{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,19]],"date-time":"2026-10-19T16:05:06Z","timestamp":1792425906782,"version":"4.5.0"},"reference-count":30,"publisher":"Springer Science and Business Media LLC","issue":"2","license":[{"start":{"date-parts":[[2013,2,7]],"date-time":"2013-02-07T00:00:00Z","timestamp":1360195200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Curr Allergy Asthma Rep"],"published-print":{"date-parts":[[2013,4]]},"DOI":"10.1007\/s11882-013-0342-3","type":"journal-article","created":{"date-parts":[[2013,2,6]],"date-time":"2013-02-06T08:35:45Z","timestamp":1360139745000},"page":"171-177","source":"Crossref","is-referenced-by-count":31,"title":["Rhinitis in Older Adults"],"prefix":"10.1007","volume":"13","author":[{"given":"Sharmilee M.","family":"Nyenhuis","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sameer K.","family":"Mathur","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2013,2,7]]},"reference":[{"key":"342_CR1","doi-asserted-by":"crossref","first-page":"1830","DOI":"10.1002\/lary.21193","volume":"121","author":"N Bhattacharyya","year":"2011","unstructured":"Bhattacharyya N. Incremental healthcare utilization and expenditures for allergic rhinitis in the United States. Laryngoscope. 2011;121:1830\u20133.","journal-title":"Laryngoscope"},{"key":"342_CR2","doi-asserted-by":"crossref","first-page":"1080","DOI":"10.1111\/j.1365-2222.2011.03935.x","volume":"42","author":"C Colas","year":"2012","unstructured":"Colas C, Galera H, Anibarro B, Soler R, Navarro A, Jauregui I, et al. Disease severity impairs sleep quality in allergic rhinitis (The SOMNIAAR study). Clin Exp Allergy. 2012;42:1080\u20137.","journal-title":"Clin Exp Allergy"},{"key":"342_CR3","doi-asserted-by":"crossref","first-page":"3","DOI":"10.2500\/aap.2007.28.2934","volume":"28","author":"RA Nathan","year":"2007","unstructured":"Nathan RA. The burden of allergic rhinitis. Allergy Asthma Proc. 2007;28:3\u20139.","journal-title":"Allergy Asthma Proc"},{"key":"342_CR4","doi-asserted-by":"crossref","first-page":"65","DOI":"10.2500\/105065898782103043","volume":"12","author":"A Sanico","year":"1998","unstructured":"Sanico A, Togias A. Noninfectious, nonallergic rhinitis (NINAR): considerations on possible mechanisms. Am J Rhinol. 1998;12:65\u201372.","journal-title":"Am J Rhinol"},{"key":"342_CR5","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1111\/j.1365-2222.1978.tb00461.x","volume":"8","author":"Y Hanneuse","year":"1978","unstructured":"Hanneuse Y, Delespesse G, Hudson D, De Halleux F, Jacques JM. Influence of Aging on IgE-Mediated Reactions in Allergic Patients. Clin Allergy. 1978;8:165\u201374.","journal-title":"Clin Allergy"},{"key":"342_CR6","doi-asserted-by":"crossref","first-page":"478","DOI":"10.1016\/S1081-1206(10)63155-9","volume":"81","author":"MS Dykewicz","year":"1998","unstructured":"Dykewicz MS, Fineman S, Skoner DP, Nicklas R, Lee R, Blessing-Moore J, et al. Diagnosis and management of rhinitis: complete guidelines of the Joint Task Force on Practice Parameters in Allergy, Asthma and Immunology. American Academy of Allergy, Asthma, and Immunology. Ann Allergy Asthma Immunol. 1998;81:478\u2013518.","journal-title":"Ann Allergy Asthma Immunol"},{"key":"342_CR7","doi-asserted-by":"crossref","first-page":"457","DOI":"10.1016\/j.iac.2011.05.011","volume":"31","author":"RA Settipane","year":"2011","unstructured":"Settipane RA. Other causes of rhinitis: mixed rhinitis, rhinitis medicamentosa, hormonal rhinitis, rhinitis of the elderly, and gustatory rhinitis. Immunol Allergy Clin North Am. 2011;31:457\u201367.","journal-title":"Immunol Allergy Clin North Am"},{"key":"342_CR8","doi-asserted-by":"crossref","first-page":"136","DOI":"10.1016\/j.jaci.2011.08.033","volume":"129","author":"K Warm","year":"2012","unstructured":"\u2022 Warm K, Backman H, Lindberg A, Lundback B, Ronmark E. Low incidence and high remission of allergic sensitization among adults. J Allergy Clin Immunol. 2012;129:136\u201342. This paper provides evidence that aging results in remission of allergic sensitivity. This is in contrast to the theories that differences in allergic sensitization in older versus younger patients are due to cohort effects.","journal-title":"J Allergy Clin Immunol"},{"key":"342_CR9","doi-asserted-by":"crossref","first-page":"582","DOI":"10.1111\/j.1398-9995.1989.tb04204.x","volume":"44","author":"M Jessen","year":"1989","unstructured":"Jessen M, Janzon L. Prevalence of non-allergic nasal complaints in an urban and a rural population in Sweden. Allergy. 1989;44:582\u20137.","journal-title":"Allergy"},{"key":"342_CR10","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1080\/0036554021000028071","volume":"123","author":"P Olsson","year":"2003","unstructured":"Olsson P, Berglind N, Bellander T, Stjarne P. Prevalence of self-reported allergic and non-allergic rhinitis symptoms in Stockholm: relation to age, gender, olfactory sense and smoking. Acta Otolaryngol. 2003;123:75\u201380.","journal-title":"Acta Otolaryngol"},{"key":"342_CR11","doi-asserted-by":"crossref","first-page":"363","DOI":"10.2500\/108854185779109124","volume":"6","author":"GA Settipane","year":"1985","unstructured":"Settipane GA, Klein DE. Non allergic rhinitis: demography of eosinophils in nasal smear, blood total eosinophil counts and IgE levels. N Engl Reg Allergy Proc. 1985;6:363\u20136.","journal-title":"N Engl Reg Allergy Proc"},{"key":"342_CR12","first-page":"175","volume":"25","author":"WW Crawford","year":"2004","unstructured":"Crawford WW, Gowda VC, Klaustermeyer WB. Age effects on objective measures of atopy in adult asthma and rhinitis. Allergy Asthma Proc. 2004;25:175\u20139.","journal-title":"Allergy Asthma Proc"},{"key":"342_CR13","first-page":"23","volume":"19","author":"RA Settipane","year":"2007","unstructured":"Settipane RA, Charnock DR. Epidemiology of rhinitis: allergic and nonallergic. Clin Allergy Immunol. 2007;19:23\u201334.","journal-title":"Clin Allergy Immunol"},{"key":"342_CR14","doi-asserted-by":"crossref","first-page":"152","DOI":"10.1016\/S1081-1206(10)62589-6","volume":"82","author":"M Simola","year":"1999","unstructured":"Simola M, Holopainene E, Malmberg H. Changes in skin and nasal sensitivity to allergens and the course of rhinitis; a long-term follow-up study. Ann Allergy Asthma Immunol. 1999;82:152\u20136.","journal-title":"Ann Allergy Asthma Immunol"},{"key":"342_CR15","unstructured":"Long, A, McFadden, C, DeVine, D, Chew, P, Kupelnick, B, and Lau, J. Management of Allergic and Nonallergic Rhinitis. Rockville (MD): Agency for Healthcare Research and Quality (US). [54]. 2002. Evidence Reports\/Technology Assessments."},{"key":"342_CR16","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1159\/000320050","volume":"155","author":"G Lorenzo Di","year":"2011","unstructured":"Di Lorenzo G, Pacor ML, Amodio E, Leto-Barone MS, La Piana S, D'Alcamo A, et al. Differences and similarities between allergic and nonallergic rhinitis in a large sample of adult patients with rhinitis symptoms. Int Arch Allergy Immunol. 2011;155:263\u201370.","journal-title":"Int Arch Allergy Immunol"},{"key":"342_CR17","doi-asserted-by":"crossref","first-page":"355","DOI":"10.1177\/194589240101500601","volume":"15","author":"EJ Moore","year":"2001","unstructured":"Moore EJ, Kern EB. Atrophic rhinitis: a review of 242 cases. Am J Rhinol. 2001;15:355\u201361.","journal-title":"Am J Rhinol"},{"key":"342_CR18","first-page":"513","volume":"64","author":"DA Moneret-Vautrin","year":"1990","unstructured":"Moneret-Vautrin DA, Hsieh V, Wayoff M, Guyot JL, Mouton C, Maria Y. Nonallergic rhinitis with eosinophilia syndrome a precursor of the triad: nasal polyposis, intrinsic asthma, and intolerance to aspirin. Ann Allergy. 1990;64:513\u20138.","journal-title":"Ann Allergy"},{"key":"342_CR19","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1016\/j.amjoto.2003.12.004","volume":"25","author":"MF Kramer","year":"2004","unstructured":"Kramer MF, de la Chaux R, Fintelmann R, Rasp G. NARES: a risk factor for obstructive sleep apnea? Am J Otolaryngol. 2004;25:173\u20137.","journal-title":"Am J Otolaryngol"},{"key":"342_CR20","doi-asserted-by":"crossref","first-page":"441","DOI":"10.1016\/j.iac.2011.05.007","volume":"31","author":"MA Kaliner","year":"2011","unstructured":"Kaliner MA. Nonallergic rhinopathy (formerly known as vasomotor rhinitis). Immunol Allergy Clin North Am. 2011;31:441\u201355.","journal-title":"Immunol Allergy Clin North Am"},{"key":"342_CR21","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1111\/j.1398-9995.1982.tb01879.x","volume":"37","author":"P Broms","year":"1982","unstructured":"Broms P, Malm L. Oral vasoconstrictors in perennial non-allergic rhinitis. Allergy. 1982;37:67\u201374.","journal-title":"Allergy"},{"key":"342_CR22","doi-asserted-by":"crossref","first-page":"373","DOI":"10.1016\/S1081-1206(10)60355-9","volume":"103","author":"MA Kaliner","year":"2009","unstructured":"Kaliner MA. Azelastine and olopatadine in the treatment of allergic rhinitis. Ann Allergy Asthma Immunol. 2009;103:373\u201380.","journal-title":"Ann Allergy Asthma Immunol"},{"key":"342_CR23","doi-asserted-by":"crossref","first-page":"255","DOI":"10.2500\/aap.2009.30.3232","volume":"30","author":"MA Kaliner","year":"2009","unstructured":"Kaliner MA, Storms W, Tilles S, Spector S, Tan R, LaForce C, et al. Comparison of olopatadine 0.6 % nasal spray versus fluticasone propionate 50 microg in the treatment of seasonal allergic rhinitis. Allergy Asthma Proc. 2009;30:255\u201362.","journal-title":"Allergy Asthma Proc"},{"key":"342_CR24","doi-asserted-by":"crossref","first-page":"74","DOI":"10.1016\/S1081-1206(10)60408-5","volume":"100","author":"PH Ratner","year":"2008","unstructured":"Ratner PH, Hampel F, van Bavel J, Amar NJ, Daftary P, Wheeler W, et al. Combination therapy with azelastine hydrochloride nasal spray and fluticasone propionate nasal spray in the treatment of patients with seasonal allergic rhinitis. Ann Allergy Asthma Immunol. 2008;100:74\u201381.","journal-title":"Ann Allergy Asthma Immunol"},{"key":"342_CR25","doi-asserted-by":"crossref","first-page":"290","DOI":"10.2500\/aap.2010.31.3349","volume":"31","author":"F Hampel","year":"2010","unstructured":"Hampel F, Ratner P, Haeusler JM. Safety and tolerability of levocetirizine dihydrochloride in infants and children with allergic rhinitis or chronic urticaria. Allergy Asthma Proc. 2010;31:290\u20135.","journal-title":"Allergy Asthma Proc"},{"key":"342_CR26","doi-asserted-by":"crossref","first-page":"132","DOI":"10.2500\/aap.2010.31.3326","volume":"31","author":"CF LaForce","year":"2010","unstructured":"LaForce CF, Carr W, Tilles SA, Chipps BE, Storms W, Meltzer EO, et al. Evaluation of olopatadine hydrochloride nasal spray, 0.6 %, used in combination with an intranasal corticosteroid in seasonal allergic rhinitis. Allergy Asthma Proc. 2010;31:132\u201340.","journal-title":"Allergy Asthma Proc"},{"key":"342_CR27","doi-asserted-by":"crossref","first-page":"467","DOI":"10.1002\/lary.22398","volume":"122","author":"LM Feazel","year":"2012","unstructured":"\u2022\u2022 Feazel LM, Robertson CE, Ramakrishnan VR, Frank DN. Microbiome complexity and Staphylococcus aureus in chronic rhinosinusitis. Laryngoscope. 2012;122:467\u201372. This paper describes a novel concept of colonized microbes contributing to the inflammatory status in the nasal cavity. Future studies will be needed to address whether modifying the nasal microbiome can impact symptoms of rhinitis.","journal-title":"Laryngoscope"},{"key":"342_CR28","doi-asserted-by":"crossref","first-page":"8334","DOI":"10.1073\/pnas.1205624109","volume":"109","author":"I Hanski","year":"2012","unstructured":"Hanski I, von Hertzen L, Fyhrquist N, Koskinen K, Torppa K, Laatikainen T, et al. Environmental biodiversity, human microbiota, and allergy are interrelated. Proc Natl Acad Sci U S A. 2012;109:8334\u20139.","journal-title":"Proc Natl Acad Sci U S A"},{"key":"342_CR29","doi-asserted-by":"crossref","first-page":"370","DOI":"10.2500\/aap.2010.31.3388","volume":"31","author":"DH Broide","year":"2010","unstructured":"Broide DH. Allergic rhinitis: Pathophysiology. Allergy Asthma Proc. 2010;31:370\u20134.","journal-title":"Allergy Asthma Proc"},{"key":"342_CR30","doi-asserted-by":"crossref","first-page":"1282","DOI":"10.1111\/all.12002","volume":"67","author":"C Rondon","year":"2012","unstructured":"\u2022\u2022 Rondon C, Campo P, Galindo L, Blanca-Lopez N, Cassinello MS, Rodriguez-Bada JL, et al. Prevalence and clinical relevance of local allergic rhinitis. Allergy. 2012;67:1282\u20138. This paper highlights a growing body of evidence suggesting rhinitis symptoms can be due to a localized allergic sensitivity. Recognition of the localized allergic sensitivity or entopy will likely lead to new diagnostic techniques and new therapeutic options.","journal-title":"Allergy"}],"container-title":["Current Allergy and Asthma Reports"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s11882-013-0342-3.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s11882-013-0342-3\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s11882-013-0342-3","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,7,9]],"date-time":"2019-07-09T09:37:19Z","timestamp":1562665039000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s11882-013-0342-3"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,2,7]]},"references-count":30,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2013,4]]}},"alternative-id":["342"],"URL":"https:\/\/doi.org\/10.1007\/s11882-013-0342-3","relation":{},"ISSN":["1529-7322","1534-6315"],"issn-type":[{"value":"1529-7322","type":"print"},{"value":"1534-6315","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013,2,7]]}}}