{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,5]],"date-time":"2026-11-05T20:34:15Z","timestamp":1793910855168,"version":"4.8.0"},"reference-count":27,"publisher":"Springer Science and Business Media LLC","issue":"5","license":[{"start":{"date-parts":[[2026,6,20]],"date-time":"2026-06-20T00:00:00Z","timestamp":1781913600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2026,6,20]],"date-time":"2026-06-20T00:00:00Z","timestamp":1781913600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"name":"University College Dublin","id":[{"id":"https:\/\/ror.org\/05m7pjf47","id-type":"ROR","asserted-by":"crossref"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Ir J Med Sci"],"published-print":{"date-parts":[[2026,10]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Community-onset sepsis accounts for most sepsis episodes, yet national-level data describing its epidemiology and outcomes remain limited in Ireland. Improved characterisation is needed to support prevention, early recognition, and service planning.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>To examine the epidemiology, infection sources, comorbidity burden, and outcomes of adult (non-maternity) community-onset sepsis in Irish hospitals.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We conducted a secondary analysis of Hospital In-Patient Enquiry data from all acute public hospitals in Ireland from January 2020 to December 2024. Sepsis admissions were identified using ICD-10-AM diagnostic codes. Demographic characteristics, comorbidity burden, infection source, critical care utilisation, and in-hospital mortality were analysed. Multivariable logistic regression was used to identify independent predictors of critical care admission and mortality.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Among 68,644 sepsis episodes, 49,268 (71.7%) were community-onset. Of these, 92.6% (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u200945,641) were adult (non-maternity). In-hospital mortality among community-onset was 19.2%. Mortality increased significantly with age, with episodes of individuals aged\u2009\u2265\u200995 years having the highest odds of death (adjOR 9.17, 95% CI 7.31\u201311.52) compared to those aged 25\u201344 years. Increasing multimorbidity was independently associated with mortality; three or more comorbidities were associated with over threefold higher odds of death (adjOR 3.24, 95% CI 2.98\u20133.52). Respiratory infections (adjOR 2.05) were associated with increased mortality, while urinary sources were associated with lower mortality (adjOR 0.50).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Community-acquired sepsis represents 72% of sepsis episodes in Ireland, predominantly affects older adults with multimorbidity. Prioritising prevention, early recognition, and timely management in the community including vaccination and prompt antibiotic treatment is essential to lowering morbidity and mortality.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1007\/s11845-026-04504-x","type":"journal-article","created":{"date-parts":[[2026,6,20]],"date-time":"2026-06-20T02:04:33Z","timestamp":1781921073000},"page":"3205-3212","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Epidemiology and outcomes of adult (non-maternity) community-onset sepsis in Ireland: a secondary analysis of acute hospital administrative data 2020\u20132024"],"prefix":"10.1007","volume":"195","author":[{"ORCID":"https:\/\/orcid.org\/0009-0001-1199-6793","authenticated-orcid":false,"given":"Nandakumar","family":"Ravichandran","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Diarmuid","family":"Quinlan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patricia","family":"Fitzpatrick","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ellen","family":"Hayes","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mick","family":"Molloy","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Etimbuk","family":"Umana","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tomas","family":"Breslin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aoife","family":"Cotter","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Walter","family":"Cullen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,6,20]]},"reference":[{"issue":"8","key":"4504_CR1","doi-asserted-by":"publisher","first-page":"801","DOI":"10.1001\/jama.2016.0287","volume":"315","author":"M Singer","year":"2016","unstructured":"Singer M, Deutschman CS, Seymour CW, Shankar-Hari M, Annane D, Bauer M et al (2016) The Third International Consensus Definitions for Sepsis and Septic Shock (Sepsis-3). 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