{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T06:15:32Z","timestamp":1790144132904,"version":"4.0.1"},"reference-count":46,"publisher":"Springer Science and Business Media LLC","issue":"6","license":[{"start":{"date-parts":[[2008,11,25]],"date-time":"2008-11-25T00:00:00Z","timestamp":1227571200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Curr Atheroscler Rep"],"published-print":{"date-parts":[[2008,12]]},"DOI":"10.1007\/s11883-008-0080-5","type":"journal-article","created":{"date-parts":[[2008,11,26]],"date-time":"2008-11-26T15:34:35Z","timestamp":1227713675000},"page":"518-522","source":"Crossref","is-referenced-by-count":34,"title":["The mediterranean diet: Rationale and evidence for its benefit"],"prefix":"10.1007","volume":"10","author":[{"given":"Michel","family":"de Lorgeril","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patricia","family":"Salen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2008,11,25]]},"reference":[{"key":"80_CR1","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1093\/eurheartj\/ehi511","volume":"27","author":"S. Sans","year":"2006","unstructured":"Sans S, Kesteloot H, Kromhout D: Dynamics of cardiovascular and all-cause mortality in Western and Eastern Europe between 1970 and 2000. Eur Heart J 2006, 27:107\u2013113.","journal-title":"Eur Heart J"},{"issue":"Suppl","key":"80_CR2","doi-asserted-by":"crossref","first-page":"1402S","DOI":"10.1093\/ajcn\/61.6.1402S","volume":"61","author":"W.C. Willett","year":"1995","unstructured":"Willett WC, Sacks F, Trichopoulou A, et al.: Mediterranean diet pyramid: a cultural model for healthy eating. Am J Clin Nutr 1995, 61(Suppl):1402S\u20131406S.","journal-title":"Am J Clin Nutr"},{"key":"80_CR3","first-page":"1","volume":"97","author":"M. Lorgeril de","year":"2007","unstructured":"de Lorgeril M, Salen P: Modified Cretan Mediterranean diet in the prevention of coronary heart disease and cancer: an update. World Rev Nutr Diet 2007, 97:1\u201332.","journal-title":"World Rev Nutr Diet"},{"key":"80_CR4","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1016\/0002-9343(86)90154-3","volume":"80","author":"I. Hjermann","year":"1986","unstructured":"Hjermann I, Holme I, Leren P: Oslo Study Diet and Antismoking Trial. Results after 102 months. Am J Med 1986, 80:7\u201311.","journal-title":"Am J Med"},{"key":"80_CR5","doi-asserted-by":"crossref","first-page":"1454","DOI":"10.1016\/S0140-6736(94)92580-1","volume":"343","author":"M. Lorgeril de","year":"1994","unstructured":"de Lorgeril M, Renaud S, Mamelle N, et al.: Mediterranean alpha-linolenic acid-rich diet in secondary prevention of coronary heart disease. Lancet 1994, 343:1454\u20131459.","journal-title":"Lancet"},{"key":"80_CR6","doi-asserted-by":"crossref","first-page":"757","DOI":"10.1016\/S0140-6736(89)90828-3","volume":"334","author":"M.L. Burr","year":"1989","unstructured":"Burr ML, Fehily AM, Gilbert JF, et al.: Effects of changes in fat, fish, and fibre intakes on death and myocardial reinfarction: Diet And Reinfarction Trial. Lancet 1989, 334:757\u2013761.","journal-title":"Lancet"},{"key":"80_CR7","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1093\/oxfordjournals.eurheartj.a015094","volume":"18","author":"M. Lorgeril de","year":"1997","unstructured":"de Lorgeril M, Salen P, Monjaud I, Delaye J: The diet heart hypothesis in secondary prevention of coronary heart disease. Eur Heart J 1997, 18:14\u201318.","journal-title":"Eur Heart J"},{"key":"80_CR8","doi-asserted-by":"crossref","first-page":"447","DOI":"10.1016\/S0140-6736(99)07072-5","volume":"354","author":"GISSI-Prevenzione Investigators","year":"1999","unstructured":"GISSI-Prevenzione Investigators: Dietary supplementation with n-3 polyunsaturated fatty acids and vitamin E after myocardial infarction: results of the GISSI-Prevenzione trial. Lancet 1999, 354:447\u2013455.","journal-title":"Lancet"},{"key":"80_CR9","doi-asserted-by":"crossref","first-page":"1113","DOI":"10.1001\/jama.1995.03520380049034","volume":"273","author":"M.W. Gilman","year":"1995","unstructured":"Gilman MW, Cupples LA, Gagnon D, et al.: Protective effect of fruits and vegetables on development of stroke in men. JAMA 1995, 273:1113\u20131117.","journal-title":"JAMA"},{"key":"80_CR10","doi-asserted-by":"crossref","first-page":"447","DOI":"10.1001\/jama.1996.03530300031036","volume":"275","author":"E.B. Rimm","year":"1996","unstructured":"Rimm EB, Ascherio A, Giovannucci E, et al.: Vegetable, fruit and cereal fiber intake and risk of coronary heart disease among men. JAMA 1996, 275:447\u2013451.","journal-title":"JAMA"},{"key":"80_CR11","doi-asserted-by":"crossref","first-page":"775","DOI":"10.1136\/bmj.313.7060.775","volume":"313","author":"T.J. Key","year":"1996","unstructured":"Key TJ, Thorogood M, Appleby PN, Burr ML: Dietary habits and mortality in 11,000 vegetarians and health conscious people: results of a 17-year follow-up. BMJ 1996, 313:775\u2013779.","journal-title":"BMJ"},{"key":"80_CR12","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1001\/jama.279.1.23","volume":"279","author":"C.M. Albert","year":"1998","unstructured":"Albert CM, Hennekens CH, O\u2019Donnell CJ, et al.: Fish consumption and risk of sudden death. JAMA 1998, 279:23\u201328.","journal-title":"JAMA"},{"key":"80_CR13","doi-asserted-by":"crossref","first-page":"1046","DOI":"10.1056\/NEJM199704103361502","volume":"336","author":"M.L. Daviglus","year":"1997","unstructured":"Daviglus ML, Stamler J, Orencia AJ, et al.: Fish consumption and the 30-year risk of fatal myocardial infarction. N Engl J Med 1997, 336:1046\u20131053.","journal-title":"N Engl J Med"},{"key":"80_CR14","doi-asserted-by":"crossref","first-page":"437","DOI":"10.1161\/01.CIR.97.5.437","volume":"97","author":"K. Robinson","year":"1998","unstructured":"Robinson K, Arheart K, Refsum H, et al.: Low circulating folate and vitamin B6 concentrations: risk factors for stroke, peripheral vascular disease and coronary heart disease. Circulation 1998, 97:437\u2013443.","journal-title":"Circulation"},{"key":"80_CR15","doi-asserted-by":"crossref","first-page":"1929","DOI":"10.1001\/jama.1996.03530480071044","volume":"275","author":"M.J. Stampfer","year":"1996","unstructured":"Stampfer MJ, Rimm EB: Folate and cardiovascular disease: why we need a trial now. JAMA 1996, 275:1929\u20131930.","journal-title":"JAMA"},{"key":"80_CR16","doi-asserted-by":"crossref","first-page":"108","DOI":"10.1161\/01.CIR.97.1.108","volume":"97","author":"R.M. Wever","year":"1998","unstructured":"Wever RM, L\u00fcscher TF, Cosentino F, Rabelink TJ: Atherosclerosis and the two faces of endothelial nitric oxide synthase. Circulation 1998, 97:108\u2013112.","journal-title":"Circulation"},{"key":"80_CR17","doi-asserted-by":"crossref","first-page":"1103","DOI":"10.1016\/S0735-1097(96)00280-X","volume":"28","author":"M. Lorgeril de","year":"1996","unstructured":"de Lorgeril M, Salen P, Martin JL, et al.: Effect of a Mediterranean-type of diet on the rate of cardiovascular complications in coronary patients. Insights into the cardioprotective effect of certain nutriments. J Am Coll Cardiol 1996, 28:1103\u20131108.","journal-title":"J Am Coll Cardiol"},{"key":"80_CR18","doi-asserted-by":"crossref","first-page":"779","DOI":"10.1161\/01.CIR.99.6.779","volume":"99","author":"M. Lorgeril de","year":"1999","unstructured":"de Lorgeril M, Salen P, Martin JL, et al.: Mediterranean diet, traditional risk factors and the rate of cardiovascular complications after myocardial infarction. Final report of the Lyon Diet Heart Study. Circulation 1999, 99:779\u2013785.","journal-title":"Circulation"},{"key":"80_CR19","doi-asserted-by":"crossref","first-page":"116","DOI":"10.1038\/sj.ejcn.1600374","volume":"51","author":"M. Lorgeril de","year":"1997","unstructured":"de Lorgeril M, Salen P, Caillat-Vallet E, et al.: Control of bias in dietary trial to prevent coronary recurrences. The Lyon Diet Heart Study. Eur J Clin Nutr 1997, 51:116\u2013122.","journal-title":"Eur J Clin Nutr"},{"key":"80_CR20","doi-asserted-by":"crossref","first-page":"1181","DOI":"10.1001\/archinte.158.11.1181","volume":"158","author":"M. Lorgeril de","year":"1998","unstructured":"de Lorgeril M, Salen P, Martin JL: Mediterranean dietary pattern in a randomized trial: Prolonged survival and possible reduced cancer rate. Arch Intern Med 1998, 158:1181\u20131187.","journal-title":"Arch Intern Med"},{"key":"80_CR21","doi-asserted-by":"crossref","first-page":"1636","DOI":"10.1136\/bmj.317.7173.1636","volume":"317","author":"J.H. Cummings","year":"1998","unstructured":"Cummings JH, Bingham SA: Diet and the prevention of cancer. BMJ 1998, 317:1636\u20131640.","journal-title":"BMJ"},{"key":"80_CR22","doi-asserted-by":"crossref","unstructured":"The Women\u2019s Healthy Eating and Living (WHEL) randomized trial. Influence of a diet very high in vegetables, fruit, and fiber and low in fat on prognosis following treatment for breast cancer. JAMA 2007, 298:289\u2013298.","DOI":"10.1001\/jama.298.3.289"},{"key":"80_CR23","doi-asserted-by":"crossref","first-page":"1957","DOI":"10.1001\/jama.1996.03540240035027","volume":"276","author":"L.C. Clark","year":"1996","unstructured":"Clark LC, Combs GF, Turnbull BW, et al.: Effects of selenium supplementation for cancer prevention in patients with carcinoma of the skin: a randomized controlled trial. JAMA 1996, 276:1957\u20131963.","journal-title":"JAMA"},{"key":"80_CR24","doi-asserted-by":"crossref","first-page":"2425","DOI":"10.1016\/j.ejca.2005.10.016","volume":"42","author":"J.A. Menendez","year":"2006","unstructured":"Menendez JA, Papadimitropoulou A, Vellon R, et al.: A genomic explanation connecting \u201cMediterranean diet\u201d, olive oil and cancer: oleic acid, the main monounsaturated fatty acid of olive oil, induces formation of inhibitory \u201cPEA3 transcription factor-PEA3 DNA binding site\u201d complexes at the Her-2\/neu (erbB-2) oncogene promoter in breast, ovarian and stomach cancer cells. Eur J Cancer 2006, 42:2425\u20132432.","journal-title":"Eur J Cancer"},{"key":"80_CR25","doi-asserted-by":"crossref","first-page":"374","DOI":"10.1111\/j.1753-4887.2005.tb00374.x","volume":"63","author":"Y.Z. Hashim","year":"2005","unstructured":"Hashim YZ, Eng M, Gill CI, et al.: Components of olive oil and chemoprevention of colorectal cancer. Nutr Rev 2005, 63:374\u2013386.","journal-title":"Nutr Rev"},{"key":"80_CR26","doi-asserted-by":"crossref","first-page":"403","DOI":"10.1001\/jama.295.4.403","volume":"295","author":"C.H. MacLean","year":"2006","unstructured":"MacLean CH, Newberry SJ, Mojica WA, et al.: Effects of omega-3 fatty acids on cancer risk. A systematic review. JAMA 2006, 295:403\u2013415.","journal-title":"JAMA"},{"key":"80_CR27","doi-asserted-by":"crossref","first-page":"935","DOI":"10.1093\/ajcn\/79.6.935","volume":"79","author":"S.C. Larsson","year":"2004","unstructured":"Larsson SC, Kumlin M, Ingelman-Sundberg M, et al.: Dietary long-chain n-3 fatty acids for the prevention of cancer: a review of potential mechanisms. Am J Clin Nutr 2004, 79:935\u2013945.","journal-title":"Am J Clin Nutr"},{"key":"80_CR28","doi-asserted-by":"crossref","first-page":"2461","DOI":"10.1001\/archinte.167.22.2461","volume":"167","author":"P.N. Mitrou","year":"2007","unstructured":"Mitrou PN, Kipnis V, Thiebaut AC, et al.: Mediterranean dietary pattern and prediction of all-cause mortality in a US population. Arch Intern Med 2007, 167:2461\u20132468.","journal-title":"Arch Intern Med"},{"key":"80_CR29","doi-asserted-by":"crossref","first-page":"2599","DOI":"10.1056\/NEJMoa025039","volume":"348","author":"A. Trichopoulou","year":"2003","unstructured":"Trichopoulou A, Costacou T, Barnia C, Trichopoulos D: Adherence to a Mediterranean diet and survival in a Greek population. N Engl J Med 2003, 348:2599\u20132608.","journal-title":"N Engl J Med"},{"key":"80_CR30","doi-asserted-by":"crossref","first-page":"1433","DOI":"10.1001\/jama.292.12.1433","volume":"292","author":"K.T. Knoops","year":"2004","unstructured":"Knoops KT, de Groot L, Kromhout D, et al.: Mediterranean diet, lifestyle factors, and 10-year mortality in elderly European men and women. The HALE Project. JAMA 2004, 292:1433\u20131439.","journal-title":"JAMA"},{"key":"80_CR31","doi-asserted-by":"crossref","first-page":"1823","DOI":"10.1161\/01.CIR.103.13.1823","volume":"103","author":"P. Kris-Etherton","year":"2001","unstructured":"Kris-Etherton P, Eckel RH, Howard BV, et al.: AHA Science Advisory: Lyon Diet Heart Study. Benefits of a Mediterranean-style, National Cholesterol Education Program\/American Heart Association Step I dietary pattern on cardiovascular disease. Circulation 2001, 103:1823\u20131825.","journal-title":"Circulation"},{"key":"80_CR32","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1159\/000069928","volume":"91","author":"S. Zeghichi","year":"2003","unstructured":"Zeghichi S, Kallithraka S, Simopoulos AP, Kypriotakis Z: Nutritional composition of selected wild plants in the diet of Crete. World Rev Nutr Diet 2003, 91:22\u201340.","journal-title":"World Rev Nutr Diet"},{"key":"80_CR33","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1016\/j.ahj.2007.08.009","volume":"155","author":"M. Lorgeril de","year":"2008","unstructured":"de Lorgeril M, Salen P, Martin JL, et al.: Interactions of wine drinking with omega-3 fatty acids in coronary heart disease patients. A fish-like effect of moderate wine drinking. Am Heart J 2008, 155:175\u2013181.","journal-title":"Am Heart J"},{"key":"80_CR34","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1159\/000073788","volume":"92","author":"A. Simopoulos","year":"2003","unstructured":"Simopoulos A: Importance of the ratio of omega-6\/omega-3 essential fatty acids: evolutionary aspects. World Rev Nutr Diet 2003, 92:1\u201322.","journal-title":"World Rev Nutr Diet"},{"key":"80_CR35","doi-asserted-by":"crossref","first-page":"747","DOI":"10.1093\/jn\/138.4.747","volume":"138","author":"M.C. Toufektsian","year":"2008","unstructured":"Toufektsian MC, de Lorgeril M, Nagy N, Salen P, et al.: Chronic dietary intake of plant-derived anthocyanins protects the rat heart against ischemia-reperfusion injury. J Nutr 2008, 138:747\u2013752.","journal-title":"J Nutr"},{"key":"80_CR36","doi-asserted-by":"crossref","first-page":"2437","DOI":"10.1001\/archinte.166.22.2437","volume":"166","author":"A. Castelnuovo Di","year":"2006","unstructured":"Di Castelnuovo A, Costanzo, S, Bagnardi V, et al.: Alcohol dosing and total mortality in men and women. An updated meta-analysis of 34 prospective studies. Arch Intern Med 2006, 166:2437\u20132445.","journal-title":"Arch Intern Med"},{"key":"80_CR37","doi-asserted-by":"crossref","first-page":"1465","DOI":"10.1161\/01.CIR.0000029745.63708.E9","volume":"106","author":"M. Lorgeril de","year":"2002","unstructured":"de Lorgeril M, Salen P, Martin JL, et al.: Wine drinking and risks of cardiovascular complications after recent acute myocardial infarction. Circulation 2002, 106:1465\u20131469.","journal-title":"Circulation"},{"key":"80_CR38","doi-asserted-by":"crossref","first-page":"1965","DOI":"10.1001\/jama.285.15.1965","volume":"285","author":"K.J. Mukamal","year":"2001","unstructured":"Mukamal KJ, Maclure M, Muller JE, et al.: Prior alcohol consumption and mortality following acute myocardial infarction. JAMA 2001, 285:1965\u20131970.","journal-title":"JAMA"},{"key":"80_CR39","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1093\/eurheartj\/ehm509","volume":"29","author":"I. Janszky","year":"2008","unstructured":"Janszky I, Ljung R, Ahnve S, et al.: Alcohol and long-term prognosis after acute myocardial infarction. The SHEEP study. Eur Heart J 2008, 29:45\u201353.","journal-title":"Eur Heart J"},{"key":"80_CR40","doi-asserted-by":"crossref","first-page":"561","DOI":"10.1016\/j.yjmcc.2004.02.003","volume":"36","author":"A. Guiraud","year":"2004","unstructured":"Guiraud A, de Lorgeril M, Boucher F, et al.: Cardioprotective effect of chronic low dose ethanol drinking: insights into the concept of ethanol preconditioning. J Mol Cell Cardiol 2004, 36:561\u2013566.","journal-title":"J Mol Cell Cardiol"},{"key":"80_CR41","doi-asserted-by":"crossref","first-page":"944","DOI":"10.1161\/01.CIR.100.9.944","volume":"100","author":"C.M. Albert","year":"1999","unstructured":"Albert CM, Manson JE, Cook NR, et al.: Moderate alcohol consumption and the risk of sudden cardiac death among US male physicians. Circulation 1999, 100:944\u2013950.","journal-title":"Circulation"},{"key":"80_CR42","doi-asserted-by":"crossref","first-page":"2158","DOI":"10.1161\/hc4301.098254","volume":"104","author":"Z.J. Zheng","year":"2001","unstructured":"Zheng ZJ, Croft JB, Giles WH, Mensah GA: Sudden cardiac death in the United States, 1989 to 1998. Circulation 2001, 104:2158\u20132163.","journal-title":"Circulation"},{"key":"80_CR43","doi-asserted-by":"crossref","first-page":"e184","DOI":"10.1371\/journal.pmed.0040184","volume":"4","author":"L. Bero","year":"2007","unstructured":"Bero L, Oostvogel F, Bacchetti P, Lee K: Factors associated with findings of published trials of drug-drug comparisons: why some statins appear more efficacious than others. PLoS Med 2007, 4:e184.","journal-title":"PLoS Med"},{"key":"80_CR44","doi-asserted-by":"crossref","first-page":"387","DOI":"10.1016\/j.numecd.2006.05.004","volume":"6","author":"M. Lorgeril de","year":"2006","unstructured":"de Lorgeril M, Salen P: Cholesterol lowering and mortality: time for a new paradigm? Nutr Metab Cardiovasc Dis 2006, 6:387\u2013390.","journal-title":"Nutr Metab Cardiovasc Dis"},{"key":"80_CR45","first-page":"213","volume":"62","author":"T.E. Strandberg","year":"2007","unstructured":"Strandberg TE, Strandberg AY, Salomaa VV, et al.: Alcoholic beverage preference, 29-year mortality, and quality of life in men in old age. J Gerontology 2007, 62:213\u2013218.","journal-title":"J Gerontology"},{"key":"80_CR46","doi-asserted-by":"crossref","first-page":"2836","DOI":"10.1161\/01.CIR.0000018653.19696.01","volume":"105","author":"A. Castelnuovo Di","year":"2002","unstructured":"Di Castelnuovo A, Rotondo S, Iacoviello L, et al.: Metaanalysis of wine and beer consumption in relation to vascular risk. Circulation 2002, 105:2836\u20132844.","journal-title":"Circulation"}],"container-title":["Current Atherosclerosis Reports"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s11883-008-0080-5.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s11883-008-0080-5\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s11883-008-0080-5","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,6,1]],"date-time":"2019-06-01T23:35:34Z","timestamp":1559432134000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s11883-008-0080-5"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2008,11,25]]},"references-count":46,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2008,12]]}},"alternative-id":["80"],"URL":"https:\/\/doi.org\/10.1007\/s11883-008-0080-5","relation":{},"ISSN":["1523-3804","1534-6242"],"issn-type":[{"value":"1523-3804","type":"print"},{"value":"1534-6242","type":"electronic"}],"subject":[],"published":{"date-parts":[[2008,11,25]]}}}