{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,9]],"date-time":"2026-10-09T22:49:21Z","timestamp":1791586161187,"version":"4.3.4"},"reference-count":33,"publisher":"Springer Science and Business Media LLC","license":[{"start":{"date-parts":[[2026,10,9]],"date-time":"2026-10-09T00:00:00Z","timestamp":1791504000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2026,10,9]],"date-time":"2026-10-09T00:00:00Z","timestamp":1791504000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Ir J Med Sci"],"DOI":"10.1007\/s11845-026-04672-w","type":"journal-article","created":{"date-parts":[[2026,10,9]],"date-time":"2026-10-09T09:24:20Z","timestamp":1791537860000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Immunonutritional status and survival after cardiac arrest: prognostic value of the prognostic nutritional index, the cholesterol-modified prognostic nutritional index, and the controlling nutritional status score in post\u2013cardiopulmonary resuscitation intensive care patients"],"prefix":"10.1007","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8501-0675","authenticated-orcid":false,"given":"Fatih","family":"Sahin","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8719-7031","authenticated-orcid":false,"given":"Havva","family":"Kocayigit","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0006-0641-3887","authenticated-orcid":false,"given":"Merve","family":"Akben","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0000-5868-0932","authenticated-orcid":false,"given":"Esra Gundogdu","family":"Eryilmaz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6994-397X","authenticated-orcid":false,"given":"Ali Fuat","family":"Erdem","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,10,9]]},"reference":[{"key":"4672_CR1","doi-asserted-by":"crossref","unstructured":"Neumar RW, Nolan JP, Adrie C, et al. Post\u2013Cardiac Arrest Syndrome: Epidemiology, Pathophysiology, Treatment, and Prognostication. Circulation. 2008;118(23):2452\u201383. doi:10.1161\/CIRCULATIONAHA.108.190652.","DOI":"10.1161\/CIRCULATIONAHA.108.190652"},{"key":"4672_CR2","doi-asserted-by":"publisher","first-page":"1876","DOI":"10.1161\/CIRCULATIONAHA.114.009711","volume":"130","author":"PS Chan","year":"2014","unstructured":"Chan PS, McNally B, Tang F et al (2014) Recent trends in survival from out-of-hospital cardiac arrest in the United States. Circulation 130:1876\u201382. https:\/\/doi.org\/10.1161\/CIRCULATIONAHA.114.009711","journal-title":"Circulation"},{"key":"4672_CR3","doi-asserted-by":"publisher","first-page":"1048","DOI":"10.1164\/rccm.201102-0331OC","volume":"184","author":"S Perbet","year":"2011","unstructured":"Perbet S, Mongardon N, Dumas F et al (2011) Early-onset pneumonia after cardiac arrest: characteristics, risk factors and influence on prognosis. Am J Respir Crit Care Med 184:1048\u201354. https:\/\/doi.org\/10.1164\/rccm.201102-0331OC","journal-title":"Am J Respir Crit Care Med"},{"key":"4672_CR4","doi-asserted-by":"crossref","unstructured":"Cunningham CA, Coppler PJ, Skolnik AB. The immunology of the post-cardiac arrest syndrome. Resuscitation. 2022;179:116\u201323. doi: 10.1016\/j.resuscitation.2022.08.013.","DOI":"10.1016\/j.resuscitation.2022.08.013"},{"key":"4672_CR5","doi-asserted-by":"publisher","DOI":"10.3389\/fnut.2025.1474039","volume":"12","author":"BC D\u00edaz Chavarro","year":"2025","unstructured":"D\u00edaz Chavarro BC, Romero-Salda\u00f1a M, Assis Reveiz JK et al (2025) Impact of nutritional screening on mortality and intensive care unit length of stay. Front Nutr 12:1474039. https:\/\/doi.org\/10.3389\/fnut.2025.1474039","journal-title":"Front Nutr"},{"key":"4672_CR6","doi-asserted-by":"crossref","unstructured":"Altuntas G, Timurkaan M, Aksu A, et al. CONUT score as a potential nutritional index for predicting mortality among septic patients. JARSS. 2025;33(4):262\u201370. doi: 10.54875\/jarss.2025.90582.","DOI":"10.54875\/jarss.2025.90582"},{"key":"4672_CR7","doi-asserted-by":"crossref","unstructured":"Ji W, Wang G, Liu J. Association between prognostic nutritional index and all-cause mortality in critically ill patients with ventilator-associated pneumonia: a retrospective study based on MIMIC-IV database. Front Nutr. 2025;12:1605032. doi:10.3389\/fnut.2025.1605032.","DOI":"10.3389\/fnut.2025.1605032"},{"key":"4672_CR8","doi-asserted-by":"crossref","unstructured":"Shi J, Liu T, Ge Y, et al. Cholesterol-modified prognostic nutritional index (CPNI) as an effective tool for assessing the nutrition status and predicting survival in patients with breast cancer. BMC Med. 2023;21(1):512. doi:10.1186\/s12916-023-03225-7.","DOI":"10.1186\/s12916-023-03225-7"},{"key":"4672_CR9","doi-asserted-by":"publisher","DOI":"10.3389\/fnut.2025.1604470","volume":"12","author":"Y Song","year":"2025","unstructured":"Song Y, Han S, Zhang S et al (2025) Controlling nutritional status (CONUT) score for predicting all-cause mortality in patients who underwent percutaneous coronary intervention after acute myocardial infarction: a cohort study. Front Nutr 12:1604470. https:\/\/doi.org\/10.3389\/fnut.2025.1604470","journal-title":"Front Nutr"},{"key":"4672_CR10","doi-asserted-by":"crossref","unstructured":"Kato T, Yaku H, Morimoto T, et al. Association with Controlling Nutritional Status (CONUT) Score and In-hospital Mortality and Infection in Acute Heart Failure. Sci Rep. 2020;10(1):3320. doi:10.1038\/s41598-020-60404-9.","DOI":"10.1038\/s41598-020-60404-9"},{"key":"4672_CR11","doi-asserted-by":"publisher","DOI":"10.3389\/fnut.2021.738045","volume":"8","author":"C Liu","year":"2021","unstructured":"Liu C, Zhu M, Yang X et al (2021) Controlling nutritional status score as a predictive marker of in-hospital mortality in older adult patients. Front Nutr 8:738045. https:\/\/doi.org\/10.3389\/fnut.2021.738045","journal-title":"Front Nutr"},{"issue":"4","key":"4672_CR12","doi-asserted-by":"publisher","first-page":"388","DOI":"10.5582\/bst.2024.01108","volume":"18","author":"K Chen","year":"2024","unstructured":"Chen K, Li G, Qiu Y et al (2024) The role of cholesterol-modified prognostic nutritional index in nutritional status assessment and predicting survival after liver resection for hepatocellular carcinoma. Biosci Trends 18(4):388\u201397. https:\/\/doi.org\/10.5582\/bst.2024.01108","journal-title":"Biosci Trends"},{"key":"4672_CR13","doi-asserted-by":"crossref","unstructured":"Yan L, Nakamura T, Casadei-Gardini A, et al. Long-term and short-term prognostic value of the prognostic nutritional index in cancer: A narrative review. Ann. Transl. Med. 2021;9:1630. doi:10.21037\/atm-21-4528.","DOI":"10.21037\/atm-21-4528"},{"key":"4672_CR14","doi-asserted-by":"crossref","unstructured":"Schupp T, Behnes M, Rusnak J, et al. Does Albumin Predict the Risk of Mortality in Patients with Cardiogenic Shock? Int. J. Mol. Sci. 2023;24:7375. doi:10.3390\/ijms24087375","DOI":"10.3390\/ijms24087375"},{"key":"4672_CR15","doi-asserted-by":"crossref","unstructured":"Evans DC, Corkins MR, Malone A, et al. The Use of Visceral Proteins as Nutrition Markers: An ASPEN Position Paper. Nutr Clin Pract. 2021;36(1):22\u2009\u2212\u20098. doi:10.1002\/ncp.10588.","DOI":"10.1002\/ncp.10588"},{"key":"4672_CR16","doi-asserted-by":"crossref","unstructured":"Allison SP, Lobo DN. The clinical significance of hypoalbuminaemia. Clin Nutr. 2024;43(4):909\u2009\u2212\u200914. doi:10.1016\/j.clnu.2024.02.018.","DOI":"10.1016\/j.clnu.2024.02.018"},{"key":"4672_CR17","unstructured":"Binks A, Nolan JP. Post-cardiac arrest syndrome. Minerva Anestesiol. 2010;76(5):362\u20138."},{"key":"4672_CR18","doi-asserted-by":"crossref","unstructured":"Yoon H, Song KJ, Shin SD, et al. Effect of serum albumin level on hospital outcomes in out-of-hospital cardiac arrest. Hong Kong J Emerg Med. 2020;27:293\u20139. doi:10.1177\/10249079198497.","DOI":"10.1177\/1024907919849786"},{"key":"4672_CR19","doi-asserted-by":"crossref","unstructured":"Yuksel Yavuz M, Dongelli H, Yavuz M, et al. The impact of the prognostic significance of the CONUT score on critical care patients in the intensive care unit - A descriptive study. Nutr Hosp. 2025;45(5):875\u201384. doi: 10.20960\/nh.05846.","DOI":"10.20960\/nh.05846"},{"key":"4672_CR20","doi-asserted-by":"crossref","unstructured":"Liu Z, Chen X, Zhang L. A retrospective analysis of the correlation between the glucose-to-albumin ratio and 28-day mortality in sepsis patients. BMC Infect Dis. 2025;25(1):715. doi:10.1186\/s12879-025-11092-1.","DOI":"10.1186\/s12879-025-11092-1"},{"key":"4672_CR21","doi-asserted-by":"crossref","unstructured":"Panchal AR, Bartos JA, Caba\u00f1as JG, et al. Part 3: Adult basic and advanced life support: 2020 American Heart Association guidelines for cardiopulmonary resuscitation and emergency cardiovascular care. Circulation. 2020;142:S366\u2013S468. doi:10.1161\/CIR.0000000000000916.","DOI":"10.1161\/CIR.0000000000000918"},{"issue":"9","key":"4672_CR22","doi-asserted-by":"publisher","first-page":"1537","DOI":"10.1007\/s00432-014-1714-3","volume":"140","author":"K Sun","year":"2014","unstructured":"Sun K, Chen S, Xu J et al (2014) The prognostic significance of the prognostic nutritional index in cancer: a systematic review and meta-analysis. J Cancer Res Clin Oncol 140(9):1537\u201349. https:\/\/doi.org\/10.1007\/s00432-014-1714-3","journal-title":"J Cancer Res Clin Oncol"},{"key":"4672_CR23","doi-asserted-by":"crossref","unstructured":"Kayhan S, Simsek M, Gulsoy K\u0131rnap N. The prognostic nutritional index is associated with mortality of patients in intensive care unit. J Surg Med. 2022;6(3):313\u20136. doi:10.28982\/josam.1055862.","DOI":"10.28982\/josam.1055862"},{"key":"4672_CR24","doi-asserted-by":"publisher","first-page":"3619","DOI":"10.2147\/IJGM.S318896","volume":"14","author":"Y Lu","year":"2021","unstructured":"Lu Y, Ren C, Jiang J (2021) The relationship between prognostic nutritional index and all-cause mortality in critically ill patients: a retrospective study. Int J Gen Med 14:3619\u201326. https:\/\/doi.org\/10.2147\/IJGM.S318896","journal-title":"Int J Gen Med"},{"issue":"3","key":"4672_CR25","doi-asserted-by":"publisher","first-page":"419","DOI":"10.1016\/j.ccl.2018.03.009","volume":"36","author":"AC Walker","year":"2018","unstructured":"Walker AC, Johnson NJ (2018) Critical care of the post-cardiac arrest patient. Cardiol Clin 36(3):419\u201328. https:\/\/doi.org\/10.1016\/j.ccl.2018.03.009","journal-title":"Cardiol Clin"},{"issue":"2","key":"4672_CR26","doi-asserted-by":"publisher","DOI":"10.3390\/jpm12020233","volume":"12","author":"J Lee","year":"2022","unstructured":"Lee J, Lee H, Oh J et al (2022) Association between initial serum cholesterol levels and outcomes of patients hospitalized after out-of-hospital cardiac arrest: a retrospective multicenter registry study. J Pers Med 12(2):233. https:\/\/doi.org\/10.3390\/jpm12020233","journal-title":"J Pers Med"},{"issue":"1","key":"4672_CR27","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-025-05808-1","volume":"15","author":"J Malik","year":"2025","unstructured":"Malik J, Valerianova A, Janota T et al (2025) Lower cholesterol level on admission predicts poor outcome after prolonged cardiac arrest. Sci Rep 15(1):20512. https:\/\/doi.org\/10.1038\/s41598-025-05808-1","journal-title":"Sci Rep"},{"issue":"5","key":"4672_CR28","doi-asserted-by":"publisher","first-page":"527","DOI":"10.1016\/0197-0186(94)00147-m","volume":"26","author":"GT Vatassery","year":"1995","unstructured":"Vatassery GT, Smith WE, Quach HT et al (1995) In vitro oxidation of vitamin E, vitamin C, thiols and cholesterol in rat brain mitochondria incubated with free radicals. Neurochem Int 26(5):527\u201335. https:\/\/doi.org\/10.1016\/0197-0186(94)00147-m","journal-title":"Neurochem Int"},{"issue":"1","key":"4672_CR29","doi-asserted-by":"publisher","DOI":"10.1186\/s12876-025-04013-8","volume":"25","author":"H Zhu","year":"2025","unstructured":"Zhu H, Zheng M, Li W et al (2025) Cholesterol-modified prognostic nutritional index as an independent prognostic biomarker in primary biliary cholangitis patients. BMC Gastroenterol 25(1):421. https:\/\/doi.org\/10.1186\/s12876-025-04013-8","journal-title":"BMC Gastroenterol"},{"key":"4672_CR30","doi-asserted-by":"crossref","unstructured":"Carrero JJ, Stenvinkel P, Cuppari L, et al. Etiology of the protein-energy wasting syndrome in chronic kidney disease: a consensus statement from the International Society of Renal Nutrition and Metabolism (ISRNM). J Ren Nutr. 2013;23(2):77\u201390. doi:10.1053\/j.jrn.2013.01.001.","DOI":"10.1053\/j.jrn.2013.01.001"},{"key":"4672_CR31","doi-asserted-by":"crossref","unstructured":"Ikizler TA. Nutrition, inflammation and chronic kidney disease. Curr Opin Nephrol Hypertens. 2008;17(2):162-7. doi:10.1097\/MNH.0b013e3282f5dbce.","DOI":"10.1097\/MNH.0b013e3282f5dbce"},{"key":"4672_CR32","doi-asserted-by":"crossref","unstructured":"Ser\u00f3n-Arbeloa C, Labarta-Monz\u00f3n L, Puzo-Foncillas J, et al. Malnutrition screening and assessment. Nutrients. 2022;14(12):2392. doi:10.3390\/nu14122392.","DOI":"10.3390\/nu14122392"},{"issue":"5","key":"4672_CR33","doi-asserted-by":"publisher","first-page":"612","DOI":"10.4103\/njcp.njcp_769_23","volume":"27","author":"MM Tiryaki","year":"2024","unstructured":"Tiryaki MM, Emren SV, Gursoy MO et al (2024) The relationship between controlling nutritional assessment score and mortality in patients with chronic coronary syndrome: a retrospective study from T\u00fcrkiye. Niger J Clin Pract 27(5):612\u20139. https:\/\/doi.org\/10.4103\/njcp.njcp_769_23","journal-title":"Niger J Clin Pract"}],"container-title":["Irish Journal of Medical Science (1971 -)"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s11845-026-04672-w.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s11845-026-04672-w","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s11845-026-04672-w.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,10,9]],"date-time":"2026-10-09T22:02:02Z","timestamp":1791583322000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s11845-026-04672-w"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,10,9]]},"references-count":33,"alternative-id":["4672"],"URL":"https:\/\/doi.org\/10.1007\/s11845-026-04672-w","relation":{},"ISSN":["0021-1265","1863-4362"],"issn-type":[{"value":"0021-1265","type":"print"},{"value":"1863-4362","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,10,9]]},"assertion":[{"value":"9 February 2026","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"1 October 2026","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"9 October 2026","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"There is no conflict of interest between these authors. This article was not financially supported by any institution.","order":1,"name":"Ethics","label":"Financial interest","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors declare that there is no conflict of interest.","order":2,"name":"Ethics","label":"Conflict of interest","group":{"name":"EthicsHeading","label":"Declarations"}}]}}