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This review summarizes recent advances in its epidemiology, multiomics, and therapeutic landscape.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Recent Findings<\/jats:title>\n                    <jats:p>T2-low inflammation is highly prevalent, affecting approximately 14%\u201339% of adults with current asthma and up to 60% of children. Its pathogenesis reflects complex non-T2 mechanisms, including IL-17 signaling, innate immune activation through IL-1\u03b2 and IL-33, and neutrophilic inflammation. Heterogeneity is further shaped by systemic factors such as obesity and immunosenescence and by environmental exposures such as ozone. Among available therapies, long-term macrolides and the anti-TSLP biologic tezepelumab have shown significant efficacy in reducing exacerbations, whereas other pathway-specific interventions have yielded inconsistent clinical benefits. Emerging metabolic approaches, including GLP-1 receptor agonists, may offer additional promise.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Summary<\/jats:title>\n                    <jats:p>Progress in T2-low asthma will require mechanism-based classification and clinically deployable biomarkers to align targeted therapies with specific biological drivers.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1007\/s11882-026-01294-1","type":"journal-article","created":{"date-parts":[[2026,9,16]],"date-time":"2026-09-16T06:53:22Z","timestamp":1789541602000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Type 2-low Asthma: Epidemiology, Multiomics, and Emerging Therapies"],"prefix":"10.1007","volume":"26","author":[{"ORCID":"https:\/\/orcid.org\/0009-0006-6395-7717","authenticated-orcid":false,"given":"Philip","family":"Mendez","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alanis","family":"Rosado","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juan Carlos","family":"Cardet","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,9,16]]},"reference":[{"issue":"6","key":"1294_CR1","doi-asserted-by":"publisher","first-page":"649","DOI":"10.1089\/respcare.12352","volume":"70","author":"JR Grunwell","year":"2025","unstructured":"Grunwell JR, Fitzpatrick AM. 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