{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,21]],"date-time":"2025-10-21T14:58:05Z","timestamp":1761058685921},"reference-count":31,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2002,1,1]],"date-time":"2002-01-01T00:00:00Z","timestamp":1009843200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2002,1,1]],"date-time":"2002-01-01T00:00:00Z","timestamp":1009843200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Curr Allergy Asthma Rep"],"published-print":{"date-parts":[[2002,1]]},"DOI":"10.1007\/s11882-002-0035-9","type":"journal-article","created":{"date-parts":[[2007,6,2]],"date-time":"2007-06-02T17:35:02Z","timestamp":1180805702000},"page":"34-39","update-policy":"http:\/\/dx.doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":30,"title":["Antiepileptic hypersensitivity syndrome: Clinicians beware and be aware"],"prefix":"10.1007","volume":"2","author":[{"given":"Olga","family":"Bessmertny","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Trinh","family":"Pham","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","reference":[{"key":"35_CR1","doi-asserted-by":"publisher","first-page":"1252","DOI":"10.1345\/aph.19062","volume":"33","author":"MJ Tafreshi","year":"1999","unstructured":"Tafreshi MJ, Melby MJ, Kaback KR, et al.: Medication-related visits to the emergency department: a prospective study. Ann Pharmacother. 1999, 33:1252\u20131257.","journal-title":"Ann Pharmacother."},{"key":"35_CR2","doi-asserted-by":"publisher","first-page":"1200","DOI":"10.1001\/jama.279.15.1200","volume":"279","author":"J Lazarou","year":"1998","unstructured":"Lazarou J, Pomeranz BH, Corey PN: Incidence of adverse drug reactions in hospitalized patients: a meta-analysis of prospective studies. JAMA 1998, 279:1200\u20131205. This reference is important because it is one of the largest metaanalyses on the incidence of adverse drug reactions.","journal-title":"JAMA"},{"key":"35_CR3","first-page":"765","volume":"137","author":"M Bigby","year":"2001","unstructured":"Bigby M: Rates of cutaneous reaction to drugs. Arch Dermatol 2001, 137:765\u2013770.","journal-title":"Arch Dermatol"},{"key":"35_CR4","first-page":"373","volume":"51","author":"IB Silbert","year":"1934","unstructured":"Silbert IB, Epstein JW: The treatment of chorea with phenylethyl-hydantoin: a study of 28 cases. Arch Pediatr 1934, 51:373\u2013382.","journal-title":"Arch Pediatr"},{"key":"35_CR5","doi-asserted-by":"publisher","first-page":"46","DOI":"10.1046\/j.1525-1470.1999.99014.x","volume":"16","author":"TS Brown","year":"1999","unstructured":"Brown TS, Appel JE, Kasteler JS, et al.: Hypersensitivity reaction in a child due to lamotrigine. Pediatr Dermatol 1999, 16:46\u201349.","journal-title":"Pediatr Dermatol"},{"key":"35_CR6","doi-asserted-by":"publisher","first-page":"557","DOI":"10.1345\/aph.18383","volume":"33","author":"E Mylonakis","year":"1999","unstructured":"Mylonakis E, Vittorio CC, Hollik DA, et al.: Lamotrigine overdose presenting as anticonvulsant hypersensitivity syndrome. Ann Pharmacother 1999, 33:557\u2013559.","journal-title":"Ann Pharmacother"},{"key":"35_CR7","doi-asserted-by":"crossref","first-page":"1172","DOI":"10.1212\/WNL.51.4.1172","volume":"51","author":"RG Schlienger","year":"1998","unstructured":"Schlienger RG, Knowles SR, Shear NH: Lamotrigine-associated anticonvulsant hypersensitivity syndrome. Neurology 1998, 51:1172\u20131175.","journal-title":"Neurology"},{"key":"35_CR8","first-page":"152","volume":"22","author":"AL Licata","year":"1996","unstructured":"Licata AL, Louis ED: Anticonvulsant hypersensitivity syndrome. Compr Ther 1996, 22:152\u2013155.","journal-title":"Compr Ther"},{"issue":"suppl 14","key":"35_CR9","first-page":"22","volume":"62","author":"AA Hebert","year":"2001","unstructured":"Hebert AA, Ralston JP: Cutaneous reactions to anticonvulsant medications. J Clin Psychiatry 2001, 62(suppl 14):22\u201326. Excellent review article describing clinical spectrum of cutaneous reactions to antiepileptics with recommendations for treatment.","journal-title":"J Clin Psychiatry"},{"key":"35_CR10","first-page":"503","volume":"17","author":"SR Knowles","year":"1999","unstructured":"Knowles SR, Shapiro LE, Shear NH: Anticonvulsant hypersensitivity syndrome: incidence, prevention, management. Drug Safety 1999, 17:503\u2013506.","journal-title":"Drug Safety"},{"key":"35_CR11","doi-asserted-by":"crossref","first-page":"542","DOI":"10.1212\/WNL.49.2.542","volume":"49","author":"P Tennis","year":"1997","unstructured":"Tennis P, Stern R: Risk of serious cutaneous disorders after initiation of the use of phenytoin, cabamazepine, or sodium valproate: a record linkage study. Neurology 1997, 49:542\u2013546.","journal-title":"Neurology"},{"key":"35_CR12","unstructured":"Disabilities among children aged < 17 years\u2014United States, 1991\u20131992. MMWR Morb Mortal Wkly Rep 1995, 44:609-612."},{"key":"35_CR13","unstructured":"Current trends in prevalence of self-reported epilepsy\u2014United States, 1986\u20131990. MMWR Morb Mortal Wkly Rep 1994, 43:810\u2013811, 817\u2013818."},{"key":"35_CR14","doi-asserted-by":"publisher","first-page":"631","DOI":"10.1016\/0002-9343(91)90216-K","volume":"91","author":"MA Gennis","year":"1991","unstructured":"Gennis MA, Vemuri R, Burns EA, et al.: Familial occurrence of hypersensitivity to phenytoin. Am J Med 1991, 91:631\u2013634.","journal-title":"Am J Med"},{"key":"35_CR15","doi-asserted-by":"publisher","first-page":"1231","DOI":"10.1046\/j.1365-2133.2001.04239.x","volume":"144","author":"M Aihara","year":"2001","unstructured":"Aihara M, Sugita Y, Takahashi S, et al.: Anticonvulsant hypersensitivity syndrome associated with reactivation of cytomegalovirus. Br J Dermatol 2001, 144:1231\u20131234.","journal-title":"Br J Dermatol"},{"key":"35_CR16","first-page":"364","volume":"13","author":"GA Kennebeck","year":"2000","unstructured":"Kennebeck GA: Anticonvulsant hypersensitivity syndrome. J Am Board Fam Pract 2000, 13:364\u2013370.","journal-title":"J Am Board Fam Pract"},{"key":"35_CR17","doi-asserted-by":"publisher","first-page":"727","DOI":"10.1016\/S0749-0704(05)70366-3","volume":"13","author":"AR Morkunas","year":"1997","unstructured":"Morkunas AR, Miller MB: Anticonvulsant hypersensitivity syndrome. Crit Care Clin 1997, 13:727\u2013739.","journal-title":"Crit Care Clin"},{"key":"35_CR18","doi-asserted-by":"publisher","first-page":"2190","DOI":"10.1016\/S0140-6736(98)05418-X","volume":"353","author":"B Rzany","year":"1999","unstructured":"Rzany B, Correia O, Kelly JP, et al.: Risk of Stevens-Johnson syndrome and toxic epidermal necrolysis during first weeks of antiepileptic therapy: a case-control study. Study Group of the International Case Control Study on Severe Cutaneous Adverse Reactions. Lancet 1999, 353:2190\u20132194.","journal-title":"Lancet"},{"key":"35_CR19","doi-asserted-by":"publisher","first-page":"533","DOI":"10.1345\/aph.10284","volume":"35","author":"O Bessmertny","year":"2001","unstructured":"Bessmertny O, Hatton RC, Gonzalez-Peralta RP: Antiepileptic hypersensitivity syndrome in children. Ann Pharmacother 2001, 35:533\u2013538. The only published case series describing clinical features, management, and outcomes of antiepileptic hypersensitivity syndrome in pediatric patients.","journal-title":"Ann Pharmacother"},{"key":"35_CR20","first-page":"728","volume":"6","author":"TR Prosser","year":"1987","unstructured":"Prosser TR, Lander R: Phenytoin-induced hypersensitivity reactions. Clin Pharm 1987, 6:728\u2013734.","journal-title":"Clin Pharm"},{"key":"35_CR21","doi-asserted-by":"crossref","first-page":"1480","DOI":"10.1212\/WNL.29.11.1480","volume":"29","author":"F Haruda","year":"1979","unstructured":"Haruda F: Phenytoin hypersensitivity: 38 cases. Neurology 1979, 29:1480\u20131485.","journal-title":"Neurology"},{"key":"35_CR22","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1177\/000992280003900206","volume":"39","author":"J Chinen","year":"2000","unstructured":"Chinen J, Piecuch S: Anticonvulsant hypersensitivity syndrome vs Kawasaki disease: a challenging clinical diagnosis with therapeutic implications. Clin Pediatr 2000, 39:109\u2013111.","journal-title":"Clin Pediatr"},{"key":"35_CR23","doi-asserted-by":"publisher","first-page":"517","DOI":"10.1016\/S0009-9120(00)00146-6","volume":"33","author":"MG Neuman","year":"2000","unstructured":"Neuman MG, Malkiewicz IM, Shear NH: A novel lymphocyte toxicity assay to assess drug hypersensitivity syndrome. Clin Biochem 2000, 33:517\u2013524. One of the few published reports with a detailed description of lymphocyte toxicity assay.","journal-title":"Clin Biochem"},{"key":"35_CR24","doi-asserted-by":"publisher","first-page":"985","DOI":"10.1111\/j.1528-1157.1999.tb00807.x","volume":"40","author":"AH Guberman","year":"1999","unstructured":"Guberman AH, Besag FMC, Brodie MJ, et al.: Lamotrigineassociated rash: risk\/benefit considerations in adults and children. Epilepsia 1999, 40:985\u2013991.","journal-title":"Epilepsia"},{"key":"35_CR25","first-page":"1193","volume":"309","author":"NA Vick","year":"1983","unstructured":"Vick NA: Suppression of carbamazepine-induced skin rash with prednisone. N Engl J Med 1983, 309:1193\u20131194.","journal-title":"N Engl J Med"},{"key":"35_CR26","doi-asserted-by":"crossref","first-page":"144","DOI":"10.1212\/WNL.41.1.144","volume":"41","author":"JM Murphy","year":"1991","unstructured":"Murphy JM, Mashman J, Miller JD, et al.: Suppression of carbamazepine-induced rash with prednisone. Neurology 1991, 41:144\u2013145.","journal-title":"Neurology"},{"key":"35_CR27","doi-asserted-by":"publisher","first-page":"231","DOI":"10.1016\/S0887-8994(99)00137-X","volume":"22","author":"R Straussberg","year":"2000","unstructured":"Straussberg R, Harel L, Ben-Amitai D, et al.: Carbamazepineinduced Stevens-Johnson syndrome treated with IV steroids and IVIG. Pediatr Neurol 2000, 22:231\u2013233.","journal-title":"Pediatr Neurol"},{"issue":"1","key":"35_CR28","doi-asserted-by":"publisher","first-page":"E14","DOI":"10.1542\/peds.107.1.e14","volume":"107","author":"O Scheuerman","year":"2001","unstructured":"Scheuerman O, Nofech-Moses Y, Rachmel A, et al.: Successful treatment of antiepileptic drug hypersensitivity syndrome with intravenous immune globulin. Pediatrics 2001, 107(1):E14.","journal-title":"Pediatrics"},{"issue":"suppl 7","key":"35_CR29","doi-asserted-by":"publisher","first-page":"S17","DOI":"10.1111\/j.1528-1157.1998.tb01680.x","volume":"39","author":"ML Griebel","year":"1998","unstructured":"Griebel ML: Acute management of hypersensivitivy reactions and seizures. Epilepsia 1998, 39(suppl 7):S17-S21.","journal-title":"Epilepsia"},{"key":"35_CR30","doi-asserted-by":"publisher","first-page":"1826","DOI":"10.1172\/JCI113798","volume":"82","author":"NH Shear","year":"1988","unstructured":"Shear NH, Spielberg SP: Anticonvulsant hypersensitivity syndrome: in vitro assessment of risk. J Clin Invest 1988, 82:1826\u20131832.","journal-title":"J Clin Invest"},{"key":"35_CR31","doi-asserted-by":"publisher","first-page":"137","DOI":"10.1097\/00007691-199902000-00022","volume":"21","author":"JC DeToledo","year":"1999","unstructured":"DeToledo JC, Minagar A, Lowe MR, et al.: Skin eruption with gabapentin in a patient with repeated AED-induced Stevens-Johnson\u2019s syndrome. Ther Drug Monit 1999, 21:137\u2013138.","journal-title":"Ther Drug Monit"}],"container-title":["Current Allergy and Asthma Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s11882-002-0035-9.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s11882-002-0035-9\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s11882-002-0035-9","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s11882-002-0035-9.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,7,29]],"date-time":"2022-07-29T10:17:10Z","timestamp":1659089830000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s11882-002-0035-9"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2002,1]]},"references-count":31,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2002,1]]}},"alternative-id":["35"],"URL":"https:\/\/doi.org\/10.1007\/s11882-002-0035-9","relation":{},"ISSN":["1529-7322","1534-6315"],"issn-type":[{"value":"1529-7322","type":"print"},{"value":"1534-6315","type":"electronic"}],"subject":[],"published":{"date-parts":[[2002,1]]},"assertion":[{"value":"This content has been made available to all.","name":"free","label":"Free to read"}]}}