{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,5]],"date-time":"2026-05-05T17:21:17Z","timestamp":1778001677175,"version":"3.51.4"},"reference-count":39,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2010,1,1]],"date-time":"2010-01-01T00:00:00Z","timestamp":1262304000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Curr Allergy Asthma Rep"],"published-print":{"date-parts":[[2010,1]]},"DOI":"10.1007\/s11882-009-0080-8","type":"journal-article","created":{"date-parts":[[2010,1,7]],"date-time":"2010-01-07T06:36:51Z","timestamp":1262846211000},"page":"34-38","source":"Crossref","is-referenced-by-count":41,"title":["Anaphylaxis and Mast Cell Disease: What Is the Risk?"],"prefix":"10.1007","volume":"10","author":[{"given":"Cem","family":"Akin","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2010,1,8]]},"reference":[{"key":"80_CR1","doi-asserted-by":"crossref","first-page":"419","DOI":"10.1146\/annurev.med.55.091902.103822","volume":"55","author":"C Akin","year":"2004","unstructured":"Akin C, Metcalfe DD: Systemic mastocytosis. Annu Rev Med 2004, 55:419\u2013432.","journal-title":"Annu Rev Med"},{"key":"80_CR2","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1136\/adc.86.5.315","volume":"86","author":"MC Carter","year":"2002","unstructured":"Carter MC, Metcalfe DD: Paediatric mastocytosis. Arch Dis Child 2002, 86:315\u2013319.","journal-title":"Arch Dis Child"},{"key":"80_CR3","doi-asserted-by":"crossref","first-page":"519","DOI":"10.1016\/S0145-2126(01)00044-3","volume":"25","author":"K Wolff","year":"2001","unstructured":"Wolff K, Komar M, Petzelbauer P: Clinical and histopathological aspects of cutaneous mastocytosis. Leuk Res 2001, 25:519\u2013528.","journal-title":"Leuk Res"},{"key":"80_CR4","doi-asserted-by":"crossref","first-page":"603","DOI":"10.1016\/S0145-2126(01)00038-8","volume":"25","author":"P Valent","year":"2001","unstructured":"Valent P, Horny H, Escribano L, et al.: Diagnostic criteria and classification of mastocytosis: a consensus proposal. Leuk Res 2001, 25:603\u2013625.","journal-title":"Leuk Res"},{"key":"80_CR5","doi-asserted-by":"crossref","first-page":"1227","DOI":"10.1016\/S0889-8588(03)00089-3","volume":"17","author":"P Valent","year":"2003","unstructured":"Valent P, Akin C, Sperr WR, et al.: Mast cell proliferative disorders: current view on variants recognized by the World Health Organization. Hematol Oncol Clin North Am 2003, 17:1227\u20131241.","journal-title":"Hematol Oncol Clin North Am"},{"key":"80_CR6","doi-asserted-by":"crossref","first-page":"514","DOI":"10.1016\/j.jaci.2009.05.003","volume":"124","author":"L Escribano","year":"2009","unstructured":"Escribano L, Alvarez-Twose I, Sanchez-Munoz L, et al.: Prognosis in adult indolent systemic mastocytosis: a long-term study of the Spanish Network on Mastocytosis in a series of 145 patients. J Allergy Clin Immunol 2009, 124:514\u2013521.","journal-title":"J Allergy Clin Immunol"},{"key":"80_CR7","doi-asserted-by":"crossref","first-page":"635","DOI":"10.1016\/S0145-2126(02)00168-6","volume":"27","author":"P Valent","year":"2003","unstructured":"Valent P, Akin C, Sperr WR, et al.: Aggressive systemic mastocytosis and related mast cell disorders: current treatment options and proposed response criteria. Leuk Res 2003, 27:635\u2013641.","journal-title":"Leuk Res"},{"key":"80_CR8","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1016\/j.jaci.2004.04.046","volume":"114","author":"C Akin","year":"2004","unstructured":"Akin C, Metcalfe DD: The biology of Kit in disease and the application of pharmacogenetics. J Allergy Clin Immunol 2004, 114:13\u201319; quiz 20","journal-title":"J Allergy Clin Immunol"},{"key":"80_CR9","doi-asserted-by":"crossref","first-page":"10560","DOI":"10.1073\/pnas.92.23.10560","volume":"92","author":"H Nagata","year":"1995","unstructured":"Nagata H, Worobec AS, Oh CK, et al.: Identification of a point mutation in the catalytic domain of the protooncogene c-kit in peripheral blood mononuclear cells of patients who have mastocytosis with an associated hematologic disorder. Proc Natl Acad Sci U S A 1995, 92:10560\u201310564.","journal-title":"Proc Natl Acad Sci U S A"},{"key":"80_CR10","doi-asserted-by":"crossref","first-page":"312","DOI":"10.1038\/ng0396-312","volume":"12","author":"BJ Longley","year":"1996","unstructured":"Longley BJ, Tyrrell L, Lu SZ, et al.: Somatic c-kit activating mutation in urticaria pigmentosa and aggressive mastocytosis: establishment of clonality in a human mast cell neoplasm. Nat Genet 1996, 12:312\u2013314.","journal-title":"Nat Genet"},{"key":"80_CR11","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1182\/blood-2003-08-2769","volume":"104","author":"C Tkaczyk","year":"2004","unstructured":"Tkaczyk C, Horejsi V, Iwaki S, et al.: NTAL phosphorylation is a pivotal link between the signaling cascades leading to human mast cell degranulation following Kit activation and Fc epsilon RI aggregation. Blood 2004, 104:207\u2013214.","journal-title":"Blood"},{"key":"80_CR12","doi-asserted-by":"crossref","first-page":"140","DOI":"10.1016\/S0301-472X(99)00145-9","volume":"28","author":"C Akin","year":"2000","unstructured":"Akin C, Kirshenbaum AS, Semere T, et al.: Analysis of the surface expression of c-kit and occurrence of the c-kit Asp816Val activating mutation in T cells, B cells, and myelomonocytic cells in patients with mastocytosis. Exp Hematol 2000, 28:140\u2013147.","journal-title":"Exp Hematol"},{"key":"80_CR13","doi-asserted-by":"crossref","first-page":"661","DOI":"10.1182\/blood-2002-01-0203","volume":"100","author":"AS Yavuz","year":"2002","unstructured":"Yavuz AS, Lipsky PE, Yavuz S, et al.: Evidence for the involvement of a hematopoietic progenitor cell in systemic mastocytosis from single-cell analysis of mutations in the c-kit gene. Blood 2002, 100:661\u2013665.","journal-title":"Blood"},{"key":"80_CR14","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1159\/000085563","volume":"114","author":"C Akin","year":"2005","unstructured":"Akin C: Clonality and molecular pathogenesis of mastocytosis. Acta Haematol 2005, 114:61\u201369.","journal-title":"Acta Haematol"},{"key":"80_CR15","doi-asserted-by":"crossref","first-page":"2731","DOI":"10.1182\/blood.V91.8.2731.2731_2731_2736","volume":"91","author":"L Escribano","year":"1998","unstructured":"Escribano L, Orfao A, Diaz-Agustin B, et al.: Indolent systemic mast cell disease in adults: immunophenotypic characterization of bone marrow mast cells and its diagnostic implications. Blood 1998, 91:2731\u20132736.","journal-title":"Blood"},{"key":"80_CR16","doi-asserted-by":"crossref","first-page":"563","DOI":"10.1016\/S0145-2126(01)00050-9","volume":"25","author":"L Escribano","year":"2001","unstructured":"Escribano L, Diaz-Agustin B, Bellas C, et al.: Utility of flow cytometric analysis of mast cells in the diagnosis and classification of adult mastocytosis. Leuk Res 2001, 25:563\u2013570.","journal-title":"Leuk Res"},{"key":"80_CR17","doi-asserted-by":"crossref","first-page":"529","DOI":"10.1016\/S0145-2126(01)00041-8","volume":"25","author":"WR Sperr","year":"2001","unstructured":"Sperr WR, Escribano L, Jordan JH, et al.: Morphologic properties of neoplastic mast cells: delineation of stages of maturation and implication for cytological grading of mastocytosis. Leuk Res 2001, 25:529\u2013536.","journal-title":"Leuk Res"},{"key":"80_CR18","doi-asserted-by":"crossref","first-page":"808","DOI":"10.1016\/S0046-8177(85)80252-5","volume":"16","author":"HP Horny","year":"1985","unstructured":"Horny HP, Parwaresch MR, Lennert K: Bone marrow findings in systemic mastocytosis. Hum Pathol 1985, 16:808\u2013814.","journal-title":"Hum Pathol"},{"key":"80_CR19","doi-asserted-by":"crossref","first-page":"2702","DOI":"10.1172\/JCI118337","volume":"96","author":"LB Schwartz","year":"1995","unstructured":"Schwartz LB, Sakai K, Bradford TR, et al.: The alpha form of human tryptase is the predominant type present in blood at baseline in normal subjects and is elevated in those with systemic mastocytosis. J Clin Invest 1995, 96:2702\u20132710.","journal-title":"J Clin Invest"},{"key":"80_CR20","doi-asserted-by":"crossref","first-page":"451","DOI":"10.1016\/j.iac.2006.05.010","volume":"26","author":"LB Schwartz","year":"2006","unstructured":"Schwartz LB: Diagnostic value of tryptase in anaphylaxis and mastocytosis. Immunol Allergy Clin North Am 2006, 26:451\u2013463.","journal-title":"Immunol Allergy Clin North Am"},{"key":"80_CR21","doi-asserted-by":"crossref","first-page":"487","DOI":"10.1016\/j.iac.2006.05.006","volume":"26","author":"JH Butterfield","year":"2006","unstructured":"Butterfield JH: Systemic mastocytosis: clinical manifestations and differential diagnosis. Immunol Allergy Clin North Am 2006, 26:487\u2013513.","journal-title":"Immunol Allergy Clin North Am"},{"key":"80_CR22","doi-asserted-by":"crossref","first-page":"465","DOI":"10.1016\/j.iac.2006.05.005","volume":"26","author":"M Castells","year":"2006","unstructured":"Castells M: Mast cell mediators in allergic inflammation and mastocytosis. Immunol Allergy Clin North Am 2006, 26:465\u2013485.","journal-title":"Immunol Allergy Clin North Am"},{"key":"80_CR23","doi-asserted-by":"crossref","first-page":"387","DOI":"10.1097\/ACI.0b013e3282a6443e","volume":"7","author":"M Greenhawt","year":"2007","unstructured":"Greenhawt M, Akin C: Mastocytosis and allergy. Curr Opin Allergy Clin Immunol 2007, 7:387\u2013392.","journal-title":"Curr Opin Allergy Clin Immunol"},{"key":"80_CR24","doi-asserted-by":"crossref","first-page":"226","DOI":"10.1111\/j.1398-9995.2007.01569.x","volume":"63","author":"K Brockow","year":"2008","unstructured":"Brockow K, Jofer C, Behrendt H, Ring J: Anaphylaxis in patients with mastocytosis: a study on history, clinical features and risk factors in 120 patients. Allergy 2008, 63:226\u2013232.","journal-title":"Allergy"},{"key":"80_CR25","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1016\/S1081-1206(10)61367-1","volume":"97","author":"LM Webb","year":"2006","unstructured":"Webb LM, Lieberman P: Anaphylaxis: a review of 601 cases. Ann Allergy Asthma Immunol 2006, 97:39\u201343.","journal-title":"Ann Allergy Asthma Immunol"},{"key":"80_CR26","doi-asserted-by":"crossref","first-page":"285","DOI":"10.1016\/S1081-1206(10)63322-4","volume":"77","author":"AM Ditto","year":"1996","unstructured":"Ditto AM, Harris KE, Krasnick J, et al.: Idiopathic anaphylaxis: a series of 335 cases. Ann Allergy Asthma Immunol 1996, 77:285\u2013291.","journal-title":"Ann Allergy Asthma Immunol"},{"key":"80_CR27","doi-asserted-by":"crossref","first-page":"S206","DOI":"10.1016\/S0091-6749(03)80711-X","volume":"111","author":"C Akin","year":"2003","unstructured":"Akin C, Metcalfe DD: Occult bone marrow mastocytosis presenting as recurrent systemic anaphylaxis [abstract]. J Allergy Clin Immunol 2003, 111:S206.","journal-title":"J Allergy Clin Immunol"},{"key":"80_CR28","doi-asserted-by":"crossref","first-page":"2331","DOI":"10.1182\/blood-2006-06-028100","volume":"110","author":"C Akin","year":"2007","unstructured":"\u2022\u2022 Akin C, Scott LM, Kocabas CN, et al.: Demonstration of an aberrant mast-cell population with clonal markers in a subset of patients with \"idiopathic\" anaphylaxis. Blood 2007, 110:2331\u20132333. This was a systematic, prospective study designed to investigate clonal mast cell disease in patients with idiopathic anaphylaxis.","journal-title":"Blood"},{"key":"80_CR29","doi-asserted-by":"crossref","first-page":"361","DOI":"10.1016\/S0140-6736(00)03647-3","volume":"357","author":"D Ludolph-Hauser","year":"2001","unstructured":"Ludolph-Hauser D, Rueff F, Fries C, et al.: Constitutively raised serum concentrations of mast-cell tryptase and severe anaphylactic reactions to Hymenoptera stings. Lancet 2001, 357:361\u2013362.","journal-title":"Lancet"},{"key":"80_CR30","doi-asserted-by":"crossref","first-page":"1216","DOI":"10.1046\/j.1365-2222.2003.01755.x","volume":"33","author":"G Haeberli","year":"2003","unstructured":"Haeberli G, Bronnimann M, Hunziker T, Muller U: Elevated basal serum tryptase and hymenoptera venom allergy: relation to severity of sting reactions and to safety and efficacy of venom immunotherapy. Clin Exp Allergy 2003, 33:1216\u20131220.","journal-title":"Clin Exp Allergy"},{"key":"80_CR31","doi-asserted-by":"crossref","first-page":"284","DOI":"10.1097\/01.all.0000235903.10548.63","volume":"6","author":"F Rueff","year":"2006","unstructured":"Rueff F, Placzek M, Przybilla B: Mastocytosis and Hymenoptera venom allergy. Curr Opin Allergy Clin Immunol 2006, 6:284\u2013288.","journal-title":"Curr Opin Allergy Clin Immunol"},{"key":"80_CR32","doi-asserted-by":"crossref","first-page":"158","DOI":"10.1159\/000096442","volume":"142","author":"K Sonneck","year":"2007","unstructured":"\u2022 Sonneck K, Florian S, Mullauer L, et al.: Diagnostic and subdiagnostic accumulation of mast cells in the bone marrow of patients with anaphylaxis: monoclonal mast cell activation syndrome. Int Arch Allergy Immunol 2007, 142:158\u2013164. This was a description of monoclonal mast cell activation syndrome.","journal-title":"Int Arch Allergy Immunol"},{"key":"80_CR33","doi-asserted-by":"crossref","first-page":"680","DOI":"10.1016\/j.jaci.2008.11.018","volume":"123","author":"P Bonadonna","year":"2009","unstructured":"\u2022\u2022 Bonadonna P, Perbellini O, Passalacqua G, et al.: Clonal mast cell disorders in patients with systemic reactions to Hymenoptera stings and increased serum tryptase levels. J Allergy Clin Immunol 2009, 123:680\u2013686. This study systematically analyzed markers of clonal mast cell disease in venom anaphylaxis and found that all patients with elevated tryptase levels had a form of mast cell disease.","journal-title":"J Allergy Clin Immunol"},{"key":"80_CR34","doi-asserted-by":"crossref","first-page":"1379","DOI":"10.1111\/j.1398-9995.2009.02108.x","volume":"64","author":"P Bonadonna","year":"2009","unstructured":"Bonadonna P, Zanotti R, Pagani M, et al.: How much specific is the association between hymenoptera venom allergy and mastocytosis? Allergy 2009, 64:1379\u20131382.","journal-title":"Allergy"},{"key":"80_CR35","doi-asserted-by":"crossref","first-page":"S29","DOI":"10.1016\/j.jaci.2006.11.132","volume":"119","author":"SI Hungness","year":"2007","unstructured":"Hungness SI, Singer AM, Akin C: Food-dependent exercise-induced anaphylaxis associated with clonal mast cells carrying an activating c-kit mutation. J Allergy Clin Immunol 2007, 119:S29.","journal-title":"J Allergy Clin Immunol"},{"key":"80_CR36","doi-asserted-by":"crossref","first-page":"301","DOI":"10.1046\/j.1365-2567.1996.d01-733.x","volume":"89","author":"TJ Lin","year":"1996","unstructured":"Lin TJ, Bissonnette EY, Hirsh A, Befus AD: Stem cell factor potentiates histamine secretion by multiple mechanisms, but does not affect tumour necrosis factor-alpha release from rat mast cells. Immunology 1996, 89:301\u2013307.","journal-title":"Immunology"},{"key":"80_CR37","doi-asserted-by":"crossref","first-page":"S68","DOI":"10.1016\/j.jaci.2007.12.273","volume":"121","author":"A Koterba","year":"2008","unstructured":"Koterba A, Akin C: Differences in the clinical presentation of anaphylaxis in patients with indolent systemic mastocytosis versus idiopathic anaphylaxis [abstract]. J Allergy Clin Immunol 2008, 121:S68.","journal-title":"J Allergy Clin Immunol"},{"key":"80_CR38","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1016\/S0091-6749(97)70314-2","volume":"99","author":"JN Oude Elberink","year":"1997","unstructured":"Oude Elberink JN, de Monchy JG, Kors JW, et al.: Fatal anaphylaxis after a yellow jacket sting, despite venom immunotherapy, in two patients with mastocytosis. J Allergy Clin Immunol 1997, 99:153\u2013154.","journal-title":"J Allergy Clin Immunol"},{"key":"80_CR39","doi-asserted-by":"crossref","first-page":"519","DOI":"10.1016\/j.jaci.2007.11.010","volume":"121","author":"D Gonzalez de Olano","year":"2008","unstructured":"\u2022 Gonzalez de Olano D, Alvarez-Twose I, Esteban-Lopez MI, et al.: Safety and effectiveness of immunotherapy in patients with indolent systemic mastocytosis presenting with Hymenoptera venom anaphylaxis. J Allergy Clin Immunol 2008, 121:519\u2013526. The study reports on valuable clinical experience in the management of patients with venom anaphylaxis.","journal-title":"J Allergy Clin Immunol"}],"container-title":["Current Allergy and Asthma Reports"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s11882-009-0080-8.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s11882-009-0080-8\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s11882-009-0080-8","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,5,26]],"date-time":"2020-05-26T13:42:53Z","timestamp":1590500573000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s11882-009-0080-8"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2010,1]]},"references-count":39,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2010,1]]}},"alternative-id":["80"],"URL":"https:\/\/doi.org\/10.1007\/s11882-009-0080-8","relation":{},"ISSN":["1529-7322","1534-6315"],"issn-type":[{"value":"1529-7322","type":"print"},{"value":"1534-6315","type":"electronic"}],"subject":[],"published":{"date-parts":[[2010,1]]}}}