{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,8]],"date-time":"2025-10-08T15:14:23Z","timestamp":1759936463657},"reference-count":48,"publisher":"Springer Science and Business Media LLC","issue":"6","license":[{"start":{"date-parts":[[2008,11,1]],"date-time":"2008-11-01T00:00:00Z","timestamp":1225497600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Curr Allergy Asthma Rep"],"published-print":{"date-parts":[[2008,11]]},"DOI":"10.1007\/s11882-008-0097-4","type":"journal-article","created":{"date-parts":[[2008,11,22]],"date-time":"2008-11-22T06:22:21Z","timestamp":1227334941000},"page":"533-539","source":"Crossref","is-referenced-by-count":25,"title":["Small airways disease in asthma"],"prefix":"10.1007","volume":"8","author":[{"given":"Jonathan","family":"Corren","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2008,11,23]]},"reference":[{"key":"97_CR1","first-page":"110","volume-title":"Asthma: Physiology, Immunopharmacology, and Treatment","author":"J.C. Hogg","year":"1993","unstructured":"Hogg JC: The pathology of asthma. In Asthma: Physiology, Immunopharmacology, and Treatment. Edited by Holgate ST, Austen KF, Lichtenstein LM, Kay AB. London: Academic Press; 1993:110\u2013135."},{"key":"97_CR2","doi-asserted-by":"crossref","first-page":"689","DOI":"10.1001\/archinte.1922.00110120002001","volume":"30","author":"H.L. Huber","year":"1922","unstructured":"Huber HL, Loessler K: The pathology of bronchial asthma. Arch Intern Med 1922, 30:689\u2013760.","journal-title":"Arch Intern Med"},{"key":"97_CR3","doi-asserted-by":"crossref","first-page":"110","DOI":"10.1007\/978-3-642-87553-3","volume-title":"Morphometry of the Human Lung","author":"E.R. Weibel","year":"1963","unstructured":"Weibel ER: Geometry and dimensions of airways conductive and transitory zone. In Morphometry of the Human Lung. New York: Springer-Verlag; 1963:110\u2013135."},{"key":"97_CR4","first-page":"233","volume":"23","author":"D.P. Tashkin","year":"2002","unstructured":"Tashkin DP: The role of small airway inflammation in asthma. Allergy Asthma Proc 2002, 23:233\u2013242.","journal-title":"Allergy Asthma Proc"},{"key":"97_CR5","doi-asserted-by":"crossref","first-page":"1016","DOI":"10.1152\/jappl.1992.72.3.1016","volume":"72","author":"M. Yanai","year":"1991","unstructured":"Yanai M, Sekizawa K, Ohrui T, et al.: Site of airway obstruction in pulmonary disease: direct measurement of intrabronchial pressure. J Appl Physiol 1991, 72:1016\u20131023.","journal-title":"J Appl Physiol"},{"key":"97_CR6","doi-asserted-by":"crossref","first-page":"1053","DOI":"10.1183\/09031936.98.12051053","volume":"12","author":"H.W. Mitchell","year":"1998","unstructured":"Mitchell HW, Cvetkowski R, Sparrow MP, et al.: Concurrent measurement of smooth muscle shortening, lumen narrowing, and flow to acetylcholine in large and small porcine bronchi. Eur Respir J 1998, 12:1053\u20131061.","journal-title":"Eur Respir J"},{"key":"97_CR7","doi-asserted-by":"crossref","first-page":"447","DOI":"10.1164\/ajrccm.157.2.9611043","volume":"157","author":"E.M. Wagner","year":"1998","unstructured":"Wagner EM, Bleecker ER, Permut S, Liu MC: Direct assessment of small airways reactivity in human subjects. Am J Respir Crit Care Med 1998, 157:447\u2013452.","journal-title":"Am J Respir Crit Care Med"},{"key":"97_CR8","doi-asserted-by":"crossref","first-page":"717","DOI":"10.1164\/ajrccm.150.3.8087342","volume":"150","author":"J.L. Ellis","year":"1994","unstructured":"Ellis JL, Hubbard WC, Meeker S, Unden BJ: Ragweed antigen E and anti-IgE in human central versus peripheral isolated bronchi. Am J Respir Crit Care Med 1994, 150:717\u2013723.","journal-title":"Am J Respir Crit Care Med"},{"key":"97_CR9","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1165\/ajrcmb\/8.1.35","volume":"8","author":"A.M. Bentley","year":"1993","unstructured":"Bentley AM, Meng Q, Robinson DS, et al.: Increases in activated T lymphocytes, eosinophils, and cytokine mRNA expression for granulocyte\/macrophage colony-stimulating factor in bronchial biopsies after allergen inhalation in atopic asthmatics. Am J Respir Cell Mol Biol 1993, 8:35\u201342.","journal-title":"Am J Respir Cell Mol Biol"},{"key":"97_CR10","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1136\/thx.8.3.207","volume":"8","author":"J.C. Houston","year":"1953","unstructured":"Houston JC, de Navaquez S, Trounce JR: A clinical and pathological study of fatal cases of status asthmaticus. Thorax 1953, 8:207\u2013213.","journal-title":"Thorax"},{"key":"97_CR11","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1136\/jcp.13.1.27","volume":"13","author":"M.S. Dunnill","year":"1960","unstructured":"Dunnill MS: The pathology of asthma, with special reference to changes in the bronchial mucosa. J Clin Pathol 1960, 13:27\u201333.","journal-title":"J Clin Pathol"},{"key":"97_CR12","doi-asserted-by":"crossref","first-page":"138","DOI":"10.1164\/ajrccm\/143.1.138","volume":"143","author":"M. Saetta","year":"1991","unstructured":"Saetta M, DiStafano A, Rosina C, et al.: Quantitative structural analysis of peripheral airways and arteries in sudden fatal asthma. Am Rev Respir Dis 1991, 143:138\u2013143.","journal-title":"Am Rev Respir Dis"},{"key":"97_CR13","doi-asserted-by":"crossref","first-page":"292","DOI":"10.1183\/09031936.97.10020292","volume":"10","author":"N. Carroll","year":"1997","unstructured":"Carroll N, Carello S, James A: The distribution of eosinophils and lymphocytes in the large and small airways of asthmatics. Eur Respir J 1997, 10:292\u2013300.","journal-title":"Eur Respir J"},{"key":"97_CR14","doi-asserted-by":"crossref","first-page":"301","DOI":"10.1183\/09031936.97.10020301","volume":"10","author":"J.L. Faul","year":"1997","unstructured":"Faul JL, Tormey VJ, Leonard C, et al.: Lung immunopathology in cases of sudden asthma death. Eur Respir J 1997, 10:301\u2013307.","journal-title":"Eur Respir J"},{"key":"97_CR15","doi-asserted-by":"crossref","first-page":"224","DOI":"10.1164\/ajrccm.154.1.8680684","volume":"154","author":"M. Synek","year":"1996","unstructured":"Synek M, Beasley R, Frew AJ, et al.: Cellular infiltration of the airways in asthma of varying severity. Am J Respir Crit Care Med 1996, 154:224\u2013230.","journal-title":"Am J Respir Crit Care Med"},{"key":"97_CR16","doi-asserted-by":"crossref","first-page":"565","DOI":"10.1164\/ajrccm.158.2.9705036","volume":"158","author":"K.J. Haley","year":"1998","unstructured":"Haley KJ, Sunday ME, Wiggs BR, et al.: Inflammatory cell distribution within and along asthmatic airways. Am J Respir Crit Care Med 1998, 158:565\u2013572.","journal-title":"Am J Respir Crit Care Med"},{"key":"97_CR17","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1016\/S0091-6749(97)70193-3","volume":"100","author":"Q. Hamid","year":"1997","unstructured":"Hamid Q, Song Y, Kotsimbos C, et al.: Inflammation of small airways in asthma. J Allergy Clin Immunol 1997, 100:44\u201351.","journal-title":"J Allergy Clin Immunol"},{"key":"97_CR18","doi-asserted-by":"crossref","first-page":"254","DOI":"10.1183\/09031936.02.00261102","volume":"303","author":"S. Balzar","year":"2002","unstructured":"Balzar S, Wenzel SE, Chu HW: Transbronchial biopsy as a tool to evaluate small airways in asthma. Eur Respir J 2002, 303:254\u2013259.","journal-title":"Eur Respir J"},{"key":"97_CR19","doi-asserted-by":"crossref","first-page":"228","DOI":"10.1164\/ajrccm.159.1.9804033","volume":"159","author":"M. Kraft","year":"1999","unstructured":"Kraft M, Martin RJ, Wilson S, et al.: Lymphocyte and eosinophil influx into alveolar tissue in nocturnal asthma. Am J Respir Crit Care Med 1999, 159:228\u2013234.","journal-title":"Am J Respir Crit Care Med"},{"key":"97_CR20","doi-asserted-by":"crossref","first-page":"983","DOI":"10.1016\/j.jaci.2005.07.029","volume":"116","author":"C. Bergeron","year":"2005","unstructured":"Bergeron C, Hauber HP, Gotfried M, et al.: Evidence of remodeling in peripheral airways of patients with mild to moderate asthma: effect of hydrofluoralkane-flunisolide. J Allergy Clin Immunol 2005, 116:983\u2013989.","journal-title":"J Allergy Clin Immunol"},{"key":"97_CR21","doi-asserted-by":"crossref","first-page":"479","DOI":"10.1067\/mai.2000.109054","volume":"106","author":"P. Christodoulopoulos","year":"2000","unstructured":"Christodoulopoulos P, Leung DY, Elliott MW, et al.: Increased number of glucocorticoid receptor-beta expressing cells in the airways in fatal asthma. J Allergy Clin Immunol 2000, 106:479\u2013484.","journal-title":"J Allergy Clin Immunol"},{"key":"97_CR22","doi-asserted-by":"crossref","first-page":"386","DOI":"10.1016\/S0091-6749(98)70252-0","volume":"101","author":"E.M. Minshall","year":"1998","unstructured":"Minshall EM, Hogg JC, Hamid QA: Cytokine mRNA expression in asthma is not restricted to the large airways. J Allergy Clin Immunol 1998, 101:386\u2013390.","journal-title":"J Allergy Clin Immunol"},{"key":"97_CR23","doi-asserted-by":"crossref","first-page":"476","DOI":"10.1016\/S0091-6749(99)70474-4","volume":"102","author":"R.A. Taha","year":"1999","unstructured":"Taha RA, Minshall EM, Miotto D, et al.: Eotaxin and monocyte chemotactic proten-4 mRNA expression in small airways of asthmatic and nonasthmatic individuals. J Allergy Clin Immunol 1999, 102:476\u2013483.","journal-title":"J Allergy Clin Immunol"},{"key":"97_CR24","doi-asserted-by":"crossref","first-page":"664","DOI":"10.1016\/j.jaci.2004.05.042","volume":"114","author":"C.H. Hung","year":"2004","unstructured":"Hung CH, Chen LC, Zhang Z, et al.: Regulation of Th2 responses by the pulmonary Clara cell secretory 10-kD protein. J Allergy Clin Immunol 2004, 114:664\u2013670.","journal-title":"J Allergy Clin Immunol"},{"key":"97_CR25","doi-asserted-by":"crossref","first-page":"930","DOI":"10.1164\/ajrccm.160.3.9803113","volume":"160","author":"N. Shijubo","year":"1999","unstructured":"Shijubo N, Itoh Y, Yamaguchi T, et al.: Clara cell proteinpositive epithelial cells are reduced in small airways of asthmatics. Am J Respir Crit Care Med 1999, 160:930\u2013933.","journal-title":"Am J Respir Crit Care Med"},{"key":"97_CR26","doi-asserted-by":"crossref","first-page":"725","DOI":"10.1016\/0002-9343(72)90078-2","volume":"52","author":"E.R. McFadden","year":"1972","unstructured":"McFadden ER, Linden DA: A reduction in maximum midexpiratory flow rate: a spirographic manifestation of small airways disease. Am J Med 1972, 52:725\u2013737.","journal-title":"Am J Med"},{"key":"97_CR27","doi-asserted-by":"crossref","first-page":"1046","DOI":"10.1016\/j.jaci.2004.03.016","volume":"113","author":"E.R. Sutherland","year":"2004","unstructured":"Sutherland ER, Martin RJ, Bowler RP, et al.: Physiologic correlates of distal lung inflammation in asthma. J Allergy Clin Immunol 2004, 113:1046\u20131050.","journal-title":"J Allergy Clin Immunol"},{"key":"97_CR28","doi-asserted-by":"crossref","first-page":"747","DOI":"10.1016\/0002-9343(72)90080-0","volume":"52","author":"D.S. McCarthy","year":"1972","unstructured":"McCarthy DS, Spencer R, Greene R, Milic-Emili J: Measurement of \u201cclosing volume\u201d as a single and sensitive test for early detection of small airway disease. Am J Med 1972, 52:747\u2013753.","journal-title":"Am J Med"},{"key":"97_CR29","doi-asserted-by":"crossref","first-page":"1277","DOI":"10.1056\/NEJM197806082982303","volume":"122","author":"M. Cosio","year":"1978","unstructured":"Cosio M, Ghezzo Hogg JC, Corbin R, et al.: The relations between structural changes in small airways and pulmonary function tests. N Engl J Med 1978, 122:1277\u20131281.","journal-title":"N Engl J Med"},{"key":"97_CR30","doi-asserted-by":"crossref","first-page":"1902","DOI":"10.1164\/ajrccm.161.6.9906075","volume":"161","author":"J.C. Veen In\u2019t","year":"2000","unstructured":"In\u2019t Veen JC, Beekman AJ, Bel EH, Sterk PJ: Recurrent exacerbations in severe asthma are associated with enhanced airway closure during stable episodes. Am J Respir Crit Care Med 2000, 161:1902\u20131906.","journal-title":"Am J Respir Crit Care Med"},{"key":"97_CR31","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1111\/j.1475-097X.2007.00772.x","volume":"28","author":"D. Aronsson","year":"2008","unstructured":"Aronsson D, Tufvesson E, Ankerst J, Bjermer L: Allergic rhinitis with hyper-responsiveness differ from asthma in degree of peripheral obstruction during methacholine challenge test. Clin Physiol Funct Imaging 2008, 28:81\u201385.","journal-title":"Clin Physiol Funct Imaging"},{"key":"97_CR32","doi-asserted-by":"crossref","unstructured":"Song TW, Kim KW, Kim ES, et al.: Utility of impulse oscillometry in young children with asthma. Pediatr Allergy Immunol 2008 Mar 7 (Epub ahead of print).","DOI":"10.1111\/j.1399-3038.2008.00734.x"},{"key":"97_CR33","doi-asserted-by":"crossref","first-page":"986","DOI":"10.1183\/09031936.05.00132404","volume":"25","author":"M. Berry","year":"2005","unstructured":"Berry M, Hargadon B, Morgan A, et al.: Alveolar nitric oxide in adults with asthma: evidence of distal lung inflammation in refractory asthma. Eur Respir J 2005, 25:986\u2013991.","journal-title":"Eur Respir J"},{"key":"97_CR34","doi-asserted-by":"crossref","first-page":"951","DOI":"10.1183\/09031936.06.00087905","volume":"27","author":"I.H. Veen Van","year":"2006","unstructured":"Van Veen IH, Sterk PJ, Schot R, et al.: Alveolar nitric oxide versus measures of peripheral airway dysfunction in severe asthma. Eur Respir J 2006, 27:951\u2013956.","journal-title":"Eur Respir J"},{"key":"97_CR35","doi-asserted-by":"crossref","first-page":"340","DOI":"10.1016\/j.jaci.2006.04.056","volume":"118","author":"S. Verbanck","year":"2006","unstructured":"Verbanck S, Schuermans D, Paiva M, Vincken W: The functional benefit of anti-inflammatory aerosols in the lung periphery. J Allergy Clin Immunol 2006, 118:340\u2013346.","journal-title":"J Allergy Clin Immunol"},{"key":"97_CR36","doi-asserted-by":"crossref","first-page":"808","DOI":"10.1016\/j.jaci.2006.12.657","volume":"119","author":"J. Blic de","year":"2007","unstructured":"de Blic J, Scheinmann P: The use of imaging techniques for assessing severe childhood asthma. J Allergy Clin Immunol 2007, 119:808\u2013810.","journal-title":"J Allergy Clin Immunol"},{"key":"97_CR37","doi-asserted-by":"crossref","first-page":"1019","DOI":"10.1016\/j.jaci.2006.07.032","volume":"118","author":"T. Ueda","year":"2006","unstructured":"Ueda T, Niimi A, Matsumoto H, et al.: Role of small airways in asthma: investigation using high-resolution computed tomography. J Allergy Clin Immunol 2006, 118:1019\u20131025.","journal-title":"J Allergy Clin Immunol"},{"key":"97_CR38","doi-asserted-by":"crossref","first-page":"1075","DOI":"10.1016\/j.jaci.2006.06.042","volume":"118","author":"M.R. Zeidler","year":"2006","unstructured":"Zeidler MR, Goldin JG, Kleerup EC, et al.: Small airways response to naturalistic cat allergen exposure in subjects with asthma. J Allergy Clin Immunol 2006, 118:1075\u20131081.","journal-title":"J Allergy Clin Immunol"},{"key":"97_CR39","doi-asserted-by":"crossref","first-page":"510","DOI":"10.1378\/chest.122.2.510","volume":"122","author":"C.L. Leach","year":"2002","unstructured":"Leach CL, Davidson PJ, Hasselquist BE: Lung deposition of hydrofluoroalkane-134a beclomethasone is greater than that of chlorofluorocarbon fluticasone and chlorofluorocarbon beclomethasone: a cross-over study in healthy volunteers. Chest 2002, 122:510\u2013516.","journal-title":"Chest"},{"key":"97_CR40","doi-asserted-by":"crossref","first-page":"35","DOI":"10.2165\/00151829-200403010-00005","volume":"3","author":"M. Zeidler","year":"2004","unstructured":"Zeidler M, Corren J: Hydrofluoroalkane formulations of inhaled corticosteroids for the treatment of asthma. Treat Respir Med 2004, 3:35\u201344.","journal-title":"Treat Respir Med"},{"key":"97_CR41","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1089\/08942680152484126","volume":"14","author":"J. Richards","year":"2001","unstructured":"Richards J, Hirst P, Pitcairn G, et al.: Deposition and pharmacokinetics of flunisolide delivered from pressurized inhalers containing non-CFC and CFC propellants. J Aerosol Med 2001, 14:197\u2013220.","journal-title":"J Aerosol Med"},{"key":"97_CR42","doi-asserted-by":"crossref","first-page":"375","DOI":"10.1016\/j.rmed.2005.09.027","volume":"100","author":"S. Newman","year":"2006","unstructured":"Newman S, Salmon A, Nave R, Drollmann A: High lung deposition of 99mTc-labeled ciclesonide administered via HFA-MDI to patients with asthma. Respir Med 2006, 100:375\u2013384.","journal-title":"Respir Med"},{"key":"97_CR43","doi-asserted-by":"crossref","first-page":"1215","DOI":"10.1016\/S0091-6749(99)70016-3","volume":"104","author":"W.W. Busse","year":"1999","unstructured":"Busse WW, Branzinsky S, Jacobson K, et al.: Efficacy response of inhaled beclomethasone dipropionate in asthma is proportional to dose and is improved by formulation with a new propellant. J Allergy Clin Immunol 1999, 104:1215\u20131222.","journal-title":"J Allergy Clin Immunol"},{"key":"97_CR44","doi-asserted-by":"crossref","first-page":"405","DOI":"10.1016\/S1081-1206(10)62922-5","volume":"87","author":"J. Corren","year":"2001","unstructured":"Corren J, Nelson H, Greos L, et al.: Effective control of asthma with hydrofluoroalkane (HFA) flunisolide delivered as an extra-fine aerosol in asthma patients. Ann Allergy Asthma Immunol 2001, 87:405\u2013411.","journal-title":"Ann Allergy Asthma Immunol"},{"key":"97_CR45","doi-asserted-by":"crossref","first-page":"58","DOI":"10.1067\/mai.2003.1612","volume":"112","author":"H.P. Hauber","year":"2003","unstructured":"Hauber HP, Gotfried M, Newman K, et al.: Effect of HFAflunisolide on peripheral lung inflammation in asthma. J Allergy Clin Immunol 2003, 112:58\u201363.","journal-title":"J Allergy Clin Immunol"},{"key":"97_CR46","doi-asserted-by":"crossref","first-page":"S258","DOI":"10.1016\/S0091-6749(99)70043-6","volume":"104","author":"J.G. Goldin","year":"1999","unstructured":"Goldin JG, Tashkin DP, Kleerup EC, et al.: Comparative effects of hydrofluoroalkane and chlorofluorocarbon beclomethasone dipropionate inhalation on small airways: assessment with functional helical thin-section computed tomography. J Allergy Clin Immunol 1999, 104:S258\u2013S267.","journal-title":"J Allergy Clin Immunol"},{"key":"97_CR47","doi-asserted-by":"crossref","first-page":"1213","DOI":"10.1183\/09031936.00082407","volume":"31","author":"J. Cohen","year":"2008","unstructured":"Cohen J, Douma WR, ten Hacken NH, et al.: Ciclesonide improves measures of small airway involvement in asthma. Eur Respir J 2008, 31:1213\u20131220.","journal-title":"Eur Respir J"},{"key":"97_CR48","doi-asserted-by":"crossref","first-page":"307","DOI":"10.1183\/09031936.06.00005605","volume":"27","author":"M.R. Zeidler","year":"2006","unstructured":"Zeidler MR, Kleerup EC, Goldin JG, et al.: Montelukast improves regional air-trapping due to small airways obstruction in asthma. Eur Respir J 2006, 27:307\u2013315.","journal-title":"Eur Respir J"}],"container-title":["Current Allergy and Asthma Reports"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s11882-008-0097-4.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s11882-008-0097-4\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s11882-008-0097-4","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,6,1]],"date-time":"2019-06-01T23:42:20Z","timestamp":1559432540000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s11882-008-0097-4"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2008,11]]},"references-count":48,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2008,11]]}},"alternative-id":["97"],"URL":"https:\/\/doi.org\/10.1007\/s11882-008-0097-4","relation":{},"ISSN":["1529-7322","1534-6315"],"issn-type":[{"value":"1529-7322","type":"print"},{"value":"1534-6315","type":"electronic"}],"subject":[],"published":{"date-parts":[[2008,11]]}}}