{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,17]],"date-time":"2026-07-17T07:05:34Z","timestamp":1784271934055,"version":"3.55.0"},"reference-count":27,"publisher":"Springer Science and Business Media LLC","license":[{"start":{"date-parts":[[2026,7,17]],"date-time":"2026-07-17T00:00:00Z","timestamp":1784246400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2026,7,17]],"date-time":"2026-07-17T00:00:00Z","timestamp":1784246400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Ir J Med Sci"],"DOI":"10.1007\/s11845-026-04560-3","type":"journal-article","created":{"date-parts":[[2026,7,17]],"date-time":"2026-07-17T06:42:58Z","timestamp":1784270578000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Differentiating septic arthritis from non-infectious inflammatory causes of acute monoarticular arthritis in children: A machine learning approach based on routine laboratory tests"],"prefix":"10.1007","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7780-0231","authenticated-orcid":false,"given":"Ozge","family":"Bayrak Demirel","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1131-7719","authenticated-orcid":false,"given":"Mehmet","family":"Demirel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5147-747X","authenticated-orcid":false,"given":"Onur Can","family":"Bayrak","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0001-1353-3178","authenticated-orcid":false,"given":"Cem","family":"Yapar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3594-7387","authenticated-orcid":false,"given":"Nuray","family":"Aktay Ayaz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3217-4075","authenticated-orcid":false,"given":"Ayse","family":"Kilic","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,7,17]]},"reference":[{"key":"4560_CR1","doi-asserted-by":"publisher","first-page":"316","DOI":"10.1136\/archdischild-2016-310594","volume":"102","author":"C Aupiais","year":"2017","unstructured":"Aupiais C, Basmaci R, Ilharreborde B and others (2017) Arthritis in children: comparison of clinical and biological characteristics of septic arthritis and juvenile idiopathic arthritis. Arch Dis Child 102:316\u2013322","journal-title":"Arch Dis Child"},{"key":"4560_CR2","first-page":"912","volume":"8","author":"L Gamalero","year":"2021","unstructured":"Gamalero L, Ferrara G, Giani T, Cimaz R (2021) Acute arthritis in children: how to discern between septic and non-septic arthritis? Children (Basel) 8:912","journal-title":"Children (Basel)"},{"key":"4560_CR3","doi-asserted-by":"publisher","first-page":"196","DOI":"10.5435\/JAAOS-D-20-00835","volume":"29","author":"M Erkilinc","year":"2021","unstructured":"Erkilinc M, Gilmore A, Weber M, Mistovich RJ (2021) Current concepts in pediatric septic arthritis. J Am Acad Orthop Surg 29:196\u2013206","journal-title":"J Am Acad Orthop Surg"},{"key":"4560_CR4","doi-asserted-by":"publisher","DOI":"10.26355\/eurrev_202302_31361","author":"\u00d6B Demirel","year":"2023","unstructured":"Demirel \u00d6B, Demirel M, \u00d6mero\u011flu R and others (2023) Acute monoarthritis in children: clinical and laboratory factors distinguishing septic arthritis from noninfectious inflammatory arthritis. Eur Rev Med Pharmacol Sci. https:\/\/doi.org\/10.26355\/eurrev_202302_31361","journal-title":"Eur Rev Med Pharmacol Sci"},{"key":"4560_CR5","doi-asserted-by":"publisher","first-page":"2215","DOI":"10.3892\/etm.2016.3583","volume":"12","author":"HB Zhang","year":"2016","unstructured":"Zhang HB, Chen J, Lan QF and others (2016) Diagnostic values of red cell distribution width, platelet distribution width and neutrophil-lymphocyte ratio for sepsis. Exp Ther Med 12:2215\u20132219","journal-title":"Exp Ther Med"},{"key":"4560_CR6","doi-asserted-by":"publisher","first-page":"1940","DOI":"10.1080\/09273948.2021.1976219","volume":"30","author":"A Elbeyli","year":"2022","unstructured":"Elbeyli A, Kurtul BE, Ozcan DO and others (2022) Assessment of red cell distribution width, platelet\/lymphocyte ratio, systemic immune-inflammation index, and neutrophil\/lymphocyte ratio values in patients with central retinal artery occlusion. Ocul Immunol Inflamm 30:1940\u20131944","journal-title":"Ocul Immunol Inflamm"},{"key":"4560_CR7","doi-asserted-by":"publisher","first-page":"39","DOI":"10.1080\/09286586.2020.1791349","volume":"28","author":"A Pinna","year":"2021","unstructured":"Pinna A, Porcu T, Marzano J and others (2021) Mean platelet volume, red cell distribution width, and complete blood cell count indices in retinal vein occlusions. Ophthalmic Epidemiol 28:39\u201347","journal-title":"Ophthalmic Epidemiol"},{"key":"4560_CR8","doi-asserted-by":"publisher","first-page":"2697","DOI":"10.3390\/biomedicines10112697","volume":"10","author":"IH Seo","year":"2022","unstructured":"Seo IH, Lee YJ (2022) Usefulness of complete blood count (CBC) to assess cardiovascular and metabolic diseases in clinical settings: a comprehensive literature review. Biomedicines 10:2697","journal-title":"Biomedicines"},{"key":"4560_CR9","doi-asserted-by":"publisher","first-page":"372","DOI":"10.3109\/14397595.2015.1091136","volume":"26","author":"B Qin","year":"2016","unstructured":"Qin B, Ma N, Tang Q and others (2016) Neutrophil to lymphocyte ratio and platelet to lymphocyte ratio were useful markers in assessment of inflammatory response and disease activity in SLE patients. Mod Rheumatol 26:372\u2013376","journal-title":"Mod Rheumatol"},{"key":"4560_CR10","doi-asserted-by":"publisher","first-page":"15075","DOI":"10.1038\/s41598-024-64469-8","volume":"14","author":"Y Zhang","year":"2024","unstructured":"Zhang Y, Peng W, Zheng X (2024) The prognostic value of the combined neutrophil-to-lymphocyte ratio and neutrophil-to-platelet ratio in sepsis. Sci Rep 14:15075","journal-title":"Sci Rep"},{"key":"4560_CR11","doi-asserted-by":"publisher","first-page":"5052","DOI":"10.1038\/s41598-023-32000-0","volume":"13","author":"T Wang","year":"2023","unstructured":"Wang T, Luo X, Li B and others (2023) Platelet to lymphocyte ratio was a risk factor in Perthes disease. Sci Rep 13:5052","journal-title":"Sci Rep"},{"key":"4560_CR12","doi-asserted-by":"publisher","first-page":"3627","DOI":"10.1038\/s41598-025-87731-z","volume":"15","author":"L Liu","year":"2025","unstructured":"Liu L, Zhao YB, Cheng ZT and others (2025) Development and validation of a prognostic model for critically ill type 2 diabetes patients in ICU based on composite inflammatory indicators. Sci Rep 15:3627","journal-title":"Sci Rep"},{"key":"4560_CR13","doi-asserted-by":"publisher","first-page":"1398713","DOI":"10.3389\/fped.2024.1398713","volume":"12","author":"Y Liu","year":"2024","unstructured":"Liu Y, Wu Y, Zhang T and others (2024) Machine learning algorithms for the early detection of bloodstream infection in children with osteoarticular infections. Front Pediatr 12:1398713","journal-title":"Front Pediatr"},{"key":"4560_CR14","doi-asserted-by":"publisher","first-page":"128","DOI":"10.1186\/s13054-022-03977-3","volume":"26","author":"Y Qin","year":"2022","unstructured":"Qin Y, Kernan KF, Fan Z and others (2022) Machine learning derivation of four computable 24-h pediatric sepsis phenotypes to facilitate enrollment in early personalized anti-inflammatory clinical trials. Crit Care 26:128","journal-title":"Crit Care"},{"key":"4560_CR15","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1080\/1744666X.2020.1850268","volume":"17","author":"SW Eng","year":"2021","unstructured":"Eng SW, Yeung RS, Morris Q (2021) The promise of machine learning to inform the management of juvenile idiopathic arthritis. Expert Rev Clin Immunol 17:1\u20133","journal-title":"Expert Rev Clin Immunol"},{"key":"4560_CR16","doi-asserted-by":"publisher","first-page":"1347","DOI":"10.1056\/NEJMra1814259","volume":"380","author":"A Rajkomar","year":"2019","unstructured":"Rajkomar A, Dean J, Kohane I (2019) Machine learning in medicine. N Engl J Med 380:1347\u20131358","journal-title":"N Engl J Med"},{"key":"4560_CR17","doi-asserted-by":"publisher","first-page":"1043","DOI":"10.1007\/s00134-003-1761-8","volume":"29","author":"JE Fischer","year":"2003","unstructured":"Fischer JE, Bachmann LM, Jaeschke R (2003) A readers\u2019 guide to the interpretation of diagnostic test properties: clinical example of sepsis. Intensive Care Med 29:1043\u20131051","journal-title":"Intensive Care Med"},{"key":"4560_CR18","doi-asserted-by":"publisher","first-page":"837","DOI":"10.2307\/2531595","volume":"44","author":"ER DeLong","year":"1988","unstructured":"DeLong ER, DeLong DM, Clarke-Pearson DL (1988) Comparing the areas under two or more correlated receiver operating characteristic curves: a nonparametric approach. Biometrics 44:837\u2013845","journal-title":"Biometrics"},{"key":"4560_CR19","doi-asserted-by":"publisher","first-page":"1629","DOI":"10.2106\/00004623-200408000-00005","volume":"86","author":"MS Kocher","year":"2004","unstructured":"Kocher MS, Mandiga R, Zurakowski D and others (2004) Validation of a clinical prediction rule for the differentiation between septic arthritis and transient synovitis of the hip in children. J Bone Joint Surg Am 86:1629\u20131635","journal-title":"J Bone Joint Surg Am"},{"key":"4560_CR20","doi-asserted-by":"publisher","first-page":"368","DOI":"10.1097\/01241398-200305000-00017","volume":"23","author":"ST Jung","year":"2003","unstructured":"Jung ST, Rowe SM, Moon ES and others (2003) Significance of laboratory and radiologic findings for differentiating between septic arthritis and transient synovitis of the hip. J Pediatr Orthop 23:368\u2013372","journal-title":"J Pediatr Orthop"},{"key":"4560_CR21","doi-asserted-by":"publisher","first-page":"1251","DOI":"10.2106\/JBJS.E.00216","volume":"88","author":"MS Caird","year":"2006","unstructured":"Caird MS, Flynn JM, Leung YL and others (2006) Factors distinguishing septic arthritis from transient synovitis of the hip in children: a prospective study. J Bone Joint Surg Am 88:1251\u20131257","journal-title":"J Bone Joint Surg Am"},{"key":"4560_CR22","doi-asserted-by":"publisher","first-page":"861","DOI":"10.1007\/s11999-009-0936-1","volume":"468","author":"M P\u00e4\u00e4kk\u00f6nen","year":"2010","unstructured":"P\u00e4\u00e4kk\u00f6nen M, Kallio MJ, Kallio PE, Peltola H (2010) Sensitivity of erythrocyte sedimentation rate and C-reactive protein in childhood bone and joint infections. Clin Orthop Relat Res 468:861\u2013866","journal-title":"Clin Orthop Relat Res"},{"key":"4560_CR23","doi-asserted-by":"publisher","first-page":"3422","DOI":"10.1038\/s41598-021-82553-1","volume":"11","author":"M Thomas","year":"2021","unstructured":"Thomas M, Bonacorsi S, Simon AL and others (2021) Acute monoarthritis in young children: comparing the characteristics of patients with juvenile idiopathic arthritis versus septic and undifferentiated arthritis. Sci Rep 11:3422","journal-title":"Sci Rep"},{"key":"4560_CR24","doi-asserted-by":"publisher","first-page":"956","DOI":"10.2106\/00004623-200405000-00011","volume":"86","author":"SJ Luhmann","year":"2004","unstructured":"Luhmann SJ, Jones A, Schootman M and others (2004) Differentiation between septic arthritis and transient synovitis of the hip in children with clinical prediction algorithms. J Bone Joint Surg Am 86:956\u2013962","journal-title":"J Bone Joint Surg Am"},{"key":"4560_CR25","doi-asserted-by":"publisher","first-page":"106693","DOI":"10.1016\/j.intimp.2020.106693","volume":"85","author":"H Yu","year":"2020","unstructured":"Yu H, Jiang L, Liu R and others (2020) Platelet distribution width as a marker for predicting lupus nephritis. Int Immunopharmacol 85:106693","journal-title":"Int Immunopharmacol"},{"key":"4560_CR26","doi-asserted-by":"crossref","unstructured":"Xie X, Wang Y, Tian S, Cao D (2025). Prognostic and diagnostic value of platelet distribution width in COPD patients with pulmonary hypertension: a retrospective study. Biotechnol Appl Biochem. [ahead of print]","DOI":"10.1002\/bab.2723"},{"key":"4560_CR27","doi-asserted-by":"publisher","first-page":"385","DOI":"10.1515\/cclm-2023-0625","volume":"62","author":"D Ligi","year":"2024","unstructured":"Ligi D, Della Franca C, Notarte KI and others (2024) Platelet distribution width as a significant correlate of COVID-19 infection severity and mortality. Clin Chem Lab Med 62:385\u2013395","journal-title":"Clin Chem Lab Med"}],"container-title":["Irish Journal of Medical Science (1971 -)"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s11845-026-04560-3.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s11845-026-04560-3","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s11845-026-04560-3.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,7,17]],"date-time":"2026-07-17T06:43:00Z","timestamp":1784270580000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s11845-026-04560-3"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,7,17]]},"references-count":27,"alternative-id":["4560"],"URL":"https:\/\/doi.org\/10.1007\/s11845-026-04560-3","relation":{},"ISSN":["0021-1265","1863-4362"],"issn-type":[{"value":"0021-1265","type":"print"},{"value":"1863-4362","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,7,17]]},"assertion":[{"value":"11 February 2026","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"9 July 2026","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"17 July 2026","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"This study was performed in line with the principles of the Declaration of Helsinki. Approval was granted by the Institutional Ethics Committee (Date: 02.06.2025 \/ No: 3345282).","order":1,"name":"Ethics","label":"Ethics approval","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"No competing interests to be declared.","order":2,"name":"Ethics","label":"Competing interests","group":{"name":"EthicsHeading","label":"Declarations"}}]}}