{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T05:33:48Z","timestamp":1761975228442},"reference-count":48,"publisher":"Springer Science and Business Media LLC","issue":"6","license":[{"start":{"date-parts":[[2011,9,8]],"date-time":"2011-09-08T00:00:00Z","timestamp":1315440000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Curr Allergy Asthma Rep"],"published-print":{"date-parts":[[2011,12]]},"DOI":"10.1007\/s11882-011-0219-2","type":"journal-article","created":{"date-parts":[[2011,9,7]],"date-time":"2011-09-07T10:48:12Z","timestamp":1315392492000},"page":"465-472","source":"Crossref","is-referenced-by-count":4,"title":["Oral Food Challenges in Children: Review and Future Perspectives"],"prefix":"10.1007","volume":"11","author":[{"given":"Matthew","family":"Greenhawt","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2011,9,8]]},"reference":[{"issue":"6 Suppl","key":"219_CR1","first-page":"S1","volume":"126","author":"JA Boyce","year":"2010","unstructured":"\u2022\u2022 Boyce JA, et al. Guidelines for the diagnosis and management of food allergy in the United States: report of the NIAID-sponsored expert panel. J Allergy Clin Immunol. 2010;126(6 Suppl):S1-58. This article is of exceptional importance as it is the most comprehensive, up-to-date peer review of food allergy and its management, from an expert panel assembled by the National Institute of Allergy and Infectious Diseases.","journal-title":"J Allergy Clin Immunol"},{"issue":"8","key":"219_CR2","doi-asserted-by":"crossref","first-page":"1135","DOI":"10.1046\/j.1365-2222.2000.00889.x","volume":"30","author":"MN Primeau","year":"2000","unstructured":"Primeau MN et al. The psychological burden of peanut allergy as perceived by adults with peanut allergy and the parents of peanut-allergic children. Clin Exp Allergy. 2000;30(8):1135\u201343.","journal-title":"Clin Exp Allergy"},{"issue":"1","key":"219_CR3","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1067\/mai.2001.112031","volume":"107","author":"SA Bock","year":"2001","unstructured":"Bock SA, Munoz-Furlong A, Sampson HA. Fatalities due to anaphylactic reactions to foods. J Allergy Clin Immunol. 2001;107(1):191\u20133.","journal-title":"J Allergy Clin Immunol"},{"issue":"4","key":"219_CR4","doi-asserted-by":"crossref","first-page":"1016","DOI":"10.1016\/j.jaci.2006.12.622","volume":"119","author":"SA Bock","year":"2007","unstructured":"Bock SA, Munoz-Furlong A, Sampson HA. Further fatalities caused by anaphylactic reactions to food, 2001\u20132006. J Allergy Clin Immunol. 2007;119(4):1016\u20138.","journal-title":"J Allergy Clin Immunol"},{"issue":"2 Pt 1","key":"219_CR5","doi-asserted-by":"crossref","first-page":"452","DOI":"10.1016\/S0091-6749(99)70392-1","volume":"104","author":"MW Yocum","year":"1999","unstructured":"Yocum MW et al. Epidemiology of anaphylaxis in Olmsted County: a population-based study. J Allergy Clin Immunol. 1999;104(2 Pt 1):452\u20136.","journal-title":"J Allergy Clin Immunol"},{"issue":"6","key":"219_CR6","doi-asserted-by":"crossref","first-page":"1549","DOI":"10.1542\/peds.2009-1210","volume":"124","author":"AM Branum","year":"2009","unstructured":"Branum AM, Lukacs SL. Food allergy among children in the United States. Pediatrics. 2009;124(6):1549\u201355.","journal-title":"Pediatrics"},{"key":"219_CR7","doi-asserted-by":"crossref","first-page":"a2880","DOI":"10.1136\/bmj.a2880","volume":"337","author":"N Christakis","year":"2008","unstructured":"Christakis N. This allergies hysteria is just nuts. BMJ. 2008;337:a2880.","journal-title":"BMJ"},{"key":"219_CR8","unstructured":"Stein J. Nut allergies: a yuppie invention. Los Angeles Times, January 9, 2009. Accessed June 20, 2011."},{"key":"219_CR9","unstructured":"Peanut allergy stirs controversy at Florida school. Available at http:\/\/news.yahoo.com\/s\/nm\/20110322\/hl_nm\/us_peanut_allergy >. Accessed April 4. 2011."},{"issue":"3 Suppl 3","key":"219_CR10","first-page":"S1","volume":"100","author":"IL Bernstein","year":"2008","unstructured":"Bernstein IL et al. Allergy diagnostic testing: an updated practice parameter. Ann Allergy Asthma Immunol. 2008;100(3 Suppl 3):S1\u2013S148.","journal-title":"Ann Allergy Asthma Immunol"},{"issue":"2","key":"219_CR11","doi-asserted-by":"crossref","first-page":"188","DOI":"10.1111\/j.1399-3038.2007.00700.x","volume":"19","author":"L Noimark","year":"2008","unstructured":"Noimark L, Cox HE. Nutritional problems related to food allergy in childhood. Pediatr Allergy Immunol. 2008;19(2):188\u201395.","journal-title":"Pediatr Allergy Immunol"},{"issue":"4","key":"219_CR12","doi-asserted-by":"crossref","first-page":"843","DOI":"10.1016\/j.jaci.2011.02.011","volume":"127","author":"WG Shreffler","year":"2011","unstructured":"\u2022\u2022 Shreffler WG. Microarrayed recombinant allergens for diagnostic testing. J Allergy Clin Immunol. 2011;127(4):843\u20139; quiz 850\u20131. This is an exceptional review of a new and exciting technique that will prove to be of exceptional utility in the future diagnosis of food allergy and help explain a great deal of clinically relevant cross-reactivity.","journal-title":"J Allergy Clin Immunol"},{"issue":"4","key":"219_CR13","doi-asserted-by":"crossref","first-page":"500","DOI":"10.1016\/0091-6749(76)90194-9","volume":"58","author":"CD May","year":"1976","unstructured":"May CD. Objective clinical and laboratory studies of immediate hypersensitivity reactions to foods in asthmatic children. J Allergy Clin Immunol. 1976;58(4):500\u201315.","journal-title":"J Allergy Clin Immunol"},{"issue":"6 Suppl","key":"219_CR14","doi-asserted-by":"crossref","first-page":"S365","DOI":"10.1016\/j.jaci.2009.03.042","volume":"123","author":"A Nowak-Wegrzyn","year":"2009","unstructured":"\u2022 Nowak-Wegrzyn A., et al. Work Group report: oral food challenge testing. J Allergy Clin Immunol. 2009;123(6 Suppl):S365-83. This is a well-written, comprehensive review and working manual for the allergy practitioner on how to conduct oral food challenges. It is a must read.","journal-title":"J Allergy Clin Immunol"},{"issue":"4","key":"219_CR15","doi-asserted-by":"crossref","first-page":"226","DOI":"10.1034\/j.1399-3038.1999.00040.x","volume":"10","author":"SH Sicherer","year":"1999","unstructured":"Sicherer SH. Food allergy: when and how to perform oral food challenges. Pediatr Allergy Immunol. 1999;10(4):226\u201334.","journal-title":"Pediatr Allergy Immunol"},{"issue":"1","key":"219_CR16","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1111\/j.1365-2222.1979.tb01519.x","volume":"9","author":"DG Wraith","year":"1979","unstructured":"Wraith DG et al. Recognition of food-allergic patients and their allergens by the RAST technique and clinical investigation. Clin Allergy. 1979;9(1):25\u201336.","journal-title":"Clin Allergy"},{"key":"219_CR17","unstructured":"Axen R., et al. A new laboratory diagnostic system applied to allergy testing. In: Johansson SGO, editor. Clinical Workshop: IgE Antibodies and the Pharmacia CAP System in Allergy Diagnosis. Uppsala: Sweden: Pharmacia Diagnostics AB; 1988. p. 3\u20134."},{"issue":"4","key":"219_CR18","doi-asserted-by":"crossref","first-page":"444","DOI":"10.1016\/S0091-6749(97)70133-7","volume":"100","author":"HA Sampson","year":"1997","unstructured":"Sampson HA, Ho DG. Relationship between food-specific IgE concentrations and the risk of positive food challenges in children and adolescents. J Allergy Clin Immunol. 1997;100(4):444\u201351.","journal-title":"J Allergy Clin Immunol"},{"issue":"5","key":"219_CR19","doi-asserted-by":"crossref","first-page":"891","DOI":"10.1067\/mai.2001.114708","volume":"107","author":"HA Sampson","year":"2001","unstructured":"Sampson HA. Utility of food-specific IgE concentrations in predicting symptomatic food allergy. J Allergy Clin Immunol. 2001;107(5):891\u20136.","journal-title":"J Allergy Clin Immunol"},{"issue":"5","key":"219_CR20","doi-asserted-by":"crossref","first-page":"651","DOI":"10.1111\/j.1365-2222.2007.02682.x","volume":"37","author":"J Wang","year":"2007","unstructured":"Wang J, Sampson HA. Food anaphylaxis. Clin Exp Allergy. 2007;37(5):651\u201360.","journal-title":"Clin Exp Allergy"},{"issue":"1","key":"219_CR21","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1016\/j.jaci.2008.04.014","volume":"122","author":"JM Maloney","year":"2008","unstructured":"Maloney JM et al. The use of serum-specific IgE measurements for the diagnosis of peanut, tree nut, and seed allergy. J Allergy Clin Immunol. 2008;122(1):145\u201351.","journal-title":"J Allergy Clin Immunol"},{"key":"219_CR22","doi-asserted-by":"crossref","unstructured":"Hamilton RG, et al. Extension of food allergen specific IgE ranges from the ImmunoCAP to the IMMULITE systems. Ann Allergy Asthma Immunol. 2011.","DOI":"10.1016\/j.anai.2011.04.012"},{"issue":"2 Suppl 2","key":"219_CR23","doi-asserted-by":"crossref","first-page":"S116","DOI":"10.1016\/j.jaci.2009.08.028","volume":"125","author":"SH Sicherer","year":"2010","unstructured":"Sicherer SH, Sampson HA. Food allergy. J Allergy Clin Immunol. 2010;125(2 Suppl 2):S116\u201325.","journal-title":"J Allergy Clin Immunol"},{"issue":"6","key":"219_CR24","doi-asserted-by":"crossref","first-page":"1027","DOI":"10.1067\/mai.2002.124775","volume":"109","author":"F Rance","year":"2002","unstructured":"Rance F, Abbal M, Lauwers-Cances V. Improved screening for peanut allergy by the combined use of skin prick tests and specific IgE assays. J Allergy Clin Immunol. 2002;109(6):1027\u201333.","journal-title":"J Allergy Clin Immunol"},{"issue":"6","key":"219_CR25","doi-asserted-by":"crossref","first-page":"1291","DOI":"10.1016\/j.jaci.2005.02.038","volume":"115","author":"G Roberts","year":"2005","unstructured":"Roberts G, Lack G. Diagnosing peanut allergy with skin prick and specific IgE testing. J Allergy Clin Immunol. 2005;115(6):1291\u20136.","journal-title":"J Allergy Clin Immunol"},{"issue":"6","key":"219_CR26","doi-asserted-by":"crossref","first-page":"1391","DOI":"10.1016\/j.jaci.2010.01.057","volume":"125","author":"NH Nieuwaal van","year":"2010","unstructured":"\u2022\u2022 van Nieuwaal NH, et al. Utility of peanut-specific IgE levels in predicting the outcome of double-blind, placebo-controlled food challenges. J Allergy Clin Immunol. 2010;125(6):1391\u20132. This is a very important article detailing the potential application for how Ara h 2 recognition is a highly specific factor for distinguishing truly clinically reactive peanut-allergic patients from those with more clinically irrelevant sensitization. This is a sentinel article for how new-generation component resolved diagnostic testing can be used.","journal-title":"J Allergy Clin Immunol"},{"issue":"5","key":"219_CR27","doi-asserted-by":"crossref","first-page":"1272","DOI":"10.1016\/j.jaci.2007.01.038","volume":"119","author":"T Komata","year":"2007","unstructured":"Komata T et al. The predictive relationship of food-specific serum IgE concentrations to challenge outcomes for egg and milk varies by patient age. J Allergy Clin Immunol. 2007;119(5):1272\u20134.","journal-title":"J Allergy Clin Immunol"},{"issue":"1","key":"219_CR28","doi-asserted-by":"crossref","first-page":"144","DOI":"10.1016\/j.jaci.2004.04.009","volume":"114","author":"TT Perry","year":"2004","unstructured":"Perry TT et al. The relationship of allergen-specific IgE levels and oral food challenge outcome. J Allergy Clin Immunol. 2004;114(1):144\u20139.","journal-title":"J Allergy Clin Immunol"},{"issue":"3","key":"219_CR29","doi-asserted-by":"crossref","first-page":"582","DOI":"10.1067\/mai.2000.104941","volume":"105","author":"SH Sicherer","year":"2000","unstructured":"Sicherer SH, Morrow EH, Sampson HA. Dose-response in double-blind, placebo-controlled oral food challenges in children with atopic dermatitis. J Allergy Clin Immunol. 2000;105(3):582\u20136.","journal-title":"J Allergy Clin Immunol"},{"key":"219_CR30","unstructured":"Mofidi S, Bock SA, editors. A health professional\u2019s guide to food challenges. Fairfax, VA. The Food Allergy & Anaphylaxis Network, 2004."},{"issue":"7","key":"219_CR31","doi-asserted-by":"crossref","first-page":"690","DOI":"10.1111\/j.1398-9995.2004.00466.x","volume":"59","author":"C Bindslev-Jensen","year":"2004","unstructured":"Bindslev-Jensen C et al. Standardization of food challenges in patients with immediate reactions to foods\u2014position paper from the European Academy of Allergology and Clinical Immunology. Allergy. 2004;59(7):690\u20137.","journal-title":"Allergy"},{"issue":"18","key":"219_CR32","doi-asserted-by":"crossref","first-page":"1848","DOI":"10.1001\/jama.2010.582","volume":"303","author":"JJ Chafen","year":"2010","unstructured":"\u2022 Chafen JJ, et al. Diagnosing and managing common food allergies: a systematic review. JAMA 2010;303(18):1848\u201356. This is a National Institutes of Health\u2013commisioned meta-analysis of the food allergy literature by an independent authorship group of nonfood allergists. It is an honest, critical appraisal of the strengths and weaknesses of the food allergy literature to date.","journal-title":"JAMA"},{"issue":"4","key":"219_CR33","doi-asserted-by":"crossref","first-page":"671","DOI":"10.1016\/j.jaci.2009.05.027","volume":"124","author":"M Plaut","year":"2009","unstructured":"Plaut M, Sawyer RT, Fenton MJ. Summary of the 2008 National Institute of Allergy and Infectious Diseases-US Food and Drug Administration Workshop on Food Allergy Clinical Trial Design. J Allergy Clin Immunol. 2009;124(4):671\u2013678 e1.","journal-title":"J Allergy Clin Immunol"},{"issue":"4","key":"219_CR34","doi-asserted-by":"crossref","first-page":"578","DOI":"10.1016\/j.jpeds.2010.09.027","volume":"158","author":"DM Fleischer","year":"2011","unstructured":"\u2022\u2022 Fleischer DM, et al. Oral food challenges in children with a diagnosis of food allergy. J Pediatr. 2011;158(4):578\u201383 e1. This was an interesting and timely study highlighting the importance of challenging children with suspected food allergy and sensitization to food to prevent unnecessary elimination diets.","journal-title":"J Pediatr"},{"issue":"3","key":"219_CR35","doi-asserted-by":"crossref","first-page":"447","DOI":"10.1016\/S0022-3476(88)80626-7","volume":"113","author":"AW Burks","year":"1988","unstructured":"Burks AW et al. Atopic dermatitis: clinical relevance of food hypersensitivity reactions. J Pediatr. 1988;113(3):447\u201351.","journal-title":"J Pediatr"},{"issue":"2","key":"219_CR36","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1034\/j.1399-3038.2000.00071.x","volume":"11","author":"PA Eigenmann","year":"2000","unstructured":"Eigenmann PA, Calza AM. Diagnosis of IgE-mediated food allergy among Swiss children with atopic dermatitis. Pediatr Allergy Immunol. 2000;11(2):95\u2013100.","journal-title":"Pediatr Allergy Immunol"},{"issue":"3","key":"219_CR37","doi-asserted-by":"crossref","first-page":"E8","DOI":"10.1542\/peds.101.3.e8","volume":"101","author":"PA Eigenmann","year":"1998","unstructured":"Eigenmann PA et al. Prevalence of IgE-mediated food allergy among children with atopic dermatitis. Pediatrics. 1998;101(3):E8.","journal-title":"Pediatrics"},{"issue":"5","key":"219_CR38","first-page":"A106","volume":"105","author":"JM Spergel","year":"2010","unstructured":"\u2022\u2022 Spergel JM, Bogunewicz M, et al. Specific IgE levels in a cohort of infants with atopic dermatitis do not predict the development of food allergy (abstract). Ann Allergy Asthma Immunol. 2010;105(5):A106. This is an interesting and much overdue re-evaluation of the relationship between serum-specific IgE levels and food allergy that shows these levels to be far less predictive than originally thought.","journal-title":"Ann Allergy Asthma Immunol"},{"issue":"1","key":"219_CR39","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1016\/j.jaci.2009.10.008","volume":"125","author":"N Nicolaou","year":"2010","unstructured":"Nicolaou N et al. Allergy or tolerance in children sensitized to peanut: prevalence and differentiation using component-resolved diagnostics. J Allergy Clin Immunol. 2010;125(1):191\u20137. e1-13.","journal-title":"J Allergy Clin Immunol"},{"issue":"2","key":"219_CR40","doi-asserted-by":"crossref","first-page":"AB71","DOI":"10.1016\/j.jaci.2010.12.294","volume":"127","author":"K Johnson","year":"2011","unstructured":"Johnson K et al. Predictive value of peanut component specific IgE in a clinical population. J Allergy Clin Immunol. 2011;127(2):AB71.","journal-title":"J Allergy Clin Immunol"},{"issue":"9","key":"219_CR41","doi-asserted-by":"crossref","first-page":"1189","DOI":"10.1111\/j.1398-9995.2010.02334.x","volume":"65","author":"A Asarnoj","year":"2010","unstructured":"Asarnoj A et al. IgE to peanut allergen components: relation to peanut symptoms and pollen sensitization in 8-year-olds. Allergy. 2010;65(9):1189\u201395.","journal-title":"Allergy"},{"issue":"3","key":"219_CR42","doi-asserted-by":"crossref","first-page":"603","DOI":"10.1016\/j.jaci.2010.09.010","volume":"127","author":"A Vereda","year":"2011","unstructured":"Vereda A et al. Peanut allergy: clinical and immunologic differences among patients from 3 different geographic regions. J Allergy Clin Immunol. 2011;127(3):603\u20137.","journal-title":"J Allergy Clin Immunol"},{"issue":"1pt2","key":"219_CR43","doi-asserted-by":"crossref","first-page":"e139","DOI":"10.1111\/j.1399-3038.2011.01112.x","volume":"22","author":"KJ Knop De","year":"2011","unstructured":"De Knop KJ et al. Age-related sensitization profiles for hazelnut (Corylus avellana) in a birch-endemic region. Pediatr Allergy Immunol. 2011;22(1pt2):e139\u201349.","journal-title":"Pediatr Allergy Immunol"},{"issue":"2","key":"219_CR44","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1067\/mai.2002.126080","volume":"110","author":"KM Jarvinen","year":"2002","unstructured":"Jarvinen KM et al. B-cell epitopes as a screening instrument for persistent cow\u2019s milk allergy. J Allergy Clin Immunol. 2002;110(2):293\u20137.","journal-title":"J Allergy Clin Immunol"},{"issue":"7","key":"219_CR45","doi-asserted-by":"crossref","first-page":"758","DOI":"10.1111\/j.1398-9995.2007.01332.x","volume":"62","author":"KM Jarvinen","year":"2007","unstructured":"Jarvinen KM et al. Specificity of IgE antibodies to sequential epitopes of hen\u2019s egg ovomucoid as a marker for persistence of egg allergy. Allergy. 2007;62(7):758\u201365.","journal-title":"Allergy"},{"key":"219_CR46","unstructured":"Jones SM, Burks AW. Chapter 51 in Pediatric Allergy: Principles and Practice. In: Donald YM, Leung DYM, Sampson HA, Geha RS, Szefler SJ. St. Louis, Mosby; 2003."},{"issue":"3","key":"219_CR47","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1016\/S0738-081X(02)00363-2","volume":"21","author":"HA Sampson","year":"2003","unstructured":"Sampson HA. The evaluation and management of food allergy in atopic dermatitis. Clin Dermatol. 2003;21(3):183\u201392.","journal-title":"Clin Dermatol"},{"key":"219_CR48","doi-asserted-by":"crossref","first-page":"633","DOI":"10.1016\/j.jaci.2010.12.004","volume":"127","author":"A DunnGalvin","year":"2011","unstructured":"DunnGalvin A et al. Highly accurate prediction of food challenge outcome using routinely available clinical data. J Allergy Clin Immunol. 2011;127:633\u20139.","journal-title":"J Allergy Clin Immunol"}],"container-title":["Current Allergy and Asthma Reports"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s11882-011-0219-2.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s11882-011-0219-2\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s11882-011-0219-2","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,4,11]],"date-time":"2024-04-11T01:28:23Z","timestamp":1712798903000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s11882-011-0219-2"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011,9,8]]},"references-count":48,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2011,12]]}},"alternative-id":["219"],"URL":"https:\/\/doi.org\/10.1007\/s11882-011-0219-2","relation":{},"ISSN":["1529-7322","1534-6315"],"issn-type":[{"value":"1529-7322","type":"print"},{"value":"1534-6315","type":"electronic"}],"subject":[],"published":{"date-parts":[[2011,9,8]]}}}