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The severity of the disease can be correlated with nasal polyps enriched in eosinophils\/IL-5 and, although\u2009\u2265\u200910 eosinophils per high power field are considered enough to determine an eosinophilic CRS, this cut-off value, the biopsy method, and the sampling location are still a matter of debate. Besides, tissue eosinophil values might also have some added value when combined with other cellular counts (e.g., eosinophil-to-lymphocyte ratio, Charcot-Leyden crystals). Structured histopathology analysis of sinonasal tissue\u2014including, for instance, tissue remodelling biomarkers, fibrosis, and eosinophilic aggregates\u2014has proven to be a valuable tool for healthcare professionals to identify different pheno-endotypes of CRSwNP and to improve the prioritisation of candidates to targeted therapies. Patients with CRSwNP are treated according to their severity with corticosteroids (intranasal and systemic), endoscopic sinus surgery, and\/or biological therapy.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Summary<\/jats:title>\n                <jats:p>A panel of expert ear, nose, and throat specialists and pathologists proposed a pragmatic checklist to improve the clinical practice around tissue analysis in CRSwNP, to facilitate communication between hospital-based healthcare professionals, and to standardize the evaluation of inflammatory biomarkers.<\/jats:p>\n              <\/jats:sec>","DOI":"10.1007\/s11882-024-01180-8","type":"journal-article","created":{"date-parts":[[2024,10,7]],"date-time":"2024-10-07T08:01:39Z","timestamp":1728288099000},"page":"657-665","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":21,"title":["When the Nose Meets the Lab: Histopathological Analysis in Chronic Rhinosinusitis with Nasal Polyps for Routine Clinical Practice"],"prefix":"10.1007","volume":"24","author":[{"given":"Isam","family":"Alobid","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Miguel","family":"Armengot-Carceller","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mayte","family":"Pinilla Urraca","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juan","family":"Maza-Solano","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Isabel","family":"Gonz\u00e1lez Guijarro","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sebasti\u00e1n","family":"Umbria Jim\u00e9nez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pilar","family":"San Miguel Fraile","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3463-5007","authenticated-orcid":false,"given":"Joaquim","family":"Mullol","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2024,10,7]]},"reference":[{"key":"1180_CR1","doi-asserted-by":"publisher","first-page":"331","DOI":"10.1146\/annurev-pathol-052016-100401","volume":"12","author":"RP Schleimer","year":"2017","unstructured":"Schleimer RP. 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They were not involved in assigning this manuscript to Associate Editors or peer reviewers and are separated and blinded from the editorial system from submission inception to decision.Isam Alobid has received honoraria for consultancy and conferences from Viatris, Roche, Sanofi, GSK, MSD, AstraZeneca, Storz, Olympus, Metronic, CINFA, Menarini, Salvat, and Novartis. Miguel Armengot-Carceller has received honoraria for consultancy and conferences from GSK. Mayte Pinilla Urraca has received honoraria for consultancy and conferences from Sanofi, GSK, AstraZeneca, and Italfarmaco. Juan Maza-Solano has received honoraria for consultancy and conferences from GSK, Sanofi, AstraZeneca, and Teva. Isabel Gonz\u00e1lez-Guijarro has received honoraria for consultancy and conferences from GSK and Schwabe Farma. Sebasti\u00e1n Umbria Jim\u00e9nez has received honoraria for consultancy and conferences from GSK. Pilar San Miguel Fraile has received honoraria for consultancy and conferences from GSK and AstraZeneca. Joaquim Mullol has received research grants from AstraZeneca, Genentech, GSK, Viatris, Novartis, Regeneron, Sanofi-Genzyme, and Noucor\/Uriach Group, consulting fees from Noucor\/Uriach Group and Sanofi-Genzyme, and attended speaker bureaus and\/or advisory boards for AstraZeneca, Genentech, GSK, Glenmark, Lilly, Menarini, Mitsubishi-Tanabe Pharma, MSD, Noucor\/Uriach Group, Novartis, Proctor & Gamble, Regeneron Pharmaceuticals Inc., Sanofi Genzyme, UCB Pharma, and Viatris.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing Interests"}},{"value":"This article does not contain any studies with human or animal subjects performed by any of the authors.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Human and Animal Rights and Informed Consent"}}]}}