{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T08:16:19Z","timestamp":1792656979017,"version":"4.5.0"},"reference-count":44,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2020,1,1]],"date-time":"2020-01-01T00:00:00Z","timestamp":1577836800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2020,1,1]],"date-time":"2020-01-01T00:00:00Z","timestamp":1577836800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Curr Allergy Asthma Rep"],"published-print":{"date-parts":[[2020,1]]},"DOI":"10.1007\/s11882-020-0900-4","type":"journal-article","created":{"date-parts":[[2020,1,28]],"date-time":"2020-01-28T20:41:30Z","timestamp":1580244090000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":15,"title":["Progestogen Sensitization: a Unique Female Presentation of Anaphylaxis"],"prefix":"10.1007","volume":"20","author":[{"given":"Jonathan A.","family":"Bernstein","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2020,1,28]]},"reference":[{"key":"900_CR1","first-page":"35","volume":"190","author":"WB Shelley","year":"1964","unstructured":"Shelley WB, Preucel RW, Spoont SS. Autoimmune progesterone dermatitis. Cure by Oophorectomy JAMA. 1964;190:35\u20138.","journal-title":"Cure by Oophorectomy JAMA"},{"issue":"12","key":"900_CR2","doi-asserted-by":"crossref","first-page":"643","DOI":"10.1111\/j.1346-8138.2009.00723.x","volume":"36","author":"J Asai","year":"2009","unstructured":"Asai J, Katoh N, Nakano M, Wada M, Kishimoto S. Case of autoimmune progesterone dermatitis presenting as fixed drug eruption. J Dermatol. 2009;36(12):643\u20135.","journal-title":"J Dermatol"},{"issue":"1","key":"900_CR3","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1186\/1476-7961-2-10","volume":"2","author":"AP Baptist","year":"2004","unstructured":"Baptist AP, Baldwin JL. Autoimmune progesterone dermatitis in a patient with endometriosis: case report and review of the literature. Clin Mol Allergy. 2004;2(1):10.","journal-title":"Clin Mol Allergy"},{"issue":"4","key":"900_CR4","doi-asserted-by":"crossref","first-page":"643","DOI":"10.1089\/jwh.2010.2468","volume":"20","author":"I. Leonard Bernstein","year":"2011","unstructured":"Bernstein IL, Bernstein DI, Lummus ZL, Bernstein JA. A case of progesterone-induced anaphylaxis, cyclic urticaria\/angioedema, and autoimmune dermatitis. J Womens health (Larchmt). 2011;20(4):643-8. This is a classic case report of woman with PH which discusses work up that elaborates on mechanisms of action based on in vitro testing used to make a diagnosis.","journal-title":"Journal of Women's Health"},{"issue":"5","key":"900_CR5","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1016\/0091-6749(71)90025-X","volume":"48","author":"FS Farah","year":"1971","unstructured":"Farah FS, Shbaklu Z. Autoimmune progesterone urticaria. J Allergy Clin Immunol. 1971;48(5):257\u201361.","journal-title":"J Allergy Clin Immunol"},{"issue":"4","key":"900_CR6","doi-asserted-by":"crossref","first-page":"426","DOI":"10.1001\/archderm.1977.01640040034003","volume":"113","author":"R Hart","year":"1977","unstructured":"Hart R. Autoimmune progesterone dermatitis. Arch Dermatol. 1977;113(4):426\u201330.","journal-title":"Arch Dermatol"},{"issue":"2 Pt 2","key":"900_CR7","doi-asserted-by":"crossref","first-page":"333","DOI":"10.1016\/0190-9622(95)90398-4","volume":"32","author":"AJ Herzberg","year":"1995","unstructured":"Herzberg AJ, Strohmeyer CR, Cirillo-Hyland VA. Autoimmune progesterone dermatitis. J Am Acad Dermatol. 1995;32(2 Pt 2):333\u20138.","journal-title":"J Am Acad Dermatol"},{"issue":"5","key":"900_CR8","doi-asserted-by":"crossref","first-page":"537","DOI":"10.1016\/j.jaip.2013.06.005","volume":"1","author":"JL Hill","year":"2013","unstructured":"Hill JL, Carr TF. Iatrogenic autoimmune progesterone dermatitis treated with a novel intramuscular progesterone desensitization protocol. J Allergy Clin Immunol Pract. 2013;1(5):537\u20138.","journal-title":"J Allergy Clin Immunol Pract"},{"issue":"5","key":"900_CR9","doi-asserted-by":"crossref","first-page":"447","DOI":"10.1111\/1346-8138.12473","volume":"41","author":"T Honda","year":"2014","unstructured":"Honda T, Kabashima K, Fujii Y, Katoh M, Miyachi Y. Autoimmune progesterone dermatitis that changed its clinical manifestation from anaphylaxis to fixed drug eruption-like erythema. J Dermatol. 2014;41(5):447\u20138.","journal-title":"J Dermatol"},{"issue":"2","key":"900_CR10","doi-asserted-by":"crossref","first-page":"353","DOI":"10.1016\/j.jaad.2007.10.646","volume":"58","author":"J Jenkins","year":"2008","unstructured":"Jenkins J, Geng A, Robinson-Bostom L. Autoimmune progesterone dermatitis associated with infertility treatment. J Am Acad Dermatol. 2008;58(2):353\u20135.","journal-title":"J Am Acad Dermatol"},{"issue":"1","key":"900_CR11","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1001\/archderm.1969.01610190063011","volume":"99","author":"WN Jones","year":"1969","unstructured":"Jones WN, Gordon VH. Auto-immune progesterone eczema. An endogenous progesterone hypersensitivity. Arch Dermatol. 1969;99(1):57\u20139.","journal-title":"Arch Dermatol"},{"issue":"4","key":"900_CR12","first-page":"190","volume":"21","author":"T Maguire","year":"2009","unstructured":"Maguire T. Autoimmune progesterone dermatitis. Dermatol Nurs. 2009;21(4):190\u20132.","journal-title":"Dermatol Nurs"},{"issue":"2","key":"900_CR13","doi-asserted-by":"crossref","first-page":"456","DOI":"10.1016\/j.jaci.2004.05.031","volume":"114","author":"JA Poole","year":"2004","unstructured":"Poole JA, Rosenwasser LJ. Chronic idiopathic urticaria exacerbated with progesterone therapy treated with novel desensitization protocol. J Allergy Clin Immunol. 2004;114(2):456\u20137.","journal-title":"J Allergy Clin Immunol"},{"issue":"3","key":"900_CR14","first-page":"1121.e9-1121.e1","volume":"95","author":"Alicia Prieto-Garcia","year":"2011","unstructured":"Prieto-Garcia A, Sloane DE, Gargiulo AR, Feldweg AM, Castells M. Autoimmune progesterone dermatitis: clinical presentation and management with progesterone desensitization for successful in vitro fertilization. Fertil Steril. 2011;95(3):1121 e9\u201313.","journal-title":"Fertility and Sterility"},{"issue":"4","key":"900_CR15","doi-asserted-by":"crossref","first-page":"245","DOI":"10.3109\/09513590009167688","volume":"14","author":"C Vasconcelos","year":"2000","unstructured":"Vasconcelos C, Xavier P, Vieira AP, Martinho M, Rodrigues J, Bodas A, et al. Autoimmune progesterone urticaria. Gynecol Endocrinol. 2000;14(4):245\u20137.","journal-title":"Gynecol Endocrinol"},{"issue":"3","key":"900_CR16","doi-asserted-by":"crossref","first-page":"316","DOI":"10.1111\/j.1365-2230.2004.01516.x","volume":"29","author":"M Wintzen","year":"2004","unstructured":"Wintzen M, Goor-van Egmond MB, Noz KC. Autoimmune progesterone dermatitis presenting with purpura and petechiae. Clin Exp Dermatol. 2004;29(3):316.","journal-title":"Clin Exp Dermatol"},{"issue":"5","key":"900_CR17","doi-asserted-by":"crossref","first-page":"407","DOI":"10.1177\/014107688507800512","volume":"78","author":"F Wojnarowska","year":"1985","unstructured":"Wojnarowska F, Greaves MW, Peachey RD, Drury PL, Besser GM. Progesterone-induced erythema multiforme. J R Soc Med. 1985;78(5):407\u20138.","journal-title":"J R Soc Med"},{"issue":"19","key":"900_CR18","doi-asserted-by":"crossref","first-page":"1236","DOI":"10.1056\/NEJM198411083111907","volume":"311","author":"WJ Meggs","year":"1984","unstructured":"Meggs WJ, Pescovitz OH, Metcalfe D, Loriaux DL, Cutler G Jr, Kaliner M. Progesterone sensitivity as a cause of recurrent anaphylaxis. N Engl J Med. 1984;311(19):1236\u20138.","journal-title":"N Engl J Med"},{"issue":"5","key":"900_CR19","doi-asserted-by":"crossref","first-page":"469","DOI":"10.1016\/S1081-1206(10)61838-8","volume":"90","author":"Joy L. Snyder","year":"2003","unstructured":"Snyder JL, Krishnaswamy G. Autoimmune progesterone dermatitis and its manifestation as anaphylaxis: a case report and literature review. Ann Allergy Asthma Immunol. 2003;90(5):469\u201377; quiz 77, 571.","journal-title":"Annals of Allergy, Asthma & Immunology"},{"issue":"4","key":"900_CR20","doi-asserted-by":"crossref","first-page":"773","DOI":"10.1016\/j.iac.2017.07.006","volume":"37","author":"D Foer","year":"2017","unstructured":"Foer D, Buchheit KM. Progestogen hypersensitivity: an evidence-based approach to diagnosis and management in clinical practice. Immunol Allergy Clin N Am. 2017;37(4):773\u201384.","journal-title":"Immunol Allergy Clin N Am"},{"issue":"4","key":"900_CR21","doi-asserted-by":"crossref","first-page":"723","DOI":"10.1016\/j.jaip.2016.03.003","volume":"4","author":"D Foer","year":"2016","unstructured":"Foer D, Buchheit KM, Gargiulo AR, Lynch DM, Castells M, Wickner PG. Progestogen hypersensitivity in 24 cases: diagnosis, management, and proposed renaming and classification. J Allergy Clin Immunol Pract. 2016;4(4):723\u20139.","journal-title":"J Allergy Clin Immunol Pract"},{"issue":"5","key":"900_CR22","doi-asserted-by":"crossref","first-page":"537","DOI":"10.1016\/S1079-2104(98)90287-6","volume":"85","author":"BK Moghadam","year":"1998","unstructured":"Moghadam BK, Hersini S, Barker BF. Autoimmune progesterone dermatitis and stomatitis. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 1998;85(5):537\u201341.","journal-title":"Oral Surg Oral Med Oral Pathol Oral Radiol Endod"},{"issue":"3","key":"900_CR23","first-page":"566","volume":"5","author":"Kathleen M. Buchheit","year":"2017","unstructured":"Buchheit KM, Bernstein JA. Progestogen hypersensitivity: heterogeneous manifestations with a common trigger. J allergy Clin Immunol Pract. 2017;5(3):566-74. This is a thorough review of PH.","journal-title":"The Journal of Allergy and Clinical Immunology: In Practice"},{"issue":"2","key":"900_CR24","doi-asserted-by":"crossref","first-page":"140","DOI":"10.1016\/j.anai.2018.11.016","volume":"122","author":"William J. Lavery","year":"2019","unstructured":"Lavery WJ, Bernstein JA. Cyclical hypersensitivity, anaphylaxis, and related hormonal reaction. Ann allergy asthma Immunol. 2019;122(2):140-7. This is a very thorough review on cyclical hypersensitivity.","journal-title":"Annals of Allergy, Asthma & Immunology"},{"issue":"2","key":"900_CR25","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1016\/j.autrev.2015.11.003","volume":"15","author":"T Nguyen","year":"2016","unstructured":"Nguyen T, Razzaque AA. Autoimmune progesterone dermatitis: update and insights. Autoimmun Rev. 2016;15(2):191\u20137.","journal-title":"Autoimmun Rev"},{"key":"900_CR26","doi-asserted-by":"crossref","first-page":"538","DOI":"10.1097\/00007611-196305000-00018","volume":"56","author":"L Meltzer","year":"1963","unstructured":"Meltzer L. Hypersensitivity to gonadal hormones. South Med J. 1963;56:538\u201342.","journal-title":"South Med J"},{"issue":"6","key":"900_CR27","doi-asserted-by":"crossref","first-page":"616","DOI":"10.1016\/j.anai.2019.03.032","volume":"122","author":"Debajyoti Ghosh","year":"2019","unstructured":"Ghosh D, Bernstein JA. Development of a progesterone-specific IgE assay for diagnosing patients with suspected progestogen hypersensitivity. Ann Allergy Asthma Immunol. 2019;122(6):616\u201322.This manuscripts describes the development of a specific progesterone assay.","journal-title":"Annals of Allergy, Asthma & Immunology"},{"issue":"10","key":"900_CR28","doi-asserted-by":"crossref","first-page":"5893","DOI":"10.4049\/jimmunol.172.10.5893","volume":"172","author":"SM Blois","year":"2004","unstructured":"Blois SM, Joachim R, Kandil J, Margni R, Tometten M, Klapp BF, et al. Depletion of CD8+ cells abolishes the pregnancy protective effect of progesterone substitution with dydrogesterone in mice by altering the Th1\/Th2 cytokine profile. J Immunol. 2004;172(10):5893\u20139.","journal-title":"J Immunol"},{"issue":"1","key":"900_CR29","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1677\/JOE-07-0317","volume":"196","author":"C Dosiou","year":"2008","unstructured":"Dosiou C, Hamilton AE, Pang Y, Overgaard MT, Tulac S, Dong J, et al. Expression of membrane progesterone receptors on human T lymphocytes and Jurkat cells and activation of G-proteins by progesterone. J Endocrinol. 2008;196(1):67\u201377.","journal-title":"J Endocrinol"},{"issue":"3","key":"900_CR30","doi-asserted-by":"crossref","first-page":"597","DOI":"10.1210\/jcem-55-3-597","volume":"55","author":"KL Cheesman","year":"1982","unstructured":"Cheesman KL, Gaynor LV, Chatterton RT Jr, Radvany RM. Identification of a 17-hydroxyprogesterone-binding immunoglobulin in the serum of a woman with periodic rashes. J Clin Endocrinol Metab. 1982;55(3):597\u20139.","journal-title":"J Clin Endocrinol Metab"},{"issue":"3","key":"900_CR31","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1111\/j.1600-0536.1992.tb00286.x","volume":"26","author":"A Schoenmakers","year":"1992","unstructured":"Schoenmakers A, Vermorken A, Degreef H, Dooms-Goossens A. Corticosteroid or steroid allergy? Contact Dermatitis. 1992;26(3):159\u201362.","journal-title":"Contact Dermatitis"},{"issue":"1","key":"900_CR32","doi-asserted-by":"crossref","first-page":"39","DOI":"10.2310\/6620.2006.05045","volume":"17","author":"D Stranahan","year":"2006","unstructured":"Stranahan D, Rausch D, Deng A, Gaspari A. The role of intradermal skin testing and patch testing in the diagnosis of autoimmune progesterone dermatitis. Dermatitis. 2006;17(1):39\u201342.","journal-title":"Dermatitis."},{"issue":"2","key":"900_CR33","first-page":"311","volume":"47","author":"S Halevy","year":"2002","unstructured":"Halevy S, Cohen AD, Lunenfeld E, Grossman N. Autoimmune progesterone dermatitis manifested as erythema annulare centrifugum: confirmation of progesterone sensitivity by in vitro interferon-gamma release. J Am Acad Dermatol. 2002;47(2):311\u20133.","journal-title":"J Am Acad Dermatol"},{"issue":"4","key":"900_CR34","first-page":"542","volume":"70","author":"JE Slater","year":"1987","unstructured":"Slater JE, Raphael G, Cutler GB Jr, Loriaux DL, Meggs WJ, Kaliner M. Recurrent anaphylaxis in menstruating women: treatment with a luteinizing hormone-releasing hormone agonist--a preliminary report. Obstet Gynecol. 1987;70(4):542\u20136.","journal-title":"Obstet Gynecol"},{"issue":"4","key":"900_CR35","doi-asserted-by":"crossref","first-page":"378","DOI":"10.1111\/j.1365-2230.2010.03979.x","volume":"36","author":"LM Toms-Whittle","year":"2011","unstructured":"Toms-Whittle LM, John LH, Griffiths DJ, Buckley DA. Autoimmune progesterone dermatitis: a diagnosis easily missed. Clin Exp Dermatol. 2011;36(4):378\u201380.","journal-title":"Clin Exp Dermatol"},{"issue":"1","key":"900_CR36","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1111\/j.1365-2133.1994.tb06897.x","volume":"130","author":"KC Yee","year":"1994","unstructured":"Yee KC, Cunliffe WJ. Progesterone-induced urticaria: response to buserelin. Br J Dermatol. 1994;130(1):121\u20133.","journal-title":"Br J Dermatol"},{"issue":"7","key":"900_CR37","doi-asserted-by":"crossref","first-page":"1393","DOI":"10.1111\/all.13397","volume":"73","author":"T Zuberbier","year":"2018","unstructured":"Zuberbier T, Aberer W, Asero R, Abdul Latiff AH, Baker D, Ballmer-Weber B, et al. The EAACI\/GA2LEN\/EDF\/WAO guideline for the definition, classification, diagnosis and management of urticaria. Allergy. 2018;73(7):1393\u2013414.","journal-title":"Allergy."},{"issue":"4","key":"900_CR38","doi-asserted-by":"crossref","first-page":"1144","DOI":"10.1016\/j.jaip.2018.04.012","volume":"6","author":"T Zuberbier","year":"2018","unstructured":"Zuberbier T, Bernstein JA. A comparison of the United States and international perspective on chronic urticaria guidelines. J Allergy Clin Immunol Pract. 2018;6(4):1144\u201351.","journal-title":"J Allergy Clin Immunol Pract"},{"issue":"5","key":"900_CR39","doi-asserted-by":"crossref","first-page":"1270","DOI":"10.1016\/j.jaci.2014.02.036","volume":"133","author":"JA Bernstein","year":"2014","unstructured":"Bernstein JA, Lang DM, Khan DA, Craig T, Dreyfus D, Hsieh F, et al. The diagnosis and management of acute and chronic urticaria: 2014 update. J Allergy Clin Immunol. 2014;133(5):1270\u20137.","journal-title":"J Allergy Clin Immunol"},{"issue":"9","key":"900_CR40","doi-asserted-by":"crossref","first-page":"708","DOI":"10.1046\/j.1365-4362.1997.00105.x","volume":"36","author":"E Shahar","year":"1997","unstructured":"Shahar E, Bergman R, Pollack S. Autoimmune progesterone dermatitis: effective prophylactic treatment with danazol. Int J Dermatol. 1997;36(9):708\u201311.","journal-title":"Int J Dermatol"},{"issue":"1","key":"900_CR41","doi-asserted-by":"crossref","first-page":"54","DOI":"10.1080\/09513590500216735","volume":"22","author":"B Cocuroccia","year":"2006","unstructured":"Cocuroccia B, Gisondi P, Gubinelli E, Girolomoni G. Autoimmune progesterone dermatitis. Gynecol Endocrinol. 2006;22(1):54\u20136.","journal-title":"Gynecol Endocrinol"},{"issue":"2","key":"900_CR42","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1016\/0091-6749(88)91010-X","volume":"82","author":"EP Brestel","year":"1988","unstructured":"Brestel EP, Thrush LB. The treatment of glucocorticosteroid-dependent chronic urticaria with stanozolol. J Allergy Clin Immunol. 1988;82(2):265\u20139.","journal-title":"J Allergy Clin Immunol"},{"issue":"3","key":"900_CR43","doi-asserted-by":"crossref","first-page":"508","DOI":"10.1046\/j.1365-2133.1998.02420.x","volume":"139","author":"JM Rodenas","year":"1998","unstructured":"Rodenas JM, Herranz MT, Tercedor J. Autoimmune progesterone dermatitis: treatment with oophorectomy. Br J Dermatol. 1998;139(3):508\u201311.","journal-title":"Br J Dermatol"},{"issue":"3","key":"900_CR44","first-page":"852","volume":"5","author":"Enrico Heffler","year":"2017","unstructured":"Heffler E, Fichera S, Nicolosi G, Crimi N. Anaphylaxis due to progesterone hypersensitivity successfully treated with omalizumab. J allergy Clin Immunol Pract. 2017;5(3):852-4. This is an index case describing successful treatment of PH with omalizumab.","journal-title":"The Journal of Allergy and Clinical Immunology: In Practice"}],"container-title":["Current Allergy and Asthma Reports"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s11882-020-0900-4.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s11882-020-0900-4\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s11882-020-0900-4.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,1,27]],"date-time":"2021-01-27T00:21:11Z","timestamp":1611706871000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s11882-020-0900-4"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,1]]},"references-count":44,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2020,1]]}},"alternative-id":["900"],"URL":"https:\/\/doi.org\/10.1007\/s11882-020-0900-4","relation":{},"ISSN":["1529-7322","1534-6315"],"issn-type":[{"value":"1529-7322","type":"print"},{"value":"1534-6315","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,1]]},"assertion":[{"value":"28 January 2020","order":1,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Compliance with Ethical Standards"}},{"value":"The authors declare no conflicts of interest relevant to this manuscript.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of Interest"}},{"value":"This article does not contain any studies with human or animal subjects performed by any of the authors.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Human and Animal Rights and Informed Consent"}}],"article-number":"4"}}