted-by":"publisher","first-page":"565","DOI":"10.1016\/j.bja.2024.05.033","volume":"133","author":"L Meng","year":"2024","unstructured":"Meng L, Zhao X, Sun Y, Cheng S, Bao L, Fang K, Yu Q, Zheng Y, Wang J, Luo M, Gunderman D, Vuckovic N, Sidhu AS, Li J, Li G, Wolfe JW, Liu Z, Adams DC (2024) Characteristics associated with effectiveness in postoperative delirium research: a systematic review of randomised controlled trials with meta-regression and meta-analysis. 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