{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,19]],"date-time":"2026-09-19T13:04:33Z","timestamp":1789823073487,"version":"4.0.1"},"reference-count":46,"publisher":"Springer Science and Business Media LLC","issue":"4","license":[{"start":{"date-parts":[[2009,7,1]],"date-time":"2009-07-01T00:00:00Z","timestamp":1246406400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Curr Allergy Asthma Rep"],"published-print":{"date-parts":[[2009,7]]},"DOI":"10.1007\/s11882-009-0040-3","type":"journal-article","created":{"date-parts":[[2009,7,23]],"date-time":"2009-07-23T13:31:09Z","timestamp":1248355869000},"page":"286-290","source":"Crossref","is-referenced-by-count":44,"title":["Basophil responsiveness in chronic urticaria"],"prefix":"10.1007","volume":"9","author":[{"given":"Sarbjit S.","family":"Saini","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2009,7,24]]},"reference":[{"key":"40_CR1","doi-asserted-by":"crossref","first-page":"664","DOI":"10.1067\/mai.2000.105706","volume":"105","author":"M. Greaves","year":"2000","unstructured":"Greaves M: Chronic urticaria. J Allergy Clin Immunol 2000, 105:664\u2013672.","journal-title":"J Allergy Clin Immunol"},{"key":"40_CR2","doi-asserted-by":"crossref","first-page":"465","DOI":"10.1016\/j.jaci.2004.02.049","volume":"114","author":"A.P. Kaplan","year":"2004","unstructured":"Kaplan AP: Chronic urticaria: pathogenesis and treatment. J Allergy Clin Immunol 2004, 114:465\u2013474.","journal-title":"J Allergy Clin Immunol"},{"key":"40_CR3","doi-asserted-by":"crossref","first-page":"869","DOI":"10.1111\/j.1398-9995.2004.00473.x","volume":"59","author":"E. Toubi","year":"2004","unstructured":"Toubi E, Kessel A, Avshovich N, et al.: Clinical and laboratory parameters in predicting chronic urticaria duration: a prospective study of 139 patients. Allergy 2004, 59:869\u2013873.","journal-title":"Allergy"},{"key":"40_CR4","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1111\/j.1365-2133.2005.06385.x","volume":"152","author":"J.J. Grob","year":"2005","unstructured":"Grob JJ, Revuz J, Ortonne JP, et al.: Comparative study of the impact of chronic urticaria, psoriasis and atopic dermatitis on the quality of life. Br J Dermatol 2005, 152:289\u2013295.","journal-title":"Br J Dermatol"},{"key":"40_CR5","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1111\/j.1365-2133.1997.tb14895.x","volume":"136","author":"B.F. O\u2019Donnell","year":"1997","unstructured":"O\u2019Donnell BF, Lawlor F, Simpson J, et al.: The impact of chronic urticaria on the quality of life. Br J Dermatol 1997, 136:197\u2013201.","journal-title":"Br J Dermatol"},{"key":"40_CR6","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1001\/archdermatol.2007.5","volume":"144","author":"L.K. Delong","year":"2008","unstructured":"Delong LK, Culler SD, Saini SS, et al.: Annual direct and indirect costs of chronic idiopathic urticaria: a cost analysis of fifty non-immunocompromised patients. Arch Dermatol 2008, 144:35\u201339.","journal-title":"Arch Dermatol"},{"key":"40_CR7","doi-asserted-by":"crossref","first-page":"360","DOI":"10.1016\/S0091-6749(95)70055-2","volume":"96","author":"C.H. Smith","year":"1995","unstructured":"Smith CH, Kepley C, Schwartz LB, Lee TH: Mast cell number and phenotype in chronic idiopathic urticaria. J Allergy Clin Immunol 1995, 96:360\u2013364.","journal-title":"J Allergy Clin Immunol"},{"key":"40_CR8","doi-asserted-by":"crossref","first-page":"1139","DOI":"10.1016\/0091-6749(92)90297-F","volume":"89","author":"P. Jacques","year":"1992","unstructured":"Jacques P, Lavoie A, Bedard PM, et al.: Chronic idiopathic urticaria: profiles of skin mast cell histamine release during active disease and remission. J Allergy Clin Immunol 1992, 89:1139\u20131143.","journal-title":"J Allergy Clin Immunol"},{"key":"40_CR9","doi-asserted-by":"crossref","first-page":"802","DOI":"10.1016\/0091-6749(86)90377-5","volume":"77","author":"R.W. Cohen","year":"1986","unstructured":"Cohen RW, Rosenstreich DL: Discrimination between urticaria-prone and other allergic patients by intradermal skin testing with codeine. J Allergy Clin Immunol 1986, 77:802\u2013807.","journal-title":"J Allergy Clin Immunol"},{"key":"40_CR10","doi-asserted-by":"crossref","first-page":"694","DOI":"10.1067\/mai.2002.123236","volume":"109","author":"S. Ying","year":"2002","unstructured":"Ying S, Kikuchi Y, Meng Q, et al.: TH1\/TH2 cytokines and inflammatory cells in skin biopsy specimens from patients with chronic idiopathic urticaria: comparison with the allergen-induced late-phase cutaneous reaction. J Allergy Clin Immunol 2002, 109:694\u2013700.","journal-title":"J Allergy Clin Immunol"},{"key":"40_CR11","doi-asserted-by":"crossref","first-page":"484","DOI":"10.1016\/S0091-6749(99)70475-6","volume":"103","author":"R.A. Sabroe","year":"1999","unstructured":"Sabroe RA, Poon E, Orchard GE, et al.: Cutaneous inflammatory cell infiltrate in chronic idiopathic urticaria: comparison of patients with and without anti-FcepsilonRI or anti-IgE autoantibodies. J Allergy Clin Immunol 1999, 103:484\u2013493.","journal-title":"J Allergy Clin Immunol"},{"key":"40_CR12","doi-asserted-by":"crossref","first-page":"621","DOI":"10.1034\/j.1600-0625.2003.00010.x","volume":"12","author":"M. Caproni","year":"2003","unstructured":"Caproni M, Volpi W, Macchia D, et al.: Infiltrating cells and related cytokines in lesional skin of patients with chronic idiopathic urticaria and positive autologous serum skin test. Exp Dermatol 2003, 12:621\u2013628.","journal-title":"Exp Dermatol"},{"key":"40_CR13","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1111\/1523-1747.ep12462239","volume":"90","author":"B.L. Gruber","year":"1988","unstructured":"Gruber BL, Baeza ML, Marchese MJ, et al.: Prevalence and functional role of anti-IgE autoantibodies in urticarial syndromes. J Invest Dermatol 1988, 90:213\u2013217.","journal-title":"J Invest Dermatol"},{"key":"40_CR14","doi-asserted-by":"crossref","first-page":"1599","DOI":"10.1056\/NEJM199306033282204","volume":"328","author":"M. Hide","year":"1993","unstructured":"Hide M, Francis DM, Grattan CE, et al.: Autoantibodies against the high-affinity IgE receptor as a cause of histamine release in chronic urticaria. N Engl J Med 1993, 328:1599\u20131604.","journal-title":"N Engl J Med"},{"key":"40_CR15","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1016\/S1081-1206(10)60588-1","volume":"100","author":"L.A. Brodell","year":"2008","unstructured":"Brodell LA, Beck LA, Saini SS: Pathophysiology of chronic urticaria. Ann Allergy Asthma Immunol 2008, 100:291\u2013297.","journal-title":"Ann Allergy Asthma Immunol"},{"key":"40_CR16","doi-asserted-by":"crossref","first-page":"403","DOI":"10.1097\/01.all.0000182540.45348.bc","volume":"5","author":"J. Sheikh","year":"2005","unstructured":"Sheikh J: Autoantibodies to the high-affinity IgE receptor in chronic urticaria: how important are they? Curr Opin Allergy Clin Immunol 2005, 5:403\u2013407.","journal-title":"Curr Opin Allergy Clin Immunol"},{"key":"40_CR17","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1038\/nri2458","volume":"9","author":"H. Karasuyama","year":"2009","unstructured":"Karasuyama H, Mukai K, Tsujimura Y, Obata K: Newly discovered roles for basophils: a neglected minority gains new respect. Nat Rev Immunol 2009, 9:9\u201313.","journal-title":"Nat Rev Immunol"},{"key":"40_CR18","doi-asserted-by":"crossref","first-page":"11","DOI":"10.2332\/allergolint.08-RAI-0059","volume":"58","author":"K. Mukai","year":"2009","unstructured":"Mukai K, Obata K, Tsujimura Y, Karasuyama H: New insights into the roles for basophils in acute and chronic allergy. Allergol Int 2009, 58:11\u201319.","journal-title":"Allergol Int"},{"key":"40_CR19","doi-asserted-by":"crossref","first-page":"913","DOI":"10.1182\/blood-2007-01-068718","volume":"110","author":"K. Obata","year":"2007","unstructured":"Obata K, Mukai K, Tsujimura Y, et al.: Basophils are essential initiators of a novel type of chronic allergic inflammation. Blood 2007, 110:913\u2013920.","journal-title":"Blood"},{"key":"40_CR20","doi-asserted-by":"crossref","first-page":"337","DOI":"10.1046\/j.1365-2222.2003.01589.x","volume":"33","author":"C.E. Grattan","year":"2003","unstructured":"Grattan CE, Dawn G, Gibbs S, Francis DM: Blood basophil numbers in chronic ordinary urticaria and healthy controls: diurnal variation, influence of loratadine and prednisolone and relationship to disease activity. Clin Exp Allergy 2003, 33:337\u2013341.","journal-title":"Clin Exp Allergy"},{"key":"40_CR21","doi-asserted-by":"crossref","first-page":"284","DOI":"10.1016\/j.clim.2004.10.007","volume":"114","author":"M. Caproni","year":"2005","unstructured":"Caproni M, Giomi B, Volpi W, et al.: Chronic idiopathic urticaria: infiltrating cells and related cytokines in autologous serum-induced wheals. Clin Immunol 2005, 114:284\u2013292.","journal-title":"Clin Immunol"},{"key":"40_CR22","doi-asserted-by":"crossref","first-page":"454","DOI":"10.1038\/292454a0","volume":"292","author":"R.P. Schleimer","year":"1981","unstructured":"Schleimer RP, Lichtenstein LM, Gillespie E: Inhibition of basophil histamine release by anti-inflammatory steroids. Nature 1981, 292:454\u2013455.","journal-title":"Nature"},{"key":"40_CR23","doi-asserted-by":"crossref","first-page":"671","DOI":"10.4049\/jimmunol.146.2.671","volume":"146","author":"E.N. Charlesworth","year":"1991","unstructured":"Charlesworth EN, Kagey-Sobotka A, Schleimer RP, et al.: Prednisone inhibits the appearance of inflammatory mediators and the influx of eosinophils and basophils associated with the cutaneous late-phase response to allergen. J Immunol 1991, 146:671\u2013676.","journal-title":"J Immunol"},{"key":"40_CR24","doi-asserted-by":"crossref","first-page":"1417","DOI":"10.1111\/j.1365-2222.1997.tb02986.x","volume":"27","author":"C.E. Grattan","year":"1997","unstructured":"Grattan CE, Walpole D, Francis DM, et al.: Flow cytometric analysis of basophil numbers in chronic urticaria: basopenia is related to serum histamine releasing activity. Clin Exp Allergy 1997, 27:1417\u20131424.","journal-title":"Clin Exp Allergy"},{"key":"40_CR25","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1111\/j.1365-2222.1974.tb01384.x","volume":"4","author":"M.W. Greaves","year":"1974","unstructured":"Greaves MW, Plummer VM, McLaughlan P, Stanworth DR: Serum and cell bound IgE in chronic urticaria. Clin Allergy 1974, 4:265\u2013271.","journal-title":"Clin Allergy"},{"key":"40_CR26","doi-asserted-by":"crossref","first-page":"1369","DOI":"10.1172\/JCI108405","volume":"57","author":"F. Kern","year":"1976","unstructured":"Kern F, Lichtenstein LM: Defective histamine release in chronic urticaria. J Clin Invest 1976, 57:1369\u20131377.","journal-title":"J Clin Invest"},{"key":"40_CR27","doi-asserted-by":"crossref","first-page":"651","DOI":"10.1016\/S0091-6749(98)70283-0","volume":"102","author":"R.A. Sabroe","year":"1998","unstructured":"Sabroe RA, Francis DM, Barr RM, et al.: Anti-Fc(episilon)RI auto antibodies and basophil histamine releasability in chronic idiopathic urticaria. J Allergy Clin Immunol 1998, 102:651\u2013658.","journal-title":"J Allergy Clin Immunol"},{"key":"40_CR28","doi-asserted-by":"crossref","first-page":"456","DOI":"10.1111\/j.1365-2222.2005.02212.x","volume":"35","author":"E. Luquin","year":"2005","unstructured":"Luquin E, Kaplan AP, Ferrer M: Increased responsiveness of basophils of patients with chronic urticaria to sera but hypo-responsiveness to other stimuli. Clin Exp Allergy 2005, 35:456\u2013460.","journal-title":"Clin Exp Allergy"},{"key":"40_CR29","doi-asserted-by":"crossref","first-page":"441","DOI":"10.1016\/j.jaci.2006.09.035","volume":"119","author":"B.M. Vonakis","year":"2007","unstructured":"Vonakis BM, Vasagar K, Gibbons J, et al.: Basophil FceRI histamine release parallels expression of Src-homology2-containing inositol phosphatases in chronic idiopathic urticaria. J Allergy Clin Immunol 2007, 119:441\u2013448.","journal-title":"J Allergy Clin Immunol"},{"key":"40_CR30","doi-asserted-by":"crossref","first-page":"770","DOI":"10.1111\/j.1365-2222.2006.02494.x","volume":"36","author":"K. Vasagar","year":"2006","unstructured":"Vasagar K, Vonakis BM, Gober L, et al.: Evidence of in vivo basophil activation in chronic idiopathic urticaria. Clin Exp Allergy 2006, 36:770\u2013776.","journal-title":"Clin Exp Allergy"},{"key":"40_CR31","doi-asserted-by":"crossref","first-page":"979","DOI":"10.1111\/j.1365-2133.2008.08499.x","volume":"158","author":"F.D. Lourenco","year":"2008","unstructured":"Lourenco FD, Azor MH, Santos JC, et al.: Activated status of basophils in chronic urticaria leads to interleukin-3 hyper-responsiveness and enhancement of histamine release induced by anti-IgE stimulus. Br J Dermatol 2008, 158:979\u2013986.","journal-title":"Br J Dermatol"},{"key":"40_CR32","doi-asserted-by":"crossref","first-page":"279","DOI":"10.1016\/S0091-6749(99)70367-2","volume":"104","author":"C.L. Kepley","year":"1999","unstructured":"Kepley CL, Youssef L, Andrews RP, et al.: Syk deficiency in nonreleaser basophils. J Allergy Clin Immunol 1999, 104:279\u2013284.","journal-title":"J Allergy Clin Immunol"},{"key":"40_CR33","doi-asserted-by":"crossref","first-page":"1317","DOI":"10.1016\/j.jaci.2004.08.037","volume":"114","author":"D. Macglashan","year":"2004","unstructured":"Macglashan D, Miura K: Loss of syk kinase during IgE-mediated stimulation of human basophils. J Allergy Clin Immunol 2004, 114:1317\u20131324.","journal-title":"J Allergy Clin Immunol"},{"key":"40_CR34","doi-asserted-by":"crossref","first-page":"626","DOI":"10.1016\/j.jaci.2006.09.040","volume":"119","author":"D.W. Macglashan Jr","year":"2007","unstructured":"Macglashan DW Jr: Relationship between spleen tyrosine kinase and phosphatidylinositol 5\u2032 phosphatase expression and secretion from human basophils in the general population. J Allergy Clin Immunol 2007, 119:626\u2013633.","journal-title":"J Allergy Clin Immunol"},{"key":"40_CR35","doi-asserted-by":"crossref","first-page":"2465","DOI":"10.1074\/jbc.R700044200","volume":"283","author":"S.J. Harris","year":"2008","unstructured":"Harris SJ, Parry RV, Westwick J, Ward SG: Phosphoinositide lipid phosphatases: natural regulators of phosphoinositide 3-kinase signaling in T lymphocytes. J Biol Chem 2008, 283:2465\u20132469.","journal-title":"J Biol Chem"},{"key":"40_CR36","doi-asserted-by":"crossref","first-page":"13991","DOI":"10.1074\/jbc.272.21.13991","volume":"272","author":"T. Kimura","year":"1997","unstructured":"Kimura T, Sakamoto H, Appella E, Siraganian RP: The negative signaling molecule SH2 domain-containing inositol-polyphosphate 5-phosphatase (SHIP) binds to the tyrosine-phosphorylated beta subunit of the high affinity IgE receptor. J Biol Chem 1997, 272:13991\u201313996.","journal-title":"J Biol Chem"},{"key":"40_CR37","doi-asserted-by":"crossref","first-page":"507","DOI":"10.4049\/jimmunol.174.1.507","volume":"174","author":"K. Gimborn","year":"2005","unstructured":"Gimborn K, Lessmann E, Kuppig S, et al.: SHIP down-regulates FcepsilonR1-induced degranulation at supraoptimal IgE or antigen levels. J Immunol 2005, 174:507\u2013516.","journal-title":"J Immunol"},{"key":"40_CR38","doi-asserted-by":"crossref","first-page":"11330","DOI":"10.1073\/pnas.95.19.11330","volume":"95","author":"M. Huber","year":"1998","unstructured":"Huber M, Helgason CD, Damen JE, et al.: The src homology 2-containing inositol phosphatase (SHIP) is the gatekeeper of mast cell degranulation. Proc Natl Acad Sci U S A 1998, 95:11330\u201311335.","journal-title":"Proc Natl Acad Sci U S A"},{"key":"40_CR39","doi-asserted-by":"crossref","first-page":"822","DOI":"10.1067\/mai.2001.119159","volume":"108","author":"B.M. Vonakis","year":"2001","unstructured":"Vonakis BM, Gibbons S Jr, Sora R, et al.: Src homology 2 domain-containing inositol 5\u2032 phosphatase is negatively associated with histamine release to human recombinant histamine-releasing factor in human basophils. J Allergy Clin Immunol 2001, 108:822\u2013831.","journal-title":"J Allergy Clin Immunol"},{"key":"40_CR40","doi-asserted-by":"crossref","first-page":"1060","DOI":"10.1016\/j.jaci.2006.07.022","volume":"118","author":"B.F. Gibbs","year":"2006","unstructured":"Gibbs BF, Rathling A, Zillikens D, et al.: Initial Fc epsilon RI-mediated signal strength plays a key role in regulating basophil signaling and deactivation. J Allergy Clin Immunol 2006, 118:1060\u20131067.","journal-title":"J Allergy Clin Immunol"},{"key":"40_CR41","doi-asserted-by":"crossref","first-page":"95","DOI":"10.4049\/jimmunol.179.1.95","volume":"179","author":"W.H. Leung","year":"2007","unstructured":"Leung WH, Bolland S: The inositol 5\u2032-phosphatase SHIP-2 negatively regulates IgE-induced mast cell degranulation and cytokine production. J Immunol 2007, 179:95\u2013102.","journal-title":"J Immunol"},{"key":"40_CR42","doi-asserted-by":"crossref","first-page":"262","DOI":"10.1016\/j.jaci.2007.10.010","volume":"121","author":"B.M. Vonakis","year":"2008","unstructured":"Vonakis BM, Saini SS: Syk-deficientbasophils from donors with chronic idiopathic urticaria exhibit a spectrum of releasability. J Allergy Clin Immunol 2008, 121:262\u2013264.","journal-title":"J Allergy Clin Immunol"},{"key":"40_CR43","doi-asserted-by":"crossref","first-page":"1956","DOI":"10.1038\/jid.2008.55","volume":"128","author":"J. Eckman","year":"2008","unstructured":"Eckman J, Hamilton RG, Gober LM, et al.: Basophil phenotypes in chronic idiopathic urticaria in relation to disease activity and autoantibodies. J Invest Dermatol 2008, 128:1956\u20131963.","journal-title":"J Invest Dermatol"},{"key":"40_CR44","doi-asserted-by":"crossref","first-page":"244","DOI":"10.1016\/S1081-1206(10)60449-8","volume":"100","author":"R. Baker","year":"2008","unstructured":"Baker R, Vasagar K, Ohameje N, et al.: Basophil histamine release activity and disease severity in chronic idiopathic urticaria. Ann Allergy Asthma Immunol 2008, 100:244\u2013249.","journal-title":"Ann Allergy Asthma Immunol"},{"key":"40_CR45","doi-asserted-by":"crossref","first-page":"403","DOI":"10.1016\/S1081-1206(10)60462-0","volume":"100","author":"M. Morgan","year":"2008","unstructured":"Morgan M, Khan DA: Therapeutic alternatives for chronic urticaria: an evidence-based review, part 1. Ann Allergy Asthma Immunol 2008, 100:403\u2013412.","journal-title":"Ann Allergy Asthma Immunol"},{"key":"40_CR46","doi-asserted-by":"crossref","first-page":"S147","DOI":"10.1016\/j.jaci.2007.12.1121","volume":"121","author":"L. Gober","year":"2008","unstructured":"Gober L, Sterba P, Eckman J, Saini S: Effect of anti-IgE (omalizumab) in chronic idiopathic urticaria patients. J Allergy Clin Immunol 2008, 121:S147.","journal-title":"J Allergy Clin Immunol"}],"container-title":["Current Allergy and Asthma Reports"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s11882-009-0040-3.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s11882-009-0040-3\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s11882-009-0040-3","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,5,26]],"date-time":"2023-05-26T03:27:13Z","timestamp":1685071633000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s11882-009-0040-3"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2009,7]]},"references-count":46,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2009,7]]}},"alternative-id":["40"],"URL":"https:\/\/doi.org\/10.1007\/s11882-009-0040-3","relation":{},"ISSN":["1529-7322","1534-6315"],"issn-type":[{"value":"1529-7322","type":"print"},{"value":"1534-6315","type":"electronic"}],"subject":[],"published":{"date-parts":[[2009,7]]}}}