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This transformation has far-reaching effects on lifestyles, impacting areas such as economics, politics, social life, and culture, all of which, in turn, have diverse influences on public health. Loss of contact with nature, alternations in the microbiota, processed food consumption, exposure to environmental pollutants including chemicals, increased stress and decreased physical activity jointly result in increases in the frequency of inflammatory disorders including allergies and many autoimmune and neuropsychiatric diseases. This review aims to investigate the relationship between Western lifestyle and inflammatory disorders.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Recent Findings<\/jats:title>\n                <jats:p>Several hypotheses have been put forth trying to explain the observed increases in these diseases, such as \u2018<jats:italic>Hygiene Hypothesis<\/jats:italic>\u2019, \u2018<jats:italic>Old Friends<\/jats:italic>\u2019, and \u2018<jats:italic>Biodiversity and Dysbiosi<\/jats:italic>s\u2019. The recently introduced \u2018<jats:italic>Epithelial Barrier Theory<\/jats:italic>\u2019 incorporates these former hypotheses and suggests that toxic substances in cleaning agents, laundry and dishwasher detergents, shampoos, toothpastes, as well as\u00a0microplastic, packaged food and air pollution damage the epithelium of our skin, lungs and gastrointestinal system. Epithelial barrier disruption leads to decreased biodiversity of the microbiome and the development of opportunistic pathogen colonization, which upon interaction with the immune system, initiates local and systemic inflammation.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Summary<\/jats:title>\n                <jats:p>Gaining a deeper comprehension of the interplay between the environment, microbiome and the immune system provides the data to assist with legally regulating the usage of toxic substances, to enable nontoxic alternatives and to mitigate these environmental challenges essential for fostering a harmonious and healthy global environment.<\/jats:p>\n              <\/jats:sec>","DOI":"10.1007\/s11882-024-01149-7","type":"journal-article","created":{"date-parts":[[2024,6,17]],"date-time":"2024-06-17T06:02:16Z","timestamp":1718604136000},"page":"331-345","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":53,"title":["Lifestyle Changes and Industrialization in the Development of Allergic Diseases"],"prefix":"10.1007","volume":"24","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9284-4520","authenticated-orcid":false,"given":"Cevdet","family":"Ozdemir","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5358-5570","authenticated-orcid":false,"given":"Umut Can","family":"Kucuksezer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8282-7762","authenticated-orcid":false,"given":"Ismail","family":"Ogulur","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4268-4933","authenticated-orcid":false,"given":"Yagiz","family":"Pat","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9094-6542","authenticated-orcid":false,"given":"Duygu","family":"Yazici","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2758-5945","authenticated-orcid":false,"given":"Sena","family":"Ardicli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0554-9943","authenticated-orcid":false,"given":"Mubeccel","family":"Akdis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2146-2955","authenticated-orcid":false,"given":"Kari","family":"Nadeau","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8020-019X","authenticated-orcid":false,"given":"Cezmi A.","family":"Akdis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2024,6,17]]},"reference":[{"issue":"8","key":"1149_CR1","doi-asserted-by":"publisher","first-page":"2232","DOI":"10.1111\/all.15807","volume":"78","author":"YH Shin","year":"2023","unstructured":"Shin YH, et al. 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