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J Clin Invest. 2008;118(5):1899\u2013910. doi: 10.1172\/JCI34192 .","journal-title":"J Clin Invest"},{"issue":"3","key":"511_CR56","doi-asserted-by":"crossref","first-page":"286","DOI":"10.1016\/j.pupt.2010.11.002","volume":"24","author":"MS Grace","year":"2011","unstructured":"Grace MS, Belvisi MG. TRPA1 receptors in cough. Pulm Pharmacol Ther. 2011;24(3):286\u20138. doi: 10.1016\/j.pupt.2010.11.002 .","journal-title":"Pulm Pharmacol Ther"},{"issue":"8","key":"511_CR57","doi-asserted-by":"crossref","first-page":"1568","DOI":"10.1111\/j.1460-9568.2009.06702.x","volume":"29","author":"MM Salas","year":"2009","unstructured":"Salas MM, Hargreaves KM, Akopian AN. TRPA1-mediated responses in trigeminal sensory neurons: interaction between TRPA1 and TRPV1. Eur J Neurosci. 2009;29(8):1568\u201378. doi: 10.1111\/j.1460-9568.2009.06702.x .","journal-title":"Eur J Neurosci"},{"key":"511_CR58","doi-asserted-by":"crossref","first-page":"404","DOI":"10.1111\/j.1749-6632.2010.05389.x","volume":"1192","author":"F Guilak","year":"2010","unstructured":"Guilak F, Leddy HA, Liedtke W. Transient receptor potential vanilloid 4: the sixth sense of the musculoskeletal system? Ann N Y Acad Sci. 2010;1192:404\u20139. doi: 10.1111\/j.1749-6632.2010.05389.x .","journal-title":"Ann N Y Acad Sci"},{"issue":"1","key":"511_CR59","doi-asserted-by":"crossref","first-page":"7","DOI":"10.2500\/ajr.2008.22.3125","volume":"22","author":"G Bhargave","year":"2008","unstructured":"Bhargave G, Woodworth BA, Xiong G, Wolfe SG, Antunes MB, Cohen NA. Transient receptor potential vanilloid type 4 channel expression in chronic rhinosinusitis. Am J Rhinol. 2008;22(1):7\u201312. doi: 10.2500\/ajr.2008.22.3125 .","journal-title":"Am J Rhinol"},{"issue":"Pt 3","key":"511_CR60","doi-asserted-by":"crossref","first-page":"715","DOI":"10.1113\/jphysiol.2006.121111","volume":"578","author":"AD Grant","year":"2007","unstructured":"Grant AD, Cottrell GS, Amadesi S, Trevisani M, Nicoletti P, Materazzi S, et al. Protease-activated receptor 2 sensitizes the transient receptor potential vanilloid 4 ion channel to cause mechanical hyperalgesia in mice. J Physiol. 2007;578(Pt 3):715\u201333. doi: 10.1113\/jphysiol.2006.121111 .","journal-title":"J Physiol"},{"key":"511_CR61","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1186\/1471-2202-8-49","volume":"8","author":"S Kaske","year":"2007","unstructured":"Kaske S, Krasteva G, Konig P, Kummer W, Hofmann T, Gudermann T, et al. TRPM5, a taste-signaling transient receptor potential ion-channel, is a ubiquitous signaling component in chemosensory cells. BMC Neurosci. 2007;8:49. doi: 10.1186\/1471-2202-8-49 .","journal-title":"BMC Neurosci"},{"issue":"16","key":"511_CR62","doi-asserted-by":"crossref","first-page":"6075","DOI":"10.1073\/pnas.1402251111","volume":"111","author":"CJ Saunders","year":"2014","unstructured":"Saunders CJ, Christensen M, Finger TE, Tizzano M. Cholinergic neurotransmission links solitary chemosensory cells to nasal inflammation. Proc Natl Acad Sci U S A. 2014;111(16):6075\u201380. doi: 10.1073\/pnas.1402251111 . Provides insight into the role of solitary chemosensory cells in the airway epithelium that synapse with the trigeminal sensory neurons and therefore may be involved in the pathogenesis of NAR.","journal-title":"Proc Natl Acad Sci U S A"},{"key":"511_CR63","doi-asserted-by":"crossref","first-page":"707","DOI":"10.1007\/978-94-007-0265-3_37","volume":"704","author":"A Zholos","year":"2011","unstructured":"Zholos A, Johnson C, Burdyga T, Melanaphy D. TRPM channels in the vasculature. Adv Exp Med Biol. 2011;704:707\u201329. doi: 10.1007\/978-94-007-0265-3_37 .","journal-title":"Adv Exp Med Biol"},{"key":"511_CR64","first-page":"147","volume":"68","author":"U Singh","year":"2014","unstructured":"Singh U, Bernstein JA. Intranasal capsaicin in management of nonallergic (vasomotor) rhinitis. Prog Drug Res. 2014;68:147\u201370. Reviews various studies that have determined the efficacy of capsaicin in treating NAR.","journal-title":"Prog Drug Res"},{"issue":"5","key":"511_CR65","doi-asserted-by":"crossref","first-page":"1332-9, 9 e1-3","DOI":"10.1016\/j.jaci.2013.08.026","volume":"133","author":"L Gerven Van","year":"2014","unstructured":"Van Gerven L, Alpizar YA, Wouters MM, Hox V, Hauben E, Jorissen M, et al. Capsaicin treatment reduces nasal hyperreactivity and transient receptor potential cation channel subfamily V, receptor 1 (TRPV1) overexpression in patients with idiopathic rhinitis. J Allergy Clin Immunol. 2014;133(5):1332-9, 9 e1-3. doi: 10.1016\/j.jaci.2013.08.026 . Emphasizes the role of TRP channels in development of NAR and thereby the role of TRPV1 agonist, capsaicin in desensitizing the TRPV1 channels, and therefore their suggested use in NAR and inflammatory lower airway disorders.","journal-title":"J Allergy Clin Immunol"},{"key":"511_CR66","doi-asserted-by":"crossref","first-page":"704","DOI":"10.1016\/j.jaci.2013.09.016","volume":"133","author":"LP McGarvey","year":"2014","unstructured":"McGarvey LP, Butler CA, Stokesberry S, Polley L, McQuaid S, Abdullah H, et al. Increased expression of bronchial epithelial transient receptor potential vanilloid 1 channels in patients with severe asthma. J Allergy Clin Immunol. 2014;133:704\u201312 e4. doi: 10.1016\/j.jaci.2013.09.016 . Determines overexpression of functional TRPV1 channels in the human airway epithelium in the airways of patients with refractory asthma.","journal-title":"J Allergy Clin Immunol"},{"issue":"3","key":"511_CR67","doi-asserted-by":"crossref","first-page":"215","DOI":"10.2500\/ajra.2014.28.4059","volume":"28","author":"U Singh","year":"2014","unstructured":"Singh U, Bernstein JA, Haar L, Luther K, Jones WK. Azelastine desensitization of transient receptor potential vanilloid 1: a potential mechanism explaining its therapeutic effect in nonallergic rhinitis. Am J Rhinol Allergy. 2014;28(3):215\u201324. doi: 10.2500\/ajra.2014.28.4059 . Determined the influence of pharmacological agents used in NAR to desensitize TRPV1 channels in sensory neurons and nasal epithelial cells and therefore investigates in-depth mechanism of action of these agents.","journal-title":"Am J Rhinol Allergy"},{"issue":"3","key":"511_CR68","doi-asserted-by":"crossref","first-page":"679","DOI":"10.1016\/j.jaci.2013.12.003","volume":"133","author":"MA Birrell","year":"2014","unstructured":"Birrell MA, Bonvini SJ, Dubuis E, Maher SA, Wortley MA, Grace MS, et al. Tiotropium modulates transient receptor potential V1 (TRPV1) in airway sensory nerves: a beneficial off-target effect? J Allergy Clin Immunol. 2014;133(3):679\u201387 e9. doi: 10.1016\/j.jaci.2013.12.003 . Study determined anti-TRPV1 activity of Tiotropium through a mechanism unrelated to its anticholinergic activity.","journal-title":"J Allergy Clin Immunol"},{"issue":"3","key":"511_CR69","doi-asserted-by":"crossref","first-page":"864","DOI":"10.1016\/j.neuroscience.2010.02.058","volume":"167","author":"A Musella","year":"2010","unstructured":"Musella A, De Chiara V, Rossi S, Cavasinni F, Castelli M, Cantarella C, et al. Transient receptor potential vanilloid 1 channels control acetylcholine\/2-arachidonoylglicerol coupling in the striatum. Neuroscience. 2010;167(3):864\u201371. doi: 10.1016\/j.neuroscience.2010.02.058 .","journal-title":"Neuroscience"},{"issue":"5","key":"511_CR70","doi-asserted-by":"crossref","first-page":"283","DOI":"10.1055\/s-0030-1256123","volume":"65","author":"QT Dinh","year":"2011","unstructured":"Dinh QT, Suhling H, Fischer A, Braun A, Welte T. Innervation of the airways in asthma bronchiale and chronic obstructive pulmonary disease (COPD). Pneumologie. 2011;65(5):283\u201392. doi: 10.1055\/s-0030-1256123 .","journal-title":"Pneumologie"},{"issue":"Suppl 86","key":"511_CR71","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1111\/j.1398-9995.2007.01620.x","volume":"63","author":"J Bousquet","year":"2008","unstructured":"Bousquet J, Khaltaev N, Cruz AA, Denburg J, Fokkens WJ, Togias A, et al. Allergic Rhinitis and its Impact on Asthma (ARIA) 2008 update (in collaboration with the World Health Organization, GA(2)LEN and AllerGen). Allergy. 2008;63 Suppl 86:8\u2013160. doi: 10.1111\/j.1398-9995.2007.01620.x .","journal-title":"Allergy"},{"issue":"11","key":"511_CR72","doi-asserted-by":"crossref","first-page":"1611","DOI":"10.1016\/j.rmed.2011.06.004","volume":"105","author":"J Eriksson","year":"2011","unstructured":"Eriksson J, Bjerg A, Lotvall J, Wennergren G, Ronmark E, Toren K, et al. Rhinitis phenotypes correlate with different symptom presentation and risk factor patterns of asthma. Respir Med. 2011;105(11):1611\u201321. doi: 10.1016\/j.rmed.2011.06.004 . Study confirmed a close relationship between nasal disease e.g., allergic rhinitis, chronic rhinitis and chronic rhinosinusitis and asthma.","journal-title":"Respir Med"},{"issue":"6","key":"511_CR73","doi-asserted-by":"crossref","first-page":"1822","DOI":"10.1111\/j.1476-5381.2012.01891.x","volume":"166","author":"I Delescluse","year":"2012","unstructured":"Delescluse I, Mace H, Adcock JJ. Inhibition of airway hyper-responsiveness by TRPV1 antagonists (SB-705498 and PF-04065463) in the unanaesthetized, ovalbumin-sensitized guinea pig. Br J Pharmacol. 2012;166(6):1822\u201332. doi: 10.1111\/j.1476-5381.2012.01891.x . Discusses the role of TRPV1 channels on airway sensory nerves in the pathogenesis of airway hyper-reactivity that hints towards modulation of TRPV1-receptor activity in treating AHR in airway disease.","journal-title":"Br J Pharmacol"},{"issue":"5","key":"511_CR74","doi-asserted-by":"crossref","first-page":"1578","DOI":"10.1073\/pnas.0406808102","volume":"102","author":"AD Kraneveld","year":"2005","unstructured":"Kraneveld AD, Kool M, van Houwelingen AH, Roholl P, Solomon A, Postma DS, et al. Elicitation of allergic asthma by immunoglobulin free light chains. Proc Natl Acad Sci U S A. 2005;102(5):1578\u201383. doi: 10.1073\/pnas.0406808102 .","journal-title":"Proc Natl Acad Sci U S A"},{"key":"511_CR75","doi-asserted-by":"crossref","unstructured":"Bernstein JA, Levin LS, Al-Shuik E, Martin VT. Clinical characteristics of chronic rhinitis patients with high vs low irritant trigger burdens. Ann Allergy Asthma Immunol. 2012;109(3):173\u20138. doi: 10.1016\/j.anai.2012.06.013 . This article demonstrates that the use of an irritant index scale is useful for phenotyping chronic rhinitis subtypes. Allergic and non-allergic rhinitis patients with a high irritant index scale had increased and more severe symptoms as well as an increase in physician diagnosed asthma.","DOI":"10.1016\/j.anai.2012.06.013"},{"issue":"2","key":"511_CR76","first-page":"252","volume":"54","author":"R Ramalho","year":"2014","unstructured":"Ramalho R, Pirraco A, Soares R, Palmares C, Delgado L, Moreira A. Neurogenic inflammation in the airways of elite swimmers. J Sports Med Phys Fitness. 2014;54(2):252\u20133. Study determined the importance of irritant index questionnaires in reclassification of physician-diagnosed rhinitis patients into different diagnostic categories with unique clinical characteristics.","journal-title":"J Sports Med Phys Fitness"},{"issue":"4","key":"511_CR77","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1513\/pats.201001-004SM","volume":"7","author":"BF Bessac","year":"2010","unstructured":"Bessac BF, Jordt SE. Sensory detection and responses to toxic gases: mechanisms, health effects, and countermeasures. Proc Am Thorac Soc. 2010;7(4):269\u201377. doi: 10.1513\/pats.201001-004SM .","journal-title":"Proc Am Thorac Soc"},{"issue":"2","key":"511_CR78","doi-asserted-by":"crossref","first-page":"e55","DOI":"10.2500\/ajra.2012.26.3725","volume":"26","author":"S Comoglu","year":"2012","unstructured":"Comoglu S, Keles N, Deger K. Inflammatory cell patterns in the nasal mucosa of patients with idiopathic rhinitis. Am J Rhinol Allergy. 2012;26(2):e55\u201362. doi: 10.2500\/ajra.2012.26.3725 .","journal-title":"Am J Rhinol Allergy"},{"issue":"4","key":"511_CR79","doi-asserted-by":"crossref","first-page":"170","DOI":"10.1016\/j.tips.2008.01.004","volume":"29","author":"M Thio","year":"2008","unstructured":"Thio M, Blokhuis BR, Nijkamp FP, Redegeld FA. Free immunoglobulin light chains: a novel target in the therapy of inflammatory diseases. Trends Pharmacol Sci. 2008;29(4):170\u20134. doi: 10.1016\/j.tips.2008.01.004 .","journal-title":"Trends Pharmacol Sci"},{"issue":"4","key":"511_CR80","doi-asserted-by":"crossref","first-page":"302","DOI":"10.2500\/ajra.2014.28.4065","volume":"28","author":"C Meng","year":"2014","unstructured":"Meng C, Sha J, Li L, An L, Zhu X, Meng X, et al. The expression and significance of immunoglobulin free light chain in the patients with allergic rhinitis and nonallergic rhinitis. Am J Rhinol Allergy. 2014;28(4):302\u20137. doi: 10.2500\/ajra.2014.28.4065 . Immunoglobulin free light chain may play an important role in inducing local nasal mucosa inflammation especially those in AR and NAR.","journal-title":"Am J Rhinol Allergy"},{"issue":"11","key":"511_CR81","doi-asserted-by":"crossref","first-page":"1006","DOI":"10.1016\/j.exphem.2010.07.001","volume":"38","author":"JE Phipps","year":"2010","unstructured":"Phipps JE, Kestler DP, Foster JS, Kennel SJ, Donnell R, Weiss DT, et al. Inhibition of pathologic immunoglobulin-free light chain production by small interfering RNA molecules. Exp Hematol. 2010;38(11):1006\u201313. doi: 10.1016\/j.exphem.2010.07.001 .","journal-title":"Exp Hematol"},{"issue":"12","key":"511_CR82","doi-asserted-by":"crossref","first-page":"1421","DOI":"10.5588\/ijtld.14.0275","volume":"18","author":"SW Lee","year":"2014","unstructured":"Lee SW, Kim HJ, Yoo KH, Park YB, Park JY, Jung JY, et al. Long-acting anticholinergic agents in patients with uncontrolled asthma: a systematic review and meta-analysis. Int J Tuberc Lung Dis. 2014;18(12):1421\u201330. doi: 10.5588\/ijtld.14.0275 . Addition of tiotropium may be beneficial for patients with poorly controlled asthma.","journal-title":"Int J Tuberc Lung Dis"},{"key":"511_CR83","author":"O Abadoglu","year":"2014","unstructured":"Abadoglu O, Berk S. Tiotropium may improve asthma symptoms and lung function in asthmatic patients with irreversible airway obstruction: the real-life data. Clin Respir J. 2014. doi: 10.1111\/crj.12230 . Study demonstrated that addition of tiotropium to standard care may be helpful in poorly controlled asthma despite of the use of ICS\/LABA.","journal-title":"Clin Respir J"},{"issue":"9","key":"511_CR84","doi-asserted-by":"crossref","first-page":"1268","DOI":"10.1016\/j.rmed.2014.06.011","volume":"108","author":"C Vogelberg","year":"2014","unstructured":"Vogelberg C, Engel M, Moroni-Zentgraf P, Leonaviciute-Klimantaviciene M, Sigmund R, Downie J, et al. Tiotropium in asthmatic adolescents symptomatic despite inhaled corticosteroids: a randomised dose-ranging study. Respir Med. 2014;108(9):1268\u201376. doi: 10.1016\/j.rmed.2014.06.011 . Hints towards the role of LAMA, Tiotropium, as add-on to the current therapeutic approaches to asthma especially if it is refractory to ICS\/LABA.","journal-title":"Respir Med"},{"issue":"31","key":"511_CR85","doi-asserted-by":"crossref","first-page":"11515","DOI":"10.1073\/pnas.1411032111","volume":"111","author":"D Trankner","year":"2014","unstructured":"Trankner D, Hahne N, Sugino K, Hoon MA, Zuker C. Population of sensory neurons essential for asthmatic hyperreactivity of inflamed airways. Proc Natl Acad Sci U S A. 2014;111(31):11515\u201320. doi: 10.1073\/pnas.1411032111 . Highlights the role of sensory neurons in development of asthma.","journal-title":"Proc Natl Acad Sci U S A"},{"key":"511_CR86","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1186\/1472-6882-13-221","volume":"13","author":"L Zhao","year":"2013","unstructured":"Zhao L, Wu J, Zhang X, Kuang H, Guo Y, Ma L. The effect of Shenmai injection on the proliferation of rat airway smooth muscle cells in asthma and underlying mechanism. 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