{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,4]],"date-time":"2026-06-04T08:57:33Z","timestamp":1780563453370,"version":"3.54.1"},"reference-count":59,"publisher":"Springer Science and Business Media LLC","issue":"3","license":[{"start":{"date-parts":[[2021,3,1]],"date-time":"2021-03-01T00:00:00Z","timestamp":1614556800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2021,3,1]],"date-time":"2021-03-01T00:00:00Z","timestamp":1614556800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Curr Allergy Asthma Rep"],"published-print":{"date-parts":[[2021,3]]},"DOI":"10.1007\/s11882-021-00997-x","type":"journal-article","created":{"date-parts":[[2021,3,18]],"date-time":"2021-03-18T23:02:52Z","timestamp":1616108572000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["Skin Testing for Penicillin Allergy: a Review of the Literature"],"prefix":"10.1007","volume":"21","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3727-7970","authenticated-orcid":false,"given":"Tracy","family":"Zembles","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michelle","family":"Mitchell","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Waleed","family":"Alqurashi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mariana","family":"Castells","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elizabeth J.","family":"Phillips","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Vyles","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2021,3,18]]},"reference":[{"key":"997_CR1","doi-asserted-by":"publisher","first-page":"1305","DOI":"10.1111\/all.12881","volume":"71","author":"L Zhou","year":"2016","unstructured":"Zhou L, Dhopeshwarkar N, Blumenthal KG, Goss F, Topaz M, Slight SP, et al. Drug allergies documented in electronic health records of a large healthcare system. Allergy. 2016;71:1305\u201313.","journal-title":"Allergy."},{"issue":"9","key":"997_CR2","doi-asserted-by":"publisher","first-page":"1288","DOI":"10.1111\/all.13168","volume":"72","author":"KA Sacco","year":"2017","unstructured":"\u2022 Sacco KA, Bates A, Brigham TJ, et al. Clinical outcomes following inpatient penicillin allergy testing: a systematic review and meta-analysis. Allergy. 2017;72(9):1288\u201396 COMMENT: Meta-analysis describing the population-weighted mean for a negative skin test in inpatient cohorts was 95.1%.","journal-title":"Allergy"},{"issue":"5 Pt 1","key":"997_CR3","doi-asserted-by":"publisher","first-page":"918","DOI":"10.1016\/S0091-6749(99)70439-2","volume":"103","author":"M Blanca","year":"1999","unstructured":"Blanca M, Torres MJ, Garcia JJ, et al. Natural evolution of skin test sensitivity in patients allergic to beta-lactam antibiotics. J Allergy Clin Immunol. 1999;103(5 Pt 1):918\u201324.","journal-title":"J Allergy Clin Immunol."},{"issue":"11","key":"997_CR4","doi-asserted-by":"publisher","first-page":"857","DOI":"10.1136\/adc.55.11.857","volume":"55","author":"RK Chandra","year":"1980","unstructured":"Chandra RK, Joglekar SA, Tomas E. Penicillin allergy: anti-penicillin IgE antibodies and immediate hypersensitivity skin reactions employing major and minor determinants of penicillin. Arch Dis Child. 1980;55(11):857\u201360.","journal-title":"Arch Dis Child."},{"issue":"3","key":"997_CR5","doi-asserted-by":"publisher","first-page":"171","DOI":"10.1016\/0091-6749(81)90180-9","volume":"68","author":"TJ Sullivan","year":"1981","unstructured":"Sullivan TJ, Wedner HJ, Shatz GS, Yecies LD, Parker CW. Skin testing to detect penicillin allergy. J Allergy Clin Immunol. 1981;68(3):171\u201380.","journal-title":"J Allergy Clin Immunol."},{"issue":"3","key":"997_CR6","doi-asserted-by":"publisher","first-page":"790","DOI":"10.1016\/j.jaci.2013.09.021","volume":"133","author":"E Macy","year":"2014","unstructured":"Macy E, Contreras R. Health care use and serious infection prevalence associated with penicillin \u201callergy\u201d in hospitalized patients: a cohort study. J Allergy Clin Immunology. 2014;133(3):790\u20136.","journal-title":"J Allergy Clin Immunology."},{"issue":"1","key":"997_CR7","doi-asserted-by":"publisher","first-page":"42","DOI":"10.1002\/phar.2054","volume":"38","author":"MN Al-Hasan","year":"2018","unstructured":"Al-Hasan MN, Acker EC, Kohn JE, Bookstaver PB, Justo JA. Impact of penicillin allergy on empirical carbapenem use in gram-negative bloodstream infections: an antimicrobial stewardship opportunity. Pharmacotherapy. 2018;38(1):42\u201350.","journal-title":"Pharmacotherapy."},{"issue":"18","key":"997_CR8","doi-asserted-by":"publisher","first-page":"2819","DOI":"10.1001\/archinte.160.18.2819","volume":"160","author":"CE Lee","year":"2000","unstructured":"Lee CE, Zembower TR, Fotis MA, Postelnick MJ, Greenberger PA, Peterson LR, et al. The incidence of antimicrobial allergies in hospitalized patients: implications regarding prescribing patterns and emerging bacterial resistance. Arch Intern Med. 2000;160(18):2819\u201322.","journal-title":"Arch Intern Med."},{"issue":"4","key":"997_CR9","doi-asserted-by":"publisher","first-page":"1148","DOI":"10.1016\/j.jaci.2015.10.026","volume":"137","author":"MN Jeffres","year":"2016","unstructured":"Jeffres MN, Narayanan PP, Shuster JE, Schramm GE. Consequences of avoiding beta-lactams in patients with beta-lactam allergies. J Allergy Clin Immunol. 2016;137(4):1148\u201353.","journal-title":"J Allergy Clin Immunol."},{"key":"997_CR10","doi-asserted-by":"publisher","first-page":"k2400","DOI":"10.1136\/bmj.k2400","volume":"361","author":"KG Blumenthal","year":"2018","unstructured":"Blumenthal KG, Lu N, Zhang Y, Li Y, Walensky RP, Choi HK. Risk of methicillin resistant Staphylococcus aureus and Clostridium difficile in patients with a documented penicillin allergy: population based matched cohort study. BMJ. 2018;361:k2400.","journal-title":"BMJ."},{"issue":"3","key":"997_CR11","doi-asserted-by":"publisher","first-page":"329","DOI":"10.1093\/cid\/cix794","volume":"66","author":"KG Blumenthal","year":"2018","unstructured":"Blumenthal KG, Ryan EE, Li Y, Lee H, Kuhlen JL, Shenoy ES. The impact of reported penicillin allergy on surgical site infection risk. Clin Infect Dis. 2018;66(3):329\u201336.","journal-title":"Clin Infect Dis."},{"issue":"9","key":"997_CR12","doi-asserted-by":"publisher","first-page":"1685","DOI":"10.1007\/s11606-019-04991-y","volume":"34","author":"KG Blumenthal","year":"2019","unstructured":"Blumenthal KG, Lu N, Zhang Y, Walensky RP, Choi HK. Recorded penicillin allergy and risk of mortality: a population-based matched cohort study. J Gen Intern Med. 2019;34(9):1685\u20137.","journal-title":"J Gen Intern Med."},{"issue":"20","key":"997_CR13","first-page":"30282","volume":"S0195-6701","author":"N Powell","year":"2020","unstructured":"Powell N, Honeyford K, Sandoe J. Impact of penicillin allergy records on antibiotic costs and patient length of hospital say: a single centre observational retrospective cohort. J Hosp Infect. 2020;S0195-6701(20):30282\u20136 (online ahead of print).","journal-title":"J Hosp Infect"},{"key":"997_CR14","unstructured":"Centers for Disease Control and Prevention. Is it really a penicillin allergy? Evaluation and diagnosis of penicillin allergy for healthcare professionals. 2018. Available at: https:\/\/www.cdc.gov\/antibiotic-use\/community\/pdfs\/penicillin-factsheet.pdf. Accessed August 6, 2020."},{"issue":"10","key":"997_CR15","doi-asserted-by":"publisher","first-page":"e51","DOI":"10.1093\/cid\/ciw118","volume":"62","author":"TF Barlam","year":"2016","unstructured":"Barlam TF, Cosgrove SE, Abbo LM, MacDougall C, Schuetz AN, Septimus EJ, et al. Implementing an antimicrobial stewardship program: guidelines by the Infectious Diseases Society of America and the Society for Healthcare Epidemiology of American. Clin Infect Dis. 2016;62(10):e51\u201377.","journal-title":"Clin Infect Dis."},{"key":"997_CR16","unstructured":"American Academy of Asthma, Allergy, and Immunology. Position statement: penicillin allergy. Available at: https:\/\/www.aaaai.org\/Aaaai\/media\/MediaLibrary\/PDF%20Documents\/Practice%20and%20Parameters\/Penicillian-Allergy-Testing-Febraury-17.pdf. Accessed August 6, 2020."},{"key":"997_CR17","doi-asserted-by":"publisher","first-page":"136","DOI":"10.1093\/ajhp\/zxy043","volume":"76","author":"CM Bland","year":"2019","unstructured":"Bland CM, Bookstaver PB, Griffith NC, Heil EL, Jones BM, Ann Justo J, et al. A practical guide for pharmacists to successfully implement penicillin allergy skin testing. Am J Health Syst Pharm. 2019;76:136\u201347.","journal-title":"Am J Health Syst Pharm."},{"key":"997_CR18","doi-asserted-by":"publisher","first-page":"188","DOI":"10.1001\/jama.2018.19283","volume":"321","author":"ES Shenoy","year":"2019","unstructured":"\u2022\u2022 Shenoy ES, Macy E, Rowe T, Blumenthal KG. Evaluation and management of penicillin allergy: a review. JAMA. 2019;321:188\u201399 COMMENT: Excellent review describing evaluation of penicillin allergy before prescribing antibiotics as an important tool for stewardship.","journal-title":"JAMA"},{"issue":"3","key":"997_CR19","doi-asserted-by":"publisher","first-page":"ofw155","DOI":"10.1093\/ofid\/ofw155","volume":"3","author":"EL Heil","year":"2016","unstructured":"Heil EL, Bork JT, Schmalzle SA, et al. Implementation of an infectious disease fellow-managed penicillin allergy skin testing service. Open Forum Infect Dis. 2016;3(3):ofw155.","journal-title":"Open Forum Infect Dis"},{"issue":"1","key":"997_CR20","doi-asserted-by":"publisher","first-page":"67","DOI":"10.1016\/j.anai.2016.04.021","volume":"117","author":"EA King","year":"2016","unstructured":"King EA, Challa S, Curtin P, Bielory L. Penicillin skin testing in hospitalized patients with beta-lactam allergies: effect on antibiotic selection and cost. Ann Allergy Asthma Immunol. 2016;117(1):67\u201371.","journal-title":"Ann Allergy Asthma Immunol."},{"issue":"3","key":"997_CR21","doi-asserted-by":"publisher","first-page":"686","DOI":"10.1016\/j.jaip.2016.09.045","volume":"5","author":"JR Chen","year":"2017","unstructured":"Chen JR, Tarver SA, Alvarez KS, Tran T, Khan DA. A proactive approach to penicillin allergy testing in hospitalized patients. J Allergy Clin Immunol Pract. 2017;5(3):686\u201393.","journal-title":"J Allergy Clin Immunol Pract."},{"issue":"3","key":"997_CR22","doi-asserted-by":"publisher","first-page":"669","DOI":"10.1016\/j.jaip.2017.02.023","volume":"5","author":"R Confino-Cohen","year":"2017","unstructured":"Confino-Cohen R, Rosman Y, Meir-Shafrir K, Stauber T, Lachover-Roth I, Hershko A, et al. Oral challenge without skin testing safely excludes clinically significant delayed-onset penicillin hypersensitivity. J Allergy Clin Immunol Pract. 2017;5(3):669\u201375.","journal-title":"J Allergy Clin Immunol Pract."},{"issue":"5","key":"997_CR23","doi-asserted-by":"publisher","first-page":"505","DOI":"10.1111\/1742-6723.12774","volume":"29","author":"J Marwood","year":"2017","unstructured":"Marwood J, Aguirrebarrena G, Kerr S, Welch SA, Rimmer J. Delabeling self-reported penicillin allergy within the emergency department through the use of skin testing and oral drug provocation testing. Emerg Med Australas. 2017;29(5):505\u201315.","journal-title":"Emerg Med Australas."},{"issue":"8","key":"997_CR24","doi-asserted-by":"publisher","first-page":"915","DOI":"10.1080\/00325481.2017.1370360","volume":"129","author":"BK Sundquist","year":"2017","unstructured":"Sundquist BK, Bowen BJ, Otabor U, Celestin J, Sorum PC. Proactive penicillin allergy testing in primary care patients labeled as allergic: outcomes and barriers. Postgrad Med. 2017;129(8):915\u201320.","journal-title":"Postgrad Med."},{"issue":"2","key":"997_CR25","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2017-0471","volume":"140","author":"D Vyles","year":"2017","unstructured":"Vyles D, Adams J, Chui A, et al. Allergy testing in children with low-risk penicillin allergy symptoms. Pediatrics. 2017;140(2):e20170471.","journal-title":"Pediatrics."},{"issue":"4","key":"997_CR26","doi-asserted-by":"publisher","first-page":"1349","DOI":"10.1016\/j.jaip.2017.11.012","volume":"6","author":"A Ramsey","year":"2018","unstructured":"\u2022 Ramsey A, Staicu ML. Use of penicillin allergy screening algorithm and penicillin skin testing for transitioning hospitalized patients to first-line antibiotic therapy. J Allergy Clin Immunol Pract. 2018;6(4):1349\u201355 COMMENT: Describes a process for using penicillin skin testing to transition patients to first line therapies.","journal-title":"J Allergy Clin Immunol Pract"},{"issue":"4","key":"997_CR27","doi-asserted-by":"publisher","first-page":"ofz109","DOI":"10.1093\/ofid\/ofz109","volume":"6","author":"BM Jones","year":"2019","unstructured":"Jones BM, Avramovski N, Concepcion AM, Crosby J, Bland CM. Clinical and economic outcomes of penicillin skin testing as an antimicrobial stewardship initiative in a community health system. Open Forum Infect Dis. 2019;6(4):ofz109.","journal-title":"Open Forum Infect Dis"},{"issue":"7","key":"997_CR28","doi-asserted-by":"publisher","first-page":"2163","DOI":"10.1016\/j.jaip.2019.05.037","volume":"7","author":"SS Mustafa","year":"2019","unstructured":"Mustafa SS, Conn K, Ramsey A. Comparing direct challenge to penicillin skin testing for the outpatient evaluation of penicillin allergy: a randomized controlled trial. J Allergy Clin Immunol Pract. 2019;7(7):2163\u201370.","journal-title":"J Allergy Clin Immunol Pract."},{"issue":"6","key":"997_CR29","doi-asserted-by":"publisher","first-page":"1876","DOI":"10.1016\/j.jaip.2019.02.040","volume":"7","author":"R Solensky","year":"2019","unstructured":"Solensky R, Jacobs J, Lester M. Lieberman, et al. Penicillin allergy evaluation: a prospective, multicenter, open-label evaluation of a comprehensive penicillin skin test kit. J Allergy Clin Immunol Pract. 2019;7(6):1876\u201385.","journal-title":"J Allergy Clin Immunol Pract."},{"issue":"7","key":"997_CR30","doi-asserted-by":"publisher","first-page":"2185","DOI":"10.1016\/j.jaip.2019.03.025","volume":"7","author":"M Taremi","year":"2019","unstructured":"Taremi M, Artau A, Foolad F, Berlin S, White C, Jiang Y, et al. Safety, efficacy, and clinical impact of penicillin skin testing in immunocompromised cancer patients. J Allergy Clin Immunol Pract. 2019;7(7):2185\u201391.","journal-title":"J Allergy Clin Immunol Pract."},{"issue":"1","key":"997_CR31","doi-asserted-by":"publisher","first-page":"58","DOI":"10.1177\/0018578718817917","volume":"55","author":"S Harmon","year":"2020","unstructured":"Harmon S, Richardson T, Simons H, Monforte S, Fanning S, Harrington K. The clinical and financial impact of a pharmacist-driven penicillin skin testing program on antimicrobial stewardship practices. Hosp Pharm. 2020;55(1):58\u201363.","journal-title":"Hosp Pharm."},{"issue":"6","key":"997_CR32","doi-asserted-by":"publisher","first-page":"583","DOI":"10.1016\/j.anai.2020.03.013","volume":"124","author":"JH Plager","year":"2020","unstructured":"Plager JH, Mancini CM, Fu X, Melnitchouk S, Shenoy ES, Banerji A, et al. Preoperative penicillin allergy testing in patients undergoing cardiac surgery. Ann Allergy Asthma Immunol. 2020;124(6):583\u20138.","journal-title":"Ann Allergy Asthma Immunol."},{"issue":"4","key":"997_CR33","doi-asserted-by":"publisher","first-page":"232","DOI":"10.2146\/ajhp160233","volume":"74","author":"BM Jones","year":"2017","unstructured":"Jones BM, Bland CM. Penicillin skin testing as an antimicrobial stewardship initiative. Am J Health Syst Pharm. 2017;74(4):232\u20137.","journal-title":"Am J Health Syst Pharm."},{"issue":"24","key":"997_CR34","first-page":"2060","volume":"76","author":"E Englert","year":"2019","unstructured":"Englert E, Weeks A. Pharmacist-driven penicillin skin testing service for adults prescribed non-preferred antibiotics in a community hospital. Am J Health Syst Pharm. 2019;76(24):2060\u20139.","journal-title":"Am J Health Syst Pharm."},{"issue":"1","key":"997_CR35","doi-asserted-by":"publisher","first-page":"50","DOI":"10.1111\/pai.12493","volume":"27","author":"E Vezir","year":"2016","unstructured":"Vezir E, Dibek Misirlioglu E, Civelek E, Capanoglu M, Guvenir H, Ginis T, et al. Direct oral provocation tests in non-immediate mild cutaneous reactions related to beta-lactam antibiotics. Pediatr Allergy Immunol. 2016;27(1):50\u20134.","journal-title":"Pediatr Allergy Immunol."},{"issue":"6","key":"997_CR36","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1001\/jamapediatrics.2016.0033","volume":"170","author":"C Mill","year":"2016","unstructured":"Mill C, Primeau MN, Medoff E, et al. Assessing the diagnostic properties of a graded oral provocation challenge for the diagnosis of immediate and nonimmediate reactions to amoxicillin in children. JAMA Pediatr. 2016;170(6):1\u20138.","journal-title":"JAMA Pediatr."},{"issue":"6","key":"997_CR37","doi-asserted-by":"publisher","first-page":"583","DOI":"10.1136\/archdischild-2014-306280","volume":"100","author":"T Marrs","year":"2015","unstructured":"Marrs T, Fox AT, Lack G, du Toit G. The diagnosis and management of antibiotic allergy in children: systematic review to inform a contemporary approach. Arch Dis Child. 2015;100(6):583\u20138.","journal-title":"Arch Dis Child."},{"issue":"2","key":"997_CR38","doi-asserted-by":"publisher","first-page":"235","DOI":"10.1016\/j.anai.2018.05.013","volume":"121","author":"MD Ib\u00e1\u00f1ez","year":"2018","unstructured":"Ib\u00e1\u00f1ez MD. Rodr\u00edguez del R\u00edo P, Lasa EM, et al. Prospective assessment of diagnostic tests for pediatric penicillin allergy: from clinical history to challenge tests. Ann Allergy Asthma Immunol. 2018;121(2):235\u201344.","journal-title":"Ann Allergy Asthma Immunol."},{"issue":"4","key":"997_CR39","doi-asserted-by":"publisher","first-page":"452","DOI":"10.1016\/j.amjmed.2019.09.017","volume":"133","author":"M DesBiens","year":"2020","unstructured":"DesBiens M, Scalia P, Ravikumar S, Glick A, Newton H, Erinne O, et al. A closer look at penicillin allergy history: systematic review and meta-analysis of tolerance to drug challenge. Am J Med. 2020;133(4):452\u201362.","journal-title":"Am J Med."},{"issue":"2","key":"997_CR40","doi-asserted-by":"publisher","first-page":"273","DOI":"10.1111\/all.13848","volume":"75","author":"CA Stone Jr","year":"2019","unstructured":"Stone CA Jr, Trubiano J, Coleman DT, Rukasin CRF, Phillips EJ. The challenge of delabeling penicillin allergy. Allergy. 2019;75(2):273\u201388.","journal-title":"Allergy."},{"issue":"1","key":"997_CR41","doi-asserted-by":"publisher","first-page":"40","DOI":"10.1016\/j.jaip.2018.07.051","volume":"7","author":"MJ Torres","year":"2019","unstructured":"Torres MJ, Adkinson NF, Caubet JC, et al. Controversies in drug allergy: beta-lactam hypersensitivity testing. J Allergy Clin Immunol Pract. 2019;7(1):40\u20135.","journal-title":"J Allergy Clin Immunol Pract."},{"issue":"4","key":"997_CR42","doi-asserted-by":"publisher","first-page":"532","DOI":"10.1111\/cea.13576","volume":"50","author":"A Reichel","year":"2020","unstructured":"Reichel A, R\u00f6ding K, Stoevesandt J, Trautmann A. De-labelling antibiotic allergy through five key questions. Clin Exp Allergy. 2020;50(4):532\u20135.","journal-title":"Clin Exp Allergy."},{"issue":"24","key":"997_CR43","doi-asserted-by":"publisher","first-page":"2338","DOI":"10.1056\/NEJMra1807761","volume":"381","author":"M Castells","year":"2019","unstructured":"\u2022\u2022 Castells M, Khan DA, Phillips EJ. Penicillin allergy. N Engl J Med. 2019;381(24):2338\u201351 COMMENT: Excellent review article describing penicillin allergy diagnosis, clinical implications, drug challenge, stewardship opportunities, and more.","journal-title":"N Engl J Med."},{"issue":"5","key":"997_CR44","doi-asserted-by":"publisher","first-page":"745","DOI":"10.1001\/jamainternmed.2020.0403","volume":"180","author":"JA Trubiano","year":"2020","unstructured":"Trubiano JA, Vogrin S, Chua KYL, Bourke J, Yun J, Douglas A, et al. Development and validation of a penicillin allergy clinical decision rule. JAMA Intern Med. 2020;180(5):745\u201352.","journal-title":"JAMA Intern Med."},{"issue":"5","key":"997_CR45","doi-asserted-by":"publisher","first-page":"1025","DOI":"10.1001\/archinte.1992.00400170105020","volume":"152","author":"DD Sogn","year":"1992","unstructured":"Sogn DD, Evans R, Shepherd GM, et al. Results of the National Institute of Allergy and Infectious Diseases collaborative clinical trial to test the predictive value of skin testing with major and minor penicillin derivatives in hospitalized adults. Arch Intern Med. 1992;152(5):1025\u201332.","journal-title":"Arch Intern Med."},{"issue":"20","key":"997_CR46","doi-asserted-by":"publisher","first-page":"2456","DOI":"10.1001\/jama.1993.03510200062033","volume":"270","author":"J Gadde","year":"1993","unstructured":"Gadde J, Spence M, Wheeler B, Adkinson NF Jr. Clinical experience with penicillin skin testing in a large inner-city STD clinic. JAMA. 1993;270(20):2456\u201363.","journal-title":"JAMA."},{"issue":"10167","key":"997_CR47","doi-asserted-by":"publisher","first-page":"183","DOI":"10.1016\/S0140-6736(18)32218-9","volume":"393","author":"KG Blumenthal","year":"2019","unstructured":"Blumenthal KG, Peter JG, Trubiano JA, Phillips EJ. Antibiotic allergy. Lancet. 2019;393(10167):183\u201398.","journal-title":"Lancet."},{"key":"997_CR48","doi-asserted-by":"publisher","first-page":"259","DOI":"10.1016\/j.anai.2010.08.002","volume":"105","author":"Joint Task Force on Practice Parameter, American Academy of Allergy Asthma and Immunology and American College of Allergy Asthma and Immunology","year":"2010","unstructured":"Joint Task Force on Practice Parameter, American Academy of Allergy Asthma and Immunology and American College of Allergy Asthma and Immunology. Drug allergy: an updated practice parameter. Ann Allergy Asthma Immunol. 2010;105:259\u201373.","journal-title":"Ann Allergy Asthma Immunol"},{"issue":"3","key":"997_CR49","first-page":"162","volume":"6","author":"G Patriarca","year":"1996","unstructured":"Patriarca G, Schiavino D, Nucera E, Milani A. Positive allergological tests may turn negative with no further exposure to the specific allergen: a long-term, prospective, follow-up study in patients allergic to penicillin. J Investig Allergol Clin Immunol. 1996;6(3):162\u20135.","journal-title":"J Investig Allergol Clin Immunol."},{"key":"997_CR50","unstructured":"Voelker D, et al. Abstract P007. Presented at: American College of Allergy, Asthma and Immunology Annual Scientific Meeting; Nov. 15-19, 2018; Seattle."},{"key":"997_CR51","doi-asserted-by":"publisher","first-page":"813","DOI":"10.1016\/j.jaip.2017.01.023","volume":"5","author":"MH Tucker","year":"2017","unstructured":"Tucker MH, Lomas CM, Ramchandar N, Waldram JD. Amoxicillin challenge without penicillin skin testing in evaluation of penicillin allergy in a cohort of Marine recruits. J Allergy Clin Immunol Pract. 2017;5:813\u20135.","journal-title":"J Allergy Clin Immunol Pract."},{"issue":"12","key":"997_CR52","doi-asserted-by":"publisher","first-page":"ofy306","DOI":"10.1093\/ofid\/ofy306","volume":"5","author":"JA Trubiano","year":"2018","unstructured":"Trubiano JA, Smibert O, Douglas A, et al. The safety and efficacy of an oral penicillin challenge program in cancer patients: a multicenter pilot study. Open Forum Infect Dis. 2018;5(12):ofy306.","journal-title":"Open Forum Infect Dis"},{"issue":"7","key":"997_CR53","doi-asserted-by":"publisher","first-page":"2294","DOI":"10.1016\/j.jaip.2020.02.033","volume":"8","author":"A Ramsey","year":"2020","unstructured":"Ramsey A, Mustafa SS, Holly AM, Staicu ML. Direct challenges to penicillin-based antibiotics in the inpatient setting. J Allergy Clin Immunol Pract. 2020;8(7):2294\u2013301.","journal-title":"J Allergy Clin Immunol Pract."},{"issue":"5","key":"997_CR54","first-page":"433","volume":"20","author":"J Jurado-Palomo","year":"2010","unstructured":"Jurado-Palomo J, Caba\u00f1as R, Prior N, Bobolea ID, Fiandor-Rom\u00e1n AM, L\u00f3pez-Serrano MC, et al. Use of the lymphocyte transformation test in the diagnosis of DRESS syndrome induced by ceftriaxone and piperacillin-tazobactam: two case reports. J Investig Allergol Clin Immunol. 2010;20(5):433\u20136.","journal-title":"J Investig Allergol Clin Immunol."},{"issue":"1","key":"997_CR55","doi-asserted-by":"publisher","first-page":"1","DOI":"10.2332\/allergolint.55.1","volume":"55","author":"T Shiohara","year":"2006","unstructured":"Shiohara T, Inaoka M, Kano Y. Drug-induced hypersensitivity syndrome (DIHS): a reaction induced by a complex interplay among herpesviruses and antiviral and antidrug immune responses. Allergol Int. 2006;55(1):1\u20138.","journal-title":"Allergol Int."},{"issue":"12","key":"997_CR56","doi-asserted-by":"publisher","first-page":"998","DOI":"10.1136\/archdischild-2013-303718","volume":"98","author":"C Ferrandiz-Pulido","year":"2013","unstructured":"Ferrandiz-Pulido C, Garcia-Patos V. A review of causes of Stevens-Johnson syndrome and toxic epidermal necrolysis in children. Arch Dis Child. 2013;98(12):998\u20131003.","journal-title":"Arch Dis Child."},{"issue":"3","key":"997_CR57","doi-asserted-by":"publisher","first-page":"330","DOI":"10.1016\/S1081-1206(10)63308-X","volume":"86","author":"AJ Tatum","year":"2001","unstructured":"Tatum AJ, Ditto AM, Patterson R. Severe serum sickness-like reaction to oral penicillin drugs: three case reports. Ann Allergy Asthma Immunol. 2001;86(3):330\u20134.","journal-title":"Ann Allergy Asthma Immunol."},{"issue":"5","key":"997_CR58","doi-asserted-by":"publisher","first-page":"705","DOI":"10.1592\/phco.26.5.705","volume":"26","author":"BM Clark","year":"2006","unstructured":"Clark BM, Kotti GH, Shah AD, Conger NG. Severe serum sickness reaction to oral and intramuscular penicillin. Pharmacotherapy. 2006;26(5):705\u20138.","journal-title":"Pharmacotherapy."},{"key":"997_CR59","doi-asserted-by":"publisher","unstructured":"Delli Colli L, Gabrielli S, Abrams EM, et al. Differentiating between \u03b2-lactam-induced serum sickness-like reactions and viral exanthem in children using a graded oral challenge. J Allergy Clin Immunol Pract. 2020. https:\/\/doi.org\/10.1016\/j.jaip.2020.08.047 Epub ahead of print.","DOI":"10.1016\/j.jaip.2020.08.047"}],"container-title":["Current Allergy and Asthma Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s11882-021-00997-x.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s11882-021-00997-x\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s11882-021-00997-x.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,1,30]],"date-time":"2023-01-30T03:12:23Z","timestamp":1675048343000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s11882-021-00997-x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,3]]},"references-count":59,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2021,3]]}},"alternative-id":["997"],"URL":"https:\/\/doi.org\/10.1007\/s11882-021-00997-x","relation":{},"ISSN":["1529-7322","1534-6315"],"issn-type":[{"value":"1529-7322","type":"print"},{"value":"1534-6315","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,3]]},"assertion":[{"value":"11 February 2021","order":1,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"18 March 2021","order":2,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Compliance with Ethical Standards"}},{"value":"The authors declare no conflicts of interest relevant to this manuscript.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of Interest"}},{"value":"This article does not contain any studies with human or animal subjects performed by any of the authors.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Human and Animal Rights and Informed Consent"}}],"article-number":"21"}}