{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,12]],"date-time":"2026-10-12T03:48:56Z","timestamp":1791776936362,"version":"4.3.4"},"reference-count":37,"publisher":"Springer Science and Business Media LLC","issue":"8","license":[{"start":{"date-parts":[[2016,8,1]],"date-time":"2016-08-01T00:00:00Z","timestamp":1470009600000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"DOI":"10.13039\/501100001827","name":"University of Amsterdam","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100001827","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Curr Allergy Asthma Rep"],"published-print":{"date-parts":[[2016,8]]},"DOI":"10.1007\/s11882-016-0638-1","type":"journal-article","created":{"date-parts":[[2016,8,2]],"date-time":"2016-08-02T22:27:35Z","timestamp":1470176855000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":38,"title":["Capsaicin for Rhinitis"],"prefix":"10.1007","volume":"16","author":[{"given":"Wytske","family":"Fokkens","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter","family":"Hellings","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christine","family":"Segboer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2016,8,3]]},"reference":[{"issue":"10","key":"638_CR1","doi-asserted-by":"crossref","first-page":"1275","DOI":"10.1111\/all.12470","volume":"69","author":"T Zuberbier","year":"2014","unstructured":"Zuberbier T, Lotvall J, Simoens S, Subramanian SV, Church MK. Economic burden of inadequate management of allergic diseases in the European Union: a GA(2) LEN review. Allergy. 2014;69(10):1275\u20139. Interesting paper on the economic burden of rhinitis.","journal-title":"Allergy"},{"issue":"5","key":"638_CR2","doi-asserted-by":"crossref","first-page":"474","DOI":"10.1111\/all.12573","volume":"70","author":"NG Papadopoulos","year":"2015","unstructured":"Papadopoulos NG, Bernstein JA, Demoly P, Dykewicz M, Fokkens W, Hellings PW, et al. Phenotypes and endotypes of rhinitis and their impact on management: a PRACTALL report. Allergy. 2015;70(5):474\u201394. Consensus document between AAAAI en EAACI concerning the phenotypes and endotypes of rhinitis.","journal-title":"Allergy"},{"issue":"12","key":"638_CR3","doi-asserted-by":"crossref","first-page":"1471","DOI":"10.1111\/j.1398-9995.2005.00975.x","volume":"60","author":"JB Rijswijk van","year":"2005","unstructured":"van Rijswijk JB, Blom HM, Fokkens WJ. Idiopathic rhinitis, the ongoing quest. Allergy. 2005;60(12):1471\u201381.","journal-title":"Allergy"},{"issue":"11","key":"638_CR4","doi-asserted-by":"crossref","first-page":"1427","DOI":"10.1111\/all.12255","volume":"68","author":"CL Segboer","year":"2013","unstructured":"Segboer CL, Holland CT, Reinartz SM, Terreehorst I, Gevorgyan A, Hellings PW, et al. Nasal hyper-reactivity is a common feature in both allergic and nonallergic rhinitis. Allergy. 2013;68(11):1427\u201334. Paper describing for the first time that hyperreactivity is equal in AR and NAR.","journal-title":"Allergy"},{"issue":"2","key":"638_CR5","doi-asserted-by":"crossref","first-page":"142","DOI":"10.4193\/Rhin13.102","volume":"52","author":"E Corso de","year":"2014","unstructured":"de Corso E, Battista M, Pandolfini M, Liberati L, Baroni S, Romanello M, et al. Role of inflammation in non-allergic rhinitis. Rhinology. 2014;52(2):142\u20139.","journal-title":"Rhinology"},{"issue":"4","key":"638_CR6","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1007\/s11882-015-0511-7","volume":"15","author":"JA Bernstein","year":"2015","unstructured":"Bernstein JA, Singh U. Neural abnormalities in nonallergic rhinitis. Curr Allergy Asthma Rep. 2015;15(4):18. Very nice review on neural abnormalities in NAR.","journal-title":"Curr Allergy Asthma Rep"},{"issue":"1","key":"638_CR7","doi-asserted-by":"crossref","first-page":"49","DOI":"10.4193\/Rhin14.047","volume":"53","author":"R Pedotti","year":"2015","unstructured":"Pedotti R, Losappio L, Farinotti M, Preziosi D, Tramacere I, Stafylaraki C, et al. Accuracy of a questionnaire for identifying respiratory allergies in epidemiological studies. Rhinology. 2015;53(1):49\u201353.","journal-title":"Rhinology"},{"issue":"6 Pt 1","key":"638_CR8","doi-asserted-by":"crossref","first-page":"1748","DOI":"10.1164\/ajrccm.157.6.9701016","volume":"157","author":"JP Braat","year":"1998","unstructured":"Braat JP, Mulder PG, Fokkens WJ, van Wijk RG, Rijntjes E. Intranasal cold dry air is superior to histamine challenge in determining the presence and degree of nasal hyperreactivity in nonallergic noninfectious perennial rhinitis. Am J Respir Crit Care Med. 1998;157(6 Pt 1):1748\u201355.","journal-title":"Am J Respir Crit Care Med"},{"issue":"12","key":"638_CR9","doi-asserted-by":"crossref","first-page":"2615","DOI":"10.1002\/lary.23495","volume":"122","author":"L Gerven Van","year":"2012","unstructured":"Van Gerven L, Boeckxstaens G, Jorissen M, Fokkens W, Hellings PW. Short-time cold dry air exposure: a useful diagnostic tool for nasal hyperresponsiveness. Laryngoscope. 2012;122(12):2615\u201320.","journal-title":"Laryngoscope"},{"issue":"1","key":"638_CR10","doi-asserted-by":"crossref","first-page":"25","DOI":"10.4193\/Rhino13.037","volume":"52","author":"G Ottaviano","year":"2014","unstructured":"Ottaviano G, Lund VJ, Nardello E, Scarpa B, Frasson G, Staffieri A, et al. Comparison between unilateral PNIF and rhinomanometry in healthy and obstructed noses. Rhinology. 2014;52(1):25\u201330.","journal-title":"Rhinology"},{"issue":"2","key":"638_CR11","doi-asserted-by":"crossref","first-page":"160","DOI":"10.4193\/Rhin15.180","volume":"54","author":"G Ottaviano","year":"2016","unstructured":"Ottaviano G, Scadding GK, Iacono V, Scarpa B, Martini A, Lund VJ. Peak nasal inspiratory flow and peak expiratory flow. Upright and sitting values in an adult population. Rhinology. 2016;54(2):160\u20133.","journal-title":"Rhinology"},{"issue":"1","key":"638_CR12","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1111\/all.12040","volume":"68","author":"PW Hellings","year":"2013","unstructured":"Hellings PW, Fokkens WJ, Akdis C, Bachert C, Cingi C, de Loos Dietz D, et al. Uncontrolled allergic rhinitis and chronic rhinosinusitis: where do we stand today? Allergy. 2013;68(1):1\u20137.","journal-title":"Allergy"},{"issue":"3","key":"638_CR13","doi-asserted-by":"crossref","first-page":"227","DOI":"10.4193\/Rhino.11.152","volume":"50","author":"L Gerven Van","year":"2012","unstructured":"Van Gerven L, Boeckxstaens G, Hellings P. Up-date on neuro-immune mechanisms involved in allergic and non-allergic rhinitis. Rhinology. 2012;50(3):227\u201335. Good overview on relevance of neuro-immune mechanisms.","journal-title":"Rhinology"},{"issue":"5","key":"638_CR14","doi-asserted-by":"crossref","first-page":"1332","DOI":"10.1016\/j.jaci.2013.08.026","volume":"133","author":"L Gerven Van","year":"2014","unstructured":"Van Gerven L, Alpizar YA, Wouters MM, Hox V, Hauben E, Jorissen M, et al. Capsaicin treatment reduces nasal hyperreactivity and transient receptor potential cation channel subfamily V, receptor 1 (TRPV1) overexpression in patients with idiopathic rhinitis. J Allergy Clin Immunol. 2014;133(5):1332\u20139, 9 e1-3. Proof of working mechanism of capsaicin.","journal-title":"J Allergy Clin Immunol"},{"issue":"4","key":"638_CR15","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1111\/j.1365-2273.1983.tb01441.x","volume":"8","author":"H Malmberg","year":"1983","unstructured":"Malmberg H, Grahne B, Holopainen E, Binder E. Ipratropium (Atrovent) in the treatment of vasomotor rhinitis of elderly patients. Clin Otolaryngol Allied Sci. 1983;8(4):273\u20136.","journal-title":"Clin Otolaryngol Allied Sci"},{"issue":"1","key":"638_CR16","first-page":"53","volume":"69","author":"HM Druce","year":"1992","unstructured":"Druce HM, Spector SL, Fireman P, Kaiser H, Meltzer EO, Boggs P, et al. Double-blind study of intranasal ipratropium bromide in nonallergic perennial rhinitis. Ann Allergy. 1992;69(1):53\u201360.","journal-title":"Ann Allergy"},{"issue":"4","key":"638_CR17","doi-asserted-by":"crossref","first-page":"349","DOI":"10.1016\/S1081-1206(10)63284-X","volume":"82","author":"R Dockhorn","year":"1999","unstructured":"Dockhorn R, Aaronson D, Bronsky E, Chervinsky P, Cohen R, Ehtessabian R, et al. Ipratropium bromide nasal spray 0.03% and beclomethasone nasal spray alone and in combination for the treatment of rhinorrhea in perennial rhinitis. Ann Allergy Asthma Immunol. 1999;82(4):349\u201359.","journal-title":"Ann Allergy Asthma Immunol"},{"issue":"11","key":"638_CR18","doi-asserted-by":"crossref","first-page":"1049","DOI":"10.1111\/j.1365-2222.1994.tb02742.x","volume":"24","author":"JW Georgitis","year":"1994","unstructured":"Georgitis JW, Banov C, Boggs PB, Dockhorn R, Grossman J, Tinkelman D, et al. Ipratropium bromide nasal spray in non-allergic rhinitis: efficacy, nasal cytological response and patient evaluation on quality of life. Clin Exp Allergy. 1994;24(11):1049\u201355.","journal-title":"Clin Exp Allergy"},{"issue":"1\u20133","key":"638_CR19","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1016\/j.ejphar.2013.10.053","volume":"720","author":"SK Sharma","year":"2013","unstructured":"Sharma SK, Vij AS, Sharma M. Mechanisms and clinical uses of capsaicin. Eur J Pharmacol. 2013;720(1\u20133):55\u201362.","journal-title":"Eur J Pharmacol"},{"issue":"6","key":"638_CR20","doi-asserted-by":"crossref","first-page":"1283","DOI":"10.1038\/mi.2014.80","volume":"7","author":"BM Assas","year":"2014","unstructured":"Assas BM, Miyan JA, Pennock JL. Cross-talk between neural and immune receptors provides a potential mechanism of homeostatic regulation in the gut mucosa. Mucosal Immunol. 2014;7(6):1283\u20139.","journal-title":"Mucosal Immunol"},{"key":"638_CR21","first-page":"293","volume":"68","author":"K Boyd","year":"2014","unstructured":"Boyd K, Shea SM, Patterson JW. The role of capsaicin in dermatology. Prog Drug Res Fortschritte der Arzneimittelforschung Progres des recherches pharmaceutiques. 2014;68:293\u2013306.","journal-title":"Prog Drug Res Fortschritte der Arzneimittelforschung Progres des recherches pharmaceutiques"},{"issue":"5","key":"638_CR22","doi-asserted-by":"crossref","first-page":"451","DOI":"10.1016\/j.autrev.2016.01.009","volume":"15","author":"Y Deng","year":"2016","unstructured":"Deng Y, Huang X, Wu H, Zhao M, Lu Q, Israeli E, et al. Some like it hot: the emerging role of spicy food (capsaicin) in autoimmune diseases. Autoimmun Rev. 2016;15(5):451\u20136.","journal-title":"Autoimmun Rev"},{"key":"638_CR23","first-page":"277","volume":"68","author":"LL Laslett","year":"2014","unstructured":"Laslett LL, Jones G. Capsaicin for osteoarthritis pain. Prog Drug Res Fortschritte der Arzneimittelforschung Progres des recherches pharmaceutiques. 2014;68:277\u201391.","journal-title":"Prog Drug Res Fortschritte der Arzneimittelforschung Progres des recherches pharmaceutiques"},{"key":"638_CR24","first-page":"h3942","volume":"351","author":"J Lv","year":"2015","unstructured":"Lv J, Qi L, Yu C, Yang L, Guo Y, Chen Y, et al. Consumption of spicy foods and total and cause specific mortality: population based cohort study. BMJ (Clin Res ed). 2015;351:h3942.","journal-title":"BMJ (Clin Res ed)"},{"issue":"3","key":"638_CR25","doi-asserted-by":"crossref","first-page":"215","DOI":"10.2500\/ajra.2014.28.4059","volume":"28","author":"U Singh","year":"2014","unstructured":"Singh U, Bernstein JA, Haar L, Luther K, Jones WK. Azelastine desensitization of transient receptor potential vanilloid 1: a potential mechanism explaining its therapeutic effect in nonallergic rhinitis. Am J Rhinol Allergy. 2014;28(3):215\u201324. Potential explanation for the effect of Azelastine in NAR.","journal-title":"Am J Rhinol Allergy"},{"issue":"3","key":"638_CR26","doi-asserted-by":"crossref","first-page":"679","DOI":"10.1016\/j.jaci.2013.12.003","volume":"133","author":"MA Birrell","year":"2014","unstructured":"Birrell MA, Bonvini SJ, Dubuis E, Maher SA, Wortley MA, Grace MS, et al. Tiotropium modulates transient receptor potential V1 (TRPV1) in airway sensory nerves: a beneficial off-target effect? J Allergy Clin Immunol. 2014;133(3):679\u201387 e9. Potential explanation for effect of\u00a0Tiotropium.","journal-title":"J Allergy Clin Immunol"},{"issue":"12","key":"638_CR27","doi-asserted-by":"crossref","first-page":"1792","DOI":"10.1046\/j.1365-2222.2000.00920.x","volume":"30","author":"R Gerth Van Wijk","year":"2000","unstructured":"Gerth Van Wijk R, Terreehorst IT, Mulder PG, Garrelds IM, Blom HM, Popering S. Intranasal capsaicin is lacking therapeutic effect in perennial allergic rhinitis to house dust mite. a placebo-controlled study. Clin Exp Allergy. 2000;30(12):1792\u20138. Study showing that Capsaicin is not effective in AR.","journal-title":"Clin Exp Allergy"},{"issue":"3","key":"638_CR28","doi-asserted-by":"crossref","first-page":"264","DOI":"10.1111\/j.1742-7843.2011.00803.x","volume":"110","author":"L Alenmyr","year":"2012","unstructured":"Alenmyr L, Greiff L, Andersson M, Sterner O, Zygmunt PM, Hogestatt ED. Effect of mucosal TRPV1 inhibition in allergic rhinitis. Basic Clin Pharmacol Toxicol. 2012;110(3):264\u20138.","journal-title":"Basic Clin Pharmacol Toxicol"},{"issue":"11","key":"638_CR29","doi-asserted-by":"crossref","first-page":"1351","DOI":"10.1046\/j.1365-2222.1998.00421.x","volume":"28","author":"HM Blom","year":"1998","unstructured":"Blom HM, Severijnen LA, Van Rijswijk JB, Mulder PG, Van Wijk RG, Fokkens WJ. The long-term effects of capsaicin aqueous spray on the nasal mucosa. Clin Exp Allergy. 1998;28(11):1351\u20138.","journal-title":"Clin Exp Allergy"},{"key":"638_CR30","doi-asserted-by":"crossref","unstructured":"Blom HM, Van Rijswijk JB, Garrelds IM, Mulder PG, Timmermans T, Gerth van Wijk R. Intranasal capsaicin is efficacious in non-allergic, non-infectious perennial rhinitis. A placebo-controlled study. Clin Exp Allergy. 1997;27(7):796\u2013801.","DOI":"10.1046\/j.1365-2222.1997.670842.x"},{"key":"638_CR31","first-page":"CD010591","volume":"7","author":"A Gevorgyan","year":"2015","unstructured":"Gevorgyan A, Segboer C, Gorissen R, van Drunen CM, Fokkens W. Capsaicin for non-allergic rhinitis. Cochrane Database Syst Rev. 2015;7:CD010591. Systematic review on efficacy of Capsacin.","journal-title":"Cochrane Database Syst Rev"},{"issue":"4","key":"638_CR32","doi-asserted-by":"crossref","first-page":"367","DOI":"10.1080\/00016480802510186","volume":"129","author":"PG Ciabatti","year":"2009","unstructured":"Ciabatti PG, D\u2019Ascanio L. Intranasal capsicum spray in idiopathic rhinitis: a randomized prospective application regimen trial. Acta Otolaryngol. 2009;129(4):367\u201371.","journal-title":"Acta Otolaryngol"},{"issue":"8","key":"638_CR33","doi-asserted-by":"crossref","first-page":"754","DOI":"10.1034\/j.1398-9995.2003.00203.x","volume":"58","author":"JB Rijswijk Van","year":"2003","unstructured":"Van Rijswijk JB, Boeke EL, Keizer JM, Mulder PG, Blom HM, Fokkens WJ. Intranasal capsaicin reduces nasal hyperreactivity in idiopathic rhinitis: a double-blind randomized application regimen study. Allergy. 2003;58(8):754\u201361.","journal-title":"Allergy"},{"issue":"2","key":"638_CR34","first-page":"107","volume":"5","author":"T Havas","year":"2002","unstructured":"Havas T, Taplin M. Intranasal neuropeptide depletion using topical capsaicin for the control of symptoms in non-allergic, non-infectious perennial rhinitis (NANIPER). Aust J Otolaryngol. 2002;5(2):107\u201313.","journal-title":"Aust J Otolaryngol"},{"issue":"2","key":"638_CR35","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1016\/j.anai.2011.05.016","volume":"107","author":"JA Bernstein","year":"2011","unstructured":"Bernstein JA, Davis BP, Picard JK, Cooper JP, Zheng S, Levin LS. A randomized, double-blind, parallel trial comparing capsaicin nasal spray with placebo in subjects with a significant component of nonallergic rhinitis. Ann Allergy Asthma Immunol. 2011;107(2):171\u20138.","journal-title":"Ann Allergy Asthma Immunol"},{"issue":"3","key":"638_CR36","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1517\/13543776.2015.1008449","volume":"25","author":"Y Lee","year":"2015","unstructured":"Lee Y, Hong S, Cui M, Sharma PK, Lee J, Choi S. Transient receptor potential vanilloid type 1 antagonists: a patent review (2011\u20132014). Expert Opin Ther Patents. 2015;25(3):291\u2013318.","journal-title":"Expert Opin Ther Patents"},{"issue":"5","key":"638_CR37","doi-asserted-by":"crossref","first-page":"777","DOI":"10.1111\/bcp.12219","volume":"77","author":"C Holland","year":"2014","unstructured":"Holland C, van Drunen C, Denyer J, Smart K, Segboer C, Terreehorst I, et al. Inhibition of capsaicin-driven nasal hyper-reactivity by SB-705498, a TRPV1 antagonist. Br J Clin Pharmacol. 2014;77(5):777\u201388.","journal-title":"Br J Clin Pharmacol"}],"container-title":["Current Allergy and Asthma Reports"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s11882-016-0638-1.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s11882-016-0638-1\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s11882-016-0638-1","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,7,4]],"date-time":"2022-07-04T19:51:42Z","timestamp":1656964302000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s11882-016-0638-1"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,8]]},"references-count":37,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2016,8]]}},"alternative-id":["638"],"URL":"https:\/\/doi.org\/10.1007\/s11882-016-0638-1","relation":{},"ISSN":["1529-7322","1534-6315"],"issn-type":[{"value":"1529-7322","type":"print"},{"value":"1534-6315","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,8]]},"article-number":"60"}}