{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T16:59:51Z","timestamp":1790269191415,"version":"4.1.0"},"reference-count":52,"publisher":"Springer Science and Business Media LLC","license":[{"start":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T00:00:00Z","timestamp":1790208000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T00:00:00Z","timestamp":1790208000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Ir J Med Sci"],"DOI":"10.1007\/s11845-026-04632-4","type":"journal-article","created":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T03:53:01Z","timestamp":1790221981000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["NMR-based metabolic profiling in urine for bipolar disorder manic episode"],"prefix":"10.1007","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5096-6116","authenticated-orcid":false,"given":"Talha","family":"A\u011fa\u00e7","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3201-5923","authenticated-orcid":false,"given":"Fatmanur","family":"K\u00f6kta\u015fo\u011flu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9442-4300","authenticated-orcid":false,"given":"Halime","family":"Dulun A\u011fa\u00e7","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4810-6771","authenticated-orcid":false,"given":"Metin","family":"Demirel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1235-3957","authenticated-orcid":false,"given":"\u015eahabettin","family":"Selek","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3173-5790","authenticated-orcid":false,"given":"Somer","family":"Bekiro\u011flu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3322-9189","authenticated-orcid":false,"given":"Mustafa","family":"Solmaz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,9,24]]},"reference":[{"key":"4632_CR1","volume-title":"DSM-5 Tan\u0131 \u00d6l\u00e7\u00fctleri Ba\u015fvuru El Kitab\u0131","author":"E K\u00f6ro\u011flu","year":"2013","unstructured":"K\u00f6ro\u011flu E (2013) DSM-5 Tan\u0131 \u00d6l\u00e7\u00fctleri Ba\u015fvuru El Kitab\u0131. Hekimler Yay\u0131n Birli\u011fi, Ankara"},{"issue":"2","key":"4632_CR2","doi-asserted-by":"publisher","first-page":"S11","DOI":"10.1016\/S0033-3182(95)71699-1","volume":"36","author":"RC Hall","year":"1995","unstructured":"Hall RC, Wise MG (1995) The clinical and financial burden of mood disorders. Cost and outcome. Psychosomatics 36(2):S11\u2013S18","journal-title":"Psychosomatics"},{"key":"4632_CR3","doi-asserted-by":"publisher","first-page":"81","DOI":"10.1016\/bs.acc.2017.12.005","volume":"84","author":"K Hashimoto","year":"2018","unstructured":"Hashimoto K (2018) Metabolomics of major depressive disorder and bipolar disorder: overview and future perspective. Adv Clin Chem 84:81\u201399","journal-title":"Adv Clin Chem"},{"issue":"11","key":"4632_CR4","doi-asserted-by":"publisher","first-page":"267","DOI":"10.1080\/14789450.2023.2267756","volume":"20","author":"HC Ribeiro","year":"2023","unstructured":"Ribeiro HC, Zandonadi FDS, Sussulini A (2023) An overview of metabolomic and proteomic profiling in bipolar disorder and its clinical value. Expert Rev Proteomics 20(11):267\u2013280","journal-title":"Expert Rev Proteomics"},{"key":"4632_CR5","doi-asserted-by":"publisher","first-page":"492","DOI":"10.1016\/j.jad.2024.01.033","volume":"350","author":"J Chen","year":"2024","unstructured":"Chen J, Amdanee N, Zuo X and others (2024) Biomarkers of bipolar disorder based on metabolomics: a systematic review. J Affect Disord 350:492\u2013503","journal-title":"J Affect Disord"},{"issue":"9","key":"4632_CR6","doi-asserted-by":"publisher","first-page":"2398","DOI":"10.1039\/C4MB00157E","volume":"10","author":"ML Liu","year":"2014","unstructured":"Liu ML, Zheng P, Liu Z and others (2014) GC-MS based metabolomics identification of possible novel biomarkers for schizophrenia in peripheral blood mononuclear cells. Mol Biosyst 10(9):2398\u20132406","journal-title":"Mol Biosyst"},{"key":"4632_CR7","doi-asserted-by":"publisher","first-page":"182","DOI":"10.1016\/j.pnpbp.2019.03.010","volume":"93","author":"M Pedrini","year":"2019","unstructured":"Pedrini M, Cao B, Nani JVS and others (2019) Advances and challenges in development of precision psychiatry through clinical metabolomics on mood and psychotic disorders. Prog Neuropsychopharmacol Biol Psychiatry 93:182\u2013188","journal-title":"Prog Neuropsychopharmacol Biol Psychiatry"},{"issue":"4","key":"4632_CR8","doi-asserted-by":"publisher","first-page":"e0214121","DOI":"10.1371\/journal.pone.0214121","volume":"14","author":"RO Bahado-Singh","year":"2019","unstructured":"Bahado-Singh RO, Yilmaz A, Bisgin H and others (2019) Artificial intelligence and the analysis of multi-platform metabolomics data for the detection of intrauterine growth restriction. PLoS ONE 14(4):e0214121","journal-title":"PLoS ONE"},{"key":"4632_CR9","doi-asserted-by":"publisher","first-page":"61","DOI":"10.1146\/annurev-biodatasci-011420-031537","volume":"3","author":"T Alexandrov","year":"2020","unstructured":"Alexandrov T (2020) Spatial metabolomics and imaging mass spectrometry in the age of artificial intelligence. Annu Rev Biomed Data Sci 3:61\u201387","journal-title":"Annu Rev Biomed Data Sci"},{"key":"4632_CR10","doi-asserted-by":"publisher","first-page":"876100","DOI":"10.3389\/frai.2022.876100","volume":"5","author":"E Irajizad","year":"2022","unstructured":"Irajizad E, Wu R, Vykoukal J and others (2022) Application of artificial intelligence to plasma metabolomics profiles to predict response to neoadjuvant chemotherapy in triple-negative breast cancer. Front Artif Intell 5:876100","journal-title":"Front Artif Intell"},{"key":"4632_CR11","doi-asserted-by":"publisher","first-page":"161","DOI":"10.1007\/978-1-4939-2377-9_13","volume":"1277","author":"AH Emwas","year":"2015","unstructured":"Emwas AH (2015) The strengths and weaknesses of NMR spectroscopy and mass spectrometry with particular focus on metabolomics research. Methods Mol Biol 1277:161\u2013193","journal-title":"Methods Mol Biol"},{"issue":"2","key":"4632_CR12","doi-asserted-by":"publisher","first-page":"205","DOI":"10.1515\/tjb-2024-0215","volume":"50","author":"E Becer","year":"2025","unstructured":"Becer E, Hano\u011flu A, \u00dcnl\u00fc A and others (2025) The cytotoxic and antiproliferative effect of Polygala saponin XLIV on the human colorectal carcinoma cell line. Turk J Biochem 50(2):205\u2013212","journal-title":"Turk J Biochem"},{"key":"4632_CR13","doi-asserted-by":"publisher","first-page":"1251955","DOI":"10.3389\/fpsyt.2023.1251955","volume":"14","author":"XL Sun","year":"2023","unstructured":"Sun XL, Ma LN, Chen ZZ and others (2023) Search for serum biomarkers in patients with bipolar disorder and major depressive disorder using metabolome analysis. Front Psychiatry 14:1251955","journal-title":"Front Psychiatry"},{"key":"4632_CR14","doi-asserted-by":"publisher","first-page":"60","DOI":"10.1016\/j.phytochem.2011.12.010","volume":"76","author":"MA Farag","year":"2012","unstructured":"Farag MA, Porzel A, Wessjohann LA (2012) Comparative metabolite profiling and fingerprinting of medicinal licorice roots using a multiplex approach of GC-MS, LC-MS and 1D NMR techniques. Phytochemistry 76:60\u201372","journal-title":"Phytochemistry"},{"key":"4632_CR15","doi-asserted-by":"publisher","first-page":"16","DOI":"10.1016\/j.jpba.2018.09.013","volume":"162","author":"W Liu","year":"2019","unstructured":"Liu W, Song Q, Cao Y and others (2019) From 1H NMR-based non-targeted to LC-MS-based targeted metabolomics strategy for in-depth chemome comparisons among four Cistanche species. J Pharm Biomed Anal 162:16\u201327","journal-title":"J Pharm Biomed Anal"},{"key":"4632_CR16","doi-asserted-by":"publisher","DOI":"10.1016\/j.neulet.2020.135515","volume":"742","author":"Y Ren","year":"2021","unstructured":"Ren Y, Chen ZZ, Sun XL, Duan H-J, Tian J-S, Wang J-Y, Yang H (2021) Metabolomic analysis to detect urinary molecular changes associated with bipolar depression. Neurosci Lett 742:135515","journal-title":"Neurosci Lett"},{"key":"4632_CR17","doi-asserted-by":"publisher","first-page":"271","DOI":"10.1007\/978-3-030-05542-4_14","volume":"1118","author":"M Quintero","year":"2019","unstructured":"Quintero M, Stanisic D, Cruz G and others (2019) Metabolomic biomarkers in mental disorders: bipolar disorder and schizophrenia. Adv Exp Med Biol 1118:271\u2013293","journal-title":"Adv Exp Med Biol"},{"issue":"5","key":"4632_CR18","doi-asserted-by":"publisher","first-page":"607","DOI":"10.3390\/metabo13050607","volume":"13","author":"K Simi\u0107","year":"2023","unstructured":"Simi\u0107 K, Miladinovi\u0107 Z, Todorovi\u0107 N and others (2023) Metabolomic profiling of bipolar disorder by 1H-NMR in Serbian patients. Metabolites 13(5):607","journal-title":"Metabolites"},{"issue":"4","key":"4632_CR19","first-page":"251","volume":"4","author":"A Akdemir","year":"1996","unstructured":"Akdemir A, \u00d6rsel S, Da\u011f \u0130 and others (1996) Hamilton Depresyon Derecelendirme \u00d6l\u00e7e\u011fi\u2019nin ge\u00e7erli\u011fi, g\u00fcvenirli\u011fi ve klinikte kullan\u0131m\u0131. Psikiyatri Psikoloji Psikofarmakoloji Dergisi 4(4):251\u2013259","journal-title":"Psikiyatri Psikoloji Psikofarmakoloji Dergisi"},{"issue":"2","key":"4632_CR20","first-page":"107","volume":"13","author":"F Karada\u011f","year":"2002","unstructured":"Karada\u011f F, Oral T, Yal\u00e7in FA and others (2002) Young mani derecelendirme ol\u00e7e\u011finin T\u00fcrkiye\u2019de ge\u00e7erlik ve g\u00fcvenilirli\u011fi [Reliability and validity of Turkish translation of Young Mania Rating Scale]. Turk Psikiyatri Derg 13(2):107\u2013114","journal-title":"Turk Psikiyatri Derg"},{"issue":"6","key":"4632_CR21","doi-asserted-by":"publisher","first-page":"569","DOI":"10.1111\/bdi.12904","volume":"22","author":"G L\u00e9da-R\u00eago","year":"2020","unstructured":"L\u00e9da-R\u00eago G, Bezerra-Filho S, Miranda-Scippa \u00c2 (2020) Functioning in euthymic patients with bipolar disorder: a systematic review and meta-analysis using the Functioning Assessment Short Test. Bipolar Disord 22(6):569\u2013581","journal-title":"Bipolar Disord"},{"issue":"1","key":"4632_CR22","first-page":"5","volume":"2","author":"\u0130 Da\u011f","year":"1991","unstructured":"Da\u011f \u0130 (1991) Belirti Tarama Listesi (SCL-90-R)\u2019nin \u00dcniversite \u00d6\u011frencileri \u0130\u00e7in G\u00fcvenirli\u011fi ve Ge\u00e7erli\u011fi. T\u00fcrk Psikiyatri Derg 2(1):5\u201312","journal-title":"T\u00fcrk Psikiyatri Derg"},{"key":"4632_CR23","doi-asserted-by":"publisher","first-page":"605","DOI":"10.3892\/mmr.2021.12242","volume":"24","author":"S Baliou","year":"2021","unstructured":"Baliou S, Adamaki M, Ioannou P and others (2021) Protective role of taurine against oxidative stress (review). Mol Med Rep 24:605","journal-title":"Mol Med Rep"},{"key":"4632_CR24","doi-asserted-by":"publisher","first-page":"101223","DOI":"10.1016\/j.redox.2019.101223","volume":"24","author":"M Jakaria","year":"2019","unstructured":"Jakaria M, Azam S, Haque ME and others (2019) Taurine and its analogs in neurological disorders: focus on therapeutic potential and molecular mechanisms. Redox Biol 24:101223","journal-title":"Redox Biol"},{"issue":"1","key":"4632_CR25","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-019-41689-x","volume":"9","author":"TN Wu","year":"2019","unstructured":"Wu TN, Chen CK, Liu IC, Wu LS-H, Cheng AT-A (2019) Effects of GADL1 overexpression on cell migration and the associated morphological changes. Sci Rep 9(1):5298","journal-title":"Sci Rep"},{"issue":"6","key":"4632_CR26","doi-asserted-by":"publisher","first-page":"1155","DOI":"10.1016\/j.pnpbp.2006.03.036","volume":"30","author":"H Mitani","year":"2006","unstructured":"Mitani H, Shirayama Y, Yamada T and others (2006) Correlation between plasma levels of glutamate, alanine and serine with severity of depression. Prog Neuropsychopharmacol Biol Psychiatry 30(6):1155\u20131158","journal-title":"Prog Neuropsychopharmacol Biol Psychiatry"},{"issue":"12","key":"4632_CR27","doi-asserted-by":"publisher","first-page":"e1610","DOI":"10.4088\/JCP.15m10185","volume":"77","author":"CP O\u2019Donnell","year":"2016","unstructured":"O\u2019Donnell CP, Allott KA, Murphy BP and others (2016) Adjunctive taurine in first-episode psychosis: a phase 2, double-blind, randomized. Placebo-Controlled Study J Clin Psychiatry 77(12):e1610\u2013e1617","journal-title":"Placebo-Controlled Study J Clin Psychiatry"},{"issue":"11","key":"4632_CR28","doi-asserted-by":"publisher","first-page":"1701","DOI":"10.1002\/elps.201200632","volume":"34","author":"MP Lorenzo","year":"2013","unstructured":"Lorenzo MP, Villase\u00f1or A, Ramamoorthy A and others (2013) Optimization and validation of a capillary electrophoresis laser-induced fluorescence method for amino acids determination in human plasma: application to bipolar disorder study. Electrophoresis 34(11):1701\u20131709","journal-title":"Electrophoresis"},{"issue":"2","key":"4632_CR29","doi-asserted-by":"publisher","first-page":"187","DOI":"10.1016\/j.jad.2012.02.008","volume":"140","author":"VL Pinto","year":"2012","unstructured":"Pinto VL, de Souza PF, Brunini TM, Oliveira MB, Moss MB, Siqueira MA, Ferraz MR, Mendes-Ribeiro AC (2012) Low plasma levels of L-arginine, impaired intraplatelet nitric oxide and platelet hyperaggregability: implications for cardiovascular disease in depressive patients. J Affect Disord 140(2):187\u2013192","journal-title":"J Affect Disord"},{"key":"4632_CR30","doi-asserted-by":"publisher","first-page":"1067","DOI":"10.2147\/NDT.S508021","volume":"21","author":"T Nakayama","year":"2025","unstructured":"Nakayama T, Umehara H, Mawatari K and others (2025) Alterations of blood plasma metabolites, including kynurenine and tryptophan, in bipolar disorder. Neuropsychiatr Dis Treat 21:1067\u20131073","journal-title":"Neuropsychiatr Dis Treat"},{"issue":"4","key":"4632_CR31","first-page":"466","volume":"88","author":"AG Moiseenok","year":"2023","unstructured":"Moiseenok AG, Kanunnikova NP (2023) Brain CoA and acetyl CoA metabolism in mechanisms of neurodegeneration. Biochemistry 88(4):466\u2013480","journal-title":"Biochemistry"},{"issue":"1","key":"4632_CR32","doi-asserted-by":"publisher","first-page":"314","DOI":"10.1186\/s12888-022-03943-x","volume":"22","author":"J Wozniak","year":"2022","unstructured":"Wozniak J, DiSalvo M, Farrell A and others (2022) Findings from a pilot open-label trial of N-acetylcysteine for the treatment of pediatric mania and hypomania. BMC Psychiatry 22(1):314","journal-title":"BMC Psychiatry"},{"issue":"2","key":"4632_CR33","doi-asserted-by":"publisher","first-page":"122","DOI":"10.1002\/ajmg.b.32680","volume":"180","author":"K MacDonald","year":"2019","unstructured":"MacDonald K, Krishnan A, Cervenka E, Hu G, Guadagno E, Trakadis Y (2019) Biomarkers for major depressive and bipolar disorders using metabolomics: a systematic review. Am J Med Genet B Neuropsychiatr Genet 180(2):122\u2013137","journal-title":"Am J Med Genet B Neuropsychiatr Genet"},{"issue":"2","key":"4632_CR34","doi-asserted-by":"publisher","first-page":"171","DOI":"10.1089\/cap.2010.0054","volume":"21","author":"DG Kondo","year":"2011","unstructured":"Kondo DG, Sung YH, Hellem TL and others (2011) Open-label uridine for treatment of depressed adolescents with bipolar disorder. J Child Adolesc Psychopharmacol 21(2):171\u2013175","journal-title":"J Child Adolesc Psychopharmacol"},{"issue":"3","key":"4632_CR35","doi-asserted-by":"publisher","first-page":"407","DOI":"10.3390\/metabo13030407","volume":"13","author":"JK Kim","year":"2023","unstructured":"Kim JK, Hong S, Park J and others (2023) Metabolic and transcriptomic changes in the mouse brain in response to short-term high-fat metabolic stress. Metabolites 13(3):407","journal-title":"Metabolites"},{"issue":"5","key":"4632_CR36","doi-asserted-by":"publisher","first-page":"1521","DOI":"10.1038\/s41380-024-02431-w","volume":"29","author":"IH Campbell","year":"2024","unstructured":"Campbell IH, Campbell H (2024) The metabolic overdrive hypothesis: hyperglycolysis and glutaminolysis in bipolar mania. Mol Psychiatry 29(5):1521\u20131527","journal-title":"Mol Psychiatry"},{"issue":"12","key":"4632_CR37","doi-asserted-by":"publisher","first-page":"2221","DOI":"10.1016\/j.euroneuro.2015.09.020","volume":"25","author":"MG Soeiro-de-Souza","year":"2015","unstructured":"Soeiro-de-Souza MG, Henning A, Machado-Vieira R and others (2015) Anterior cingulate glutamate-glutamine cycle metabolites are altered in euthymic bipolar I disorder. Eur Neuropsychopharmacol 25(12):2221\u20132229","journal-title":"Eur Neuropsychopharmacol"},{"key":"4632_CR38","doi-asserted-by":"publisher","first-page":"640977","DOI":"10.3389\/fpsyt.2021.640977","volume":"12","author":"J Shen","year":"2021","unstructured":"Shen J, Tomar JS (2021) Elevated brain glutamate levels in bipolar disorder and pyruvate carboxylase-mediated anaplerosis. Front Psychiatry 12:640977","journal-title":"Front Psychiatry"},{"issue":"8","key":"4632_CR39","doi-asserted-by":"publisher","first-page":"718","DOI":"10.1016\/j.biopsych.2008.05.014","volume":"64","author":"D \u00d6ng\u00fcr","year":"2008","unstructured":"\u00d6ng\u00fcr D, Jensen JE, Prescot AP and others (2008) Abnormal glutamatergic neurotransmission and neuronal-glial interactions in acute mania. Biol Psychiatry 64(8):718\u2013726","journal-title":"Biol Psychiatry"},{"issue":"3","key":"4632_CR40","doi-asserted-by":"publisher","first-page":"383","DOI":"10.3390\/biom15030383","volume":"15","author":"Y Kageyama","year":"2025","unstructured":"Kageyama Y, Okura S, Sukigara A and others (2025) The association among bipolar disorder, mitochondrial dysfunction, and reactive oxygen species. Biomolecules 15(3):383","journal-title":"Biomolecules"},{"issue":"12","key":"4632_CR41","doi-asserted-by":"publisher","first-page":"1199","DOI":"10.3390\/brainsci14121199","volume":"14","author":"A Gim\u00e9nez-Palomo","year":"2024","unstructured":"Gim\u00e9nez-Palomo A, Andreu H, de Juan O and others (2024) Mitochondrial dysfunction as a biomarker of illness state in bipolar disorder: a critical review. Brain Sci 14(12):1199","journal-title":"Brain Sci"},{"issue":"4","key":"4632_CR42","doi-asserted-by":"publisher","DOI":"10.1002\/mbo3.1006","volume":"9","author":"M L\u00f3pez-S\u00e1mano","year":"2020","unstructured":"L\u00f3pez-S\u00e1mano M, Beltr\u00e1n LFL, S\u00e1nchez-Thomas R, D\u00e1valos A, Villase\u00f1or T, Garc\u00eda\u2010Garc\u00eda JD, Garc\u00eda\u2010de los Santos A (2020) A novel way to synthesize pantothenate in bacteria involves \u03b2-alanine synthase present in uracil degradation pathway. Microbiolopen 9(4):e1006","journal-title":"Microbiolopen"},{"issue":"1","key":"4632_CR43","doi-asserted-by":"publisher","first-page":"83","DOI":"10.1186\/s12929-025-01177-z","volume":"32","author":"WL Wang","year":"2025","unstructured":"Wang WL, Shih YT, Wei SY and others (2025) Impacts of aging and fluid shear stress on vascular endothelial metabolism and atherosclerosis development. J Biomed Sci 32(1):83","journal-title":"J Biomed Sci"},{"key":"4632_CR44","doi-asserted-by":"publisher","first-page":"151","DOI":"10.1016\/j.bbacli.2016.03.008","volume":"5","author":"N Yoshimi","year":"2016","unstructured":"Yoshimi N, Futamura T, Kakumoto K and others (2016) Blood metabolomics analysis identifies abnormalities in the citric acid cycle, urea cycle, and amino acid metabolism in bipolar disorder. BBA Clin 5:151\u2013158","journal-title":"BBA Clin"},{"issue":"16","key":"4632_CR45","doi-asserted-by":"publisher","first-page":"8974","DOI":"10.3390\/ijms23168974","volume":"23","author":"J Chabert","year":"2022","unstructured":"Chabert J, Allauze E, Pereira B and others (2022) Glutamatergic and N-Acetylaspartate metabolites in bipolar disorder: a systematic review and meta-analysis of proton magnetic resonance spectroscopy studies. Int J Mol Sci 23(16):8974","journal-title":"Int J Mol Sci"},{"key":"4632_CR46","doi-asserted-by":"publisher","first-page":"117","DOI":"10.1111\/bdi.12980","volume":"23","author":"S Jim\u00e9nez-Fern\u00e1ndez","year":"2021","unstructured":"Jim\u00e9nez-Fern\u00e1ndez S, Gurpegui M, Garrote-Rojas D and others (2021) Oxidative stress parameters and antioxidants in patients with bipolar disorder: results from a meta-analysis comparing patients, including stratification by polarity and euthymic status, with healthy controls. Bipolar Disord 23:117\u2013129","journal-title":"Bipolar Disord"},{"issue":"2","key":"4632_CR47","doi-asserted-by":"publisher","first-page":"163","DOI":"10.1007\/s13167-024-00358-4","volume":"15","author":"O Golubnitschaja","year":"2024","unstructured":"Golubnitschaja O, Kapinova A, Sargheini N and others (2024) Mini-encyclopedia of mitochondria-relevant nutraceuticals protecting health in primary and secondary care-clinically relevant 3PM innovation. EPMA J 15(2):163\u2013205","journal-title":"EPMA J"},{"issue":"2","key":"4632_CR48","doi-asserted-by":"publisher","first-page":"e54","DOI":"10.1093\/nutrit\/nuae021","volume":"83","author":"RH Kabthymer","year":"2025","unstructured":"Kabthymer RH, Saadati S, Lee M and others (2025) Carnosine\/histidine-containing dipeptide supplementation improves depression and quality of life: systematic review and meta-analysis of randomized controlled trials. Nutr Rev 83(2):e54\u2013e64","journal-title":"Nutr Rev"},{"key":"4632_CR49","doi-asserted-by":"publisher","first-page":"1460631","DOI":"10.3389\/fpsyt.2024.1460631","volume":"15","author":"J Yang","year":"2024","unstructured":"Yang J, Yuan M, Zhang W (2024) The major biogenic amine metabolites in mood disorders. Front Psychiatry 15:1460631","journal-title":"Front Psychiatry"},{"key":"4632_CR50","doi-asserted-by":"publisher","first-page":"816","DOI":"10.1038\/s44220-026-00637-1","volume":"4","author":"D Martins","year":"2026","unstructured":"Martins D, Veronese M, van Wamelen D and others (2026) Mapping histamine pathway networks in the human brain across cognition and psychiatric disorders. Nat Ment Health 4:816\u2013828","journal-title":"Nat Ment Health"},{"issue":"5","key":"4632_CR51","doi-asserted-by":"publisher","first-page":"432","DOI":"10.1111\/cts.12324","volume":"8","author":"KJ Burghardt","year":"2015","unstructured":"Burghardt KJ, Evans SJ, Wiese KM and others (2015) An untargeted metabolomics analysis of antipsychotic use in bipolar disorder. Clin Transl Sci 8(5):432\u2013440","journal-title":"Clin Transl Sci"},{"issue":"4","key":"4632_CR52","doi-asserted-by":"publisher","first-page":"236","DOI":"10.1097\/FPC.0b013e32835ea0b2","volume":"23","author":"Y Ghodke-Puranik","year":"2013","unstructured":"Ghodke-Puranik Y, Thorn CF, Lamba JK and others (2013) Valproic acid pathway: pharmacokinetics and pharmacodynamics. Pharmacogenet Genomics 23(4):236\u2013241","journal-title":"Pharmacogenet Genomics"}],"container-title":["Irish Journal of Medical Science (1971 -)"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s11845-026-04632-4.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s11845-026-04632-4","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s11845-026-04632-4.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T16:02:36Z","timestamp":1790265756000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s11845-026-04632-4"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,9,24]]},"references-count":52,"alternative-id":["4632"],"URL":"https:\/\/doi.org\/10.1007\/s11845-026-04632-4","relation":{},"ISSN":["0021-1265","1863-4362"],"issn-type":[{"value":"0021-1265","type":"print"},{"value":"1863-4362","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,9,24]]},"assertion":[{"value":"3 February 2026","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"12 September 2026","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"24 September 2026","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"The authors declared no potential conflicts of interest with respect to the research, authorship, and\/or publication of this article.","order":1,"name":"Ethics","label":"Conflicts of interest","group":{"name":"EthicsHeading","label":"Declarations"}}]}}