{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,21]],"date-time":"2026-07-21T08:03:25Z","timestamp":1784621005691,"version":"3.55.0"},"reference-count":32,"publisher":"Springer Science and Business Media LLC","license":[{"start":{"date-parts":[[2026,7,21]],"date-time":"2026-07-21T00:00:00Z","timestamp":1784592000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2026,7,21]],"date-time":"2026-07-21T00:00:00Z","timestamp":1784592000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"funder":[{"DOI":"10.13039\/100032697","name":"Vinayaka Missions Research Foundation","doi-asserted-by":"crossref","award":["VMRF\/Seed Money\/Aug 2021\/VMKVMCH-Salem\/1"],"award-info":[{"award-number":["VMRF\/Seed Money\/Aug 2021\/VMKVMCH-Salem\/1"]}],"id":[{"id":"10.13039\/100032697","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Ir J Med Sci"],"DOI":"10.1007\/s11845-026-04564-z","type":"journal-article","created":{"date-parts":[[2026,7,21]],"date-time":"2026-07-21T07:27:11Z","timestamp":1784618831000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Serum erythropoietin level in cases of iron deficiency anemia with thrombocytosis: A cross-sectional study"],"prefix":"10.1007","author":[{"given":"Anbu Lenin","family":"Kulandaivel","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kumudhini Priya","family":"Gunasekaran","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gowri Sankar","family":"Ramalingam","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K. S. B.","family":"Ramanees","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,7,21]]},"reference":[{"key":"4564_CR1","doi-asserted-by":"publisher","first-page":"e000759","DOI":"10.1136\/bmjgast-2021-000759","volume":"9","author":"A Kumar","year":"2022","unstructured":"Kumar A, Sharma E, Marley A, Samaan MA, Brookes MJ (2022) Iron deficiency anaemia: pathophysiology, assessment, practical management. BMJ Open Gastroenterol 9:e000759","journal-title":"BMJ Open Gastroenterol"},{"issue":"11","key":"4564_CR2","first-page":"1","volume":"15","author":"TG Janz","year":"2013","unstructured":"Janz TG, Johnson RL, Rubenstein SD (2013) Anemia in the emergency department: evaluation and treatment. Emerg Med Pract 15(11):1\u201315","journal-title":"Emerg Med Pract"},{"issue":"2","key":"4564_CR3","doi-asserted-by":"publisher","first-page":"139","DOI":"10.1016\/j.critrevonc.2007.06.006","volume":"64","author":"VM Hodges","year":"2007","unstructured":"Hodges VM, Rainey S, Lappin TR, Maxwell AP (2007) Pathophysiology of anemia and erythrocytosis. Crit Rev Oncol Hematol 64(2):139\u2013158","journal-title":"Crit Rev Oncol Hematol"},{"issue":"3","key":"4564_CR4","doi-asserted-by":"publisher","first-page":"823","DOI":"10.1182\/blood.V96.3.823","volume":"96","author":"LT Goodnough","year":"2000","unstructured":"Goodnough LT, Skikne B, Brugnara C (2000) Erythropoietin, iron, and erythropoiesis. Blood 96(3):823\u2013833","journal-title":"Blood"},{"issue":"3","key":"4564_CR5","doi-asserted-by":"publisher","first-page":"152","DOI":"10.1159\/000041038","volume":"103","author":"H Akan","year":"2000","unstructured":"Akan H, G\u00fcven N, Aydogdu I, Arat M, Beksa\u00e7 M, Dalva K (2000) Thrombopoietic cytokines in patients with iron deficiency anemia with or without thrombocytosis. Acta Haematol 103(3):152\u2013156","journal-title":"Acta Haematol"},{"issue":"5","key":"4564_CR6","doi-asserted-by":"publisher","first-page":"217","DOI":"10.1007\/s002770050446","volume":"77","author":"M Uppenkamp","year":"1998","unstructured":"Uppenkamp M, Makarova E, Petrasch S, Brittinger G (1998) Thrombopoietin serum concentration in patients with reactive and myeloproliferative thrombocytosis. Ann Hematol 77(5):217\u2013223","journal-title":"Ann Hematol"},{"issue":"5","key":"4564_CR7","doi-asserted-by":"publisher","first-page":"524","DOI":"10.1002\/ajh.23682","volume":"89","author":"R Evstatiev","year":"2014","unstructured":"Evstatiev R, Bukaty A, Jimenez K, Kulnigg-Dabsch S, Surman L, Schmid W et al (2014) Iron deficiency alters megakaryopoiesis and platelet phenotype independent of thrombopoietin. Am J Hematol 89(5):524\u2013529","journal-title":"Am J Hematol"},{"issue":"18","key":"4564_CR8","doi-asserted-by":"publisher","first-page":"1547","DOI":"10.1182\/blood.2019002039","volume":"134","author":"J Xavier-Ferrucio","year":"2019","unstructured":"Xavier-Ferrucio J, Scanlon V, Li X, Zhang PX, Lozovatsky L, Ayala-Lopez N et al (2019) Low iron promotes megakaryocytic commitment of megakaryocytic-erythroid progenitors in humans and mice. Blood 134(18):1547\u20131557","journal-title":"Blood"},{"issue":"1","key":"4564_CR9","doi-asserted-by":"publisher","first-page":"71","DOI":"10.17511\/jopm.2017.i01.13","volume":"3","author":"R Ramu","year":"2017","unstructured":"Ramu R, Narayana Murthy C (2017) Study of iron deficiency anemia with thrombocytosis in association with serum erythropoietin levels. Trop J Pathol Microbiol 3(1):71\u201376","journal-title":"Trop J Pathol Microbiol"},{"issue":"4","key":"4564_CR10","doi-asserted-by":"publisher","first-page":"1519","DOI":"10.18203\/2349-3291.ijcp20192748","volume":"6","author":"S Jain","year":"2019","unstructured":"Jain S, Chandra J, Sharma S (2019) Clinico-hematological study of abnormalities of platelet count in children with iron deficiency anemia. Int J Contemp Pediatr 6(4):1519\u20131523","journal-title":"Int J Contemp Pediatr"},{"issue":"4","key":"4564_CR11","doi-asserted-by":"publisher","first-page":"e8596","DOI":"10.1002\/ccr3.8596","volume":"12","author":"K Aboujabal","year":"2024","unstructured":"Aboujabal K, Sadek K, Obaid K, Sawaf B, Habas E, Habib MB (2024) Iron deficiency-induced thrombocytosis presenting with blue toe syndrome. Clin Case Rep 12(4):e8596","journal-title":"Clin Case Rep"},{"issue":"3","key":"4564_CR12","doi-asserted-by":"publisher","first-page":"661","DOI":"10.3324\/haematol.2020.270496","volume":"106","author":"H Al-Samkari","year":"2021","unstructured":"Al-Samkari H, Kessler CM, Auerbach M (2021) Recognition of thrombotic risk of thrombocytosis in iron deficiency. Haematologica 106(3):661\u2013663","journal-title":"Haematologica"},{"issue":"9","key":"4564_CR13","first-page":"e17893","volume":"13","author":"D Venugopalan Pathiyil","year":"2021","unstructured":"Venugopalan Pathiyil D, Henry RA, Joseph J, Oomen AT, Janardhanan Kakkra J (2021) Severe iron deficiency anemia leading to thrombocytosis with arterial and venous thrombosis. Cureus 13(9):e17893","journal-title":"Cureus"},{"issue":"Suppl 1","key":"4564_CR14","doi-asserted-by":"publisher","first-page":"22","DOI":"10.1634\/theoncologist.2009-S1-22","volume":"14","author":"A Besarab","year":"2009","unstructured":"Besarab A, H\u00f6rl WH, Silverberg D (2009) Iron metabolism, iron deficiency, thrombocytosis, and the cardiorenal anemia syndrome. Oncologist 14(Suppl 1):22\u201333","journal-title":"Oncologist"},{"key":"4564_CR15","first-page":"398","volume":"98","author":"G Kadikoylu","year":"2006","unstructured":"Kadikoylu G, Yavasoglu I, Bolaman Z, Senturk T (2006) Platelet parameters in women with iron deficiency anemia. J Natl Med Assoc 98:398\u2013402","journal-title":"J Natl Med Assoc"},{"key":"4564_CR16","doi-asserted-by":"publisher","first-page":"1096","DOI":"10.1136\/jcp.2004.016758","volume":"57","author":"N Kakkar","year":"2004","unstructured":"Kakkar N (2004) Spurious rise in the automated platelet count because of bacteria. J Clin Pathol 57:1096\u20131097","journal-title":"J Clin Pathol"},{"key":"4564_CR17","doi-asserted-by":"publisher","first-page":"280","DOI":"10.1111\/j.1365-2141.2006.06236.x","volume":"135","author":"CV Hutchinson","year":"2006","unstructured":"Hutchinson CV, Stelfox P, Rees-Unwin KS (2006) Needle-like cryoglobulin crystals presenting as spurious thrombocytosis. Br J Haematol 135:280","journal-title":"Br J Haematol"},{"key":"4564_CR18","doi-asserted-by":"publisher","first-page":"942","DOI":"10.1001\/archinte.1981.00340070122027","volume":"141","author":"HS Ballard","year":"1981","unstructured":"Ballard HS, Sidhu G (1981) Cytoplasmic fragments causing spurious platelet counts in hairy cell leukemia: ultrastructural characterization. Arch Intern Med 141:942\u2013944","journal-title":"Arch Intern Med"},{"key":"4564_CR19","doi-asserted-by":"publisher","first-page":"154","DOI":"10.1097\/SHK.0000000000001484","volume":"54","author":"RL Ball","year":"2020","unstructured":"Ball RL, Keyloun JW, Brummel-Ziedins K, Orfeo T, Palmieri TL, Johnson LS et al (2020) Burn-induced coagulopathies: a comprehensive review. Shock 54:154\u2013167","journal-title":"Shock"},{"key":"4564_CR20","doi-asserted-by":"publisher","first-page":"295","DOI":"10.1046\/j.1365-2796.1999.00452.x","volume":"245","author":"M Griesshammer","year":"1999","unstructured":"Griesshammer M, Bangerter M, Sauer T, Wennauer R, Bergmann L, Heimpel H (1999) Aetiology and clinical significance of thrombocytosis: analysis of 732 patients with an elevated platelet count. J Intern Med 245:295\u2013300","journal-title":"J Intern Med"},{"key":"4564_CR21","doi-asserted-by":"publisher","first-page":"135","DOI":"10.1097\/01.COC.0000017093.79897.DE","volume":"26","author":"MG Alexandrakis","year":"2003","unstructured":"Alexandrakis MG, Passam FH, Moschandrea IA, Christophoridou AV, Pappa CA, Coulocheri SA et al (2003) Levels of serum cytokines and acute phase proteins in patients with essential and cancer-related thrombocytosis. Am J Clin Oncol 26:135\u2013140","journal-title":"Am J Clin Oncol"},{"key":"4564_CR22","first-page":"107","volume":"95","author":"IC Haznedaroglu","year":"1996","unstructured":"Haznedaroglu IC, Ertenli I, Ozcebe OI, Kiraz S, Ozdemir O, Sayinalp NM et al (1996) Megakaryocyte-related interleukins in reactive thrombocytosis versus autonomous thrombocythemia. Acta Haematol 95:107\u2013111","journal-title":"Acta Haematol"},{"key":"4564_CR23","first-page":"67","volume":"93","author":"K Dan","year":"1995","unstructured":"Dan K, Gomi S, Inokuchi K, Ogata K, Yamada T, Ohki I et al (1995) Effects of interleukin-1 and tumor necrosis factor on megakaryocytopoiesis: mechanism of reactive thrombocytosis. Acta Haematol 93:67\u201372","journal-title":"Acta Haematol"},{"key":"4564_CR24","doi-asserted-by":"publisher","first-page":"401","DOI":"10.1080\/09537100903137306","volume":"20","author":"I Kuku","year":"2009","unstructured":"Kuku I, Kaya E, Yologlu S, Gokdeniz R, Baydin A (2009) Platelet counts in adults with iron deficiency anemia. Platelets 20:401\u2013405","journal-title":"Platelets"},{"key":"4564_CR25","first-page":"541","volume":"84","author":"Y Beguin","year":"1999","unstructured":"Beguin Y (1999) Erythropoietin and platelet production. Haematologica 84:541\u2013547","journal-title":"Haematologica"},{"key":"4564_CR26","first-page":"1","volume":"3","author":"GS Sharadamani","year":"2017","unstructured":"Sharadamani GS (2017) Iron deficiency anemia among rural population attending tertiary care teaching hospital. Trop J Pathol Microbiol 3:1\u20138","journal-title":"Trop J Pathol Microbiol"},{"key":"4564_CR27","first-page":"296","volume":"3","author":"H Kaur","year":"2014","unstructured":"Kaur H, Piplani S, Madan M, Paul M, Rao SG (2014) Prevalence of anemia and micronutrient deficiency in elderly. Int J Med Dent Sci 3:296\u2013302","journal-title":"Int J Med Dent Sci"},{"key":"4564_CR28","doi-asserted-by":"publisher","first-page":"165","DOI":"10.1111\/j.1365-2141.2004.05329.x","volume":"129","author":"C Dame","year":"2005","unstructured":"Dame C, Sutor AH (2005) Primary and secondary thrombocytosis in childhood. Br J Haematol 129:165\u2013177","journal-title":"Br J Haematol"},{"key":"4564_CR29","first-page":"90","volume":"5","author":"O Tania","year":"2016","unstructured":"Tania O, Alka B (2016) To study hematological abnormalities of platelet count in children with iron deficiency anemia in India. Int J Sci Res 5:90\u201395","journal-title":"Int J Sci Res"},{"key":"4564_CR30","doi-asserted-by":"publisher","first-page":"1519","DOI":"10.18203\/2349-3291.ijcp20192748","volume":"6","author":"S Ray","year":"2019","unstructured":"Ray S, Chandra J, Sharma S (2019) Clinico-hematological study of platelet abnormalities in iron deficiency anemia. Int J Contemp Pediatr 6:1519\u20131523","journal-title":"Int J Contemp Pediatr"},{"issue":"1","key":"4564_CR31","first-page":"232","volume":"2020","author":"RT Means Jr","year":"2020","unstructured":"Means RT Jr (2020) Iron deficiency and erythropoiesis. Hematol Am Soc Hematol Educ Program 2020(1):232\u2013238","journal-title":"Hematol Am Soc Hematol Educ Program"},{"key":"4564_CR32","doi-asserted-by":"publisher","first-page":"1547","DOI":"10.1182\/blood.2019002039","volume":"134","author":"J Xavier-Ferrucio","year":"2019","unstructured":"Xavier-Ferrucio J, Scanlon V, Li X, Zhang PX, Lozovatsky L, Ayala-Lopez N et al (2019) Iron deficiency promotes megakaryocytic commitment. Blood 134:1547\u20131557","journal-title":"Blood"}],"container-title":["Irish Journal of Medical Science (1971 -)"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s11845-026-04564-z.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s11845-026-04564-z","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s11845-026-04564-z.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,7,21]],"date-time":"2026-07-21T07:27:14Z","timestamp":1784618834000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s11845-026-04564-z"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,7,21]]},"references-count":32,"alternative-id":["4564"],"URL":"https:\/\/doi.org\/10.1007\/s11845-026-04564-z","relation":{},"ISSN":["0021-1265","1863-4362"],"issn-type":[{"value":"0021-1265","type":"print"},{"value":"1863-4362","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,7,21]]},"assertion":[{"value":"2 February 2026","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"10 July 2026","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"21 July 2026","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"The authors declare no conflicts of interest.","order":1,"name":"Ethics","label":"Competing interests","group":{"name":"EthicsHeading","label":"Declarations"}}]}}