{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,21]],"date-time":"2026-09-21T03:48:23Z","timestamp":1789962503463,"version":"4.0.1"},"reference-count":72,"publisher":"Springer Science and Business Media LLC","issue":"9","license":[{"start":{"date-parts":[[2020,6,19]],"date-time":"2020-06-19T00:00:00Z","timestamp":1592524800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2020,6,19]],"date-time":"2020-06-19T00:00:00Z","timestamp":1592524800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"DOI":"10.13039\/501100000761","name":"Imperial College London","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100000761","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Curr Allergy Asthma Rep"],"published-print":{"date-parts":[[2020,9]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Purpose of Review<\/jats:title>\n                    <jats:p>To critically review the evidence in favor or against the use of house dust mite (HDM) allergen avoidance measures in patients with asthma.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Recent Findings<\/jats:title>\n                    <jats:p>Systematic reviews and meta-analyses suggested no positive effect of mite allergen avoidance strategies on asthma outcomes, resulting in a lack of consensus regarding the utility of these measures. However, such analyses have a number limitations and might not be the most adequate tool to evaluate current evidence and to derive clinical recommendations regarding mite allergen avoidance in asthmatic patients. We should not disproportionately rely on the results of meta-analyses and systematic reviews to inform clinical practice and asthma guidelines in this area. Recent high-quality evidence from randomized controlled trial in children confirmed that mite allergen\u2013impermeable bed encasings reduce emergency hospital attendance with acute severe asthma exacerbations.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Summary<\/jats:title>\n                    <jats:p>Until better evidence is available, we suggest that physicians should adopt a pragmatic approach to mite allergen avoidance and advise sensitized patients to implement a multifaceted set of measures to achieve as great a reduction in exposure as possible. Potential predictors of positive response (e.g., patient\u2019s sensitization and exposure status) can pragmatically be evaluated using the size of skin test wheal or the titer of allergen-specific IgE. Finally, the intervention should be started as early as possible.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1007\/s11882-020-00948-y","type":"journal-article","created":{"date-parts":[[2020,6,19]],"date-time":"2020-06-19T07:05:43Z","timestamp":1592550343000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":47,"title":["Update on House Dust Mite Allergen Avoidance Measures for Asthma"],"prefix":"10.1007","volume":"20","author":[{"given":"Chiara","family":"Zuiani","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5218-7071","authenticated-orcid":false,"given":"Adnan","family":"Custovic","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2020,6,19]]},"reference":[{"issue":"1","key":"948_CR1","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1016\/j.jaci.2014.10.012","volume":"136","author":"MA Calder\u00f3n","year":"2015","unstructured":"Calder\u00f3n MA, Linneberg A, Kleine-Tebbe J, De Blay F, Hernandez Fernandez de Rojas D, Virchow JC, et al. Respiratory allergy caused by house dust mites: what do we really know? J Allergy Clin Immunol. 2015;136(1):38\u201348.","journal-title":"J Allergy Clin Immunol"},{"issue":"1","key":"948_CR2","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1164\/ajrccm.153.1.8542107","volume":"153","author":"JK Peat","year":"1996","unstructured":"Peat JK, Tovey E, Toelle BG, Haby MM, Gray EJ, Mahmic A, et al. House dust mite allergens. A major risk factor for childhood asthma in Australia. Am J Respir Crit Care Med. 1996;153(1):141\u20136.","journal-title":"Am J Respir Crit Care Med"},{"issue":"4","key":"948_CR3","doi-asserted-by":"crossref","first-page":"744","DOI":"10.1016\/j.jaci.2005.06.032","volume":"116","author":"A Simpson","year":"2005","unstructured":"Simpson A, Soderstrom L, Ahlstedt S, Murray CS, Woodcock A, Custovic A. IgE antibody quantification and the probability of wheeze in preschool children. J Allergy Clin Immunol. 2005;116(4):744\u20139.","journal-title":"J Allergy Clin Immunol"},{"issue":"3","key":"948_CR4","doi-asserted-by":"crossref","first-page":"391","DOI":"10.1046\/j.1365-2222.2001.01050.x","volume":"31","author":"BM Simpson","year":"2001","unstructured":"Simpson BM, Custovic A, Simpson A, Hallam CL, Walsh D, Marolia H, et al. NAC Manchester Asthma and Allergy Study (NACMAAS): risk factors for asthma and allergic disorders in adults. Clin Exp Allergy J Br Soc Allergy Clin Immunol. 2001;31(3):391\u20139.","journal-title":"Clin Exp Allergy J Br Soc Allergy Clin Immunol"},{"issue":"6","key":"948_CR5","doi-asserted-by":"crossref","first-page":"1760","DOI":"10.1164\/ajrccm.156.6.9704026","volume":"156","author":"SP Squillace","year":"1997","unstructured":"Squillace SP, Sporik RB, Rakes G, Couture N, Lawrence A, Merriam S, et al. Sensitization to dust mites as a dominant risk factor for asthma among adolescents living in Central Virginia. Multiple regression analysis of a population-based study. Am J Respir Crit Care Med. 1997;156(6):1760\u20134.","journal-title":"Am J Respir Crit Care Med"},{"issue":"6 Pt 1","key":"948_CR6","doi-asserted-by":"crossref","first-page":"1805","DOI":"10.1164\/ajrccm.152.6.8520740","volume":"152","author":"M Chan-Yeung","year":"1995","unstructured":"Chan-Yeung M, Manfreda J, Dimich-Ward H, Lam J, Ferguson A, Warren P, et al. Mite and cat allergen levels in homes and severity of asthma. Am J Respir Crit Care Med. 1995;152(6 Pt 1):1805\u201311.","journal-title":"Am J Respir Crit Care Med"},{"issue":"1","key":"948_CR7","doi-asserted-by":"crossref","first-page":"64","DOI":"10.1016\/S0091-6749(96)70227-0","volume":"98","author":"A Custovic","year":"1996","unstructured":"Custovic A, Taggart SC, Francis HC, Chapman MD, Woodcock A. Exposure to house dust mite allergens and the clinical activity of asthma. J Allergy Clin Immunol. 1996;98(1):64\u201372.","journal-title":"J Allergy Clin Immunol"},{"issue":"8300","key":"948_CR8","doi-asserted-by":"crossref","first-page":"675","DOI":"10.1016\/S0140-6736(82)90709-7","volume":"2","author":"TA Platts-Mills","year":"1982","unstructured":"Platts-Mills TA, Tovey ER, Mitchell EB, Moszoro H, Nock P, Wilkins SR. Reduction of bronchial hyperreactivity during prolonged allergen avoidance. Lancet Lond Engl. 1982;2(8300):675\u20138.","journal-title":"Lancet Lond Engl"},{"key":"948_CR9","unstructured":"Asthma NAE and PP Third Expert Panel on the Diagnosis and Management of. Expert Panel Report 3: Guidelines for the Diagnosis and Management of Asthma. National Heart, Lung, and Blood Institute (US); 2007."},{"key":"948_CR10","unstructured":"2020 GINA Main Report. Global Initiative for Asthma - GINA. [cited 2020 Apr 18]. Available from: https:\/\/ginasthma.org\/gina-reports\/"},{"key":"948_CR11","unstructured":"BTS\/SIGN Asthma Guideline 2019. [cited 2020 Apr 18]. Available from: https:\/\/www.bsaci.org\/announcements\/sign-bts-asthma-guideline-2019"},{"key":"948_CR12","unstructured":"Guidance NICE. Asthma: diagnosis, monitoring and chronic asthma management | [cited 2020 Apr 18]. Available from: https:\/\/www.nice.org.uk\/guidance\/ng80."},{"issue":"10","key":"948_CR13","doi-asserted-by":"crossref","first-page":"929","DOI":"10.1080\/17476348.2019.1651647","volume":"13","author":"A Custovic","year":"2019","unstructured":"Custovic A, Murray CS, Simpson A. Dust-mite inducing asthma: what advice can be given to patients? Expert Rev Respir Med. 2019;13(10):929\u201336.","journal-title":"Expert Rev Respir Med"},{"issue":"1","key":"948_CR14","doi-asserted-by":"crossref","first-page":"54","DOI":"10.1111\/cea.12450","volume":"45","author":"A Custovic","year":"2015","unstructured":"Custovic A. To what extent is allergen exposure a risk factor for the development of allergic disease? Clin Exp Allergy. 2015;45(1):54\u201362.","journal-title":"Clin Exp Allergy"},{"issue":"8","key":"948_CR15","doi-asserted-by":"crossref","first-page":"502","DOI":"10.1056\/NEJM199008233230802","volume":"323","author":"R Sporik","year":"1990","unstructured":"Sporik R, Holgate ST, Platts-Mills TA, Cogswell JJ. Exposure to house-dust mite allergen (Der p I) and the development of asthma in childhood. A prospective study. N Engl J Med. 1990;323(8):502\u20137.","journal-title":"N Engl J Med"},{"issue":"1","key":"948_CR16","doi-asserted-by":"crossref","first-page":"144","DOI":"10.1016\/j.jaci.2007.03.037","volume":"120","author":"JC Celed\u00f3n","year":"2007","unstructured":"Celed\u00f3n JC, Milton DK, Ramsey CD, Litonjua AA, Ryan L, Platts-Mills TAE, et al. Exposure to dust mite allergen and endotoxin in early life and asthma and atopy in childhood. J Allergy Clin Immunol. 2007;120(1):144\u20139.","journal-title":"J Allergy Clin Immunol"},{"issue":"1","key":"948_CR17","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1016\/j.jaci.2004.04.007","volume":"114","author":"C Cole Johnson","year":"2004","unstructured":"Cole Johnson C, Ownby DR, Havstad SL, Peterson EL. Family history, dust mite exposure in early childhood, and risk for pediatric atopy and asthma. J Allergy Clin Immunol. 2004;114(1):105\u201310.","journal-title":"J Allergy Clin Immunol"},{"issue":"1","key":"948_CR18","doi-asserted-by":"crossref","first-page":"114","DOI":"10.1016\/j.jaci.2008.05.010","volume":"122","author":"ER Tovey","year":"2008","unstructured":"Tovey ER, Almqvist C, Li Q, Crisafulli D, Marks GB. Nonlinear relationship of mite allergen exposure to mite sensitization and asthma in a birth cohort. J Allergy Clin Immunol. 2008;122(1):114\u2013118.e5.","journal-title":"J Allergy Clin Immunol"},{"issue":"1","key":"948_CR19","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1016\/S1081-1206(10)63612-5","volume":"90","author":"PM Carter","year":"2003","unstructured":"Carter PM, Peterson EL, Ownby DR, Zoratti EM, Johnson CC. Relationship of house-dust mite allergen exposure in children\u2019s bedrooms in infancy to bronchial hyperresponsiveness and asthma diagnosis by age 6 to 7. Ann Allergy Asthma Immunol. 2003;90(1):41\u20134.","journal-title":"Ann Allergy Asthma Immunol"},{"issue":"7","key":"948_CR20","doi-asserted-by":"crossref","first-page":"820","DOI":"10.1111\/all.12626","volume":"70","author":"L Casas","year":"2015","unstructured":"Casas L, Sunyer J, Tischer C, Gehring U, Wickman M, Garcia-Esteban R, et al. Early-life house dust mite allergens, childhood mite sensitization, and respiratory outcomes. Allergy. 2015;70(7):820\u20137.","journal-title":"Allergy."},{"issue":"9537","key":"948_CR21","doi-asserted-by":"crossref","first-page":"763","DOI":"10.1016\/S0140-6736(06)69286-6","volume":"368","author":"S Illi","year":"2006","unstructured":"Illi S, von Mutius E, Lau S, Niggemann B, Gr\u00fcber C, Wahn U, et al. Perennial allergen sensitisation early in life and chronic asthma in children: a birth cohort study. Lancet Lond Engl. 2006;368(9537):763\u201370.","journal-title":"Lancet Lond Engl"},{"issue":"3","key":"948_CR22","doi-asserted-by":"crossref","first-page":"258","DOI":"10.1006\/eesa.1996.1511","volume":"36","author":"EJ Calabrese","year":"1997","unstructured":"Calabrese EJ, Stanek EJ, Pekow P, Barnes RM. Soil ingestion estimates for children residing on a superfund site. Ecotoxicol Environ Saf. 1997;36(3):258\u201368.","journal-title":"Ecotoxicol Environ Saf"},{"issue":"2","key":"948_CR23","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1016\/0273-2300(89)90019-6","volume":"10","author":"EJ Calabrese","year":"1989","unstructured":"Calabrese EJ, Barnes R, Stanek EJ, Pastides H, Gilbert CE, Veneman P, et al. How much soil do young children ingest: an epidemiologic study. Regul Toxicol Pharmacol. 1989;10(2):123\u201337.","journal-title":"Regul Toxicol Pharmacol"},{"issue":"4","key":"948_CR24","doi-asserted-by":"crossref","first-page":"867","DOI":"10.1016\/j.jaci.2014.08.011","volume":"134","author":"HA Brough","year":"2014","unstructured":"Brough HA, Simpson A, Makinson K, Hankinson J, Brown S, Douiri A, et al. Peanut allergy: effect of environmental peanut exposure in children with filaggrin loss-of-function mutations. J Allergy Clin Immunol. 2014;134(4):867\u2013875.e1.","journal-title":"J Allergy Clin Immunol"},{"issue":"3","key":"948_CR25","doi-asserted-by":"crossref","first-page":"993","DOI":"10.1016\/j.jaci.2019.08.041","volume":"145","author":"A Simpson","year":"2020","unstructured":"\u2022\u2022 Simpson A, Brough HA, Haider S, Belgrave D, Murray CS, Custovic A. Early-life inhalant allergen exposure, filaggrin genotype, and the development of sensitization from infancy to adolescence. J Allergy Clin Immunol. 2020;145(3):993\u20131001. Evaluation of the association between early-life exposure to inhalant allergens, allergen sensitisation and FLG mutations in a birth cohort which demonstrated that the impact of domestic mite allergen exposure on the risk of dust mite sensitization is considerably higher in children with FLG loss-of-function mutations compared to those without, particularly in early life.","journal-title":"J Allergy Clin Immunol."},{"issue":"6","key":"948_CR26","doi-asserted-by":"crossref","first-page":"602","DOI":"10.1111\/j.1398-9995.1998.tb03936.x","volume":"53","author":"A Simpson","year":"1998","unstructured":"Simpson A, Hassall R, Custovic A, Woodcock A. Variability of house-dust-mite allergen levels within carpets. Allergy. 1998;53(6):602\u20137.","journal-title":"Allergy."},{"issue":"5","key":"948_CR27","doi-asserted-by":"crossref","first-page":"465","DOI":"10.1007\/s11882-012-0285-0","volume":"12","author":"E Tovey","year":"2012","unstructured":"Tovey E, Ferro A. Time for new methods for avoidance of house dust mite and other allergens. Curr Allergy Asthma Rep. 2012;12(5):465\u201377.","journal-title":"Curr Allergy Asthma Rep"},{"issue":"2","key":"948_CR28","doi-asserted-by":"crossref","first-page":"362","DOI":"10.1067\/mai.2003.1654","volume":"112","author":"SJ Langley","year":"2003","unstructured":"Langley SJ, Goldthorpe S, Craven M, Morris J, Woodcock A, Custovic A. Exposure and sensitization to indoor allergens: association with lung function, bronchial reactivity, and exhaled nitric oxide measures in asthma. J Allergy Clin Immunol. 2003;112(2):362\u20138.","journal-title":"J Allergy Clin Immunol"},{"issue":"19","key":"948_CR29","doi-asserted-by":"crossref","first-page":"1356","DOI":"10.1056\/NEJM199705083361904","volume":"336","author":"DL Rosenstreich","year":"1997","unstructured":"Rosenstreich DL, Eggleston P, Kattan M, Baker D, Slavin RG, Gergen P, et al. The role of cockroach allergy and exposure to cockroach allergen in causing morbidity among inner-city children with asthma. N Engl J Med. 1997;336(19):1356\u201363.","journal-title":"N Engl J Med"},{"issue":"10","key":"948_CR30","doi-asserted-by":"crossref","first-page":"996","DOI":"10.1001\/archpedi.158.10.996","volume":"158","author":"LA Lowe","year":"2004","unstructured":"Lowe LA, Woodcock A, Murray CS, Morris J, Simpson A, Custovic A. Lung function at age 3 years: effect of pet ownership and exposure to indoor allergens. Arch Pediatr Adolesc Med. 2004;158(10):996\u20131001.","journal-title":"Arch Pediatr Adolesc Med"},{"issue":"5","key":"948_CR31","doi-asserted-by":"crossref","first-page":"376","DOI":"10.1136\/thx.2005.042523","volume":"61","author":"CS Murray","year":"2006","unstructured":"Murray CS, Poletti G, Kebadze T, Morris J, Woodcock A, Johnston SL, et al. Study of modifiable risk factors for asthma exacerbations: virus infection and allergen exposure increase the risk of asthma hospital admissions in children. Thorax. 2006;61(5):376\u201382.","journal-title":"Thorax."},{"issue":"7340","key":"948_CR32","doi-asserted-by":"crossref","first-page":"763","DOI":"10.1136\/bmj.324.7340.763","volume":"324","author":"RM Green","year":"2002","unstructured":"Green RM, Custovic A, Sanderson G, Hunter J, Johnston SL, Woodcock A. Synergism between allergens and viruses and risk of hospital admission with asthma: case-control study. BMJ. 2002;324(7340):763.","journal-title":"BMJ."},{"issue":"1","key":"948_CR33","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1136\/thx.2004.027839","volume":"60","author":"SJ Langley","year":"2005","unstructured":"Langley SJ, Goldthorpe S, Craven M, Woodcock A, Custovic A. Relationship between exposure to domestic allergens and bronchial hyperresponsiveness in non-sensitised, atopic asthmatic subjects. Thorax. 2005;60(1):17\u201321.","journal-title":"Thorax."},{"issue":"9","key":"948_CR34","doi-asserted-by":"crossref","first-page":"1299","DOI":"10.1046\/j.1365-2222.2002.01472.x","volume":"32","author":"KE Sidenius","year":"2002","unstructured":"Sidenius KE, Hallas TE, Brygge T, Poulsen LK, Mosbech H. House dust mites and their allergens at selected locations in the homes of house dust mite-allergic patients. Clin Exp Allergy J Br Soc Allergy Clin Immunol. 2002;32(9):1299\u2013304.","journal-title":"Clin Exp Allergy J Br Soc Allergy Clin Immunol."},{"issue":"5798","key":"948_CR35","doi-asserted-by":"crossref","first-page":"592","DOI":"10.1038\/289592a0","volume":"289","author":"ER Tovey","year":"1981","unstructured":"Tovey ER, Chapman MD, Platts-Mills TA. Mite faeces are a major source of house dust allergens. Nature. 1981;289(5798):592\u20133.","journal-title":"Nature."},{"issue":"4","key":"948_CR36","doi-asserted-by":"crossref","first-page":"1211","DOI":"10.1002\/1521-4141(200104)31:4<1211::AID-IMMU1211>3.0.CO;2-R","volume":"31","author":"AM Ghaemmaghami","year":"2001","unstructured":"Ghaemmaghami AM, Robins A, Gough L, Sewell HF, Shakib F. Human T cell subset commitment determined by the intrinsic property of antigen: the proteolytic activity of the major mite allergen Der p 1 conditions T cells to produce more IL-4 and less IFN-gamma. Eur J Immunol. 2001;31(4):1211\u20136.","journal-title":"Eur J Immunol"},{"issue":"5","key":"948_CR37","first-page":"630","volume":"124","author":"ER Tovey","year":"1981","unstructured":"Tovey ER, Chapman MD, Wells CW, Platts-Mills TA. The distribution of dust mite allergen in the houses of patients with asthma. Am Rev Respir Dis. 1981;124(5):630\u20135.","journal-title":"Am Rev Respir Dis"},{"issue":"1","key":"948_CR38","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1515\/REVEH.2001.16.1.65","volume":"16","author":"P Paufler","year":"2001","unstructured":"Paufler P, Gebel T, Dunkelberg H. Quantification of house dust mite allergens in ambient air. Rev Environ Health. 2001;16(1):65\u201380.","journal-title":"Rev Environ Health"},{"key":"948_CR39","unstructured":"\u2022\u2022 Wilson JM, Platts-Mills TAE. Home environmental interventions for house dust mite. J Allergy Clin Immunol Pract. 2018;6(1):1\u20137 Excellent review about dust mite avoidance measures, highlighting practical methods that have been shown to be effective as part of a multifaceted approach to dust mite avoidance."},{"issue":"4","key":"948_CR40","doi-asserted-by":"crossref","first-page":"977","DOI":"10.1016\/j.jaci.2007.06.048","volume":"120","author":"JD Miller","year":"2007","unstructured":"Miller JD, Naccara L, Satinover S, Platts-Mills TAE. Nonwoven in contrast to woven mattress encasings accumulate mite and cat allergen. J Allergy Clin Immunol. 2007;120(4):977\u20139.","journal-title":"J Allergy Clin Immunol"},{"issue":"1","key":"948_CR41","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1186\/1710-1492-9-44","volume":"9","author":"N Tsurikisawa","year":"2013","unstructured":"Tsurikisawa N, Saito A, Oshikata C, Nakazawa T, Yasueda H, Akiyama K. Encasing bedding in covers made of microfine fibers reduces exposure to house mite allergens and improves disease management in adult atopic asthmatics. Allergy Asthma Clin Immunol. 2013;9(1):44.","journal-title":"Allergy Asthma Clin Immunol"},{"issue":"9","key":"948_CR42","doi-asserted-by":"crossref","first-page":"784","DOI":"10.1136\/thorax.57.9.784","volume":"57","author":"LHM Rijssenbeek-Nouwens","year":"2002","unstructured":"Rijssenbeek-Nouwens LHM, Oosting AJ, de Bruin-Weller MS, Bregman I, de Monchy JGR, Postma DS. Clinical evaluation of the effect of anti-allergic mattress covers in patients with moderate to severe asthma and house dust mite allergy: a randomised double blind placebo controlled study. Thorax. 2002;57(9):784\u201390.","journal-title":"Thorax."},{"issue":"4","key":"948_CR43","doi-asserted-by":"crossref","first-page":"858","DOI":"10.1016\/j.jaci.2004.05.069","volume":"114","author":"L van den Bemt","year":"2004","unstructured":"van den Bemt L, van Knapen L, de Vries MP, Jansen M, Cloosterman S, van Schayck CP. Clinical effectiveness of a mite allergen\u2013impermeable bed-covering system in asthmatic mite-sensitive patients. J Allergy Clin Immunol. 2004;114(4):858\u201362.","journal-title":"J Allergy Clin Immunol"},{"issue":"4","key":"948_CR44","doi-asserted-by":"crossref","first-page":"407","DOI":"10.1034\/j.1398-9995.1999.00066.x","volume":"54","author":"C Hallam","year":"1999","unstructured":"Hallam C, Custovic A, Simpson B, Houghton N, Simpson A, Woodcock A. Mite allergens in feather and synthetic pillows. Allergy. 1999;54(4):407\u20138.","journal-title":"Allergy."},{"issue":"4 Pt 1","key":"948_CR45","doi-asserted-by":"crossref","first-page":"599","DOI":"10.1016\/0091-6749(92)90132-L","volume":"90","author":"LG McDonald","year":"1992","unstructured":"McDonald LG, Tovey E. The role of water temperature and laundry procedures in reducing house dust mite populations and allergen content of bedding. J Allergy Clin Immunol. 1992;90(4 Pt 1):599\u2013608.","journal-title":"J Allergy Clin Immunol"},{"issue":"1","key":"948_CR46","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1111\/j.1398-9995.2005.00946.x","volume":"61","author":"RB Gore","year":"2006","unstructured":"Gore RB, Durrell B, Bishop S, Curbishley L, Woodcock A, Custovic A. High-efficiency vacuum cleaners increase personal mite allergen exposure, but only slightly. Allergy. 2006;61(1):119\u201323.","journal-title":"Allergy."},{"issue":"2","key":"948_CR47","doi-asserted-by":"crossref","first-page":"536","DOI":"10.1016\/0091-6749(92)90320-2","volume":"89","author":"ML Hayden","year":"1992","unstructured":"Hayden ML, Rose G, Diduch KB, Domson P, Chapman MD, Heymann PW, et al. Benzyl benzoate moist powder: investigation of acaricidal [correction of acarical] activity in cultures and reduction of dust mite allergens in carpets. J Allergy Clin Immunol. 1992;89(2):536\u201345.","journal-title":"J Allergy Clin Immunol"},{"issue":"8","key":"948_CR48","doi-asserted-by":"crossref","first-page":"594","DOI":"10.1111\/j.1398-9995.1991.tb00629.x","volume":"46","author":"L Antonicelli","year":"1991","unstructured":"Antonicelli L, Bil\u00f2 MB, Pucci S, Schou C, Bonifazi F. Efficacy of an air-cleaning device equipped with a high efficiency particulate air filter in house dust mite respiratory allergy. Allergy. 1991;46(8):594\u2013600.","journal-title":"Allergy."},{"issue":"6","key":"948_CR49","doi-asserted-by":"crossref","first-page":"1050","DOI":"10.1016\/0091-6749(90)90050-E","volume":"85","author":"RE Reisman","year":"1990","unstructured":"Reisman RE, Mauriello PM, Davis GB, Georgitis JW, DeMasi JM. A double-blind study of the effectiveness of a high-efficiency particulate air (HEPA) filter in the treatment of patients with perennial allergic rhinitis and asthma. J Allergy Clin Immunol. 1990;85(6):1050\u20137.","journal-title":"J Allergy Clin Immunol"},{"issue":"4","key":"948_CR50","doi-asserted-by":"crossref","first-page":"852","DOI":"10.1016\/S0091-6749(99)70298-8","volume":"104","author":"LG Arlian","year":"1999","unstructured":"Arlian LG, Neal JS, Vyszenski-Moher DL. Reducing relative humidity to control the house dust mite Dermatophagoides farinae. J Allergy Clin Immunol. 1999;104(4):852\u20136.","journal-title":"J Allergy Clin Immunol"},{"issue":"6","key":"948_CR51","doi-asserted-by":"crossref","first-page":"803","DOI":"10.1046\/j.1365-2222.2001.01110.x","volume":"31","author":"A Simpson","year":"2001","unstructured":"Simpson A, Woodcock A, Custovic A. Housing characteristics and mite allergen levels: to humidity and beyond. Clin Exp Allergy. 2001;31(6):803\u20135.","journal-title":"Clin Exp Allergy"},{"key":"948_CR52","volume":"6","author":"M Singh","year":"2013","unstructured":"Singh M, Jaiswal N. Dehumidifiers for chronic asthma. Cochrane Database Syst Rev. 2013;6:CD003563.","journal-title":"Cochrane Database Syst Rev"},{"issue":"7","key":"948_CR53","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0069900","volume":"8","author":"ER Tovey","year":"2013","unstructured":"Tovey ER, Willenborg CM, Crisafulli DA, Rimmer J, Marks GB. Most personal exposure to house dust mite aeroallergen occurs during the day. PLoS One. 2013;8(7):e69900.","journal-title":"PLoS One"},{"issue":"7166","key":"948_CR54","doi-asserted-by":"crossref","first-page":"1105","DOI":"10.1136\/bmj.317.7166.1105","volume":"317","author":"PC G\u00f8tzsche","year":"1998","unstructured":"G\u00f8tzsche PC, Hammarquist C, Burr M. House dust mite control measures in the management of asthma: meta-analysis. BMJ. 1998;317(7166):1105\u201310 discussion 1110.","journal-title":"BMJ."},{"key":"948_CR55","volume":"4","author":"PC G\u00f8tzsche","year":"2004","unstructured":"G\u00f8tzsche PC, Johansen HK, Schmidt LM, Burr ML. House dust mite control measures for asthma. Cochrane Database Syst Rev. 2004;4:CD001187.","journal-title":"Cochrane Database Syst Rev"},{"issue":"6","key":"948_CR56","doi-asserted-by":"crossref","first-page":"646","DOI":"10.1111\/j.1398-9995.2008.01690.x","volume":"63","author":"PC G\u00f8tzsche","year":"2008","unstructured":"G\u00f8tzsche PC, Johansen HK. House dust mite control measures for asthma: systematic review. Allergy. 2008;63(6):646\u201359.","journal-title":"Allergy."},{"issue":"5","key":"948_CR57","doi-asserted-by":"crossref","first-page":"1854","DOI":"10.1016\/j.jaci.2018.02.001","volume":"141","author":"BF Leas","year":"2018","unstructured":"Leas BF, D\u2019Anci KE, Apter AJ, Bryant-Stephens T, Lynch MP, Kaczmarek JL, et al. Effectiveness of indoor allergen reduction in asthma management: a systematic review. J Allergy Clin Immunol. 2018;141(5):1854\u201369.","journal-title":"J Allergy Clin Immunol"},{"issue":"4","key":"948_CR58","doi-asserted-by":"crossref","first-page":"400","DOI":"10.1111\/cea.13340","volume":"49","author":"FE van Boven","year":"2019","unstructured":"van Boven FE, Arends LR, Braunstahl G, van Wijk RG. A reintroduction of environmental mite allergen control strategies for asthma treatment and the debate on their effectiveness. Clin Exp Allergy. 2019;49(4):400\u20139.","journal-title":"Clin Exp Allergy"},{"issue":"3","key":"948_CR59","first-page":"74","volume":"45","author":"G Pingitore","year":"2013","unstructured":"Pingitore G, Pinter E. Environmental interventions for mite-induced asthma: a journey between systematic reviews, contrasting evidence and clinical practice. Eur Ann Allergy Clin Immunol. 2013;45(3):74\u20137.","journal-title":"Eur Ann Allergy Clin Immunol"},{"issue":"4","key":"948_CR60","doi-asserted-by":"crossref","first-page":"723","DOI":"10.1016\/j.jaci.2011.07.009","volume":"128","author":"ER Tovey","year":"2011","unstructured":"Tovey ER, Marks GB. It\u2019s time to rethink mite allergen avoidance. J Allergy Clin Immunol. 2011;128(4):723\u2013727.e6.","journal-title":"J Allergy Clin Immunol"},{"issue":"4","key":"948_CR61","doi-asserted-by":"crossref","first-page":"694","DOI":"10.1016\/j.jaci.2008.07.045","volume":"122","author":"TAE Platts-Mills","year":"2008","unstructured":"Platts-Mills TAE. Allergen avoidance in the treatment of asthma: problems with the meta-analyses. J Allergy Clin Immunol. 2008;122(4):694\u20136.","journal-title":"J Allergy Clin Immunol"},{"issue":"2","key":"948_CR62","doi-asserted-by":"crossref","first-page":"158","DOI":"10.1111\/j.1398-9995.2011.02752.x","volume":"67","author":"U Nurmatov","year":"2012","unstructured":"Nurmatov U, van Schayck CP, Hurwitz B, Sheikh A. House dust mite avoidance measures for perennial allergic rhinitis: an updated Cochrane systematic review. Allergy. 2012;67(2):158\u201365.","journal-title":"Allergy."},{"key":"948_CR63","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1186\/s13601-019-0306-3","volume":"10","author":"FE van Boven","year":"2020","unstructured":"\u2022\u2022 van Boven FE, de Jong NW, Braunstahl G-J, Gerth van Wijk R, Arends LR. A meta-analysis of baseline characteristics in trials on mite allergen avoidance in asthmatics: room for improvement. Clin Transl Allergy. 2020;10:2. Meta-analysis evaluating baseline characteristics of patients included in mite avoidance trials, emphasising that most mite avoidance studies included mild to moderate asthmatics and with varying and sometimes negligible levels of allergen exposure.","journal-title":"Clin Transl Allergy"},{"issue":"5","key":"948_CR64","doi-asserted-by":"crossref","first-page":"1046","DOI":"10.1016\/0091-6749(92)90228-T","volume":"89","author":"TA Platts-Mills","year":"1992","unstructured":"Platts-Mills TA, Thomas WR, Aalberse RC, Vervloet D, Champman MD. Dust mite allergens and asthma: report of a second international workshop. J Allergy Clin Immunol. 1992;89(5):1046\u201360.","journal-title":"J Allergy Clin Immunol"},{"issue":"3","key":"948_CR65","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1056\/NEJMoa023175","volume":"349","author":"A Woodcock","year":"2003","unstructured":"Woodcock A, Forster L, Matthews E, Martin J, Letley L, Vickers M, et al. Control of exposure to mite allergen and allergen-impermeable bed covers for adults with asthma. N Engl J Med. 2003;349(3):225\u201336.","journal-title":"N Engl J Med"},{"issue":"3","key":"948_CR66","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1056\/NEJMoa023171","volume":"349","author":"I Terreehorst","year":"2003","unstructured":"Terreehorst I, Hak E, Oosting AJ, Tempels-Pavlica Z, de Monchy JGR, Bruijnzeel-Koomen CAFM, et al. Evaluation of impermeable covers for bedding in patients with allergic rhinitis. N Engl J Med. 2003;349(3):237\u201346.","journal-title":"N Engl J Med"},{"issue":"2","key":"948_CR67","doi-asserted-by":"crossref","first-page":"150","DOI":"10.1164\/rccm.201609-1966OC","volume":"196","author":"CS Murray","year":"2017","unstructured":"\u2022\u2022 Murray CS, Foden P, Sumner H, Shepley E, Custovic A, Simpson A. Preventing Severe Asthma Exacerbations in Children. A randomized trial of mite-impermeable bedcovers. Am J Respir Crit Care Med. 2017;196(2):150\u20138. A key study showing a significant reduction (~50%) in severe asthma exacerbation leading to hospital presentation in children as result of using mite proof bedding encasing.","journal-title":"Am J Respir Crit Care Med"},{"issue":"11","key":"948_CR68","doi-asserted-by":"crossref","first-page":"1068","DOI":"10.1056\/NEJMoa032097","volume":"351","author":"WJ Morgan","year":"2004","unstructured":"Morgan WJ, Crain EF, Gruchalla RS, O\u2019Connor GT, Kattan M, Evans R, et al. Results of a home-based environmental intervention among urban children with asthma. N Engl J Med. 2004;351(11):1068\u201380.","journal-title":"N Engl J Med"},{"key":"948_CR69","doi-asserted-by":"crossref","unstructured":"Halken S, H\u00f8st A, Niklassen U, Hansen LG, Nielsen F, Pedersen S, \u00d8sterballe O, Veggerby C, Poulsen LK Effect of mattress and pillow encasings on children with asthma and house dust mite allergy. J Allergy Clin Immunol 2003;111(1):169\u2013176.","DOI":"10.1067\/mai.2003.5"},{"issue":"5","key":"948_CR70","doi-asserted-by":"crossref","first-page":"732","DOI":"10.1067\/mai.2001.119155","volume":"108","author":"MC Carter","year":"2001","unstructured":"Carter MC, Perzanowski MS, Raymond A, Platts-Mills TAE. Home intervention in the treatment of asthma among inner-city children. J Allergy Clin Immunol. 2001;108(5):732\u20137.","journal-title":"J Allergy Clin Immunol"},{"issue":"6","key":"948_CR71","doi-asserted-by":"crossref","first-page":"1069","DOI":"10.1016\/S0091-6749(99)70181-8","volume":"103","author":"GG Shapiro","year":"1999","unstructured":"Shapiro GG, Wighton TG, Chinn T, Zuckrman J, Eliassen AH, Picciano JF, et al. House dust mite avoidance for children with asthma in homes of low-income families. J Allergy Clin Immunol. 1999;103(6):1069\u201374.","journal-title":"J Allergy Clin Immunol"},{"issue":"4","key":"948_CR72","doi-asserted-by":"crossref","first-page":"386","DOI":"10.1111\/j.1365-2222.1996.tb00554.x","volume":"26","author":"F Carswell","year":"1996","unstructured":"Carswell F, Birmingham K, Oliver J, Crewes A, Weeks J. The respiratory effects of reduction of mite allergen in the bedrooms of asthmatic children--a double-blind controlled trial. Clin Exp Allergy J Br Soc Allergy Clin Immunol. 1996;26(4):386\u201396.","journal-title":"Clin Exp Allergy J Br Soc Allergy Clin Immunol."}],"container-title":["Current Allergy and Asthma Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s11882-020-00948-y.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s11882-020-00948-y\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s11882-020-00948-y.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,6,18]],"date-time":"2021-06-18T20:04:01Z","timestamp":1624046641000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s11882-020-00948-y"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,6,19]]},"references-count":72,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2020,9]]}},"alternative-id":["948"],"URL":"https:\/\/doi.org\/10.1007\/s11882-020-00948-y","relation":{},"ISSN":["1529-7322","1534-6315"],"issn-type":[{"value":"1529-7322","type":"print"},{"value":"1534-6315","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,6,19]]},"assertion":[{"value":"19 June 2020","order":1,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Compliance with Ethical Standards"}},{"value":"Dr. Custovic reports personal fees from Novartis, personal fees from Thermo Fisher Scientific, personal fees from Philips, personal fees from Sanofi, and personal fees from Stallergenes Greer, outside the submitted work. Dr. Zuiani declares no conflict of interest relevant to this manuscript.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of Interest"}},{"value":"This article does not contain any studies with human or animal subjects performed by any of the authors.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Human and Animal Rights and Informed Consent"}}],"article-number":"50"}}