{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,10]],"date-time":"2026-10-10T21:16:22Z","timestamp":1791666982382,"version":"4.3.4"},"reference-count":24,"publisher":"Springer Science and Business Media LLC","license":[{"start":{"date-parts":[[2026,7,16]],"date-time":"2026-07-16T00:00:00Z","timestamp":1784160000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2026,7,16]],"date-time":"2026-07-16T00:00:00Z","timestamp":1784160000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Ir J Med Sci"],"DOI":"10.1007\/s11845-026-04561-2","type":"journal-article","created":{"date-parts":[[2026,7,16]],"date-time":"2026-07-16T06:44:44Z","timestamp":1784184284000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Timing of endoscopy and its impact on prognosis in patients admitted to the emergency department with upper gastrointestinal bleeding"],"prefix":"10.1007","author":[{"ORCID":"https:\/\/orcid.org\/0009-0007-6159-6476","authenticated-orcid":false,"given":"Mehmet","family":"Gorur","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6080-4287","authenticated-orcid":false,"given":"Salim","family":"Satar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5080-3501","authenticated-orcid":false,"given":"Muge","family":"Gulen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4390-6593","authenticated-orcid":false,"given":"Selen","family":"Acehan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0271-9305","authenticated-orcid":false,"given":"Sarper","family":"Sevdimbas","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0000-7067-6370","authenticated-orcid":false,"given":"Kadir","family":"Nigiz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,7,16]]},"reference":[{"key":"4561_CR1","doi-asserted-by":"publisher","unstructured":"Hearnshaw SA, Logan RFA, Lowe D, Travis SPL, Murphy MF, Palmer KR (2011) Acute upper gastrointestinal bleeding in the UK: patient characteristics, diagnoses and outcomes in the 2007 UK audit. https:\/\/doi.org\/10.1136\/gut.2010.228437","DOI":"10.1136\/gut.2010.228437"},{"key":"4561_CR2","doi-asserted-by":"publisher","first-page":"415","DOI":"10.1016\/j.giec.2015.02.010","volume":"25","author":"T Tielleman","year":"2015","unstructured":"Tielleman T, Bujanda D, Cryer B (2015) Epidemiology and Risk Factors for Upper Gastrointestinal Bleeding. Gastrointest Endosc Clin N Am 25:415\u2013428. https:\/\/doi.org\/10.1016\/j.giec.2015.02.010","journal-title":"Gastrointest Endosc Clin N Am"},{"key":"4561_CR3","doi-asserted-by":"publisher","first-page":"345","DOI":"10.1038\/ajg.2011.480","volume":"107","author":"L Laine","year":"2012","unstructured":"Laine L, Jensen DM (2012) Management of Patients With Ulcer Bleeding. Off J Am Coll Gastroenterol ACG 107:345. https:\/\/doi.org\/10.1038\/ajg.2011.480","journal-title":"Off J Am Coll Gastroenterol ACG"},{"key":"4561_CR4","doi-asserted-by":"publisher","unstructured":"Guo CLT, Wong SH, Lau LHS, Lui RNS, Mak JWY, Tang RSY, Yip TCF, Wu WKK, Wong GLH, Chan FKL, Lau JYW, Sung JJY (2022) Timing of endoscopy for acute upper gastrointestinal bleeding: a territory-wide cohort study. https:\/\/doi.org\/10.1136\/gutjnl-2020-323054","DOI":"10.1136\/gutjnl-2020-323054"},{"key":"4561_CR5","doi-asserted-by":"publisher","first-page":"1299","DOI":"10.1056\/NEJMoa1912484","volume":"382","author":"JYW Lau","year":"2020","unstructured":"Lau JYW, Yu Y, Tang RSY, Chan HCH, Yip H-C, Chan SM, Luk SWY, Wong SH, Lau LHS, Lui RN, Chan TT, Mak JWY, Chan FKL, Sung JJY (2020) Timing of Endoscopy for Acute Upper Gastrointestinal Bleeding. N Engl J Med 382:1299\u20131308. https:\/\/doi.org\/10.1056\/NEJMoa1912484","journal-title":"N Engl J Med"},{"key":"4561_CR6","doi-asserted-by":"publisher","first-page":"1393","DOI":"10.1001\/archinte.161.11.1393","volume":"161","author":"BMR Spiegel","year":"2001","unstructured":"Spiegel BMR, Vakil NB, Ofman JJ (2001) Endoscopy for Acute Nonvariceal Upper Gastrointestinal Tract Hemorrhage: Is Sooner Better? A Systematic Review. Arch Intern Med 161:1393\u20131404. https:\/\/doi.org\/10.1001\/archinte.161.11.1393","journal-title":"Arch Intern Med"},{"key":"4561_CR7","doi-asserted-by":"publisher","unstructured":"Consensus Recommendations for Managing Patients with Nonvariceal Upper Gastrointestinal Bleeding | Annals of Internal Medicine https:\/\/doi.org\/10.7326\/0003-4819-139-10-200311180-00012. Accessed 25 Feb 2026","DOI":"10.7326\/0003-4819-139-10-200311180-00012"},{"key":"4561_CR8","unstructured":"Outcomes and Role of Urgent Endoscopy in High-Risk Patients With Acute Nonvariceal Gastrointestinal Bleeding - Clinical Gastroenterology and Hepatology. https:\/\/www.cghjournal.org\/article\/S1542-3565(17)30736-X\/fulltext. Accessed 25 Feb 2026"},{"key":"4561_CR9","doi-asserted-by":"publisher","first-page":"936","DOI":"10.1016\/j.gie.2016.08.049","volume":"85","author":"SB Laursen","year":"2017","unstructured":"Laursen SB, Leontiadis GI, Stanley AJ, M\u00f8ller MH, Hansen JM, Schaffalitzky de Muckadell OB (2017) Relationship between timing of endoscopy and mortality in patients with peptic ulcer bleeding: a nationwide cohort study. Gastrointest Endosc 85:936\u2013944e3. https:\/\/doi.org\/10.1016\/j.gie.2016.08.049","journal-title":"Gastrointest Endosc"},{"key":"4561_CR10","doi-asserted-by":"publisher","first-page":"105","DOI":"10.1186\/s12873-026-01519-6","volume":"26","author":"\u0130 Ayan","year":"2026","unstructured":"Ayan \u0130, Y\u00fcksel M, Ay MO, \u0130\u015fler Y, Kaya H, Akar M, Sark\u0131 HH (2026) Investigation of the relationship between shock index and BUN\/Albumin ratio with clinical outcomes in patients presenting to the emergency department with upper gastrointestinal bleeding. BMC Emerg Med 26:105. https:\/\/doi.org\/10.1186\/s12873-026-01519-6","journal-title":"BMC Emerg Med"},{"key":"4561_CR11","doi-asserted-by":"publisher","first-page":"1331","DOI":"10.1007\/s11739-020-02563-1","volume":"16","author":"E Merola","year":"2021","unstructured":"Merola E, Michielan A, de Pretis G (2021) Optimal timing of endoscopy for acute upper gastrointestinal bleeding: a systematic review and meta-analysis. Intern Emerg Med 16:1331\u20131340","journal-title":"Intern Emerg Med"},{"key":"4561_CR12","unstructured":"European Journal of Gastroenterology & Hepatology. https:\/\/journals.lww.com\/eurojgh\/abstract\/2021\/08000\/does_timing_of_endoscopy_affect_outcomes_in.3.aspx. Accessed 25 Feb 2026"},{"key":"4561_CR13","unstructured":"Does Early Endoscopy Affect the Clinical Outcomes of Patients with Acute Nonvariceal Upper Gastrointestinal Bleeding? A Systematic Review and Meta-Analysis - PMC. https:\/\/pmc.ncbi.nlm.nih.gov\/articles\/PMC10352052\/. Accessed 25 Feb 2026"},{"key":"4561_CR14","doi-asserted-by":"publisher","first-page":"277","DOI":"10.1016\/j.ajem.2018.05.049","volume":"37","author":"N Jeong","year":"2019","unstructured":"Jeong N, Kim KS, Jung YS, Kim T, Shin SM (2019) Delayed endoscopy is associated with increased mortality in upper gastrointestinal hemorrhage. Am J Emerg Med 37:277\u2013280. https:\/\/doi.org\/10.1016\/j.ajem.2018.05.049","journal-title":"Am J Emerg Med"},{"key":"4561_CR15","doi-asserted-by":"publisher","first-page":"47","DOI":"10.5946\/ce.2018.093","volume":"52","author":"G Alexandrino","year":"2019","unstructured":"Alexandrino G, Domingues TD, Carvalho R, Costa MN, Louren\u00e7o LC, Reis J (2019) Endoscopy Timing in Patients with Acute Upper Gastrointestinal Bleeding. Clin Endosc 52:47\u201352. https:\/\/doi.org\/10.5946\/ce.2018.093","journal-title":"Clin Endosc"},{"key":"4561_CR16","doi-asserted-by":"publisher","first-page":"502455","DOI":"10.1016\/j.gastrohep.2025.502455","volume":"48","author":"J Tejedor-Tejada","year":"2025","unstructured":"Tejedor-Tejada J, Hermida B, Camblor C, Emara M, Youssef Mohamed S, Perez-Pariente JM (2025) Timing of endoscopy in high-risk patients with acute upper gastrointestinal bleeding: Results of a multicenter international cohort study. Gastroenterol Hepatol 48:502455. https:\/\/doi.org\/10.1016\/j.gastrohep.2025.502455","journal-title":"Gastroenterol Hepatol"},{"key":"4561_CR17","doi-asserted-by":"publisher","unstructured":"Saleem SA, Kudaravalli P, Riaz S, Pendela VS, Wang D, Lowe D, Manocha D Outcomes of upper gastrointestinal bleeding based on time to endoscopy: a retrospective study. Cureus 12:e7325. https:\/\/doi.org\/10.7759\/cureus.7325","DOI":"10.7759\/cureus.7325"},{"key":"4561_CR18","doi-asserted-by":"publisher","first-page":"260","DOI":"10.1111\/den.14144","volume":"34","author":"JYW Lau","year":"2022","unstructured":"Lau JYW (2022) Management of acute upper gastrointestinal bleeding: Urgent versus early endoscopy. Dig Endosc 34:260\u2013264. https:\/\/doi.org\/10.1111\/den.14144","journal-title":"Dig Endosc"},{"key":"4561_CR19","doi-asserted-by":"publisher","first-page":"178","DOI":"10.1016\/j.gastrohep.2022.05.002","volume":"46","author":"\u0130E G\u00fcven","year":"2023","unstructured":"G\u00fcven \u0130E, Ba\u015fp\u0131nar B, Durak MB, Y\u00fcksel \u0130 (2023) Comparison of urgent and early endoscopy for acute non-variceal upper gastrointestinal bleeding in high-risk patients. Gastroenterol Hepatol 46:178\u2013184. https:\/\/doi.org\/10.1016\/j.gastrohep.2022.05.002","journal-title":"Gastroenterol Hepatol"},{"key":"4561_CR20","doi-asserted-by":"publisher","first-page":"612","DOI":"10.1016\/j.gastre.2023.01.001","volume":"46","author":"J Lucas Ramos","year":"2023","unstructured":"Lucas Ramos J, Yebra Carmona J, Andaluz Garc\u00eda I, Cuadros Mart\u00ednez M, Mayor Delgado P, Ruiz Ram\u00edrez M\u00c1, Poza Cord\u00f3n J, Su\u00e1rez Ferrer C, Delgado Su\u00e1rez A, Gonzalo Bada N, Froil\u00e1n Torres C (2023) Urgent endoscopy versus early endoscopy: Does urgent endoscopy play a role in acute non-variceal upper gastrointestinal bleeding? Gastroenterol Hepatol Engl Ed 46:612\u2013620. https:\/\/doi.org\/10.1016\/j.gastre.2023.01.001","journal-title":"Gastroenterol Hepatol Engl Ed"},{"key":"4561_CR21","doi-asserted-by":"publisher","first-page":"86","DOI":"10.1186\/s12876-025-03673-w","volume":"25","author":"A Chang","year":"2025","unstructured":"Chang A, Sitthinamsuwan N, Pungpipattrakul N, Chienwichai K, Akarapatima K, Sangkaew S, Rugivarodom M, Rattanasupar A, Ovartlarnporn B, Prachayakul V (2025) Impact of duration to endoscopy in patients with non-variceal upper gastrointestinal bleeding: propensity score matching analysis of real-world data from Thailand. BMC Gastroenterol 25:86. https:\/\/doi.org\/10.1186\/s12876-025-03673-w","journal-title":"BMC Gastroenterol"},{"key":"4561_CR22","doi-asserted-by":"publisher","first-page":"96","DOI":"10.1159\/000516945","volume":"29","author":"M Freitas","year":"2022","unstructured":"Freitas M, Macedo Silva V, C\u00fardia Gon\u00e7alves T, Marinho C, Cotter J (2022) How Can Patient\u2019s Risk Dictate the Timing of Endoscopy in Upper Gastrointestinal Bleeding? GE -. Port J Gastroenterol 29:96\u2013105. https:\/\/doi.org\/10.1159\/000516945","journal-title":"GE Port J Gastroenterol"},{"key":"4561_CR23","doi-asserted-by":"publisher","first-page":"267","DOI":"10.7704\/kjhugr.2024.0028","volume":"24","author":"SW Jeon","year":"2024","unstructured":"Jeon SW, Kwon JG, Lee JY, Lee SH, Lee HJ, Daegu-Gyeongbuk Gastrointestinal Study Group (DGSG) (2024) The Time of Endoscopy for Nonvariceal Upper Gastrointestinal Bleeding: An Observational Study. Korean J Helicobacter Up Gastrointest Res 24:267\u2013275. https:\/\/doi.org\/10.7704\/kjhugr.2024.0028","journal-title":"Korean J Helicobacter Up Gastrointest Res"},{"key":"4561_CR24","doi-asserted-by":"publisher","first-page":"285","DOI":"10.4253\/wjge.v15.i4.285","volume":"15","author":"S Weissman","year":"2023","unstructured":"Weissman S, Aziz M, Bangolo AI, Ehrlich D, Forlemu A, Willie A, Gangwani MK, Waqar D, Terefe H, Singh A, Gonzalez DM, Sajja J, Emiroglu FL, Dinko N, Mohamed A, Fallorina MA, Kosoy D, Shenoy A, Nanavati A, Feuerstein JD, Tabibian JH (2023) Relationships of hospitalization outcomes and timing to endoscopy in non-variceal upper gastrointestinal bleeding: A nationwide analysis. World J Gastrointest Endosc 15:285\u2013296. https:\/\/doi.org\/10.4253\/wjge.v15.i4.285","journal-title":"World J Gastrointest Endosc"}],"container-title":["Irish Journal of Medical Science (1971 -)"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s11845-026-04561-2.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s11845-026-04561-2","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s11845-026-04561-2.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,7,16]],"date-time":"2026-07-16T06:44:47Z","timestamp":1784184287000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s11845-026-04561-2"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,7,16]]},"references-count":24,"alternative-id":["4561"],"URL":"https:\/\/doi.org\/10.1007\/s11845-026-04561-2","relation":{},"ISSN":["0021-1265","1863-4362"],"issn-type":[{"value":"0021-1265","type":"print"},{"value":"1863-4362","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,7,16]]},"assertion":[{"value":"14 May 2026","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"10 July 2026","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"16 July 2026","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"No potential conflict of interest relevant to this article was reported.","order":1,"name":"Ethics","label":"Conflict of interest","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"This research did not receive any specific grant from funding agencies in the public, commercial, or not-for-profit sectors.","order":2,"name":"Ethics","label":"Financial support","group":{"name":"EthicsHeading","label":"Declarations"}}]}}