{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T18:59:47Z","timestamp":1790189987602,"version":"4.1.0"},"reference-count":30,"publisher":"Springer Science and Business Media LLC","license":[{"start":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T00:00:00Z","timestamp":1790121600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T00:00:00Z","timestamp":1790121600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Ir J Med Sci"],"DOI":"10.1007\/s11845-026-04594-7","type":"journal-article","created":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T05:53:07Z","timestamp":1790142787000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Determinants of relapse and delayed convalescence in patients with Brucellosis: a one-year prospective follow-up"],"prefix":"10.1007","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5287-4904","authenticated-orcid":false,"given":"Necati","family":"Mumcu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7428-5091","authenticated-orcid":false,"given":"Yusuf Emre","family":"Ozdemir","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7201-268X","authenticated-orcid":false,"given":"Melike","family":"Civak","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4620-6755","authenticated-orcid":false,"given":"Nagehan","family":"Damar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3928-3840","authenticated-orcid":false,"given":"Meryem Sahin","family":"Ozdemir","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7239-1133","authenticated-orcid":false,"given":"Serkan","family":"Surme","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,9,23]]},"reference":[{"issue":"2","key":"4594_CR1","doi-asserted-by":"crossref","first-page":"86","DOI":"10.36519\/kd.2023.4576","volume":"36","author":"S Yavuz","year":"2023","unstructured":"Yavuz S, \u00d6zger S, Benli A et al (2023) T\u00fcrk klinik mikrobiyoloji ve infeksiyon hastal\u0131klar\u0131 derne\u011fi kan\u0131ta dayal\u0131 bruselloz tan\u0131 ve tedavi klinik uygulama rehberi. Klimik Dergisi 36(2):86\u2013123","journal-title":"Klimik Dergisi"},{"key":"4594_CR2","unstructured":"G\u00fcl HC, Erdem H (2020) Brucellosis ( Brucella Species). In: Mandell GL, Bennett JE, Dolin R (eds) Principles and Practice of Infectious Diseases. 9 ed. Elsevier, vol 226, pp 2753\u20138.e2"},{"issue":"1","key":"4594_CR3","doi-asserted-by":"publisher","first-page":"51","DOI":"10.46332\/aemj.1549183","volume":"9","author":"N Mumcu","year":"2025","unstructured":"Mumcu N, \u00d6zdemir Y, \u00c7ivak M et al (2025) Evaluation of clinical and laboratory findings in patients with brucellosis. Ahi Evran Med J 9(1):51\u201361. https:\/\/doi.org\/10.46332\/aemj.1549183","journal-title":"Ahi Evran Med J"},{"issue":"2","key":"4594_CR4","doi-asserted-by":"publisher","first-page":"2295398","DOI":"10.1080\/07853890.2023.2295398","volume":"55","author":"KA Qureshi","year":"2023","unstructured":"Qureshi KA, Parvez A, Fahmy NA and others (2023) Brucellosis: epidemiology, pathogenesis, diagnosis and treatment-a comprehensive review. Ann Med 55(2):2295398","journal-title":"Ann Med"},{"key":"4594_CR5","unstructured":"Corbel MJ (2006) Brucellosis in humans and animals. World Health Organization. Availableat:\u00a0https:\/\/iris.who.int\/bitstream\/handle\/10665\/43597\/WHO_CDS_EPR_2006.7_eng.pdf?sequence=1. Accessed on: 24\/05\/2025"},{"issue":"7","key":"4594_CR6","doi-asserted-by":"publisher","first-page":"e0010635","DOI":"10.1371\/journal.pntd.0010635","volume":"16","author":"S Mode","year":"2022","unstructured":"Mode S, Ketterer M, Qu\u00e9batte M, Dehio C (2022) Antibiotic persistence of intracellular Brucella abortus. PLoS Negl Trop Dis 16(7):e0010635. https:\/\/doi.org\/10.1371\/journal.pntd.0010635","journal-title":"PLoS Negl Trop Dis"},{"key":"4594_CR7","first-page":"863","volume-title":"Enfeksiyon Hastal\u0131klar\u0131 ve Mikrobiyolojisi","author":"E Alp","year":"2017","unstructured":"Alp E, Do\u011fanay M (2017) Bruselloz. In: Top\u00e7u AW, S\u00f6yletir G, Do\u011fanay M (eds) Enfeksiyon Hastal\u0131klar\u0131 ve Mikrobiyolojisi, 4 ed. Nobel T\u0131p Kitap Evleri, \u0130stanbul, pp 863\u2013872","edition":"4 ed"},{"issue":"4","key":"4594_CR8","doi-asserted-by":"publisher","first-page":"419","DOI":"10.1001\/archinte.1951.03810100003001","volume":"88","author":"WW Spink","year":"1951","unstructured":"Spink WW, Hall WH, Magoffin R (1951) Follow-up study of therapy in forty-eight culturally proved cases of Brucellosis: Streptomycin and Sulfadiazine, Aureomycin, and Chloramphenicol (Chloromycetin\u00ae). AMA Arch Internal Med 88(4):419\u2013432","journal-title":"AMA Arch Internal Med"},{"key":"4594_CR9","doi-asserted-by":"publisher","first-page":"1776","DOI":"10.1086\/426024","volume":"39","author":"J Solera","year":"2004","unstructured":"Solera J, Geijo P, Largo J et al (2004) Grupo de Estudio de Castilla-la Mancha de Enfermedades Infecciosas. A randomized, double-blind study to assess the optimal duration of doxycycline treatment for human brucellosis. Clin Infect Dis. 39:1776\u201382","journal-title":"Clin Infect Dis."},{"key":"4594_CR10","doi-asserted-by":"publisher","first-page":"4163","DOI":"10.1128\/JCM.37.12.4163-4166.1999","volume":"37","author":"P Morata","year":"1999","unstructured":"Morata P, Queipo-Ortu\u00f1o MI, Reguera JM et al (1999) Post treatment follow-up of brucellosis by PCR assay. J Clin Microbiol 37:4163\u20134166","journal-title":"J Clin Microbiol"},{"issue":"7","key":"4594_CR11","doi-asserted-by":"publisher","first-page":"e0013270","DOI":"10.1371\/journal.pntd.0013270","volume":"19","author":"I Bahabri","year":"2025","unstructured":"Bahabri I, Hakeem A, Alturki MS et al (2025) Brucellosis relapse: rate, patient characteristics, and clinical outcomes in an endemic region. PLoS Negl Trop Dis 19(7):e0013270. https:\/\/doi.org\/10.1371\/journal.pntd.0013270","journal-title":"PLoS Negl Trop Dis"},{"issue":"10","key":"4594_CR12","doi-asserted-by":"publisher","first-page":"1562","DOI":"10.15537\/1658-3175.3152","volume":"26","author":"SM Fallatah","year":"2005","unstructured":"Fallatah SM, Oduloju AJ, Al-Dusari SN, Fakunle YM (2005) Human brucellosis in Northern Saudi Arabia. Saudi Med J 26(10):1562\u20131566","journal-title":"Saudi Med J"},{"key":"4594_CR13","doi-asserted-by":"publisher","first-page":"5","DOI":"10.1186\/1471-2334-3-5","volume":"3","author":"LF Nimri","year":"2003","unstructured":"Nimri LF (2003) Diagnosis of recent and relapsed cases of human brucellosis by PCR assay. BMC Infect Dis 3:5. https:\/\/doi.org\/10.1186\/1471-2334-3-5","journal-title":"BMC Infect Dis"},{"issue":"6","key":"4594_CR14","doi-asserted-by":"publisher","first-page":"e469","DOI":"10.1016\/j.ijid.2009.06.031","volume":"14","author":"T Buzgan","year":"2010","unstructured":"Buzgan T, Karahocagil MK, Irmak H et al (2010) Clinical manifestations and complications in 1028 cases of brucellosis: a retrospective evaluation and review of the literature. Int J Infect Dis 14(6):e469\u2013e478. https:\/\/doi.org\/10.1016\/j.ijid.2009.06.031","journal-title":"Int J Infect Dis"},{"key":"4594_CR15","doi-asserted-by":"publisher","first-page":"5712920","DOI":"10.1155\/2018\/5712920","volume":"2018","author":"R Zheng","year":"2018","unstructured":"Zheng R, Xie S, Lu X et al (2018) A systematic review and meta-analysis of epidemiology and clinical manifestations of human brucellosis in China. Biomed Res Int 2018:5712920. https:\/\/doi.org\/10.1155\/2018\/5712920","journal-title":"Biomed Res Int"},{"issue":"5","key":"4594_CR16","doi-asserted-by":"publisher","first-page":"1241","DOI":"10.1093\/clinids\/20.5.1241","volume":"20","author":"J Ariza","year":"1995","unstructured":"Ariza J, Corredoira J, Pallares R et al (1995) Characteristics of and risk factors for relapse of brucellosis in humans. Clin Infect Dis 20(5):1241\u20131249","journal-title":"Clin Infect Dis"},{"issue":"1","key":"4594_CR17","doi-asserted-by":"publisher","first-page":"85","DOI":"10.1016\/s0163-4453(98)93342-4","volume":"36","author":"J Solera","year":"1998","unstructured":"Solera J, Mart\u00ednez-Alfaro E, Espinosa A et al (1998) Multivariate model for predicting relapse in human brucellosis. J Infect 36(1):85\u201392. https:\/\/doi.org\/10.1016\/s0163-4453(98)93342-4","journal-title":"J Infect"},{"issue":"3","key":"4594_CR18","doi-asserted-by":"publisher","first-page":"206","DOI":"10.4314\/gmj.v55i3.5","volume":"55","author":"A Mohammadbeigi","year":"2021","unstructured":"Mohammadbeigi A, Saghafipour A, Hamta A et al (2021) Epidemiological features of brucellosis and factors affecting its treatment failure and relapse in Qom Province, Iran. Ghana Med J 55(3):206\u2013212. https:\/\/doi.org\/10.4314\/gmj.v55i3.5","journal-title":"Ghana Med J"},{"issue":"1","key":"4594_CR19","first-page":"46","volume":"25","author":"M Alavi","year":"2009","unstructured":"Alavi M, Alavi MR, Alavi L (2009) Relapsed human. Brucellosis and related risk factors. Pak J Med Sci. 25(1):46\u201350","journal-title":"Pak J Med Sci."},{"issue":"7","key":"4594_CR20","doi-asserted-by":"publisher","first-page":"77","DOI":"10.5539\/gjhs.v8n7p77","volume":"8","author":"MR Hasanjani Roushan","year":"2015","unstructured":"Hasanjani Roushan MR, Moulana Z, Mohseni Afshar Z, Ebrahimpour S (2015) Risk factors for relapse of human brucellosis. Glob J Health Sci 8(7):77\u201382. https:\/\/doi.org\/10.5539\/gjhs.v8n7p77","journal-title":"Glob J Health Sci"},{"issue":"3","key":"4594_CR21","doi-asserted-by":"publisher","first-page":"164","DOI":"10.36519\/kd.2021.3548","volume":"34","author":"B Uysal","year":"2021","unstructured":"Uysal B, Mumcu N, Y\u0131ld\u0131z O, Aygen B (2021) Bruselloz Tan\u0131s\u0131nda Kullan\u0131lan Y\u00f6ntemlerin Kar\u015f\u0131la\u015ft\u0131r\u0131lmas\u0131. Klimik Journal\/Klimik Dergisi 34(3):164","journal-title":"Klimik Journal\/Klimik Dergisi"},{"key":"4594_CR22","doi-asserted-by":"publisher","first-page":"1259479","DOI":"10.3389\/fmicb.2023.1259479","volume":"14","author":"B Liu","year":"2023","unstructured":"Liu B, Liu G, Ma X et al (2023) Epidemiology, clinical manifestations, and laboratory findings of 1,590 human brucellosis cases in Ningxia, China. Front Microbiol 14:1259479. https:\/\/doi.org\/10.3389\/fmicb.2023.1259479","journal-title":"Front Microbiol"},{"issue":"3","key":"4594_CR23","doi-asserted-by":"publisher","first-page":"258","DOI":"10.1111\/j.1365-2796.2010.02332.x","volume":"269","author":"R Huttunen","year":"2011","unstructured":"Huttunen R, Heikkinen T, Syrj\u00e4nen J (2011) Smoking and the outcome of infection. J Intern Med 269(3):258\u2013269. https:\/\/doi.org\/10.1111\/j.1365-2796.2010.02332.x","journal-title":"J Intern Med"},{"issue":"8000","key":"4594_CR24","doi-asserted-by":"publisher","first-page":"827","DOI":"10.1038\/s41586-023-06968-8","volume":"626","author":"V Saint-Andr\u00e9","year":"2024","unstructured":"Saint-Andr\u00e9 V, Charbit B, Biton A et al (2024) Smoking changes adaptive immunity with persistent effects. Nature. 626(8000):827\u2013835. https:\/\/doi.org\/10.1038\/s41586-023-06968-8","journal-title":"Nature."},{"key":"4594_CR31","doi-asserted-by":"publisher","unstructured":"Abd elbaser E, Mohammed H (2018) Brucellosis relapse: a retrospective study of risk factors among Saudi patients. Afro-Egypt J Infect Endem Dis 8(3):149\u2013154 https:\/\/doi.org\/10.21608\/aeji.2018.13526","DOI":"10.21608\/aeji.2018.13526"},{"key":"4594_CR32","doi-asserted-by":"publisher","unstructured":"Imboden JB, Canter A, Cluff LE, Trever RW (1959) Brucellosis. III. Psychologic aspects of delayed convalescence. AMA Arch Intern Med 103(3):406\u2013414. https:\/\/doi.org\/10.1001\/archinte.1959.00270030062006","DOI":"10.1001\/archinte.1959.00270030062006"},{"key":"4594_CR33","doi-asserted-by":"publisher","unstructured":"Cluff LE (1991) Medical aspects of delayed convalescence. Rev Infect Dis 13(Suppl 1):S138\u2013S140. https:\/\/doi.org\/10.1093\/clinids\/13.supplement_1.s138","DOI":"10.1093\/clinids\/13.supplement_1.s138"},{"key":"4594_CR34","doi-asserted-by":"publisher","unstructured":"Talbot NC, Spillers NJ, Luther P et al (2023) Lyme disease and post-treatment Lyme disease syndrome: current and developing treatment options. Cureus 15(8):e43112. https:\/\/doi.org\/10.7759\/cureus.43112","DOI":"10.7759\/cureus.43112"},{"key":"4594_CR35","doi-asserted-by":"publisher","unstructured":"Wong KH, Shapiro ED, Soffer GK (2022) A review of post-treatment Lyme disease syndrome and chronic Lyme disease for the practicing immunologist. Clin Rev Allergy Immunol 62(1):264\u2013271. https:\/\/doi.org\/10.1007\/s12016-021-08906-w","DOI":"10.1007\/s12016-021-08906-w"},{"key":"4594_CR36","doi-asserted-by":"publisher","unstructured":"Casta\u00f1o MJ, Solera J. Chronic brucellosis and persistence of Brucella melitensis DNA. J Clin Microbiol. 2009 Jul;47(7):2084-9.  https:\/\/doi.org\/10.1128\/JCM.02159-08","DOI":"10.1128\/JCM.02159-08"}],"container-title":["Irish Journal of Medical Science (1971 -)"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s11845-026-04594-7.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s11845-026-04594-7","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s11845-026-04594-7.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T18:03:08Z","timestamp":1790186588000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s11845-026-04594-7"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,9,23]]},"references-count":30,"alternative-id":["4594"],"URL":"https:\/\/doi.org\/10.1007\/s11845-026-04594-7","relation":{},"ISSN":["0021-1265","1863-4362"],"issn-type":[{"value":"0021-1265","type":"print"},{"value":"1863-4362","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,9,23]]},"assertion":[{"value":"26 March 2026","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"24 August 2026","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"23 September 2026","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"Ethical approval for the research was obtained from the Ethics Committee of Kars Kafkas University on September 22, 2021 (Document No. 142, Decision No. 11, 2021). All procces in this research was carried out in accordance with the ethical standards of the Declaration of Helsinki. The patients\/participants provided their written informed consent in the local language (T\u00fcrk\u00e7e) to participate in this study. The consent included the title of the study, purpose, benefits and the right to not participate in the study if he\/she does not wish to. Throughout the course of the study, confidentiality of the participants was maintained.","order":1,"name":"Ethics","label":"Ethics approval and consent to participate","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"Written informed consent for publication of anonymized data was obtained from all participants or their legal guardians.","order":2,"name":"Ethics","label":"Consent for publish","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors declare no competing interests.","order":3,"name":"Ethics","label":"Competing interests","group":{"name":"EthicsHeading","label":"Declarations"}}]}}