{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,4,8]],"date-time":"2025-04-08T00:10:09Z","timestamp":1744071009919,"version":"3.40.3"},"reference-count":8,"publisher":"Springer Science and Business Media LLC","issue":"5","license":[{"start":{"date-parts":[[2010,7,11]],"date-time":"2010-07-11T00:00:00Z","timestamp":1278806400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2010,7,11]],"date-time":"2010-07-11T00:00:00Z","timestamp":1278806400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Curr Allergy Asthma Rep"],"published-print":{"date-parts":[[2010,9]]},"DOI":"10.1007\/s11882-010-0135-x","type":"journal-article","created":{"date-parts":[[2010,7,11]],"date-time":"2010-07-11T21:17:30Z","timestamp":1278883050000},"page":"303-305","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Defective B-cell Response to Toll-like Receptor-9 Ligands in Common Variable Immunodeficiency"],"prefix":"10.1007","volume":"10","author":[{"given":"Julie Y.","family":"Patel","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sapandeep K.","family":"Singh","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David P.","family":"Huston","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2010,7,11]]},"reference":[{"key":"135_CR1","doi-asserted-by":"publisher","first-page":"34","DOI":"10.1006\/clim.1999.4725","volume":"92","author":"C Cunningham-Rundles","year":"1999","unstructured":"Cunningham-Rundles C, Bodian C: Common variable immunodeficiency: clinical and immunological features of 248 patients. Clin Immunol 1999, 92:34\u201348.","journal-title":"Clin Immunol"},{"key":"135_CR2","doi-asserted-by":"crossref","first-page":"1978","DOI":"10.4049\/jimmunol.176.3.1978","volume":"176","author":"C Cunningham-Rundles","year":"2006","unstructured":"Cunningham-Rundles C, Radigan L, Knight AK, et al.: TLR9 activation is defective in common variable immune deficiency. J Immunol 2006, 176:1978\u20131987.","journal-title":"J Immunol"},{"key":"135_CR3","doi-asserted-by":"publisher","first-page":"349","DOI":"10.1016\/j.jaci.2009.05.019","volume":"124","author":"JE Yu","year":"2009","unstructured":"Yu JE, Knight AK, Radigan L, et al.: Toll-like receptor 7 and 9 defects in common variable immunodeficiency. J Allergy Clin Immunol 2009, 124:349\u2013356.","journal-title":"J Allergy Clin Immunol"},{"key":"135_CR4","doi-asserted-by":"crossref","first-page":"401","DOI":"10.1111\/j.1365-2249.2007.03461.x","volume":"149","author":"C Bacchelli","year":"2007","unstructured":"Bacchelli C, Buckridge S, Thrasher AJ, Gaspar HB: Translational mini-review series on immunodeficiency: molecular defects in common variable immunodeficiency. Clin Exp Immunol 2007, 149:401\u2013409.","journal-title":"Clin Exp Immunol"},{"key":"135_CR5","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1007\/3-540-32636-7_1","volume":"311","author":"A Akira","year":"2006","unstructured":"Akira A: TLR signaling. Curr Top Microbiol Immunol 2006, 311:1\u201316.","journal-title":"TLR signaling. Curr Top Microbiol Immunol"},{"key":"135_CR6","doi-asserted-by":"publisher","first-page":"4500","DOI":"10.1182\/blood-2002-11-3569","volume":"101","author":"NL Bernasconi","year":"2003","unstructured":"Bernasconi NL, Onai N, Lanzavecchia A: A role for Toll-like receptors in acquired immunity: up-regulation of TLR9 by BCR triggering in na\u00efve B cells and constitutive expression in memory B cells. Blood 2003, 101:4500\u20134505.","journal-title":"Blood"},{"key":"135_CR7","doi-asserted-by":"publisher","first-page":"810","DOI":"10.1002\/eji.200535744","volume":"36","author":"CR Ruprecht","year":"2006","unstructured":"Ruprecht CR, Lanzavecchia A: Toll-like receptor stimulation as a third signal required for activation of human na\u00efve B cells. Eur J Immunol 2006, 36:810\u2013816.","journal-title":"Eur J Immunol"},{"key":"135_CR8","doi-asserted-by":"publisher","first-page":"58","DOI":"10.1111\/j.1749-6632.2009.05123.x","volume":"1183","author":"SP Crampton","year":"2010","unstructured":"Crampton SP, Voynova E, Bolland S: Innate pathways to B-cell activation and tolerance. Ann N Y Acad Sci 2010, 1183:58\u201368.","journal-title":"Ann N Y Acad Sci"}],"container-title":["Current Allergy and Asthma Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s11882-010-0135-x.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s11882-010-0135-x\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s11882-010-0135-x","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s11882-010-0135-x.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,7]],"date-time":"2025-04-07T23:36:38Z","timestamp":1744068998000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s11882-010-0135-x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2010,7,11]]},"references-count":8,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2010,9]]}},"alternative-id":["135"],"URL":"https:\/\/doi.org\/10.1007\/s11882-010-0135-x","relation":{},"ISSN":["1529-7322","1534-6315"],"issn-type":[{"type":"print","value":"1529-7322"},{"type":"electronic","value":"1534-6315"}],"subject":[],"published":{"date-parts":[[2010,7,11]]},"assertion":[{"value":"11 July 2010","order":1,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}}]}}