{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T10:08:54Z","timestamp":1792058934555,"version":"4.4.0"},"reference-count":66,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2010,1,1]],"date-time":"2010-01-01T00:00:00Z","timestamp":1262304000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2010,1,1]],"date-time":"2010-01-01T00:00:00Z","timestamp":1262304000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Curr Allergy Asthma Rep"],"published-print":{"date-parts":[[2010,1]]},"DOI":"10.1007\/s11882-009-0077-3","type":"journal-article","created":{"date-parts":[[2010,1,7]],"date-time":"2010-01-07T07:44:47Z","timestamp":1262850287000},"page":"13-20","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":69,"title":["Lyme Disease: A Review"],"prefix":"10.1007","volume":"10","author":[{"given":"Adriana R.","family":"Marques","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2010,1,8]]},"reference":[{"key":"77_CR1","first-page":"1","volume":"57","author":"RM Bacon","year":"2008","unstructured":"Bacon RM, Kugeler KJ, Mead PS: Surveillance for Lyme disease\u2014United States, 1992\u20132006. MMWR Surveill Summ 2008, 57:1\u20139.","journal-title":"MMWR Surveill Summ"},{"key":"77_CR2","doi-asserted-by":"publisher","first-page":"7","DOI":"10.1002\/art.1780200102","volume":"20","author":"AC Steere","year":"1977","unstructured":"Steere AC, Malawista SE, Snydman DR, et al.: Lyme arthritis: an epidemic of oligoarticular arthritis in children and adults in three connecticut communities. Arthritis Rheum 1977, 20:7\u201317.","journal-title":"Arthritis Rheum"},{"key":"77_CR3","doi-asserted-by":"publisher","first-page":"1317","DOI":"10.1126\/science.7043737","volume":"216","author":"W Burgdorfer","year":"1982","unstructured":"Burgdorfer W, Barbour AG, Hayes SF, et al.: Lyme disease\u2014a tick-borne spirochetosis? Science 1982, 216:1317\u20131319.","journal-title":"Science"},{"key":"77_CR4","doi-asserted-by":"publisher","first-page":"6124","DOI":"10.1128\/JB.00459-06","volume":"188","author":"D Terekhova","year":"2006","unstructured":"Terekhova D, Iyer R, Wormser GP, Schwartz I: Comparative genome hybridization reveals substantial variation among clinical isolates of Borrelia burgdorferi sensu stricto with different pathogenic properties. J Bacteriol 2006, 188:6124\u20136134.","journal-title":"J Bacteriol"},{"key":"77_CR5","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.plasmid.2004.10.006","volume":"53","author":"PE Stewart","year":"2005","unstructured":"Stewart PE, Byram R, Grimm D, et al.: The plasmids of Borrelia burgdorferi: essential genetic elements of a pathogen. Plasmid 2005, 53:1\u201313.","journal-title":"Plasmid"},{"key":"77_CR6","doi-asserted-by":"publisher","first-page":"561","DOI":"10.1172\/JCI9427","volume":"106","author":"U Pal","year":"2000","unstructured":"Pal U, de Silva AM, Montgomery RR, et al.: Attachment of Borrelia burgdorferi within Ixodes scapularis mediated by outer surface protein A. J Clin Invest 2000, 106:561\u2013569.","journal-title":"J Clin Invest"},{"key":"77_CR7","doi-asserted-by":"publisher","first-page":"2909","DOI":"10.1073\/pnas.92.7.2909","volume":"92","author":"TG Schwan","year":"1995","unstructured":"Schwan TG, Piesman J, Golde WT, et al.: Induction of an outer surface protein on Borrelia burgdorferi during tick feeding. Proc Natl Acad Sci U S A 1995, 92:2909\u20132913.","journal-title":"Proc Natl Acad Sci U S A"},{"key":"77_CR8","doi-asserted-by":"publisher","first-page":"3554","DOI":"10.1128\/IAI.01950-05","volume":"74","author":"K Tilly","year":"2006","unstructured":"Tilly K, Krum JG, Bestor A, et al.: Borrelia burgdorferi OspC protein required exclusively in a crucial early stage of mammalian infection. Infect Immun 2006, 74:3554\u20133564.","journal-title":"Infect Immun"},{"key":"77_CR9","doi-asserted-by":"publisher","first-page":"5059","DOI":"10.1128\/JCM.41.11.5059-5065.2003","volume":"41","author":"V Lagal","year":"2003","unstructured":"Lagal V, Postic D, Rubic-Sabljic E, Baranton G: Genetic diversity among Borrelia strains determined by single-strand conformation polymorphism analysis of the ospC gene and its association with invasiveness. J Clin Microbiol 2003, 41:5059\u20135065.","journal-title":"J Clin Microbiol"},{"key":"77_CR10","doi-asserted-by":"crossref","first-page":"3518","DOI":"10.1128\/IAI.67.7.3518-3524.1999","volume":"67","author":"G Seinost","year":"1999","unstructured":"Seinost G, Dykhuizen DE, Dattwyler RJ, et al.: Four clones of Borrelia burgdorferi sensu stricto cause invasive infection in humans. Infect Immun 1999, 67:3518\u20133524.","journal-title":"Infect Immun"},{"key":"77_CR11","doi-asserted-by":"publisher","first-page":"4608","DOI":"10.1128\/IAI.71.8.4608-4613.2003","volume":"71","author":"M Labandeira-Rey","year":"2003","unstructured":"Labandeira-Rey M, Seshu J, Skare JT: The absence of linear plasmid 25 or 28-1 of Borrelia burgdorferi dramatically alters the kinetics of experimental infection via distinct mechanisms. Infect Immun 2003, 71:4608\u20134613.","journal-title":"Infect Immun"},{"key":"77_CR12","doi-asserted-by":"publisher","first-page":"e1000293","DOI":"10.1371\/journal.ppat.1000293","volume":"5","author":"L Coutte","year":"2009","unstructured":"Coutte L, Botkin DJ, Gao L, Norris SJ: Detailed analysis of sequence changes occurring during vlsE antigenic variation in the mouse model of Borrelia burgdorferi infection. PLoS Pathog 2009, 5:e1000293.","journal-title":"PLoS Pathog"},{"key":"77_CR13","doi-asserted-by":"crossref","first-page":"2382","DOI":"10.4049\/jimmunol.163.5.2382","volume":"163","author":"M Hirschfeld","year":"1999","unstructured":"Hirschfeld M, Kirschning CJ, Schwandner R, et al.: Cutting edge: inflammatory signaling by Borrelia burgdorferi lipoproteins is mediated by Toll-like receptor 2. J Immunol 1999, 163:2382\u20132386.","journal-title":"J Immunol"},{"key":"77_CR14","doi-asserted-by":"crossref","first-page":"2660","DOI":"10.4049\/jimmunol.171.5.2660","volume":"171","author":"JC Salazar","year":"2003","unstructured":"Salazar JC, Pope CD, Sellati TJ, et al.: Coevolution of markers of innate and adaptive immunity in skin and peripheral blood of patients with erythema migrans. J Immunol 2003, 171:2660\u20132670.","journal-title":"J Immunol"},{"key":"77_CR15","doi-asserted-by":"crossref","first-page":"2003","DOI":"10.4049\/jimmunol.173.3.2003","volume":"173","author":"DD Bolz","year":"2004","unstructured":"Bolz DD, Sundsbak RS, Ma Y, et al.: MyD88 plays a unique role in host defense but not arthritis development in Lyme disease. J Immunol 2004, 173:2003\u20132010.","journal-title":"J Immunol"},{"key":"77_CR16","doi-asserted-by":"publisher","first-page":"5279","DOI":"10.4049\/jimmunol.0901390","volume":"183","author":"MM Petzke","year":"2009","unstructured":"Petzke MM, Brooks A, Krupna MA, et al.: Recognition of Borrelia burgdorferi, the Lyme disease spirochete, by TLR7 and TLR9 induces a type I IFN response by human immune cells. J Immunol 2009, 183:5279\u20135292.","journal-title":"J Immunol"},{"key":"77_CR17","doi-asserted-by":"crossref","first-page":"8492","DOI":"10.4049\/jimmunol.181.12.8492","volume":"181","author":"JC Miller","year":"2008","unstructured":"Miller JC, Ma Y, Bian J, et al.: A critical role for type I IFN in arthritis development following Borrelia burgdorferi infection of mice. J Immunol 2008, 181:8492\u20138503.","journal-title":"J Immunol"},{"key":"77_CR18","doi-asserted-by":"crossref","first-page":"767","DOI":"10.1645\/GE-1416.1","volume":"94","author":"NS Zeidner","year":"2008","unstructured":"Zeidner NS, Schneider BS, Rutherford JS, Dolan MC: Suppression of Th2 cytokines reduces tick-transmitted Borrelia burgdorferi load in mice. J Parasitol 2008, 94:767\u2013769.","journal-title":"J Parasitol"},{"key":"77_CR19","doi-asserted-by":"publisher","first-page":"189","DOI":"10.1111\/j.1365-2249.2007.03474.x","volume":"150","author":"C Ekerfelt","year":"2007","unstructured":"Ekerfelt C, Andersson M, Olausson A, et al.: Mercury exposure as a model for deviation of cytokine responses in experimental Lyme arthritis: HgCl2 treatment decreases T helper cell type 1-like responses and arthritis severity but delays eradication of Borrelia burgdorferi in C3H\/HeN mice. Clin Exp Immunol 2007, 150:189\u2013197.","journal-title":"Clin Exp Immunol"},{"key":"77_CR20","doi-asserted-by":"publisher","first-page":"485","DOI":"10.1111\/j.1365-3024.2007.00966.x","volume":"29","author":"UU Muller-Doblies","year":"2007","unstructured":"Muller-Doblies UU, Maxwell SS, Boppana VD, et al.: Feeding by the tick, Ixodes scapularis, causes CD4(+) T cells responding to cognate antigen to develop the capacity to express IL-4. Parasite Immunol 2007, 29:485\u2013499.","journal-title":"Parasite Immunol"},{"key":"77_CR21","doi-asserted-by":"crossref","first-page":"557","DOI":"10.1128\/jcm.25.3.557-558.1987","volume":"25","author":"J Piesman","year":"1987","unstructured":"Piesman J, Mather TN, Sinsky RJ, Spielman A: Duration of tick attachment and Borrelia burgdorferi transmission. J Clin Microbiol 1987, 25:557\u2013558.","journal-title":"J Clin Microbiol"},{"key":"77_CR22","doi-asserted-by":"publisher","first-page":"502","DOI":"10.1016\/S0002-9343(95)99915-9","volume":"100","author":"RB Nadelman","year":"1996","unstructured":"Nadelman RB, Nowakowski J, Forseter G, et al.: The clinical spectrum of early Lyme borreliosis in patients with culture-confirmed erythema migrans. Am J Med 1996, 100:502\u2013508.","journal-title":"Am J Med"},{"key":"77_CR23","doi-asserted-by":"crossref","first-page":"32","DOI":"10.7326\/0003-4819-130-1-199901050-00006","volume":"130","author":"F Strle","year":"1999","unstructured":"Strle F, Nadelman RB, Cimperman J, et al.: Comparison of culture-confirmed erythema migrans caused by Borrelia burgdorferi sensu stricto in New York State and by Borrelia afzelii in Slovenia. Ann Intern Med 1999, 130:32\u201336.","journal-title":"Ann Intern Med"},{"key":"77_CR24","doi-asserted-by":"publisher","first-page":"58","DOI":"10.1016\/S0002-9343(02)01440-7","volume":"114","author":"AC Steere","year":"2003","unstructured":"Steere AC, Dhar A, Hernandez J, et al.: Systemic symptoms without erythema migrans as the presenting picture of early Lyme disease. Am J Med 2003, 114:58\u201362.","journal-title":"Am J Med"},{"key":"77_CR25","doi-asserted-by":"crossref","first-page":"725","DOI":"10.7326\/0003-4819-107-5-725","volume":"107","author":"AC Steere","year":"1987","unstructured":"Steere AC, Schoen RT, Taylor E: The clinical evolution of Lyme arthritis. Ann Intern Med 1987, 107:725\u2013731.","journal-title":"Ann Intern Med"},{"key":"77_CR26","doi-asserted-by":"publisher","first-page":"2323","DOI":"10.1016\/j.molimm.2007.11.010","volume":"45","author":"EE Drouin","year":"2008","unstructured":"Drouin EE, Glickstein LJ, Kwok WW, et al.: Searching for borrelial T cell epitopes associated with antibiotic-refractory Lyme arthritis. Mol Immunol 2008, 45:2323\u20132332.","journal-title":"Mol Immunol"},{"key":"77_CR27","doi-asserted-by":"publisher","first-page":"961","DOI":"10.1084\/jem.20052471","volume":"203","author":"AC Steere","year":"2006","unstructured":"Steere AC, Klitz W, Drouin EE, et al.: Antibiotic-refractory Lyme arthritis is associated with HLA-DR molecules that bind a Borrelia burgdorferi peptide. J Exp Med 2006, 203:961\u2013971.","journal-title":"J Exp Med"},{"key":"77_CR28","doi-asserted-by":"publisher","first-page":"703","DOI":"10.1126\/science.281.5377.703","volume":"281","author":"DM Gross","year":"1998","unstructured":"Gross DM, Forsthuber T, Tary-Lehmann M, et al.: Identification of LFA-1 as a candidate autoantigen in treatment-resistant Lyme arthritis. Science 1998, 281:703\u2013706.","journal-title":"Science"},{"key":"77_CR29","doi-asserted-by":"publisher","first-page":"180","DOI":"10.1016\/j.molimm.2007.04.017","volume":"45","author":"EE Drouin","year":"2008","unstructured":"Drouin EE, Glickstein LJ, Kwok WW, et al.: Human homologues of a Borrelia T cell epitope associated with antibiotic-refractory Lyme arthritis. Mol Immunol 2008, 45:180\u2013189.","journal-title":"Mol Immunol"},{"key":"77_CR30","doi-asserted-by":"publisher","first-page":"2174","DOI":"10.1002\/art.24812","volume":"60","author":"KL Jones","year":"2009","unstructured":"Jones KL, McHugh GA, Glickstein LJ, Steere AC: Analysis of Borrelia burgdorferi genotypes in patients with Lyme arthritis: high frequency of ribosomal RNA intergenic spacer type 1 strains in antibiotic-refractory arthritis. Arthritis Rheum 2009, 60:2174\u20132182.","journal-title":"Arthritis Rheum"},{"key":"77_CR31","doi-asserted-by":"publisher","first-page":"3609","DOI":"10.1002\/art.23972","volume":"58","author":"G Codolo","year":"2008","unstructured":"Codolo G, Amedei A, Steere AC, et al.: Borrelia burgdorferi NapA-driven Th17 cell inflammation in lyme arthritis. Arthritis Rheum 2008, 58:3609\u20133617.","journal-title":"Arthritis Rheum"},{"key":"77_CR32","doi-asserted-by":"crossref","first-page":"8076","DOI":"10.4049\/jimmunol.179.12.8076","volume":"179","author":"BP Iliopoulou","year":"2007","unstructured":"Iliopoulou BP, Alroy J, Huber BT: CD28 deficiency exacerbates joint inflammation upon Borrelia burgdorferi infection, resulting in the development of chronic Lyme arthritis. J Immunol 2007, 179:8076\u20138082.","journal-title":"J Immunol"},{"key":"77_CR33","doi-asserted-by":"crossref","first-page":"1571","DOI":"10.1212\/WNL.41.10.1571","volume":"41","author":"JJ Halperin","year":"1991","unstructured":"Halperin JJ, Volkman DJ, Wu P: Central nervous system abnormalities in Lyme neuroborreliosis. Neurology 1991, 41:1571\u20131582.","journal-title":"Neurology"},{"key":"77_CR34","doi-asserted-by":"publisher","first-page":"1207","DOI":"10.1093\/brain\/113.4.1207","volume":"113","author":"J Halperin","year":"1990","unstructured":"Halperin J, Luft BJ, Volkman DJ, Dattwyler RJ: Lyme neuroborreliosis. Peripheral nervous system manifestations. Brain 1990, 113:1207\u20131221.","journal-title":"Brain"},{"key":"77_CR35","doi-asserted-by":"publisher","first-page":"1375","DOI":"10.1038\/70946","volume":"5","author":"B Hemmer","year":"1999","unstructured":"Hemmer B, Gran B, Zhao Y, et al.: Identification of candidate T-cell epitopes and molecular mimics in chronic Lyme disease. Nat Med 1999, 5:1375\u20131382.","journal-title":"Nat Med"},{"key":"77_CR36","doi-asserted-by":"publisher","first-page":"1422","DOI":"10.1056\/NEJMra072023","volume":"357","author":"HM Feder Jr","year":"2007","unstructured":"Feder HM Jr, Johnson BJ, O\u2019Connell S, et al.: A critical appraisal of \u201cchronic Lyme disease.\u201d N Engl J Med 2007, 357:1422\u20131430.","journal-title":"N Engl J Med"},{"key":"77_CR37","doi-asserted-by":"crossref","first-page":"341","DOI":"10.1016\/j.idc.2007.12.011","volume":"22","author":"A Marques","year":"2008","unstructured":"Marques A: Chronic Lyme disease: a review. Infect Dis Clin North Am 2008, 22:341\u2013360, vii\u2013viii.","journal-title":"Infect Dis Clin North Am"},{"key":"77_CR38","first-page":"2001","volume":"57","author":"Effect of electronic laboratory reporting on the burden of lyme disease surveillance\u2014New Jersey","year":"2008","unstructured":"Effect of electronic laboratory reporting on the burden of lyme disease surveillance\u2014New Jersey, 2001\u20132006. MMWR Morb Mortal Wkly Rep 2008, 57:42\u201345.","journal-title":"MMWR Morb Mortal Wkly Rep"},{"key":"77_CR39","doi-asserted-by":"publisher","first-page":"217","DOI":"10.1016\/S0002-9343(00)00701-4","volume":"110","author":"MS Klempner","year":"2001","unstructured":"Klempner MS, Schmid CH, Hu L, et al.: Intralaboratory reliability of serologic and urine testing for Lyme disease. Am J Med 2001, 110:217\u2013219.","journal-title":"Am J Med"},{"key":"77_CR40","doi-asserted-by":"publisher","first-page":"910","DOI":"10.1086\/591529","volume":"47","author":"GP Wormser","year":"2008","unstructured":"Wormser GP, Liveris D, Hanincova K, et al.: Effect of Borrelia burgdorferi genotype on the sensitivity of C6 and 2-tier testing in North American patients with culture-confirmed Lyme disease. Clin Infect Dis 2008, 47:910\u2013914.","journal-title":"Clin Infect Dis"},{"key":"77_CR41","doi-asserted-by":"publisher","first-page":"704","DOI":"10.1086\/506936","volume":"43","author":"F Strle","year":"2006","unstructured":"Strle F, Ruzic-Sabljic E, Cimperman J, et al.: Comparison of findings for patients with Borrelia garinii and Borrelia afzelii isolated from cerebrospinal fluid. Clin Infect Dis 2006, 43:704\u2013710.","journal-title":"Clin Infect Dis"},{"key":"77_CR42","doi-asserted-by":"publisher","first-page":"1358","DOI":"10.1086\/592279","volume":"198","author":"GP Wormser","year":"2008","unstructured":"Wormser GP, Brisson D, Liveris D, et al.: Borrelia burgdorferi genotype predicts the capacity for hematogenous dissemination during early Lyme disease. J Infect Dis 2008, 198:1358\u20131364.","journal-title":"J Infect Dis"},{"key":"77_CR43","doi-asserted-by":"publisher","first-page":"2023","DOI":"10.1086\/324490","volume":"33","author":"J Nowakowski","year":"2001","unstructured":"Nowakowski J, Schwartz I, Liveris D, et al.: Laboratory diagnostic techniques for patients with early Lyme disease associated with erythema migrans: a comparison of different techniques. Clin Infect Dis 2001, 33:2023\u20132027.","journal-title":"Clin Infect Dis"},{"key":"77_CR44","doi-asserted-by":"publisher","first-page":"653","DOI":"10.1111\/j.1469-0691.2008.02013.x","volume":"14","author":"T Cerar","year":"2008","unstructured":"Cerar T, Rusic-Sabljic E, Glinsek U, et al.: Comparison of PCR methods and culture for the detection of Borrelia spp. in patients with erythema migrans. Clin Microbiol Infect 2008, 14:653\u2013658.","journal-title":"Clin Microbiol Infect"},{"key":"77_CR45","doi-asserted-by":"publisher","first-page":"1249","DOI":"10.1128\/JCM.40.4.1249-1253.2002","volume":"40","author":"D Liveris","year":"2002","unstructured":"Liveris D, Wang G, Girao G, et al.: Quantitative detection of Borrelia burgdorferi in 2-millimeter skin samples of erythema migrans lesions: correlation of results with clinical and laboratory findings. J Clin Microbiol 2002, 40:1249\u20131253.","journal-title":"J Clin Microbiol"},{"key":"77_CR46","doi-asserted-by":"publisher","first-page":"229","DOI":"10.1056\/NEJM199401273300401","volume":"330","author":"JJ Nocton","year":"1994","unstructured":"Nocton JJ, Dressler F, Rutledge BJ, et al.: Detection of Borrelia burgdorferi DNA by polymerase chain reaction in synovial fluid from patients with Lyme arthritis. N Engl J Med 1994, 330:229\u2013234.","journal-title":"N Engl J Med"},{"key":"77_CR47","doi-asserted-by":"crossref","first-page":"623","DOI":"10.1093\/infdis\/174.3.623","volume":"174","author":"JJ Nocton","year":"1996","unstructured":"Nocton JJ, Bloom BJ, Rutledge BJ, et al.: Detection of Borrelia burgdorferi DNA by polymerase chain reaction in cerebrospinal fluid in Lyme neuroborreliosis. J Infect Dis 1996, 174:623\u2013627.","journal-title":"J Infect Dis"},{"key":"77_CR48","doi-asserted-by":"crossref","first-page":"139","DOI":"10.2165\/00066982-200005020-00007","volume":"5","author":"AM Lebech","year":"2000","unstructured":"Lebech AM, Hansen K, Brandrup F, et al.: Diagnostic value of PCR for detection of Borrelia burgdorferi DNA in clinical specimens from patients with erythema migrans and Lyme neuroborreliosis. Mol Diagn 2000, 5:139\u2013150.","journal-title":"Mol Diagn"},{"key":"77_CR49","first-page":"606","volume":"114","author":"A Zore","year":"2002","unstructured":"Zore A, Ruzic-Sabljic E, Maraspin V, et al.: Sensitivity of culture and polymerase chain reaction for the etiologic diagnosis of erythema migrans. Wien Klin Wochenschr 2002, 114:606\u2013609.","journal-title":"Wien Klin Wochenschr"},{"key":"77_CR50","doi-asserted-by":"publisher","first-page":"1187","DOI":"10.1086\/374395","volume":"187","author":"RM Bacon","year":"2003","unstructured":"Bacon RM, Biggerstaff BJ, Schriefer ME, et al.: Serodiagnosis of Lyme disease by kinetic enzyme-linked immunosorbent assay using recombinant VlsE1 or peptide antigens of Borrelia burgdorferi compared with 2-tiered testing using whole-cell lysates. J Infect Dis 2003, 187:1187\u20131199.","journal-title":"J Infect Dis"},{"key":"77_CR51","doi-asserted-by":"publisher","first-page":"93","DOI":"10.1159\/000111505","volume":"216","author":"M Glatz","year":"2008","unstructured":"Glatz M, Fingerle V, Wilske B, et al.: Immunoblot analysis of the seroreactivity to recombinant Borrelia burgdorferi sensu lato antigens, including VlsE, in the long-term course of treated patients with erythema migrans. Dermatology 2008, 216:93\u2013103.","journal-title":"Dermatology"},{"key":"77_CR52","doi-asserted-by":"publisher","first-page":"780","DOI":"10.1086\/322669","volume":"33","author":"RA Kalish","year":"2001","unstructured":"Kalish RA, McHugh G, Granquist, J, et al.: Persistence of immunoglobulin M or immunoglobulin G antibody responses to Borrelia burgdorferi 10\u201320\u00a0years after active Lyme disease. Clin Infect Dis 2001, 33:780\u2013785.","journal-title":"Clin Infect Dis"},{"key":"77_CR53","doi-asserted-by":"crossref","first-page":"1106","DOI":"10.7326\/0003-4819-127-12-199712150-00010","volume":"127","author":"Guidelines for laboratory evaluation in the diagnosis of Lyme disease","year":"1997","unstructured":"Guidelines for laboratory evaluation in the diagnosis of Lyme disease. American College of Physicians. Ann Intern Med 1997, 127:1106\u20131108.","journal-title":"Ann Intern Med"},{"key":"77_CR54","unstructured":"Notice to readers: caution regarding testing for Lyme disease. MMWR CDC Surveill Summ 2005, 54:125."},{"key":"77_CR55","doi-asserted-by":"publisher","first-page":"1249","DOI":"10.1128\/CVI.00167-09","volume":"16","author":"A Marques","year":"2009","unstructured":"Marques A, Brown MR, Fleisher TA: Natural killer cell counts are not different between patients with post-Lyme disease syndrome and controls. Clin Vaccine Immunol 2009, 16:1249\u20131250.","journal-title":"Clin Vaccine Immunol"},{"key":"77_CR56","first-page":"590","volume":"44","author":"Recommendations for test performance and interpretation from the Second National Conference on Serologic Diagnosis of Lyme Disease","year":"1995","unstructured":"Recommendations for test performance and interpretation from the Second National Conference on Serologic Diagnosis of Lyme Disease. MMWR Morb Mortal Wkly Rep 1995, 44:590\u2013591.","journal-title":"MMWR Morb Mortal Wkly Rep"},{"key":"77_CR57","doi-asserted-by":"crossref","first-page":"3990","DOI":"10.1128\/JCM.37.12.3990-3996.1999","volume":"37","author":"FT Liang","year":"1999","unstructured":"Liang FT, Steere AC, Marques AR, et al.: Sensitive and specific serodiagnosis of Lyme disease by enzyme-linked immunosorbent assay with a peptide based on an immunodominant conserved region of Borrelia burgdorferi vlsE. J Clin Microbiol 1999, 37:3990\u20133996.","journal-title":"J Clin Microbiol"},{"key":"77_CR58","doi-asserted-by":"publisher","first-page":"1796","DOI":"10.1128\/CVI.00195-08","volume":"15","author":"TB Ledue","year":"2008","unstructured":"Ledue TB, Collins MF, Young J, Schriefer ME: Evaluation of the recombinant VlsE-based liaison chemiluminescence immunoassay for detection of Borrelia burgdorferi and diagnosis of Lyme disease. Clin Vaccine Immunol 2008, 15:1796\u20131804.","journal-title":"Clin Vaccine Immunol"},{"key":"77_CR59","doi-asserted-by":"publisher","first-page":"188","DOI":"10.1086\/589242","volume":"47","author":"AC Steere","year":"2008","unstructured":"Steere AC, McHugh G, Damle N, Sikand VK: Prospective study of serologic tests for lyme disease. Clin Infect Dis 2008, 47:188\u2013195.","journal-title":"Clin Infect Dis"},{"key":"77_CR60","doi-asserted-by":"publisher","first-page":"953","DOI":"10.1212\/01.wnl.0000269672.17807.e0","volume":"69","author":"F Blanc","year":"2007","unstructured":"Blanc F, Jaulhac B, Fleury M, et al.: Relevance of the antibody index to diagnose Lyme neuroborreliosis among seropositive patients. Neurology 2007, 69:953\u2013958.","journal-title":"Neurology"},{"key":"77_CR61","doi-asserted-by":"crossref","first-page":"433","DOI":"10.1016\/j.idc.2008.03.011","volume":"22","author":"JS Bakken","year":"2008","unstructured":"Bakken JS, Dumler S: Human granulocytic anaplasmosis. Infect Dis Clin North Am 2008, 22:433\u2013448, viii.","journal-title":"Infect Dis Clin North Am"},{"key":"77_CR62","doi-asserted-by":"crossref","first-page":"469","DOI":"10.1016\/j.idc.2008.03.010","volume":"22","author":"E Vannier","year":"2008","unstructured":"Vannier E, Gewurz BE, Krause PJ: Human babesiosis. Infect Dis Clin North Am 2008, 22:469\u2013488, viii\u2013ix.","journal-title":"Infect Dis Clin North Am"},{"key":"77_CR63","doi-asserted-by":"publisher","first-page":"1089","DOI":"10.1086\/508667","volume":"43","author":"GP Wormser","year":"2006","unstructured":"Wormser GP, Dattwyler RJ, Shapiro ED, et al.: The clinical assessment, treatment, and prevention of lyme disease, human granulocytic anaplasmosis, and babesiosis: clinical practice guidelines by the Infectious Diseases Society of America. Clin Infect Dis 2006, 43:1089\u20131134.","journal-title":"Clin Infect Dis"},{"key":"77_CR64","doi-asserted-by":"crossref","first-page":"361","DOI":"10.1016\/j.idc.2007.12.010","volume":"22","author":"EJ Masters","year":"2008","unstructured":"Masters EJ, Grigery CN, Masters RW: STARI, or Masters disease: Lone Star tick-vectored Lyme-like illness. Infect Dis Clin North Am 2008, 22:361\u2013376, viii.","journal-title":"Infect Dis Clin North Am"},{"key":"77_CR65","doi-asserted-by":"publisher","first-page":"625","DOI":"10.1007\/s00508-006-0687-x","volume":"118","author":"AC Steere","year":"2006","unstructured":"Steere AC: Lyme borreliosis in 2005, 30\u00a0years after initial observations in Lyme Connecticut. Wien Klin Wochenschr 2006, 118:625\u2013633.","journal-title":"Wien Klin Wochenschr"},{"key":"77_CR66","doi-asserted-by":"publisher","first-page":"1179","DOI":"10.1002\/art.24418","volume":"60","author":"R Ball","year":"2009","unstructured":"Ball R, Shadomy SV, Meyer A, et al.: HLA type and immune response to Borrelia burgdorferi outer surface protein A in people in whom arthritis developed after Lyme disease vaccination. Arthritis Rheum 2009, 60:1179\u20131186.","journal-title":"Arthritis Rheum"}],"container-title":["Current Allergy and Asthma Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s11882-009-0077-3.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s11882-009-0077-3\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s11882-009-0077-3","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s11882-009-0077-3.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,5,29]],"date-time":"2023-05-29T11:47:32Z","timestamp":1685360852000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s11882-009-0077-3"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2010,1]]},"references-count":66,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2010,1]]}},"alternative-id":["77"],"URL":"https:\/\/doi.org\/10.1007\/s11882-009-0077-3","relation":{},"ISSN":["1529-7322","1534-6315"],"issn-type":[{"value":"1529-7322","type":"print"},{"value":"1534-6315","type":"electronic"}],"subject":[],"published":{"date-parts":[[2010,1]]},"assertion":[{"value":"8 January 2010","order":1,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"This content has been made available to all.","name":"free","label":"Free to read"}]}}