{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T05:29:59Z","timestamp":1761974999957},"reference-count":54,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2002,1,1]],"date-time":"2002-01-01T00:00:00Z","timestamp":1009843200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Curr Allergy Asthma Rep"],"published-print":{"date-parts":[[2002,1]]},"DOI":"10.1007\/s11882-002-0036-8","type":"journal-article","created":{"date-parts":[[2007,6,2]],"date-time":"2007-06-02T17:35:02Z","timestamp":1180805702000},"page":"40-45","source":"Crossref","is-referenced-by-count":23,"title":["Idiopathic anaphylaxis"],"prefix":"10.1007","volume":"2","author":[{"given":"Johannes","family":"Ring","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ulf","family":"Darsow","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","reference":[{"key":"36_CR1","doi-asserted-by":"crossref","first-page":"1225","DOI":"10.1016\/S0140-6736(97)07302-9","volume":"351","author":"The International Study of Asthma and Allergies in Childhood (ISAAC) Steering Committee","year":"1998","unstructured":"The International Study of Asthma and Allergies in Childhood (ISAAC) Steering Committee: Worldwide variation in prevalence of symptoms of asthma, allergic rhinoconjunctivitis, and atopic eczema. Lancet 1998, 351:1225\u20131232.","journal-title":"Lancet"},{"key":"36_CR2","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1159\/000235067","volume":"90","author":"B W\u00fcthrich","year":"1989","unstructured":"W\u00fcthrich B: Epidemiology of the allergic diseases: are they really on the increase? Int Arch Allergy Appl Immunol 1989, 90:3\u201310.","journal-title":"Int Arch Allergy Appl Immunol"},{"key":"36_CR3","doi-asserted-by":"crossref","first-page":"701","DOI":"10.1016\/S0952-7915(01)00282-5","volume":"13","author":"J Ring","year":"2001","unstructured":"Ring J, Kr\u00e4mer U, Sch\u00e4fer T, Behrendt H: Why are allergies increasing? Curr Opin Immunol 2001, 13:701\u2013708.","journal-title":"Curr Opin Immunol"},{"key":"36_CR4","volume-title":"Allergy: Theory and Practice","author":"PE Korenblat","year":"1992","unstructured":"Korenblat PE, Wedner HJ: Allergy: Theory and Practice, edn. 2. Philadelphia: WB Saunders; 1992.","edition":"edn. 2"},{"key":"36_CR5","first-page":"249","volume-title":"Allergie 2000: Probleme, Strategien und praktische Konsequenzen","author":"U M\u00fcller","year":"2001","unstructured":"M\u00fcller U: Sp\u00e4tkomplikationen bei Anaphylaxie. In Allergie 2000: Probleme, Strategien und praktische Konsequenzen. Edited by Ring J, Darsow U. M\u00fcnchen, Germany: Dustri; 2001:249\u2013252."},{"key":"36_CR6","doi-asserted-by":"crossref","first-page":"452","DOI":"10.1016\/S0091-6749(99)70392-1","volume":"104","author":"MW Yocum","year":"1999","unstructured":"Yocum MW, Butterfield JH, Klein JS, et al.: Epidemiology of anaphylaxis in Olmsted County: A population-based study. J Allergy Clin Immunol 1999, 104:452\u2013456. Few data on anaphylaxis are available on a population-based study background. This study provides evidence for prevalence that previously was assumed from clinical observations.","journal-title":"J Allergy Clin Immunol"},{"key":"36_CR7","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1056\/NEJM199106203242506","volume":"324","author":"BS Bochner","year":"1991","unstructured":"Bochner BS, Lichtenstein LM: Anaphylaxis. N Engl J Med 1991, 324:81\u201388.","journal-title":"N Engl J Med"},{"key":"36_CR8","doi-asserted-by":"crossref","first-page":"637","DOI":"10.1016\/S0091-6749(95)70329-2","volume":"95","author":"JS Klein","year":"1995","unstructured":"Klein JS, Yocum MW: Underreporting of anaphylaxis in a community emergency room. J Allergy Clin Immunol 1995, 95:637\u2013638.","journal-title":"J Allergy Clin Immunol"},{"key":"36_CR9","doi-asserted-by":"crossref","first-page":"288","DOI":"10.1111\/j.1398-9995.1989.tb01071.x","volume":"44","author":"HT Sorensen","year":"1989","unstructured":"Sorensen HT, Nielsen B, Ostergaard Nielsen J: Anaphylactic shock occurring outside hospitals. Allergy 1989, 44:288\u2013290.","journal-title":"Allergy"},{"key":"36_CR10","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1016\/S0091-6749(99)70363-5","volume":"104","author":"S Weiler","year":"1999","unstructured":"Weiler S: Anaphylaxis in the general population: a frequent and occasionally fatal disorder that is underrecognized. J Allergy Clin Immunol 1999, 104:271\u2013273.","journal-title":"J Allergy Clin Immunol"},{"key":"36_CR11","doi-asserted-by":"crossref","first-page":"387","DOI":"10.1007\/BF02737644","volume":"17","author":"J Ring","year":"1999","unstructured":"Ring J, Behrendt H: Anaphylaxis and anaphylactoid reactions. classification and pathophysiology. Clin Rev Allergy Immunol 1999, 17:387\u2013399.","journal-title":"Clin Rev Allergy Immunol"},{"key":"36_CR12","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1111\/j.1600-0536.1986.tb01272.x","volume":"15","author":"J Ring","year":"1986","unstructured":"Ring J, Galosi A, Przybilla B: Contact anaphylaxis from emulgade F. Contact Dermatitis 1986, 15:49\u201340.","journal-title":"Contact Dermatitis"},{"key":"36_CR13","first-page":"170","volume":"54","author":"C Richet","year":"1902","unstructured":"Richet C, Portier P: De l\u2019action anaphylactique de certains venins. C R Soc Biol (Paris) 1902, 54:170.","journal-title":"C R Soc Biol (Paris)"},{"key":"36_CR14","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1159\/000231676","volume":"52","author":"H Hedin","year":"1976","unstructured":"Hedin H, Richter W, Ring J: Dextran-induced anaphylactoid reactions in man. Int Arch Allergy Appl Immunol 1976, 52:145\u2013159.","journal-title":"Int Arch Allergy Appl Immunol"},{"key":"36_CR15","doi-asserted-by":"crossref","first-page":"466","DOI":"10.1016\/S0140-6736(77)91953-5","volume":"1","author":"J Ring","year":"1977","unstructured":"Ring J, Messmer K: Incidence and severity of anaphylactoid reactions to colloid volume substitutes. Lancet 1977, 1:466\u2013469.","journal-title":"Lancet"},{"key":"36_CR16","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1111\/j.1748-1716.1979.tb06389.x","volume":"106","author":"G Smedegard","year":"1979","unstructured":"Smedegard G, Reven\u00e4s B, Arfors KE: Anaphylaxis in the monkey: hemodynamics and blood flow distribution. Acta Physiol Scand 1979, 106:191.","journal-title":"Acta Physiol Scand"},{"key":"36_CR17","doi-asserted-by":"crossref","first-page":"1072","DOI":"10.1172\/JCI109936","volume":"66","author":"PL Smith","year":"1980","unstructured":"Smith PL, Kagey-Sobotka A, Bleecker ER et al.: Physiologic manifestations of human anaphylaxis. J Clin Invest 1980, 66:1072\u20131080.","journal-title":"J Clin Invest"},{"key":"36_CR18","doi-asserted-by":"crossref","first-page":"597","DOI":"10.1056\/NEJM196403192701202","volume":"270","author":"LP James","year":"1964","unstructured":"James LP, Austen KF: Fatal systemic anaphylaxis in man. N Engl J Med 1964, 270:597\u2013603.","journal-title":"N Engl J Med"},{"key":"36_CR19","doi-asserted-by":"crossref","first-page":"1749","DOI":"10.1001\/archinte.1995.00430160077008","volume":"155","author":"SF Kemp","year":"1995","unstructured":"Kemp SF, Lockey RF, Wolf BL, Lieberman P: Anaphylaxis: a review of 266 cases. Arch Intern Med 1995, 155:1749\u20131754.","journal-title":"Arch Intern Med"},{"key":"36_CR20","doi-asserted-by":"crossref","first-page":"666","DOI":"10.1016\/S0091-6749(87)80164-1","volume":"79","author":"RF Lockey","year":"1987","unstructured":"Lockey RF, Benedict LM, Turkeltaub TB, Bukantz SC: Fatalities from immunotherapy (IT) and skin testing (ST). J Allergy Clin Immunol 1987, 79:666\u2013677.","journal-title":"J Allergy Clin Immunol"},{"key":"36_CR21","doi-asserted-by":"crossref","first-page":"1144","DOI":"10.1046\/j.1365-2222.2000.00864.x","volume":"30","author":"RS Pumphrey","year":"2000","unstructured":"Pumphrey RS: Lessons for management of anaphylaxis from a study of fatal reactions. Clin Exp Allergy 2000, 30:1144\u20131150.","journal-title":"Clin Exp Allergy"},{"key":"36_CR22","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1016\/0091-6749(86)90117-X","volume":"78","author":"BJ Stark","year":"1986","unstructured":"Stark BJ, Sullivan TJ: Biphasic and protracted anaphylaxis. J Allergy Clin Immunol 1986, 78:76\u201383.","journal-title":"J Allergy Clin Immunol"},{"key":"36_CR23","volume-title":"Late Phase Reactions","year":"1991","unstructured":"Dorsch W, ed.: Late Phase Reactions. Boca Raton, FL: CRC Press; 1991."},{"key":"36_CR24","doi-asserted-by":"crossref","first-page":"520","DOI":"10.1161\/01.RES.36.4.520","volume":"36","author":"N Capurro","year":"1975","unstructured":"Capurro N, Levi R: The heart as target organ in systemic allergic reactions: Circ Res 1975, 36:520\u2013528.","journal-title":"Circ Res"},{"key":"36_CR25","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1177\/0310057X8601400105","volume":"17","author":"MMD Fisher","year":"1986","unstructured":"Fisher MMD: Clinical observations on the pathophysiology and treatment of anaphylactic cardiovascular collapse. Anesth Intensive Care 1986, 17:17\u201321.","journal-title":"Anesth Intensive Care"},{"key":"36_CR26","doi-asserted-by":"crossref","first-page":"72","DOI":"10.1159\/000236935","volume":"107","author":"G Marone","year":"1995","unstructured":"Marone G, Patelle V, de Crescanzo A, Genovese M: Human heart mast cells in anaphylaxis and cardiovascular disease. Int Arch Allergy Immunol 1995, 107:72\u201375.","journal-title":"Int Arch Allergy Immunol"},{"key":"36_CR27","doi-asserted-by":"crossref","first-page":"941","DOI":"10.1007\/BF01716952","volume":"60","author":"K Pavek","year":"1982","unstructured":"Pavek K, Wegmann A, Nordstr\u00f6m L, Schwander D: Cardiovascular and respiratory mechanisms in anaphylactic and anaphylactoid shock reactions. Klin Wochenschr 1982, 60:941\u2013947.","journal-title":"Klin Wochenschr"},{"key":"36_CR28","doi-asserted-by":"crossref","first-page":"2161","DOI":"10.1001\/jama.1982.03330170065033","volume":"248","author":"TJ Sullivan","year":"1982","unstructured":"Sullivan TJ: Cardiac disorders in penicillin-induced anaphylaxis: association with intravenous epinephrine therapy. JAMA 1982, 248:2161.","journal-title":"JAMA"},{"key":"36_CR29","doi-asserted-by":"crossref","first-page":"525","DOI":"10.1520\/JFS10141J","volume":"17","author":"C Delage","year":"1972","unstructured":"Delage C, Irey HC: Anaphylactic deaths: a clinicopathologic study of 43 cases. J Forensic Sci 1972, 17:525\u2013540.","journal-title":"J Forensic Sci"},{"key":"36_CR30","doi-asserted-by":"crossref","first-page":"2881","DOI":"10.1001\/jama.1987.03400200087009","volume":"258","author":"MD Valentine","year":"1987","unstructured":"Valentine MD, Lichtenstein LM: Anaphylaxis and stinging insect hypersensitivity. JAMA 1987, 258:2881\u20132885.","journal-title":"JAMA"},{"key":"36_CR31","doi-asserted-by":"crossref","first-page":"106","DOI":"10.1016\/0091-6749(80)90056-1","volume":"66","author":"AL Sheffer","year":"1980","unstructured":"Sheffer AL, Austen KF: Exercise-induced anaphylaxis. J Allergy Clin Immunol 1980, 66:106\u2013111.","journal-title":"J Allergy Clin Immunol"},{"key":"36_CR32","first-page":"987","volume":"6","author":"SB Felix","year":"1990","unstructured":"Felix SB, Baumann G, Hashemi T, et al.: Characterization of cardiovascular events mediated by the platelet-activating factor during systemic anaphylaxis. J Cardiovasc Pharmacol 1990, 6:987\u2013997. Platelet-activating factor as a mediator in anaphylaxis may explain cardiovascular symptoms.","journal-title":"J Cardiovasc Pharmacol"},{"key":"36_CR33","doi-asserted-by":"crossref","first-page":"458","DOI":"10.1016\/S0091-6749(97)70135-0","volume":"100","author":"K Brockow","year":"1997","unstructured":"Brockow K, Kiehn M, Rietm\u00fcller C, et al.: Efficacy of antihistamine pretreatment in the prevention of adverse reactions to hymenopta venom immunotherapy: a prospective randomized placebo-controlled trial. J Allergy Clin Immunol 1997, 100:458\u2013463.","journal-title":"J Allergy Clin Immunol"},{"key":"36_CR34","doi-asserted-by":"crossref","first-page":"264","DOI":"10.1213\/00000539-198908000-00030","volume":"69","author":"H De Soto","year":"1989","unstructured":"De Soto H, Turk P: Cimetidine in anaphylactic shock refractory to standard therapy. Anesth Analg 1989, 69:264\u2013265.","journal-title":"Anesth Analg"},{"key":"36_CR35","doi-asserted-by":"crossref","first-page":"1304","DOI":"10.1056\/NEJM200104263441707","volume":"344","author":"MS Eisenberg","year":"2001","unstructured":"Eisenberg MS, Mengest TJ: Cardiac resuscitation. New Engl J Med 2001, 344:1304\u20131313.","journal-title":"New Engl J Med"},{"key":"36_CR36","volume-title":"Allergy","year":"2001","unstructured":"Holgate T, Church MK, Lichtenstein LM, eds: Allergy, edn 2. London: Mosby; 2001.","edition":"edn 2"},{"key":"36_CR37","doi-asserted-by":"crossref","first-page":"1040","DOI":"10.1542\/peds.106.5.1040","volume":"106","author":"FE Simons","year":"2000","unstructured":"Simons FE, Gu X, Johnston LM, Simons KJ: Can epinephrine inhalations be substituted for epinephrine injection in children at risk for systemic anaphylaxis? Pediatrics 2000, 106:1040\u20131044.","journal-title":"Pediatrics"},{"key":"36_CR38","first-page":"211","volume":"3","author":"M Tryba","year":"1994","unstructured":"Tryba M, Ahnefeld FW, Barth J, et al.: Akuttherapie anaphylaktoider Reaktionen. Ergebnisse einer interdisziplin\u00e4ren Konsensuskonferenz. Allergo J 1994, 3:211\u2013222.","journal-title":"Allergo J"},{"key":"36_CR39","volume-title":"Care of the Critically Ill Patient","author":"K Me\u03b2mer","year":"1983","unstructured":"Me\u03b2mer K: Plasma substitutes and indications for their use. In Care of the Critically Ill Patient. Edited by Tinker J, Rapin M. Berlin: Springer; 1983."},{"key":"36_CR40","doi-asserted-by":"crossref","first-page":"331","DOI":"10.1148\/132.2.331","volume":"132","author":"B Endrich","year":"1979","unstructured":"Endrich B, Ring J, Intaglietta M: Effects of radiopaque contrast media on the microcirculation of the rabbit omentum. Radiology 1979, 132:331\u2013339.","journal-title":"Radiology"},{"key":"36_CR41","first-page":"1079","volume-title":"Allergy: Principles and Practice","author":"P Lieberman","year":"1998","unstructured":"Lieberman P: Anaphylaxis and anaphylactoid reactions. In Allergy: Principles and Practice, vol 2, edn 5. Edited by Middleton E, Ellis EF, Yunginger JW, et al. St. Louis: Mosby Year-Book; 1998:1079\u20131902.","edition":"edn 5"},{"key":"36_CR42","doi-asserted-by":"crossref","first-page":"190","DOI":"10.1007\/BF01533368","volume":"14","author":"LB Schwartz","year":"1994","unstructured":"Schwartz LB, Bradford TR, Rouse C, et al.: Development of a new, more sensitive immunoassay for human tryptase: use in systemic anaphylaxis. J Clin Immunol 1994, 14:190\u2013204.","journal-title":"J Clin Immunol"},{"key":"36_CR43","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1016\/S0091-6749(99)70141-7","volume":"104","author":"K Brockow","year":"1999","unstructured":"Brockow K, Vieluf D, P\u00fcschel K, et al.: Increased postmortem serum mast cell tryptase in a fatal anaphylactoid reaction to nonionic radiocontrast medium. J Allergy Clin Immunol 1999, 104:237\u2013238. Description of methods to provide post-mortem evidence of anaphylaxis.","journal-title":"J Allergy Clin Immunol"},{"key":"36_CR44","first-page":"113","volume":"59","author":"A Szczeklik","year":"1987","unstructured":"Szczeklik A: Adverse reactions to aspirin and nonsteroidal antiinflammatory drugs. Ann Allergy 1987, 59:113\u2013118.","journal-title":"Ann Allergy"},{"key":"36_CR45","first-page":"1536","volume":"308","author":"PJ Hannaway","year":"1983","unstructured":"Hannaway PJ, Hoppler GDK: Severe anaphylaxis and drug induced beta-blockage. N Engl J Med 1983, 308:1536.","journal-title":"N Engl J Med"},{"key":"36_CR46","doi-asserted-by":"crossref","first-page":"1414","DOI":"10.1056\/NEJM198312083092303","volume":"309","author":"MJ Brown","year":"1983","unstructured":"Brown MJ, Brown DC, Murphy MB: Hypokalemia from beta-2-receptor stimulation by circulating epinephrine. N Engl J Med 1983, 309:1414\u20131419. Low levels of angiotensin II are associated with more severe anaphylactic symptoms.","journal-title":"N Engl J Med"},{"key":"36_CR47","doi-asserted-by":"crossref","first-page":"65","DOI":"10.7326\/0003-4819-105-1-65","volume":"105","author":"GP Zaloga","year":"1986","unstructured":"Zaloga GP, Delacey W, Holmboe E, Chernow B: Glucagon reversal of hypotension in a case of anaphylactoid shock. Ann Intern Med 1986, 105:65\u201366.","journal-title":"Ann Intern Med"},{"key":"36_CR48","doi-asserted-by":"crossref","first-page":"757","DOI":"10.1016\/S0889-8561(22)00073-X","volume":"11","author":"RF Horan","year":"1991","unstructured":"Horan RF, Sheffer AL: Food-dependent, exercise-induced anaphylaxis. Immunol Allergy Clin North Am 1991, 11:757.","journal-title":"Immunol Allergy Clin North Am"},{"key":"36_CR49","doi-asserted-by":"crossref","first-page":"433","DOI":"10.1016\/0091-6749(79)90218-5","volume":"63","author":"RM Maulitz","year":"1979","unstructured":"Maulitz RM, Pratt DS, Schocket AL: Exercise-induced anaphylactic reaction to shellfish. J Allergy Clin Immunol 1979, 63:433\u2013434.","journal-title":"J Allergy Clin Immunol"},{"key":"36_CR50","first-page":"53","volume":"128","author":"CL Rohrer","year":"1998","unstructured":"Rohrer CL, Pichler WJ, Helbling A, et al.: Anaphylaxis: clinical aspects, etiology and course in 118 patients [in German]. Schweiz Med Wochenschr 1998, 128:53\u201363.","journal-title":"Schweiz Med Wochenschr"},{"key":"36_CR51","doi-asserted-by":"crossref","first-page":"849","DOI":"10.1016\/0091-6749(88)90089-9","volume":"82","author":"CA Wiggins","year":"1988","unstructured":"Wiggins CA, Dykowicz MS, Patterson R: Idiopathic anaphylaxis. Classification, evaluation and treatment of 123 patients. J Allergy Clin Immunol 1988, 82:849\u2013855.","journal-title":"J Allergy Clin Immunol"},{"key":"36_CR52","doi-asserted-by":"crossref","first-page":"361","DOI":"10.1016\/S0140-6736(00)03647-3","volume":"357","author":"B Przybilla","year":"2001","unstructured":"Przybilla B, Ludolph-Hauser D, Rueff F, et al.: Constitutively raised serum concentrations of mast-cell tryptase and severe anaphylactic reactions to Hymenoptera stings. Lancet 2001, 357:361\u2013362. Occult systemic mastocytosis described as underestimated cause for anaphylactic reactions.","journal-title":"Lancet"},{"key":"36_CR53","first-page":"1599","volume":"328","author":"MW Greaves","year":"1995","unstructured":"Greaves MW, Hide M, Francis DM, Grattan CEH: Autoantibodies against the high affinity IgE receptor as a cause for histamine release in chronic urticaria. N Engl J Med 1995, 328:1599\u20131604. This paper describes a new pathophysiologic mechanism of chronic idiopathic urticaria.","journal-title":"N Engl J Med"},{"key":"36_CR54","doi-asserted-by":"crossref","first-page":"285","DOI":"10.1016\/0091-6749(87)90033-9","volume":"80","author":"JE Slater","year":"1987","unstructured":"Slater JE, Kaliner M: Effects of sex hormones on the histamine release in the recurrent idiopathic anaphylaxis. J Allergy Clin Immunol 1987, 80:285\u2013290.","journal-title":"J Allergy Clin Immunol"}],"container-title":["Current Allergy and Asthma Reports"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s11882-002-0036-8.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s11882-002-0036-8\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s11882-002-0036-8","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,5,12]],"date-time":"2023-05-12T04:26:01Z","timestamp":1683865561000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s11882-002-0036-8"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2002,1]]},"references-count":54,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2002,1]]}},"alternative-id":["36"],"URL":"https:\/\/doi.org\/10.1007\/s11882-002-0036-8","relation":{},"ISSN":["1529-7322","1534-6315"],"issn-type":[{"value":"1529-7322","type":"print"},{"value":"1534-6315","type":"electronic"}],"subject":[],"published":{"date-parts":[[2002,1]]}}}