{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,4]],"date-time":"2026-08-04T10:48:58Z","timestamp":1785840538015,"version":"3.56.0"},"reference-count":101,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2026,8,4]],"date-time":"2026-08-04T00:00:00Z","timestamp":1785801600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2026,8,4]],"date-time":"2026-08-04T00:00:00Z","timestamp":1785801600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"crossref","award":["82272685"],"award-info":[{"award-number":["82272685"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"crossref","award":["82273018"],"award-info":[{"award-number":["82273018"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Curr. Treat. Options in Oncol."],"published-print":{"date-parts":[[2026,12]]},"DOI":"10.1007\/s11864-026-01408-x","type":"journal-article","created":{"date-parts":[[2026,8,4]],"date-time":"2026-08-04T10:18:07Z","timestamp":1785838687000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Local Recurrence After Pancreatic Cancer Resection: A Multidisciplinary Review of Risk Factors and Potential Causes, Diagnostic Innovations, Emerging Therapeutic Frontiers, and Prevention Strategies"],"prefix":"10.1007","volume":"27","author":[{"given":"Rui","family":"Wang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Senhao","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Junjie","family":"Ding","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yunwei","family":"Sun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jin","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bing","family":"Peng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0004-4976-7306","authenticated-orcid":false,"given":"Zhong","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,8,4]]},"reference":[{"issue":"10485","key":"1408_CR1","doi-asserted-by":"publisher","first-page":"1182","DOI":"10.1016\/s0140-6736(25)00261-2","volume":"405","author":"TF Stoop","year":"2025","unstructured":"Stoop TF, Javed AA, Oba A, Koerkamp BG, Seufferlein T, Wilmink JW, et al. Pancreatic cancer. Lancet. 2025;405(10485):1182\u2013202. https:\/\/doi.org\/10.1016\/s0140-6736(25)00261-2.","journal-title":"Lancet"},{"issue":"5","key":"1408_CR2","doi-asserted-by":"publisher","first-page":"936","DOI":"10.1097\/sla.0000000000002234","volume":"267","author":"VP Groot","year":"2018","unstructured":"Groot VP, Rezaee N, Wu W, Cameron JL, Fishman EK, Hruban RH, et al. Patterns, Timing, and Predictors of Recurrence Following Pancreatectomy for Pancreatic Ductal Adenocarcinoma. Ann Surg. 2018;267(5):936\u201345. https:\/\/doi.org\/10.1097\/sla.0000000000002234.","journal-title":"Ann Surg"},{"issue":"4","key":"1408_CR3","doi-asserted-by":"publisher","first-page":"785","DOI":"10.1097\/js9.0000000000000296","volume":"109","author":"XP Zhang","year":"2023","unstructured":"Zhang XP, Xu S, Gao YX, Zhao ZM, Zhao GD, Hu MG, et al. Early and late recurrence patterns of pancreatic ductal adenocarcinoma after pancreaticoduodenectomy: a multicenter study. Int J Surg. 2023;109(4):785\u201393. https:\/\/doi.org\/10.1097\/js9.0000000000000296.","journal-title":"Int J Surg"},{"issue":"6","key":"1408_CR4","doi-asserted-by":"publisher","first-page":"775","DOI":"10.1016\/j.acra.2018.07.025","volume":"26","author":"JD Kova\u010d","year":"2019","unstructured":"Kova\u010d JD, Mayer P, Hackert T, Klauss M. The Time to and Type of Pancreatic Cancer Recurrence after Surgical Resection: Is Prediction Possible? Acad Radiol. 2019;26(6):775\u201381. https:\/\/doi.org\/10.1016\/j.acra.2018.07.025.","journal-title":"Acad Radiol"},{"issue":"2","key":"1408_CR5","doi-asserted-by":"publisher","first-page":"317","DOI":"10.1097\/sla.0000000000006142","volume":"280","author":"IF Rompen","year":"2024","unstructured":"Rompen IF, Levine J, Habib JR, Sereni E, Mughal N, Hewitt DB, et al. Progression of Site-specific Recurrence of Pancreatic Cancer and Implications for Treatment. Ann Surg. 2024;280(2):317\u201324. https:\/\/doi.org\/10.1097\/sla.0000000000006142.","journal-title":"Ann Surg"},{"issue":"9","key":"1408_CR6","doi-asserted-by":"publisher","first-page":"4003","DOI":"10.21873\/anticanres.17229","volume":"44","author":"M Matsumoto","year":"2024","unstructured":"Matsumoto M, Furukawa K, Uwagawa T, Shirai Y, Tsunematsu M, Onda S, et al. Effect of Chemoradiotherapy on Locoregional Recurrence After Pancreatectomy for Pancreatic Cancer. Anticancer Res. 2024;44(9):4003\u201310. https:\/\/doi.org\/10.21873\/anticanres.17229.","journal-title":"Anticancer Res"},{"key":"1408_CR7","doi-asserted-by":"publisher","DOI":"10.1097\/sla.0000000000006272","author":"J Lucocq","year":"2024","unstructured":"Lucocq J, Halle-Smith J, Haugk B, Joseph N, Hawkyard J, Lye J, et al. Long-term Outcomes following Resection of Adenocarcinoma Arising from Intraductal Papillary Mucinous Neoplasm (A-IPMN) versus Pancreatic Ductal Adenocarcinoma (PDAC): A Propensity-score Matched Analysis. Ann Surg. 2024. https:\/\/doi.org\/10.1097\/sla.0000000000006272.","journal-title":"Ann Surg"},{"issue":"9","key":"1408_CR8","doi-asserted-by":"publisher","first-page":"1171","DOI":"10.1002\/bjs.10842","volume":"105","author":"T Hank","year":"2018","unstructured":"Hank T, Hinz U, Tarantino I, Kaiser J, Niesen W, Bergmann F, et al. Validation of at least 1\u00a0mm as cut-off for resection margins for pancreatic adenocarcinoma of the body and tail. Br J Surg. 2018;105(9):1171\u201381. https:\/\/doi.org\/10.1002\/bjs.10842.","journal-title":"Br J Surg"},{"issue":"4","key":"1408_CR9","doi-asserted-by":"publisher","first-page":"759","DOI":"10.1097\/sla.0000000000004054","volume":"275","author":"M Loos","year":"2022","unstructured":"Loos M, Kester T, Klaiber U, Mihaljevic AL, Mehrabi A, M\u00fcller-Stich BM, et al. Arterial Resection in Pancreatic Cancer Surgery: Effective After a Learning Curve. Ann Surg. 2022;275(4):759\u201368. https:\/\/doi.org\/10.1097\/sla.0000000000004054.","journal-title":"Ann Surg"},{"issue":"8821","key":"1408_CR10","doi-asserted-by":"publisher","first-page":"685","DOI":"10.1016\/0140-6736(92)92230-d","volume":"340","author":"F Lindemann","year":"1992","unstructured":"Lindemann F, Schlimok G, Dirschedl P, Witte J, Riethm\u00fcller G. Prognostic significance of micrometastatic tumour cells in bone marrow of colorectal cancer patients. Lancet. 1992;340(8821):685\u20139. https:\/\/doi.org\/10.1016\/0140-6736(92)92230-d.","journal-title":"Lancet"},{"issue":"8","key":"1408_CR11","doi-asserted-by":"publisher","first-page":"525","DOI":"10.1056\/nejm200002243420801","volume":"342","author":"S Braun","year":"2000","unstructured":"Braun S, Pantel K, M\u00fcller P, Janni W, Hepp F, Kentenich CR, et al. Cytokeratin-positive cells in the bone marrow and survival of patients with stage I, II, or III breast cancer. N Engl J Med. 2000;342(8):525\u201333. https:\/\/doi.org\/10.1056\/nejm200002243420801.","journal-title":"N Engl J Med"},{"issue":"10","key":"1408_CR12","doi-asserted-by":"publisher","first-page":"1549","DOI":"10.1200\/jco.2008.17.0563","volume":"27","author":"D Weckermann","year":"2009","unstructured":"Weckermann D, Polzer B, Ragg T, Blana A, Schlimok G, Arnholdt H, et al. Perioperative activation of disseminated tumor cells in bone marrow of patients with prostate cancer. J Clin Oncol. 2009;27(10):1549\u201356. https:\/\/doi.org\/10.1200\/jco.2008.17.0563.","journal-title":"J Clin Oncol"},{"issue":"Suppl 4","key":"1408_CR13","doi-asserted-by":"publisher","first-page":"111","DOI":"10.1093\/annonc\/10.suppl_4.S111","volume":"10","author":"S Thorban","year":"1999","unstructured":"Thorban S, Roder JD, Siewert JR. Detection of micrometastasis in bone marrow of pancreatic cancer patients. Ann Oncol. 1999;10(Suppl 4):111\u20133.","journal-title":"Ann Oncol"},{"issue":"5","key":"1408_CR14","doi-asserted-by":"publisher","first-page":"1458","DOI":"10.1016\/j.surg.2024.07.026","volume":"176","author":"D Tamburrino","year":"2024","unstructured":"Tamburrino D, Arcangeli C, De Stefano F, Belfiori G, Macchini M, Orsi G, et al. Pathologic complete response following neoadjuvant chemotherapy in pancreatic ductal adenocarcinoma: Impact on survival and recurrence. Surgery. 2024;176(5):1458\u201365. https:\/\/doi.org\/10.1016\/j.surg.2024.07.026.","journal-title":"Surgery"},{"issue":"12","key":"1408_CR15","doi-asserted-by":"publisher","first-page":"1133","DOI":"10.1007\/s00535-024-02149-0","volume":"59","author":"M Miki","year":"2024","unstructured":"Miki M, Masuda A, Takenaka M, Shiomi H, Iemoto T, Tsumura H, et al. Association of pancreatic atrophy patterns with intraductal extension of early pancreatic ductal adenocarcinoma: a multicenter retrospective study. J Gastroenterol. 2024;59(12):1133\u201342. https:\/\/doi.org\/10.1007\/s00535-024-02149-0.","journal-title":"J Gastroenterol"},{"issue":"2","key":"1408_CR16","doi-asserted-by":"publisher","first-page":"180","DOI":"10.21147\/j.issn.1000-9604.2016.02.05","volume":"28","author":"L Zhang","year":"2016","unstructured":"Zhang L, Guo L, Tao M, Fu W, Xiu D. Parasympathetic neurogenesis is strongly associated with tumor budding and correlates with an adverse prognosis in pancreatic ductal adenocarcinoma. Chin J Cancer Res. 2016;28(2):180\u20136. https:\/\/doi.org\/10.21147\/j.issn.1000-9604.2016.02.05.","journal-title":"Chin J Cancer Res"},{"issue":"1","key":"1408_CR17","doi-asserted-by":"publisher","first-page":"172","DOI":"10.1186\/s13148-021-01165-8","volume":"13","author":"Y Sunagawa","year":"2021","unstructured":"Sunagawa Y, Hayashi M, Yamada S, Tanabe H, Kurimoto K, Tanaka N, et al. Impact of molecular surgical margin analysis on the prediction of pancreatic cancer recurrences after pancreaticoduodenectomy. Clin Epigenetics. 2021;13(1):172. https:\/\/doi.org\/10.1186\/s13148-021-01165-8.","journal-title":"Clin Epigenetics"},{"issue":"2","key":"1408_CR18","doi-asserted-by":"publisher","first-page":"101","DOI":"10.1038\/s41571-020-0422-y","volume":"18","author":"A Lugli","year":"2021","unstructured":"Lugli A, Zlobec I, Berger MD, Kirsch R, Nagtegaal ID. Tumour budding in solid cancers. Nat Rev Clin Oncol. 2021;18(2):101\u201315. https:\/\/doi.org\/10.1038\/s41571-020-0422-y.","journal-title":"Nat Rev Clin Oncol"},{"issue":"3","key":"1408_CR19","doi-asserted-by":"publisher","first-page":"504","DOI":"10.1111\/his.14839","volume":"82","author":"AL Kiemen","year":"2023","unstructured":"Kiemen AL, Choi Y, Braxton AM, Almagro P\u00e9rez C, Graham S, Grahn MP, et al. Intraparenchymal metastases as a cause for local recurrence of pancreatic cancer. Histopathology. 2023;82(3):504\u20136. https:\/\/doi.org\/10.1111\/his.14839.","journal-title":"Histopathology"},{"issue":"3","key":"1408_CR20","doi-asserted-by":"publisher","first-page":"1602","DOI":"10.1245\/s10434-020-09066-5","volume":"28","author":"T Imamura","year":"2021","unstructured":"Imamura T, Yamamoto Y, Sugiura T, Okamura Y, Ito T, Ashida R, et al. Reconsidering the Optimal Regional Lymph Node Station According to Tumor Location for Pancreatic Cancer. Ann Surg Oncol. 2021;28(3):1602\u201311. https:\/\/doi.org\/10.1245\/s10434-020-09066-5.","journal-title":"Ann Surg Oncol"},{"issue":"5","key":"1408_CR21","doi-asserted-by":"publisher","first-page":"2275","DOI":"10.21037\/jgo-21-55","volume":"12","author":"HC Gits","year":"2021","unstructured":"Gits HC, Tang AH, Harmsen WS, Bamlet WR, Graham RP, Petersen GM, et al. Intact SMAD-4 is a predictor of increased locoregional recurrence in upfront resected pancreas cancer receiving adjuvant therapy. J Gastrointest Oncol. 2021;12(5):2275\u201386. https:\/\/doi.org\/10.21037\/jgo-21-55.","journal-title":"J Gastrointest Oncol"},{"issue":"3","key":"1408_CR22","doi-asserted-by":"publisher","first-page":"e173420","DOI":"10.1001\/jamaoncol.2017.3420","volume":"4","author":"ZR Qian","year":"2018","unstructured":"Qian ZR, Rubinson DA, Nowak JA, Morales-Oyarvide V, Dunne RF, Kozak MM, et al. Association of Alterations in Main Driver Genes With Outcomes of Patients With Resected Pancreatic Ductal Adenocarcinoma. JAMA Oncol. 2018;4(3):e173420. https:\/\/doi.org\/10.1001\/jamaoncol.2017.3420.","journal-title":"JAMA Oncol"},{"issue":"5","key":"1408_CR23","doi-asserted-by":"publisher","first-page":"437","DOI":"10.1007\/s00535-018-01535-9","volume":"54","author":"D Hashimoto","year":"2019","unstructured":"Hashimoto D, Arima K, Nakagawa S, Negoro Y, Hirata T, Hirota M, et al. Pancreatic cancer arising from the remnant pancreas after pancreatectomy: a multicenter retrospective study by the Kyushu Study Group of Clinical Cancer. J Gastroenterol. 2019;54(5):437\u201348. https:\/\/doi.org\/10.1007\/s00535-018-01535-9.","journal-title":"J Gastroenterol"},{"issue":"6","key":"1408_CR24","doi-asserted-by":"publisher","first-page":"792","DOI":"10.1158\/2159-8290.Cd-19-1508","volume":"10","author":"H Sakamoto","year":"2020","unstructured":"Sakamoto H, Attiyeh MA, Gerold JM, Makohon-Moore AP, Hayashi A, Hong J, et al. The Evolutionary Origins of Recurrent Pancreatic Cancer. Cancer Discov. 2020;10(6):792\u2013805. https:\/\/doi.org\/10.1158\/2159-8290.Cd-19-1508.","journal-title":"Cancer Discov"},{"key":"1408_CR25","doi-asserted-by":"publisher","unstructured":"De Grandis MC, Ascenti V, Lanza C, Di Paolo G, Galassi B, Ierardi AM, et al. Locoregional therapies and remodeling of tumor microenvironment in pancreatic cancer. Int J Mol Sci. 2023;24(16). https:\/\/doi.org\/10.3390\/ijms241612681.","DOI":"10.3390\/ijms241612681"},{"issue":"5","key":"1408_CR26","doi-asserted-by":"publisher","first-page":"859","DOI":"10.1053\/j.gastro.2024.01.028","volume":"166","author":"B George","year":"2024","unstructured":"George B, Kudryashova O, Kravets A, Thalji S, Malarkannan S, Kurzrock R, et al. Transcriptomic-Based Microenvironment Classification Reveals Precision Medicine Strategies for Pancreatic Ductal Adenocarcinoma. Gastroenterology. 2024;166(5):859\u2013e871853. https:\/\/doi.org\/10.1053\/j.gastro.2024.01.028.","journal-title":"Gastroenterology"},{"issue":"8","key":"1408_CR27","doi-asserted-by":"publisher","first-page":"1523","DOI":"10.1136\/gutjnl-2022-329371","volume":"72","author":"E Karamitopoulou","year":"2023","unstructured":"Karamitopoulou E, Wenning AS, Acharjee A, Zlobec I, Aeschbacher P, Perren A, et al. Spatially restricted tumour-associated and host-associated immune drivers correlate with the recurrence sites of pancreatic cancer. Gut. 2023;72(8):1523\u201333. https:\/\/doi.org\/10.1136\/gutjnl-2022-329371.","journal-title":"Gut"},{"issue":"1","key":"1408_CR28","doi-asserted-by":"publisher","first-page":"385","DOI":"10.1186\/s12885-021-08123-w","volume":"21","author":"G Askan","year":"2021","unstructured":"Askan G, Sahin IH, Chou JF, Yavas A, Capanu M, Iacobuzio-Donahue CA, et al. Pancreatic cancer stem cells may define tumor stroma characteristics and recurrence patterns in pancreatic ductal adenocarcinoma. BMC Cancer. 2021;21(1):385. https:\/\/doi.org\/10.1186\/s12885-021-08123-w.","journal-title":"BMC Cancer"},{"issue":"2","key":"1408_CR29","doi-asserted-by":"publisher","first-page":"278","DOI":"10.1158\/2159-8290.Cd-22-0876","volume":"13","author":"C Falcomat\u00e0","year":"2023","unstructured":"Falcomat\u00e0 C, B\u00e4rthel S, Schneider G, Rad R, Schmidt-Supprian M, Saur D. Context-Specific Determinants of the Immunosuppressive Tumor Microenvironment in Pancreatic Cancer. Cancer Discov. 2023;13(2):278\u201397. https:\/\/doi.org\/10.1158\/2159-8290.Cd-22-0876.","journal-title":"Cancer Discov"},{"issue":"10","key":"1408_CR30","doi-asserted-by":"publisher","first-page":"2414","DOI":"10.1158\/2159-8290.Cd-22-0661","volume":"12","author":"J Abrego","year":"2022","unstructured":"Abrego J, Sanford-Crane H, Oon C, Xiao X, Betts CB, Sun D, et al. A Cancer Cell-Intrinsic GOT2-PPAR\u03b4 Axis Suppresses Antitumor Immunity. Cancer Discov. 2022;12(10):2414\u201333. https:\/\/doi.org\/10.1158\/2159-8290.Cd-22-0661.","journal-title":"Cancer Discov"},{"issue":"7","key":"1408_CR31","doi-asserted-by":"publisher","first-page":"1324","DOI":"10.1158\/2159-8290.Cd-23-0428","volume":"14","author":"JI Belle","year":"2024","unstructured":"Belle JI, Sen D, Baer JM, Liu X, Lander VE, Ye J, et al. Senescence Defines a Distinct Subset of Myofibroblasts That Orchestrates Immunosuppression in Pancreatic Cancer. Cancer Discov. 2024;14(7):1324\u201355. https:\/\/doi.org\/10.1158\/2159-8290.Cd-23-0428.","journal-title":"Cancer Discov"},{"issue":"11","key":"1408_CR32","doi-asserted-by":"publisher","first-page":"2012","DOI":"10.1111\/j.1349-7006.2012.02411.x","volume":"103","author":"K Yoshikawa","year":"2012","unstructured":"Yoshikawa K, Mitsunaga S, Kinoshita T, Konishi M, Takahashi S, Gotohda N, et al. Impact of tumor-associated macrophages on invasive ductal carcinoma of the pancreas head. Cancer Sci. 2012;103(11):2012\u201320. https:\/\/doi.org\/10.1111\/j.1349-7006.2012.02411.x.","journal-title":"Cancer Sci"},{"issue":"4","key":"1408_CR33","doi-asserted-by":"publisher","first-page":"1069","DOI":"10.1158\/1078-0432.Ccr-20-3141","volume":"27","author":"SA V\u00e4yrynen","year":"2021","unstructured":"V\u00e4yrynen SA, Zhang J, Yuan C, V\u00e4yrynen JP, Dias Costa A, Williams H, et al. Composition, Spatial Characteristics, and Prognostic Significance of Myeloid Cell Infiltration in Pancreatic Cancer. Clin Cancer Res. 2021;27(4):1069\u201381. https:\/\/doi.org\/10.1158\/1078-0432.Ccr-20-3141.","journal-title":"Clin Cancer Res"},{"issue":"2","key":"1408_CR34","doi-asserted-by":"publisher","first-page":"338","DOI":"10.1053\/j.gastro.2016.05.004","volume":"151","author":"E G\u00fcrlevik","year":"2016","unstructured":"G\u00fcrlevik E, Fleischmann-Mundt B, Brooks J, Demir IE, Steiger K, Ribback S, et al. Administration of Gemcitabine After Pancreatic Tumor Resection in Mice Induces an Antitumor Immune Response Mediated by Natural Killer Cells. Gastroenterology. 2016;151(2):338\u2013e350337. https:\/\/doi.org\/10.1053\/j.gastro.2016.05.004.","journal-title":"Gastroenterology"},{"issue":"2","key":"1408_CR35","doi-asserted-by":"publisher","first-page":"475","DOI":"10.1158\/0008-5472.Can-17-2415","volume":"78","author":"J Brooks","year":"2018","unstructured":"Brooks J, Fleischmann-Mundt B, Woller N, Niemann J, Ribback S, Peters K, et al. Perioperative, Spatiotemporally Coordinated Activation of T and NK Cells Prevents Recurrence of Pancreatic Cancer. Cancer Res. 2018;78(2):475\u201388. https:\/\/doi.org\/10.1158\/0008-5472.Can-17-2415.","journal-title":"Cancer Res"},{"key":"1408_CR36","doi-asserted-by":"publisher","first-page":"995715","DOI":"10.3389\/fimmu.2022.995715","volume":"13","author":"HM Aziz","year":"2022","unstructured":"Aziz HM, Saida L, de Koning W, Stubbs AP, Li Y, Sideras K, et al. Spatial genomics reveals a high number and specific location of B cells in the pancreatic ductal adenocarcinoma microenvironment of long-term survivors. Front Immunol. 2022;13:995715. https:\/\/doi.org\/10.3389\/fimmu.2022.995715.","journal-title":"Front Immunol"},{"issue":"1","key":"1408_CR37","doi-asserted-by":"publisher","first-page":"101","DOI":"10.1007\/s00535-020-01730-7","volume":"56","author":"K Tezuka","year":"2021","unstructured":"Tezuka K, Okamura Y, Sugiura T, Ito T, Yamamoto Y, Ashida R, et al. The influence of familial pancreatic cancer on postoperative outcome in pancreatic cancer: relevance to adjuvant chemotherapy. J Gastroenterol. 2021;56(1):101\u201313. https:\/\/doi.org\/10.1007\/s00535-020-01730-7.","journal-title":"J Gastroenterol"},{"issue":"12","key":"1408_CR38","doi-asserted-by":"publisher","first-page":"8264","DOI":"10.1245\/s10434-024-15664-4","volume":"31","author":"I van Goor","year":"2024","unstructured":"van Goor I, Andel PCM, Buijs FS, Besselink MG, Bonsing BA, Bosscha K, et al. Prediction of Isolated Local Recurrence After Resection of Pancreatic Ductal Adenocarcinoma: A Nationwide Study. Ann Surg Oncol. 2024;31(12):8264\u201375. https:\/\/doi.org\/10.1245\/s10434-024-15664-4.","journal-title":"Ann Surg Oncol"},{"issue":"1","key":"1408_CR39","doi-asserted-by":"publisher","first-page":"85","DOI":"10.1038\/s41698-024-00571-4","volume":"8","author":"M Abdelrahim","year":"2024","unstructured":"Abdelrahim M, Esmail A, Kasi A, Esnaola NF, Xiu J, Baca Y, et al. Comparative molecular profiling of pancreatic ductal adenocarcinoma of the head versus body and tail. NPJ Precis Oncol. 2024;8(1):85. https:\/\/doi.org\/10.1038\/s41698-024-00571-4.","journal-title":"NPJ Precis Oncol"},{"issue":"1","key":"1408_CR40","doi-asserted-by":"publisher","first-page":"105","DOI":"10.1002\/jhbp.854","volume":"28","author":"JR Kim","year":"2021","unstructured":"Kim JR, Kim H, Kwon W, Jang JY, Kim SW. Pattern of local recurrence after curative resection in pancreatic ductal adenocarcinoma according to the initial location of the tumor. J Hepatobiliary Pancreat Sci. 2021;28(1):105\u201314. https:\/\/doi.org\/10.1002\/jhbp.854.","journal-title":"J Hepatobiliary Pancreat Sci"},{"issue":"6","key":"1408_CR41","doi-asserted-by":"publisher","first-page":"697","DOI":"10.1007\/s00423-010-0593-6","volume":"395","author":"MJ Kang","year":"2010","unstructured":"Kang MJ, Jang JY, Lee SE, Lim CS, Lee KU, Kim SW. Comparison of the long-term outcomes of uncinate process cancer and non-uncinate process pancreas head cancer: poor prognosis accompanied by early locoregional recurrence. Langenbecks Arch Surg. 2010;395(6):697\u2013706. https:\/\/doi.org\/10.1007\/s00423-010-0593-6.","journal-title":"Langenbecks Arch Surg"},{"issue":"1","key":"1408_CR42","doi-asserted-by":"publisher","first-page":"122","DOI":"10.1007\/s00423-024-03301-3","volume":"409","author":"JC L\u00f3pez","year":"2024","unstructured":"L\u00f3pez JC, Ielpo B, Iglesias M, Pinilla FB, S\u00e1nchez-Vel\u00e1zquez P. The impact of vascular margin invasion on local recurrence after pancreatoduodenectomy in pancreatic adenocarcinoma. Langenbecks Arch Surg. 2024;409(1):122. https:\/\/doi.org\/10.1007\/s00423-024-03301-3.","journal-title":"Langenbecks Arch Surg"},{"issue":"8","key":"1408_CR43","doi-asserted-by":"publisher","first-page":"1218","DOI":"10.1097\/mpa.0000000000001897","volume":"50","author":"JV Groen","year":"2021","unstructured":"Groen JV, van Manen L, van Roessel S, van Dam JL, Bonsing BA, Doukas M, et al. Resection of the Portal-Superior Mesenteric Vein in Pancreatic Cancer: Pathological Assessment and Recurrence Patterns. Pancreas. 2021;50(8):1218\u201329. https:\/\/doi.org\/10.1097\/mpa.0000000000001897.","journal-title":"Pancreas"},{"key":"1408_CR44","doi-asserted-by":"publisher","DOI":"10.1097\/sla.0000000000006567","author":"D Henault","year":"2024","unstructured":"Henault D, Kunde H, Zatzman C, Bevacqua D, Arshinoff D, Cleary SP, et al. Vascular Resection for Pancreas Cancer\u2009\u2013\u200910-year Experience from a Single High Volume-center. Ann Surg. 2024. https:\/\/doi.org\/10.1097\/sla.0000000000006567.","journal-title":"Ann Surg"},{"key":"1408_CR45","doi-asserted-by":"publisher","DOI":"10.1097\/sla.0000000000006605","author":"H Ishida","year":"2024","unstructured":"Ishida H, Watanabe S, Franco R, Franklin S, Stoop O, Kirsch TF, M. J., et al. Portomesenteric Venous Thrombosis after Pancreatic Cancer Surgery with Venous Resection and Reconstruction: Timing, Incidence, and Risk Factors. Ann Surg. 2024. https:\/\/doi.org\/10.1097\/sla.0000000000006605.","journal-title":"Ann Surg"},{"issue":"2","key":"1408_CR46","doi-asserted-by":"publisher","first-page":"691","DOI":"10.1016\/j.surg.2022.02.010","volume":"172","author":"T Nakajima","year":"2022","unstructured":"Nakajima T, Ikuta S, Nakamura I, Aihara T, Kasai M, Iwama H, et al. Impact of the aberrant right hepatic artery on local recurrence of pancreatic ductal adenocarcinoma after pancreaticoduodenectomy. Surgery. 2022;172(2):691\u20139. https:\/\/doi.org\/10.1016\/j.surg.2022.02.010.","journal-title":"Surgery"},{"issue":"5","key":"1408_CR47","doi-asserted-by":"publisher","first-page":"1078","DOI":"10.1016\/j.surg.2013.04.015","volume":"154","author":"T Sugiura","year":"2013","unstructured":"Sugiura T, Uesaka K, Mihara K, Sasaki K, Kanemoto H, Mizuno T, et al. Margin status, recurrence pattern, and prognosis after resection of pancreatic cancer. Surgery. 2013;154(5):1078\u201386. https:\/\/doi.org\/10.1016\/j.surg.2013.04.015.","journal-title":"Surgery"},{"issue":"8","key":"1408_CR48","doi-asserted-by":"publisher","first-page":"1055","DOI":"10.1002\/bjs.11115","volume":"106","author":"WS Tummers","year":"2019","unstructured":"Tummers WS, Groen JV, Mulder S, Farina-Sarasqueta BG, Morreau A, Putter J, H., et al. Impact of resection margin status on recurrence and survival in pancreatic cancer surgery. Br J Surg. 2019;106(8):1055\u201365. https:\/\/doi.org\/10.1002\/bjs.11115.","journal-title":"Br J Surg"},{"key":"1408_CR49","doi-asserted-by":"publisher","first-page":"109114","DOI":"10.1016\/j.surg.2024.109114","volume":"180","author":"IF Rompen","year":"2025","unstructured":"Rompen IF, Marchetti A, Levine J, Swett B, Galimberti V, Han J, et al. Impact of resection margin status on recurrence and survival in patients with resectable, borderline resectable, and locally advanced pancreatic cancer. Surgery. 2025;180:109114. https:\/\/doi.org\/10.1016\/j.surg.2024.109114.","journal-title":"Surgery"},{"issue":"8","key":"1408_CR50","doi-asserted-by":"publisher","first-page":"527","DOI":"10.1016\/j.clon.2021.03.007","volume":"33","author":"AM Elamir","year":"2021","unstructured":"Elamir AM, Hutchinson S, Albaba H, Keshavarzi S, Xu W, Moulton CA, et al. A Risk Score Model for Locoregional Recurrence Following Upfront Surgery for Pancreatic Adenocarcinoma: Implications for Adjuvant Therapy. Clin Oncol (R Coll Radiol). 2021;33(8):527\u201335. https:\/\/doi.org\/10.1016\/j.clon.2021.03.007.","journal-title":"Clin Oncol (R Coll Radiol)"},{"issue":"16","key":"1408_CR51","doi-asserted-by":"publisher","first-page":"1763","DOI":"10.1200\/jco.19.02274","volume":"38","author":"E Versteijne","year":"2020","unstructured":"Versteijne E, Suker M, Groothuis K, Akkermans-Vogelaar JM, Besselink MG, Bonsing BA, et al. Preoperative Chemoradiotherapy Versus Immediate Surgery for Resectable and Borderline Resectable Pancreatic Cancer: Results of the Dutch Randomized Phase III PREOPANC Trial. J Clin Oncol. 2020;38(16):1763\u201373. https:\/\/doi.org\/10.1200\/jco.19.02274.","journal-title":"J Clin Oncol"},{"issue":"5","key":"1408_CR52","doi-asserted-by":"publisher","first-page":"1220","DOI":"10.1016\/j.surg.2022.10.025","volume":"173","author":"K Kobayashi","year":"2023","unstructured":"Kobayashi K, Ono Y, Sato S, Kato T, Oba A, Sato T, et al. Evaluation of local recurrence after pancreaticoduodenectomy for borderline resectable pancreatic head cancer with neoadjuvant chemotherapy: Can the resection level change after chemotherapy? Surgery. 2023;173(5):1220\u20138. https:\/\/doi.org\/10.1016\/j.surg.2022.10.025.","journal-title":"Surgery"},{"issue":"5","key":"1408_CR53","doi-asserted-by":"publisher","first-page":"900","DOI":"10.1097\/sla.0000000000000968","volume":"260","author":"F Liebl","year":"2014","unstructured":"Liebl F, Demir IE, Mayer K, Schuster T, D\u02bcHaese JG, Becker K et al. The impact of neural invasion severity in gastrointestinal malignancies: a clinicopathological study. Ann Surg. 2014;260(5):900\u2013907; discussion 907\u2013908. https:\/\/doi.org\/10.1097\/sla.0000000000000968","journal-title":"Ann Surg"},{"key":"1408_CR54","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-025-08735-3","author":"V Thiel","year":"2025","unstructured":"Thiel V, Renders S, Panten J, Dross N, Bauer K, Azorin D, et al. Characterization of single neurons reprogrammed by pancreatic cancer. Nature. 2025. https:\/\/doi.org\/10.1038\/s41586-025-08735-3.","journal-title":"Nature"},{"issue":"11","key":"1408_CR55","doi-asserted-by":"publisher","first-page":"5029","DOI":"10.7150\/thno.42440","volume":"10","author":"D Su","year":"2020","unstructured":"Su D, Guo X, Huang L, Ye H, Li Z, Lin L, et al. Tumor-neuroglia interaction promotes pancreatic cancer metastasis. Theranostics. 2020;10(11):5029\u201347. https:\/\/doi.org\/10.7150\/thno.42440.","journal-title":"Theranostics"},{"issue":"10","key":"1408_CR56","doi-asserted-by":"publisher","first-page":"1991","DOI":"10.1158\/0008-5472.Can-19-2689","volume":"80","author":"MW Yang","year":"2020","unstructured":"Yang MW, Tao LY, Jiang YS, Yang JY, Huo YM, Liu DJ, et al. Perineural Invasion Reprograms the Immune Microenvironment through Cholinergic Signaling in Pancreatic Ductal Adenocarcinoma. Cancer Res. 2020;80(10):1991\u20132003. https:\/\/doi.org\/10.1158\/0008-5472.Can-19-2689.","journal-title":"Cancer Res"},{"issue":"1","key":"1408_CR57","doi-asserted-by":"publisher","first-page":"57","DOI":"10.1186\/s12935-025-03682-5","volume":"25","author":"X Zhang","year":"2025","unstructured":"Zhang X, Zhao LX, Cheng SQ, Liu YF. Expression of stearoyl coenzyme a desaturase in neuronal cells facilitates pancreatic cancer progression. Cancer Cell Int. 2025;25(1):57. https:\/\/doi.org\/10.1186\/s12935-025-03682-5.","journal-title":"Cancer Cell Int"},{"issue":"8","key":"1408_CR58","doi-asserted-by":"publisher","first-page":"642","DOI":"10.1002\/cac2.12188","volume":"41","author":"J Li","year":"2021","unstructured":"Li J, Kang R, Tang D. Cellular and molecular mechanisms of perineural invasion of pancreatic ductal adenocarcinoma. Cancer Commun (Lond). 2021;41(8):642\u201360. https:\/\/doi.org\/10.1002\/cac2.12188.","journal-title":"Cancer Commun (Lond)"},{"issue":"5","key":"1408_CR59","doi-asserted-by":"publisher","first-page":"630","DOI":"10.1016\/j.hpb.2024.01.017","volume":"26","author":"SS Raza","year":"2024","unstructured":"Raza SS, Khan H, Hajibandeh S, Hajibandeh S, Bartlett D, Chatzizacharias N, et al. Can preoperative Carbohydrate Antigen 19\u2009\u2013\u20099 predict metastatic pancreatic cancer? Results of a systematic review and meta-analysis. HPB (Oxford). 2024;26(5):630\u20138. https:\/\/doi.org\/10.1016\/j.hpb.2024.01.017.","journal-title":"HPB (Oxford)"},{"issue":"2","key":"1408_CR60","doi-asserted-by":"publisher","first-page":"479","DOI":"10.1007\/s13304-024-01758-x","volume":"76","author":"H Imamura","year":"2024","unstructured":"Imamura H, Tomimaru Y, Kobayashi S, Yamada D, Noda T, Takahashi H, et al. Diagnostic impact of postoperative CA19-9 dynamics on pancreatic cancer recurrence: a single-institution retrospective study. Updates Surg. 2024;76(2):479\u201386. https:\/\/doi.org\/10.1007\/s13304-024-01758-x.","journal-title":"Updates Surg"},{"issue":"10","key":"1408_CR61","doi-asserted-by":"publisher","first-page":"3135","DOI":"10.1007\/s00261-023-04012-x","volume":"48","author":"H Akkaya","year":"2023","unstructured":"Akkaya H, \u00d6zdemir S, Dilek O, Topaloglu AC, Bayhan AZ, Ta\u015f ZA, et al. Evaluation of the performance of and interobserver agreement on postoperative baseline CT findings in the identification of locoregional recurrence in patients with pancreatic ductal adenocarcinoma. Abdom Radiol (NY). 2023;48(10):3135\u201346. https:\/\/doi.org\/10.1007\/s00261-023-04012-x.","journal-title":"Abdom Radiol (NY)"},{"issue":"1","key":"1408_CR62","doi-asserted-by":"publisher","first-page":"11","DOI":"10.1097\/MPA.0b013e3182550d77","volume":"42","author":"A Asagi","year":"2013","unstructured":"Asagi A, Ohta K, Nasu J, Tanada M, Nadano S, Nishimura R, et al. Utility of contrast-enhanced FDG-PET\/CT in the clinical management of pancreatic cancer: impact on diagnosis, staging, evaluation of treatment response, and detection of recurrence. Pancreas. 2013;42(1):11\u20139. https:\/\/doi.org\/10.1097\/MPA.0b013e3182550d77.","journal-title":"Pancreas"},{"issue":"2","key":"1408_CR63","doi-asserted-by":"publisher","first-page":"47","DOI":"10.1007\/s12032-023-02271-8","volume":"41","author":"D Saponjski","year":"2024","unstructured":"Saponjski D, Djuric-Stefanovic A, Jovanovic MM, Jankovic A, Kovac J, Milosevic S, et al. Utility of MRI in detection of PET-CT proven local recurrence of pancreatic adenocarcinoma after surgery. Med Oncol. 2024;41(2):47. https:\/\/doi.org\/10.1007\/s12032-023-02271-8.","journal-title":"Med Oncol"},{"issue":"11","key":"1408_CR64","doi-asserted-by":"publisher","first-page":"4184","DOI":"10.7150\/thno.95329","volume":"14","author":"G Metzger","year":"2024","unstructured":"Metzger G, Bayerl C, Rogasch JM, Furth C, Wetz C, Beck M, et al. (68)Ga-labeled fibroblast activation protein inhibitor (FAPI) PET\/CT for locally advanced or recurrent pancreatic cancer staging and restaging after chemoradiotherapy. Theranostics. 2024;14(11):4184\u201397. https:\/\/doi.org\/10.7150\/thno.95329.","journal-title":"Theranostics"},{"issue":"1","key":"1408_CR65","doi-asserted-by":"publisher","first-page":"26","DOI":"10.1186\/s41747-025-00567-0","volume":"9","author":"Z Alagic","year":"2025","unstructured":"Alagic Z, Duran CV, Svensson-Marcial A, Koskinen SK. Contrast-enhanced photon-counting detector CT for discriminating local recurrence from postoperative changes after resection of pancreatic ductal adenocarcinoma. Eur Radiol Exp. 2025;9(1):26. https:\/\/doi.org\/10.1186\/s41747-025-00567-0.","journal-title":"Eur Radiol Exp"},{"key":"1408_CR66","doi-asserted-by":"publisher","first-page":"109944","DOI":"10.1016\/j.ejrad.2021.109944","volume":"143","author":"RM Mathy","year":"2021","unstructured":"Mathy RM, Fritz F, Mayer P, Klauss M, Grenacher L, Stiller W, et al. Iodine concentration and tissue attenuation in dual-energy contrast-enhanced CT as a potential quantitative parameter in early detection of local pancreatic carcinoma recurrence after surgical resection. Eur J Radiol. 2021;143:109944. https:\/\/doi.org\/10.1016\/j.ejrad.2021.109944.","journal-title":"Eur J Radiol"},{"issue":"11","key":"1408_CR67","doi-asserted-by":"publisher","first-page":"1834","DOI":"10.1016\/j.cgh.2018.02.031","volume":"16","author":"GD Lang","year":"2018","unstructured":"Lang GD, Mullady DK, Early DS, Hollander T, Edmundowicz SA, Murad FM, et al. Utility of Endoscopic Ultrasound in Evaluating Local Recurrence After Surgery for Pancreatic Cancer. Clin Gastroenterol Hepatol. 2018;16(11):1834\u20135. https:\/\/doi.org\/10.1016\/j.cgh.2018.02.031.","journal-title":"Clin Gastroenterol Hepatol"},{"issue":"5","key":"1408_CR68","doi-asserted-by":"publisher","first-page":"1076","DOI":"10.1016\/j.gie.2010.07.007","volume":"72","author":"J DeWitt","year":"2010","unstructured":"DeWitt J, Sherman S, Al-Haddad M, McHenry L, Cote GA, Leblanc JK. EUS-guided FNA of local recurrence of pancreatic cancer after surgical resection. Gastrointest Endosc. 2010;72(5):1076\u201380. https:\/\/doi.org\/10.1016\/j.gie.2010.07.007.","journal-title":"Gastrointest Endosc"},{"issue":"10","key":"1408_CR69","doi-asserted-by":"publisher","first-page":"2907","DOI":"10.1007\/s10620-019-06006-6","volume":"65","author":"K Matsumoto","year":"2020","unstructured":"Matsumoto K, Kato H, Nouso K, Ako S, Kinugasa H, Horiguchi S, et al. Evaluation of Local Recurrence of Pancreatic Cancer by KRAS Mutation Analysis Using Washes from Endoscopic Ultrasound-Guided Fine-Needle Aspiration. Dig Dis Sci. 2020;65(10):2907\u201313. https:\/\/doi.org\/10.1007\/s10620-019-06006-6.","journal-title":"Dig Dis Sci"},{"issue":"5","key":"1408_CR70","doi-asserted-by":"publisher","first-page":"1049","DOI":"10.1016\/j.surg.2018.05.050","volume":"164","author":"S Yamada","year":"2018","unstructured":"Yamada S, Kobayashi A, Nakamori S, Baba H, Yamamoto M, Yamaue H, et al. Resection for recurrent pancreatic cancer in the remnant pancreas after pancreatectomy is clinically promising: Results of a project study for pancreatic surgery by the Japanese Society of Hepato-Biliary-Pancreatic Surgery. Surgery. 2018;164(5):1049\u201356. https:\/\/doi.org\/10.1016\/j.surg.2018.05.050.","journal-title":"Surgery"},{"issue":"3","key":"1408_CR71","doi-asserted-by":"publisher","first-page":"964","DOI":"10.1245\/s10434-012-2762-z","volume":"20","author":"O Strobel","year":"2013","unstructured":"Strobel O, Hartwig W, Hackert T, Hinz U, Berens V, Grenacher L, et al. Re-resection for isolated local recurrence of pancreatic cancer is feasible, safe, and associated with encouraging survival. Ann Surg Oncol. 2013;20(3):964\u201372. https:\/\/doi.org\/10.1245\/s10434-012-2762-z.","journal-title":"Ann Surg Oncol"},{"key":"1408_CR72","doi-asserted-by":"publisher","first-page":"15","DOI":"10.1016\/j.jss.2017.07.016","volume":"221","author":"Y Nakayama","year":"2018","unstructured":"Nakayama Y, Sugimoto M, Gotohda N, Konishi M, Takahashi S. Efficacy of completion pancreatectomy for recurrence of adenocarcinoma in the remnant pancreas. J Surg Res. 2018;221:15\u201323. https:\/\/doi.org\/10.1016\/j.jss.2017.07.016.","journal-title":"J Surg Res"},{"issue":"30","key":"1408_CR73","doi-asserted-by":"publisher","first-page":"e4191","DOI":"10.1097\/md.0000000000004191","volume":"95","author":"SC Chang","year":"2016","unstructured":"Chang SC, Hsu CP, Tsai CY, Liu YY, Liu KH, Hsu JT, et al. Selective reoperation after primary resection as a feasible and safe treatment strategy for recurrent pancreatic cancer. Med (Baltim). 2016;95(30):e4191. https:\/\/doi.org\/10.1097\/md.0000000000004191.","journal-title":"Med (Baltim)"},{"issue":"3","key":"1408_CR74","doi-asserted-by":"publisher","first-page":"315","DOI":"10.14701\/ahbps.24-041","volume":"28","author":"S Hajibandeh","year":"2024","unstructured":"Hajibandeh S, Hajibandeh S, Evans D, Athwal TS. Meta-analysis of pancreatic re-resection for locally recurrent pancreatic cancer following index pancreatectomy. Ann Hepatobiliary Pancreat Surg. 2024;28(3):315\u201324. https:\/\/doi.org\/10.14701\/ahbps.24-041.","journal-title":"Ann Hepatobiliary Pancreat Surg"},{"issue":"3","key":"1408_CR75","doi-asserted-by":"publisher","first-page":"1402","DOI":"10.21037\/jgo-22-38","volume":"13","author":"AV Reddy","year":"2022","unstructured":"Reddy AV, Hill CS, Sehgal S, He J, Zheng L, Herman JM, et al. Stereotactic body radiation therapy for the treatment of locally recurrent pancreatic cancer after surgical resection. J Gastrointest Oncol. 2022;13(3):1402\u201312. https:\/\/doi.org\/10.21037\/jgo-22-38.","journal-title":"J Gastrointest Oncol"},{"issue":"10","key":"1408_CR76","doi-asserted-by":"publisher","first-page":"100818","DOI":"10.1016\/j.tranon.2020.100818","volume":"13","author":"J Li","year":"2020","unstructured":"Li J, Wang Z, Li AM, Zhou H, Zhu XX. Analysis of the efficacy, safety and survival factors of stereotactic body radiation therapy in patients with recurrence of pancreatic cancer. Transl Oncol. 2020;13(10):100818. https:\/\/doi.org\/10.1016\/j.tranon.2020.100818.","journal-title":"Transl Oncol"},{"issue":"4","key":"1408_CR77","doi-asserted-by":"publisher","first-page":"735","DOI":"10.1016\/j.ejso.2016.12.012","volume":"43","author":"T Comito","year":"2017","unstructured":"Comito T, Cozzi L, Zerbi A, Franzese C, Clerici E, Tozzi A, et al. Clinical results of stereotactic body radiotherapy (SBRT) in the treatment of isolated local recurrence of pancreatic cancer after R0 surgery: A retrospective study. Eur J Surg Oncol. 2017;43(4):735\u201342. https:\/\/doi.org\/10.1016\/j.ejso.2016.12.012.","journal-title":"Eur J Surg Oncol"},{"issue":"5","key":"1408_CR78","doi-asserted-by":"publisher","first-page":"485","DOI":"10.1007\/s00066-014-0610-8","volume":"190","author":"A Nakamura","year":"2014","unstructured":"Nakamura A, Itasaka S, Takaori K, Kawaguchi Y, Shibuya K, Yoshimura M, et al. Radiotherapy for patients with isolated local recurrence of primary resected pancreatic cancer. Prolonged disease-free interval associated with favorable prognosis. Strahlenther Onkol. 2014;190(5):485\u201390. https:\/\/doi.org\/10.1007\/s00066-014-0610-8.","journal-title":"Strahlenther Onkol"},{"issue":"1","key":"1408_CR79","doi-asserted-by":"publisher","first-page":"101","DOI":"10.1016\/j.radonc.2018.02.003","volume":"129","author":"S Kawashiro","year":"2018","unstructured":"Kawashiro S, Yamada S, Isozaki Y, Nemoto K, Tsuji H, Kamada T. Carbon-ion radiotherapy for locoregional recurrence after primary surgery for pancreatic cancer. Radiother Oncol. 2018;129(1):101\u20134. https:\/\/doi.org\/10.1016\/j.radonc.2018.02.003.","journal-title":"Radiother Oncol"},{"issue":"8","key":"1408_CR80","doi-asserted-by":"publisher","first-page":"2587","DOI":"10.1245\/s10434-019-07471-z","volume":"26","author":"T Mizumoto","year":"2019","unstructured":"Mizumoto T, Terashima K, Matsuo Y, Nagano F, Demizu Y, Mima M, et al. Proton Radiotherapy for Isolated Local Recurrence of Primary Resected Pancreatic Ductal Adenocarcinoma. Ann Surg Oncol. 2019;26(8):2587\u201394. https:\/\/doi.org\/10.1245\/s10434-019-07471-z.","journal-title":"Ann Surg Oncol"},{"issue":"1","key":"1408_CR81","doi-asserted-by":"publisher","first-page":"212","DOI":"10.1148\/radiol.2019191109","volume":"294","author":"AH Ruarus","year":"2020","unstructured":"Ruarus AH, Vroomen L, Geboers B, van Veldhuisen E, Puijk RS, Nieuwenhuizen S, et al. Percutaneous Irreversible Electroporation in Locally Advanced and Recurrent Pancreatic Cancer (PANFIRE-2): A Multicenter, Prospective, Single-Arm, Phase II Study. Radiology. 2020;294(1):212\u201320. https:\/\/doi.org\/10.1148\/radiol.2019191109.","journal-title":"Radiology"},{"issue":"2","key":"1408_CR82","doi-asserted-by":"publisher","first-page":"741","DOI":"10.4081\/cp.2015.741","volume":"5","author":"C Pusceddu","year":"2015","unstructured":"Pusceddu C, Melis L, Sotgia B, Fancellu A, Meloni GB. Computed Tomography-Guided Cryoablation of Local Recurrence after Primary Resection of Pancreatic Adenocarcinoma. Clin Pract. 2015;5(2):741. https:\/\/doi.org\/10.4081\/cp.2015.741.","journal-title":"Clin Pract"},{"issue":"1","key":"1408_CR83","first-page":"34","volume":"7","author":"R Wilkowski","year":"2006","unstructured":"Wilkowski R, Thoma M, Bruns C, D\u00fchmke E, Heinemann V. Combined chemoradiotherapy for isolated local recurrence after primary resection of pancreatic cancer. Jop. 2006;7(1):34\u201340.","journal-title":"Jop"},{"key":"1408_CR84","doi-asserted-by":"publisher","first-page":"27","DOI":"10.1186\/1748-717x-8-27","volume":"8","author":"D Habermehl","year":"2013","unstructured":"Habermehl D, Brecht IC, Bergmann F, Welzel T, Rieken S, Werner J, et al Chemoradiation in patients with isolated recurrent pancreatic cancer - therapeutical efficacy and probability of re-resection. Radiat Oncol. 2013;8:27. https:\/\/doi.org\/10.1186\/1748-717x-8-27.","journal-title":"Radiat Oncol"},{"issue":"3","key":"1408_CR85","doi-asserted-by":"publisher","first-page":"e105","DOI":"10.1016\/s1470-2045(22)00066-3","volume":"23","author":"X Zhu","year":"2020","unstructured":"Zhu X, Cao Y, Liu W, Ju X, Zhao X, Jiang L. Stereotactic body radiotherapy plus pembrolizumab and trametinib versus stereotactic body radiotherapy plus gemcitabine for locally recurrent pancreatic cancer after surgical resection: an open-label, randomised, controlled, phase 2 trial. Lancet Oncol. 2020;23(3):e105\u201315. https:\/\/doi.org\/10.1016\/s1470-2045(22)00066-3","journal-title":"Lancet Oncol"},{"issue":"2","key":"1408_CR86","doi-asserted-by":"publisher","first-page":"247","DOI":"10.11152\/mu-2031","volume":"22","author":"D Dimitrov","year":"2020","unstructured":"Dimitrov D, Stanislavova N, Yotsov T, Zhou K. Recurrent pancreatic cancer patient treated by chemotherapy and focused ultrasound surgery. A case report. Med Ultrason. 2020;22(2):247\u20139. https:\/\/doi.org\/10.11152\/mu-2031.","journal-title":"Med Ultrason"},{"issue":"1","key":"1408_CR87","doi-asserted-by":"publisher","first-page":"34","DOI":"10.1111\/hpb.12058","volume":"16","author":"P Papavasiliou","year":"2014","unstructured":"Papavasiliou P, Hoffman JP, Cohen SJ, Meyer JE, Watson JC, Chun YS. Impact of preoperative therapy on patterns of recurrence in pancreatic cancer. HPB (Oxford). 2014;16(1):34\u20139. https:\/\/doi.org\/10.1111\/hpb.12058.","journal-title":"HPB (Oxford)"},{"issue":"6","key":"1408_CR88","doi-asserted-by":"publisher","first-page":"1629","DOI":"10.1245\/s10434-018-07131-8","volume":"26","author":"Y Nagakawa","year":"2019","unstructured":"Nagakawa Y, Sahara Y, Hosokawa Y, Murakami Y, Yamaue H, Satoi S, et alClinical impact of neoadjuvant chemotherapy and chemoradiotherapy in borderline resectable pancreatic cancer: analysis of 884 patients at facilities specializing in pancreatic surgery. Ann Surg Oncol. 2019;26(6):1629\u201336. https:\/\/doi.org\/10.1245\/s10434-018-07131-8.","journal-title":"Ann Surg Oncol"},{"key":"1408_CR89","doi-asserted-by":"publisher","unstructured":"Leung PQ, Elghonaimy EA, Elamir AM, Wachsmann M, Zhang S, Barrows N. (2025). Presurgical ablative radiation is associated with local control and immune response in pancreatic cancer. Clin Cancer Res. https:\/\/doi.org\/10.1158\/1078-0432.Ccr-24-3582","DOI":"10.1158\/1078-0432.Ccr-24-3582"},{"issue":"12","key":"1408_CR90","doi-asserted-by":"publisher","first-page":"1130","DOI":"10.1097\/00029330-200806020-00018","volume":"121","author":"QS Shao","year":"2008","unstructured":"Shao QS, Ye ZY, Li SG, Chen K. Radical pancreatoduodenectomy combined with retroperitoneal nerve, lymph, and soft-tissue dissection in pancreatic head cancer. Chin Med J (Engl). 2008;121(12):1130\u20133.","journal-title":"Chin Med J (Engl)"},{"issue":"5","key":"1408_CR91","doi-asserted-by":"publisher","first-page":"1773","DOI":"10.4251\/wjgo.v16.i5.1773","volume":"16","author":"JH Chen","year":"2024","unstructured":"Chen JH, Zhu LY, Cai ZW, Hu X, Ahmed AA, Ge JQ, et al. TRIANGLE operation, combined with adequate adjuvant chemotherapy, can improve the prognosis of pancreatic head cancer: A retrospective study. World J Gastrointest Oncol. 2024;16(5):1773\u201386. https:\/\/doi.org\/10.4251\/wjgo.v16.i5.1773.","journal-title":"World J Gastrointest Oncol"},{"issue":"4","key":"1408_CR92","doi-asserted-by":"publisher","first-page":"445","DOI":"10.1016\/j.hpb.2024.11.015","volume":"27","author":"PLZ Labib","year":"2025","unstructured":"Labib PLZ, Russell TB, Denson JL, Puckett MA, Ausania F, Pando E, et al. Patterns, timing and predictors of recurrence following pancreaticoduodenectomy for pancreatic ductal adenocarcinoma: an international multicentre retrospective cohort study. HPB (Oxford). 2025;27(4):445\u201360. https:\/\/doi.org\/10.1016\/j.hpb.2024.11.015.","journal-title":"HPB (Oxford)"},{"issue":"12","key":"1408_CR93","doi-asserted-by":"publisher","first-page":"7798","DOI":"10.1097\/js9.0000000000002153","volume":"110","author":"J Padillo-Ruiz","year":"2024","unstructured":"Padillo-Ruiz J, Garcia C, Suarez G, Blanco G, Mu\u00f1oz-Bellvis L, Justo I, et al. Intraoperative liquid biopsy as a tool for detecting R1 resection during pancreatoduodenectomy in patients with pancreatic carcinoma: the CETUPANC trial (part II). Int J Surg. 2024;110(12):7798\u2013805. https:\/\/doi.org\/10.1097\/js9.0000000000002153.","journal-title":"Int J Surg"},{"issue":"4","key":"1408_CR94","doi-asserted-by":"publisher","first-page":"1094","DOI":"10.1016\/j.ijrobp.2007.07.2346","volume":"70","author":"V Valentini","year":"2008","unstructured":"Valentini V, Morganti AG, Macchia G, Mantini G, Mattiucci GC, Brizi MG, et al. Intraoperative radiation therapy in resected pancreatic carcinoma: long-term analysis. Int J Radiat Oncol Biol Phys. 2008;70(4):1094\u20139. https:\/\/doi.org\/10.1016\/j.ijrobp.2007.07.2346.","journal-title":"Int J Radiat Oncol Biol Phys"},{"issue":"8","key":"1408_CR95","doi-asserted-by":"publisher","first-page":"2116","DOI":"10.1245\/s10434-009-0498-1","volume":"16","author":"TN Showalter","year":"2009","unstructured":"Showalter TN, Rao AS, Anne R, Rosato P, Rosato FE, Andrel EL, J., et al. Does intraoperative radiation therapy improve local tumor control in patients undergoing pancreaticoduodenectomy for pancreatic adenocarcinoma? A propensity score analysis. Ann Surg Oncol. 2009;16(8):2116\u201322. https:\/\/doi.org\/10.1245\/s10434-009-0498-1.","journal-title":"Ann Surg Oncol"},{"issue":"11","key":"1408_CR96","doi-asserted-by":"publisher","first-page":"1571","DOI":"10.1001\/jamaoncol.2022.3829","volume":"8","author":"T Conroy","year":"2022","unstructured":"Conroy T, Castan F, Lopez A, Turpin A, Ben Abdelghani M, Wei AC, et al. Five-Year Outcomes of FOLFIRINOX vs Gemcitabine as Adjuvant Therapy for Pancreatic Cancer: A Randomized Clinical Trial. JAMA Oncol. 2022;8(11):1571\u20138. https:\/\/doi.org\/10.1001\/jamaoncol.2022.3829.","journal-title":"JAMA Oncol"},{"issue":"26","key":"1408_CR97","doi-asserted-by":"publisher","first-page":"3083","DOI":"10.1200\/jco.23.02585","volume":"42","author":"FR van \u2019t Land","year":"2024","unstructured":"van \u2018t Land FR, Willemsen M, Bezemer K, van der Burg SH, van den Bosch TPP, Doukas M, et al. Dendritic Cell-Based Immunotherapy in Patients With Resected Pancreatic Cancer. J Clin Oncol. 2024;42(26):3083\u201393. https:\/\/doi.org\/10.1200\/jco.23.02585.","journal-title":"J Clin Oncol"},{"issue":"8056","key":"1408_CR98","doi-asserted-by":"publisher","first-page":"1042","DOI":"10.1038\/s41586-024-08508-4","volume":"639","author":"Z Sethna","year":"2025","unstructured":"Sethna Z, Guasp P, Reiche C, Milighetti M, Ceglia N, Patterson E, et al. RNA neoantigen vaccines prime long-lived CD8(+) T cells in pancreatic cancer. Nature. 2025;639(8056):1042\u201351. https:\/\/doi.org\/10.1038\/s41586-024-08508-4.","journal-title":"Nature"},{"issue":"1","key":"1408_CR99","doi-asserted-by":"publisher","first-page":"74","DOI":"10.1001\/jamasurg.2024.5024","volume":"160","author":"PCM Andel","year":"2025","unstructured":"Andel PCM, van Goor I, Augustinus S, Berrevoet F, Besselink MG, Bhojwani R, et al. Routine Imaging or Symptomatic Follow-Up After Resection of Pancreatic Adenocarcinoma. JAMA Surg. 2025;160(1):74\u201384. https:\/\/doi.org\/10.1001\/jamasurg.2024.5024.","journal-title":"JAMA Surg"},{"issue":"3","key":"1408_CR100","doi-asserted-by":"publisher","first-page":"317","DOI":"10.1016\/j.jconrel.2004.09.007","volume":"100","author":"T Manabe","year":"2004","unstructured":"Manabe T, Okino H, Maeyama R, Mizumoto K, Nagai E, Tanaka M, et al. Novel strategic therapeutic approaches for prevention of local recurrence of pancreatic cancer after resection: trans-tissue, sustained local drug-delivery systems. J Control Release. 2004;100(3):317\u201330. https:\/\/doi.org\/10.1016\/j.jconrel.2004.09.007.","journal-title":"J Control Release"},{"issue":"1","key":"1408_CR101","doi-asserted-by":"publisher","first-page":"2001159","DOI":"10.1080\/2162402x.2021.2001159","volume":"10","author":"D Delitto","year":"2021","unstructured":"Delitto D, Zabransky DJ, Chen F, Thompson ED, Zimmerman JW, Armstrong TD, et al. Implantation of a neoantigen-targeted hydrogel vaccine prevents recurrence of pancreatic adenocarcinoma after incomplete resection. Oncoimmunology. 2021;10(1):2001159. https:\/\/doi.org\/10.1080\/2162402x.2021.2001159.","journal-title":"Oncoimmunology"}],"container-title":["Current Treatment Options in Oncology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s11864-026-01408-x.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s11864-026-01408-x","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s11864-026-01408-x.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,4]],"date-time":"2026-08-04T10:18:09Z","timestamp":1785838689000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s11864-026-01408-x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,8,4]]},"references-count":101,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2026,12]]}},"alternative-id":["1408"],"URL":"https:\/\/doi.org\/10.1007\/s11864-026-01408-x","relation":{},"ISSN":["1527-2729","1534-6277"],"issn-type":[{"value":"1527-2729","type":"print"},{"value":"1534-6277","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,8,4]]},"assertion":[{"value":"24 June 2026","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"28 July 2026","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"4 August 2026","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"The authors declare no competing interests.","order":1,"name":"Ethics","label":"Competing interests","group":{"name":"EthicsHeading","label":"Declarations"}}],"article-number":"42"}}